| UniProt: | P33590 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12075 | ||
| Length: | 524 (492) | ||
| Sequences: | 9570 | ||
| Seq/Len: | 19.45 |
| NIKA
Paralog alert: 0.87 [within 20: 0.29] - ratio of genomes with paralogs Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 190_Q | 201_V | 4.629 | 1.00 | |
| 286_A | 343_K | 4.016 | 1.00 | |
| 136_S | 139_E | 3.929 | 1.00 | |
| 298_K | 302_D | 3.866 | 1.00 | |
| 135_L | 141_Q | 3.817 | 1.00 | |
| 336_K | 339_A | 3.737 | 1.00 | |
| 133_K | 141_Q | 3.718 | 1.00 | |
| 91_D | 138_T | 3.589 | 1.00 | |
| 455_K | 459_E | 3.383 | 1.00 | |
| 188_I | 201_V | 3.349 | 1.00 | |
| 463_T | 468_Q | 3.27 | 1.00 | |
| 107_A | 111_R | 3.18 | 1.00 | |
| 107_A | 134_A | 3.048 | 1.00 | |
| 75_S | 88_T | 2.995 | 1.00 | |
| 291_L | 386_M | 2.913 | 1.00 | |
| 339_A | 343_K | 2.882 | 1.00 | |
| 280_A | 283_N | 2.866 | 1.00 | |
| 452_L | 455_K | 2.855 | 1.00 | |
| 296_N | 299_S | 2.837 | 1.00 | |
| 104_E | 134_A | 2.837 | 1.00 | |
| 77_T | 88_T | 2.81 | 1.00 | |
| 293_Y | 336_K | 2.81 | 1.00 | |
| 63_Q | 67_S | 2.742 | 1.00 | |
| 285_L | 289_E | 2.594 | 1.00 | |
| 60_V | 76_W | 2.588 | 1.00 | |
| 468_Q | 471_A | 2.578 | 1.00 | |
| 286_A | 340_L | 2.54 | 1.00 | |
| 101_F | 184_T | 2.53 | 1.00 | |
| 450_K | 483_E | 2.529 | 1.00 | |
| 286_A | 289_E | 2.494 | 1.00 | |
| 387_R | 392_D | 2.464 | 1.00 | |
| 84_T | 141_Q | 2.41 | 1.00 | |
| 133_K | 143_T | 2.381 | 1.00 | |
| 363_R | 394_S | 2.368 | 1.00 | |
| 79_S | 83_K | 2.359 | 1.00 | |
| 465_D | 468_Q | 2.318 | 1.00 | |
| 452_L | 475_D | 2.314 | 1.00 | |
| 84_T | 143_T | 2.311 | 1.00 | |
| 86_T | 141_Q | 2.289 | 1.00 | |
| 450_K | 479_R | 2.289 | 1.00 | |
| 94_K | 100_P | 2.285 | 1.00 | |
| 188_I | 204_E | 2.283 | 1.00 | |
| 110_F | 142_I | 2.281 | 1.00 | |
| 63_Q | 69_I | 2.254 | 1.00 | |
| 88_T | 139_E | 2.248 | 1.00 | |
| 93_V | 101_F | 2.244 | 1.00 | |
| 96_S | 203_N | 2.242 | 1.00 | |
| 74_K | 91_D | 2.241 | 1.00 | |
| 78_H | 85_W | 2.22 | 1.00 | |
| 27_E | 215_K | 2.215 | 1.00 | |
| 459_E | 472_L | 2.208 | 1.00 | |
| 130_V | 145_K | 2.165 | 1.00 | |
| 199_V | 215_K | 2.159 | 1.00 | |
| 94_K | 205_N | 2.158 | 1.00 | |
| 106_A | 140_L | 2.15 | 1.00 | |
| 471_A | 475_D | 2.134 | 1.00 | |
| 187_W | 213_I | 2.133 | 1.00 | |
| 361_P | 392_D | 2.122 | 1.00 | |
| 363_R | 392_D | 2.097 | 1.00 | |
| 102_D | 105_A | 2.083 | 1.00 | |
| 275_L | 487_L | 2.039 | 1.00 | |
