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SGRR - HTH-type transcriptional regulator SgrR
UniProt: P33595 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12094
Length: 551 (431)
Sequences: 5340
Seq/Len: 12.39
SGRR
Paralog alert: 0.72 [within 20: 0.22] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
274_I 284_Q 4.4 1.00
363_T 367_Y 4.295 1.00
224_T 227_T 4.232 1.00
351_Q 398_P 4.125 1.00
221_V 229_D 3.838 1.00
186_P 226_W 3.709 1.00
393_I 396_E 3.705 1.00
223_P 229_D 3.682 1.00
485_W 489_A 3.54 1.00
272_A 284_Q 3.432 1.00
173_Q 183_F 3.057 1.00
202_I 222_S 3.038 1.00
171_H 183_F 3.038 1.00
356_V 426_L 3.015 1.00
158_N 163_E 2.95 1.00
202_I 206_K 2.858 1.00
351_Q 354_D 2.81 1.00
482_P 485_W 2.778 1.00
345_H 348_A 2.772 1.00
199_D 222_S 2.762 1.00
253_R 257_T 2.695 1.00
205_L 230_I 2.62 1.00
272_A 287_D 2.612 1.00
350_Q 354_D 2.604 1.00
361_S 364_N 2.595 1.00
158_N 165_E 2.588 1.00
179_H 231_H 2.584 1.00
405_T 434_K 2.536 1.00
495_G 498_N 2.521 1.00
271_Y 296_I 2.507 1.00
196_L 268_T 2.501 1.00
529_R 547_A 2.474 1.00
170_H 186_P 2.459 1.00
427_A 432_T 2.452 1.00
358_Y 393_I 2.439 1.00
188_V 196_L 2.402 1.00
155_T 172_W 2.401 1.00
405_T 432_T 2.397 1.00
221_V 231_H 2.324 1.00
179_H 229_D 2.306 1.00
183_F 227_T 2.305 1.00
340_F 513_V 2.304 1.00
529_R 545_W 2.297 1.00
121_I 298_E 2.242 1.00
192_H 252_P 2.138 1.00
356_V 431_V 2.118 1.00
189_H 195_E 2.117 1.00
134_L 207_R 2.115 1.00
482_P 502_W 2.102 1.00
189_H 288_D 2.095 1.00
194_R 254_E 2.077 1.00
140_R 143_E 2.065 1.00
158_N 161_N 2.061 1.00
187_G 195_E 1.985 1.00
201_V 228_L 1.967 1.00
218_A 233_T 1.961 1.00
354_D 393_I 1.95 1.00
498_N 502_W 1.946 1.00
200_D 253_R 1.945 1.00
197_E 200_D 1.942 1.00
282_K 298_E 1.903 1.00
199_D 253_R 1.901 1.00
199_D 225_P 1.898 1.00
498_N 501_N 1.893 1.00
340_F 452_I 1.849 1.00
502_W 505_Q 1.848 1.00
121_I 300_N 1.842 1.00
347_G 356_V 1.831 1.00
191_H 286_F 1.826 1.00
152_S 167_D 1.826 1.00
194_R 252_P 1.805 1.00
199_D 202_I 1.787 1.00
230_I 239_L 1.771 1.00
295_L 545_W 1.771 1.00
181_R 229_D 1.762 1.00
380_A 517_H 1.756 1.00
198_M 222_S 1.748 1.00
489_A 495_G 1.746 1.00
505_Q 509_S 1.732 1.00
172_W 182_F 1.721 1.00
486_Q 502_W 1.719 1.00
344_T 451_D 1.712 1.00
489_A 499_L 1.708 1.00
125_L 315_L 1.7 1.00
490_A 499_L 1.695 1.00
347_G 406_L 1.682 1.00
123_R 300_N 1.682 1.00
170_H 183_F 1.681 1.00
188_V 268_T 1.681 1.00
174_Q 178_L 1.677 1.00
423_Q 427_A 1.606 1.00
352_V 399_A 1.594 1.00
480_C 510_K 1.584 1.00
276_N 279_N 1.565 1.00
499_L 502_W 1.559 1.00
120_H 297_D 1.554 1.00
155_T 182_F 1.539 1.00
274_I 298_E 1.525 1.00
407_T 434_K 1.523 1.00
360_L 422_M 1.514 1.00
223_P 227_T 1.498 1.00
219_D 231_H 1.492 1.00
180_W 239_L 1.48 1.00
390_A 393_I 1.467 1.00
276_N 280_Q 1.466 1.00
407_T 436_K 1.461 1.00
357_S 511_A 1.457 1.00
181_R 227_T 1.452 1.00
152_S 290_F 1.448 1.00
284_Q 298_E 1.428 1.00
185_R 188_V 1.394 0.99