| 289_E | 336_K | 2.02 | 1.00 | |
| 279_K | 413_G | 1.995 | 1.00 | |
| 57_E | 71_W | 1.969 | 1.00 | |
| 453_I | 476_I | 1.946 | 1.00 | |
| 40_N | 112_A | 1.943 | 1.00 | |
| 478_T | 482_D | 1.934 | 1.00 | |
| 104_E | 137_K | 1.907 | 1.00 | |
| 456_E | 475_D | 1.89 | 1.00 | |
| 27_E | 217_T | 1.888 | 1.00 | |
| 92_D | 100_P | 1.886 | 1.00 | |
| 312_A | 491_Y | 1.879 | 1.00 | |
| 230_A | 235_D | 1.877 | 1.00 | |
| 193_K | 196_Q | 1.864 | 1.00 | |
| 460_V | 473_Y | 1.852 | 1.00 | |
| 31_A | 236_I | 1.832 | 1.00 | |
| 291_L | 391_A | 1.831 | 1.00 | |
| 365_E | 396_I | 1.828 | 1.00 | |
| 275_L | 414_M | 1.825 | 1.00 | |
| 191_E | 199_V | 1.821 | 1.00 | |
| 104_E | 107_A | 1.807 | 1.00 | |
| 472_L | 475_D | 1.782 | 1.00 | |
| 475_D | 478_T | 1.77 | 1.00 | |
| 74_K | 88_T | 1.762 | 1.00 | |
| 295_V | 382_I | 1.762 | 1.00 | |
| 292_N | 484_A | 1.745 | 1.00 | |
| 76_W | 87_F | 1.741 | 1.00 | |
| 201_V | 215_K | 1.727 | 1.00 | |
| 383_Q | 387_R | 1.726 | 1.00 | |
| 342_E | 355_R | 1.724 | 1.00 | |
| 460_V | 472_L | 1.724 | 1.00 | |
| 131_D | 143_T | 1.705 | 1.00 | |
| 191_E | 197_Y | 1.699 | 1.00 | |
| 333_D | 336_K | 1.699 | 1.00 | |
| 285_L | 483_E | 1.696 | 1.00 | |
| 202_R | 214_K | 1.683 | 1.00 | |
| 60_V | 87_F | 1.68 | 1.00 | |
| 29_T | 217_T | 1.679 | 1.00 | |
| 190_Q | 215_K | 1.676 | 1.00 | |
| 451_P | 455_K | 1.672 | 1.00 | |
| 259_A | 500_P | 1.67 | 1.00 | |
| 282_T | 291_L | 1.657 | 1.00 | |
| 287_V | 344_A | 1.642 | 1.00 | |
| 232_E | 253_R | 1.639 | 1.00 | |
| 459_E | 468_Q | 1.636 | 1.00 | |
| 103_A | 134_A | 1.626 | 1.00 | |
| 338_K | 342_E | 1.623 | 1.00 | |
| 365_E | 394_S | 1.608 | 1.00 | |
| 26_D | 214_K | 1.605 | 1.00 | |
| 93_V | 184_T | 1.593 | 1.00 | |
| 167_S | 171_N | 1.586 | 1.00 | |
| 452_L | 479_R | 1.583 | 1.00 | |
| 221_I | 230_A | 1.577 | 1.00 | |
| 193_K | 197_Y | 1.573 | 1.00 | |
| 298_K | 311_V | 1.572 | 1.00 | |
| 294_A | 389_I | 1.571 | 1.00 | |
| 79_S | 86_T | 1.561 | 1.00 | |
| 406_R | 411_R | 1.553 | 1.00 | |
| 79_S | 84_T | 1.548 | 1.00 | |
| 456_E | 472_L | 1.545 | 1.00 | |
| 436_P | 449_D | 1.538 | 1.00 | |
| 287_V | 341_L | 1.535 | 1.00 | |
| 342_E | 347_T | 1.532 | 1.00 | |
| 340_L | 343_K | 1.525 | 1.00 | |
| 74_K | 90_R | 1.517 | 1.00 | |
| 405_A | 409_D | 1.511 | 1.00 | |
| 102_D | 137_K | 1.511 | 1.00 | |
| 96_S | 188_I | 1.509 | 1.00 | |
| 425_D | 469_R | 1.508 | 1.00 | |
| 301_I | 311_V | 1.505 | 1.00 | |
| 335_Q | 338_K | 1.501 | 1.00 | |
| 471_A | 474_R | 1.491 | 1.00 | |
| 142_I | 151_F | 1.484 | 1.00 | |
| 468_Q | 472_L | 1.463 | 1.00 | |
| 479_R | 483_E | 1.462 | 1.00 | |
| 252_A | 255_S | 1.461 | 1.00 | |
| 197_Y | 217_T | 1.453 | 1.00 | |
| 399_E | 402_S | 1.449 | 1.00 | |
| 470_Q | 474_R | 1.448 | 1.00 | |
| 135_L | 139_E | 1.446 | 1.00 | |
| 86_T | 139_E | 1.44 | 1.00 | |
| 100_P | 138_T | 1.43 | 1.00 | |
| 289_E | 484_A | 1.42 | 1.00 | |
| 90_R | 93_V | 1.415 | 1.00 | |
| 57_E | 184_T | 1.413 | 1.00 | |
| 199_V | 217_T | 1.405 | 0.99 | |
| 282_T | 364_I | 1.373 | 0.99 | |
| 230_A | 236_I | 1.371 | 0.99 | |
| 456_E | 479_R | 1.37 | 0.99 | |
| 285_L | 482_D | 1.369 | 0.99 | |
| 57_E | 207_W | 1.365 | 0.99 | |
| 130_V | 143_T | 1.362 | 0.99 | |
| 200_F | 218_F | 1.36 | 0.99 | |
| 88_T | 138_T | 1.352 | 0.99 | |
| 46_P | 49_M | 1.351 | 0.99 | |
| 134_A | 137_K | 1.35 | 0.99 | |
| 463_T | 472_L | 1.345 | 0.99 | |
| 449_D | 454_D | 1.342 | 0.99 | |
| 94_K | 203_N | 1.338 | 0.99 | |
| 339_A | 342_E | 1.323 | 0.99 | |
| 261_H | 500_P | 1.322 | 0.99 | |
| 447_L | 483_E | 1.319 | 0.99 | |
| 103_A | 135_L | 1.31 | 0.99 | |
| 237_D | 499_K | 1.299 | 0.99 | |
| 376_K | 380_E | 1.297 | 0.99 | |
| 385_D | 388_Q | 1.292 | 0.99 | |
| 334_P | 389_I | 1.291 | 0.99 | |
| 436_P | 454_D | 1.28 | 0.99 | |
| 96_S | 189_L | 1.279 | 0.99 | |
| 88_T | 91_D | 1.272 | 0.99 | |
| 261_H | 498_S | 1.271 | 0.99 | |
| 226_T | 230_A | 1.27 | 0.99 | |
| 85_W | 151_F | 1.268 | 0.99 | |
| 279_K | 283_N | 1.258 | 0.99 | |
| 289_E | 340_L | 1.258 | 0.99 | |
| 202_R | 211_P | 1.248 | 0.99 | |
| 29_T | 219_N | 1.24 | 0.98 | |
| 381_I | 385_D | 1.235 | 0.98 | |
| 201_V | 204_E | 1.23 | 0.98 | |
| 107_A | 132_V | 1.222 | 0.98 | |
| 335_Q | 339_A | 1.221 | 0.98 | |
| 70_P | 76_W | 1.22 | 0.98 | |
| 166_P | 170_K | 1.217 | 0.98 | |
| 318_P | 491_Y | 1.212 | 0.98 | |
| 455_K | 458_G | 1.212 | 0.98 | |
| 72_L | 184_T | 1.21 | 0.98 | |
| 31_A | 227_R | 1.209 | 0.98 | |
| 88_T | 136_S | 1.204 | 0.98 | |
| 396_I | 406_R | 1.2 | 0.98 | |
| 452_L | 456_E | 1.195 | 0.98 | |
| 190_Q | 199_V | 1.191 | 0.98 | |
| 456_E | 459_E | 1.179 | 0.98 | |
| 334_P | 338_K | 1.178 | 0.98 | |
| 79_S | 82_G | 1.174 | 0.98 | |
| 146_S | 462_A | 1.171 | 0.98 | |
| 96_S | 205_N | 1.17 | 0.97 | |
| 28_I | 502_L | 1.168 | 0.97 | |
| 293_Y | 330_S | 1.153 | 0.97 | |