486_Q 499_L 1.392 0.99
170_H 185_R 1.386 0.99
285_A 297_D 1.376 0.99
479_H 510_K 1.373 0.99
350_Q 509_S 1.368 0.99
483_I 503_C 1.361 0.99
480_C 506_L 1.355 0.99
446_G 449_E 1.345 0.99
495_G 499_L 1.339 0.99
363_T 379_P 1.339 0.99
486_Q 489_A 1.334 0.99
324_E 526_R 1.315 0.99
197_E 225_P 1.313 0.99
252_P 255_W 1.311 0.99
201_V 250_I 1.301 0.99
406_L 433_L 1.299 0.99
282_K 300_N 1.293 0.99
490_A 500_A 1.29 0.99
168_I 268_T 1.289 0.99
392_T 395_S 1.285 0.99
202_I 220_I 1.281 0.99
198_M 223_P 1.275 0.99
359_V 429_H 1.27 0.99
183_F 186_P 1.265 0.99
191_H 272_A 1.255 0.99
416_R 420_G 1.249 0.99
195_E 226_W 1.249 0.99
403_S 432_T 1.246 0.98
202_I 228_L 1.246 0.98
497_M 501_N 1.244 0.98
421_I 425_I 1.24 0.98
183_F 224_T 1.237 0.98
122_L 528_M 1.232 0.98
125_L 310_E 1.232 0.98
183_F 226_W 1.231 0.98
283_I 301_V 1.226 0.98
366_V 379_P 1.225 0.98
339_L 453_W 1.214 0.98
168_I 201_V 1.208 0.98
359_V 426_L 1.201 0.98
284_Q 287_D 1.183 0.98
192_H 254_E 1.165 0.97
482_P 506_L 1.163 0.97
180_W 240_P 1.159 0.97
326_E 526_R 1.159 0.97
185_R 290_F 1.152 0.97
222_S 225_P 1.15 0.97
316_M 525_Q 1.148 0.97
483_I 507_V 1.147 0.97
391_R 395_S 1.143 0.97
482_P 486_Q 1.136 0.97
506_L 510_K 1.133 0.97
232_L 239_L 1.126 0.97
166_A 172_W 1.119 0.96
386_R 517_H 1.118 0.96
472_C 484_D 1.117 0.96
280_Q 300_N 1.115 0.96
439_D 442_Q 1.111 0.96
218_A 231_H 1.11 0.96
191_H 273_V 1.106 0.96
528_M 546_F 1.103 0.96
304_L 315_L 1.103 0.96
152_S 268_T 1.098 0.96
291_G 542_K 1.098 0.96
365_L 418_I 1.096 0.96
392_T 396_E 1.095 0.96
156_R 165_E 1.093 0.96
174_Q 181_R 1.093 0.96
344_T 348_A 1.087 0.96
499_L 503_C 1.078 0.95
280_Q 302_W 1.078 0.95
472_C 479_H 1.076 0.95
440_Y 444_H 1.068 0.95
285_A 294_A 1.067 0.95
423_Q 435_I 1.065 0.95
182_F 230_I 1.064 0.95
459_F 462_P 1.063 0.95
174_Q 177_P 1.062 0.95
357_S 362_P 1.058 0.95
197_E 253_R 1.054 0.95
350_Q 510_K 1.054 0.95
203_A 253_R 1.05 0.94
181_R 223_P 1.05 0.94
436_K 446_G 1.048 0.94
474_V 477_L 1.041 0.94
206_K 222_S 1.036 0.94
329_S 519_W 1.036 0.94
334_G 458_N 1.03 0.94
123_R 302_W 1.026 0.94
419_A 435_I 1.026 0.94
485_W 488_D 1.024 0.93
220_I 230_I 1.023 0.93
360_L 365_L 1.022 0.93
156_R 167_D 1.021 0.93
391_R 429_H 1.017 0.93
440_Y 443_W 1.014 0.93
153_S 249_M 1.014 0.93
200_D 204_S 1.013 0.93
478_Q 510_K 1.012 0.93
220_I 228_L 1.011 0.93
461_L 496_E 1.009 0.93
255_W 266_I 1.006 0.93
150_I 273_V 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3m8uA10.78041000.411Contact Map0.807
1uqwA20.80761000.413Contact Map0.794
1dpeA10.76951000.414Contact Map0.806
3zs6A10.7751000.415Contact Map0.772
3tpaA10.78951000.416Contact Map0.782
4gl8A20.81491000.42Contact Map0.776
1xocA10.80221000.42Contact Map0.768
3o9pA10.79851000.421Contact Map0.769
1jetA10.79131000.424Contact Map0.822
4fajA10.85841000.429Contact Map0.768
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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