| 383_Q | 395_L | 1.151 | 0.97 | |
| 231_F | 497_V | 1.151 | 0.97 | |
| 132_V | 140_L | 1.143 | 0.97 | |
| 87_F | 142_I | 1.139 | 0.97 | |
| 294_A | 386_M | 1.137 | 0.97 | |
| 61_K | 69_I | 1.137 | 0.97 | |
| 74_K | 138_T | 1.125 | 0.97 | |
| 386_M | 393_V | 1.124 | 0.97 | |
| 305_L | 309_Q | 1.123 | 0.97 | |
| 90_R | 207_W | 1.121 | 0.97 | |
| 100_P | 137_K | 1.119 | 0.96 | |
| 459_E | 475_D | 1.118 | 0.96 | |
| 299_S | 385_D | 1.117 | 0.96 | |
| 292_N | 297_K | 1.115 | 0.96 | |
| 275_L | 291_L | 1.113 | 0.96 | |
| 86_T | 135_L | 1.112 | 0.96 | |
| 300_L | 378_M | 1.109 | 0.96 | |
| 400_E | 404_Y | 1.105 | 0.96 | |
| 301_I | 309_Q | 1.099 | 0.96 | |
| 165_A | 168_Q | 1.098 | 0.96 | |
| 459_E | 463_T | 1.098 | 0.96 | |
| 35_N | 192_S | 1.092 | 0.96 | |
| 58_P | 71_W | 1.085 | 0.96 | |
| 61_K | 71_W | 1.08 | 0.95 | |
| 237_D | 501_E | 1.08 | 0.95 | |
| 467_T | 470_Q | 1.079 | 0.95 | |
| 105_A | 109_N | 1.075 | 0.95 | |
| 28_I | 213_I | 1.067 | 0.95 | |
| 85_W | 152_L | 1.061 | 0.95 | |
| 368_F | 395_L | 1.054 | 0.95 | |
| 29_T | 237_D | 1.048 | 0.94 | |
| 347_T | 360_Q | 1.048 | 0.94 | |
| 95_F | 105_A | 1.046 | 0.94 | |
| 338_K | 348_L | 1.046 | 0.94 | |
| 264_L | 493_S | 1.045 | 0.94 | |
| 315_L | 488_P | 1.043 | 0.94 | |
| 382_I | 386_M | 1.04 | 0.94 | |
| 232_E | 257_N | 1.033 | 0.94 | |
| 202_R | 210_K | 1.027 | 0.94 | |
| 28_I | 238_L | 1.025 | 0.93 | |
| 285_L | 484_A | 1.02 | 0.93 | |
| 111_R | 134_A | 1.017 | 0.93 | |
| 26_D | 212_A | 1.008 | 0.93 | |
| 77_T | 86_T | 1.007 | 0.93 | |
| 442_Q | 446_G | 1.006 | 0.93 | |
| 188_I | 203_N | 1.006 | 0.93 | |
| 221_I | 236_I | 1.005 | 0.93 | |
| 111_R | 115_D | 1.003 | 0.93 | |
| 286_A | 344_A | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2nooA | 1 | 0.958 | 100 | 0.141 | Contact Map | 0.754 |
| 1xocA | 1 | 0.9523 | 100 | 0.156 | Contact Map | 0.755 |
| 1uqwA | 2 | 0.9504 | 100 | 0.18 | Contact Map | 0.776 |
| 3zs6A | 1 | 0.9141 | 100 | 0.184 | Contact Map | 0.776 |
| 3o9pA | 1 | 0.9332 | 100 | 0.185 | Contact Map | 0.744 |
| 3drfA | 1 | 0.9485 | 100 | 0.188 | Contact Map | 0.701 |
| 4fajA | 1 | 0.9466 | 100 | 0.188 | Contact Map | 0.72 |
| 3m8uA | 1 | 0.916 | 100 | 0.19 | Contact Map | 0.795 |
| 3t66A | 1 | 0.9256 | 100 | 0.192 | Contact Map | 0.669 |
| 1dpeA | 1 | 0.9084 | 100 | 0.193 | Contact Map | 0.795 |
Sequence Conservation (Image Generated using WebLogo v3)