| UniProt: | P23847 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10248 | ||
| Length: | 535 (501) | ||
| Sequences: | 9386 | ||
| Seq/Len: | 18.73 |
| DPPA
Paralog alert: 0.87 [within 20: 0.29] - ratio of genomes with paralogs Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 216_Q | 227_K | 4.55 | 1.00 | |
| 103_D | 111_R | 4.404 | 1.00 | |
| 308_K | 365_E | 4.03 | 1.00 | |
| 320_D | 324_K | 3.876 | 1.00 | |
| 159_D | 162_T | 3.874 | 1.00 | |
| 158_V | 164_Q | 3.791 | 1.00 | |
| 358_K | 361_A | 3.723 | 1.00 | |
| 156_K | 164_Q | 3.678 | 1.00 | |
| 97_K | 161_N | 3.499 | 1.00 | |
| 469_D | 473_P | 3.31 | 1.00 | |
| 477_T | 482_K | 3.299 | 1.00 | |
| 214_Q | 227_K | 3.267 | 1.00 | |
| 119_V | 123_D | 3.149 | 1.00 | |
| 462_W | 497_Q | 3.067 | 1.00 | |
| 450_C | 463_C | 2.995 | 1.00 | |
| 119_V | 157_K | 2.989 | 1.00 | |
| 81_K | 94_H | 2.988 | 1.00 | |
| 466_P | 469_D | 2.891 | 1.00 | |
| 313_L | 400_W | 2.889 | 1.00 | |
| 373_S | 406_Q | 2.877 | 1.00 | |
| 361_A | 365_E | 2.869 | 1.00 | |
| 302_K | 305_D | 2.8 | 1.00 | |
| 116_D | 157_K | 2.767 | 1.00 | |
| 68_K | 73_E | 2.749 | 1.00 | |
| 315_Y | 358_K | 2.738 | 1.00 | |
| 83_E | 94_H | 2.726 | 1.00 | |
| 318_N | 321_A | 2.721 | 1.00 | |
| 450_C | 468_E | 2.68 | 1.00 | |
| 307_V | 311_Q | 2.589 | 1.00 | |
| 188_K | 192_D | 2.575 | 1.00 | |
| 65_V | 82_W | 2.551 | 1.00 | |
| 308_K | 362_L | 2.527 | 1.00 | |
| 482_K | 485_E | 2.525 | 1.00 | |
| 464_Y | 497_Q | 2.477 | 1.00 | |
| 308_K | 311_Q | 2.465 | 1.00 | |
| 401_A | 406_Q | 2.422 | 1.00 | |
| 464_Y | 493_V | 2.418 | 1.00 | |
| 113_L | 210_T | 2.39 | 1.00 | |
| 90_T | 164_Q | 2.359 | 1.00 | |
| 466_P | 489_Q | 2.358 | 1.00 | |
| 85_S | 89_K | 2.336 | 1.00 | |
| 156_K | 166_V | 2.314 | 1.00 | |
| 80_E | 97_K | 2.268 | 1.00 | |
| 92_T | 164_Q | 2.262 | 1.00 | |
| 90_T | 166_V | 2.255 | 1.00 | |
| 479_D | 482_K | 2.254 | 1.00 | |
| 214_Q | 230_D | 2.253 | 1.00 | |
| 94_H | 162_T | 2.23 | 1.00 | |
| 122_F | 165_F | 2.204 | 1.00 | |
| 375_D | 408_K | 2.195 | 1.00 | |
| 473_P | 486_L | 2.191 | 1.00 | |
| 84_V | 91_Y | 2.187 | 1.00 | |
| 68_K | 75_I | 2.185 | 1.00 | |
| 102_H | 229_F | 2.182 | 1.00 | |
| 100_K | 112_E | 2.181 | 1.00 | |
| 100_K | 231_G | 2.168 | 1.00 | |
| 99_V | 113_L | 2.152 | 1.00 | |
| 225_R | 241_T | 2.147 | 1.00 | |
| 118_V | 163_V | 2.094 | 1.00 | |
| 485_E | 489_Q | 2.067 | 1.00 | |
| 111_R | 189_E | 2.059 | 1.00 | |
| 153_S | 168_T | 2.036 | 1.00 | |
| 30_T | 241_T | 2.036 | 1.00 | |
| 213_F | 239_I | 2.034 | 1.00 | |
| 297_Y | 501_L | 2.024 | 1.00 | |
| 373_S | 408_K | 1.967 | 1.00 | |
| 297_Y | 428_T | 1.95 | 1.00 | |
| 311_Q | 358_K | 1.949 | 1.00 | |
| 114_N | 117_D | 1.932 | 1.00 | |
| 62_N | 77_G | 1.928 | 1.00 | |
| 301_K | 427_Q | 1.926 | 1.00 | |
| 43_N | 124_R | 1.91 | 1.00 | |
| 116_D | 188_K | 1.908 | 1.00 | |
| 70_G | 73_E | 1.905 | 1.00 | |
| 467_F | 490_A | 1.892 | 1.00 | |
| 492_V | 496_D | 1.842 | 1.00 | |
| 313_L | 405_V | 1.841 | 1.00 | |
| 116_D | 119_V | 1.839 | 1.00 | |
| 256_K | 261_E | 1.838 | 1.00 | |
| 117_D | 188_K | 1.828 | 1.00 | |
| 219_Q | 222_S | 1.824 | 1.00 | |
| 470_L | 489_Q | 1.824 | 1.00 | |
| 474_A | 487_Y | 1.823 | 1.00 | |
| 30_T | 243_V | 1.823 | 1.00 | |
| 98_G | 112_E | 1.819 | 1.00 | |
| 116_D | 160_D | 1.811 | 1.00 | |
| 217_Q | 225_R | 1.802 | 1.00 | |
| 334_A | 505_H | 1.767 | 1.00 | |
| 489_Q | 492_V | 1.761 | 1.00 | |
| 486_L | 489_Q | 1.756 | 1.00 | |
| 397_Q | 401_A | 1.75 | 1.00 | |
| 80_E | 94_H | 1.744 | 1.00 | |
| 314_T | 498_A | 1.713 | 1.00 | |
| 317_V | 396_I | 1.708 | 1.00 | |
| 227_K | 241_T | 1.707 | 1.00 | |
| 474_A | 486_L | 1.704 | 1.00 | |
| 281_S | 514_K | 1.701 | 1.00 | |
| 228_A | 240_D | 1.691 | 1.00 | |
| 154_E | 166_V | 1.69 | 1.00 | |
| 304_L | 313_L | 1.679 | 1.00 | |
| 34_C | 262_C | 1.667 | 1.00 | |
| 307_V | 497_Q | 1.658 | 1.00 | |
| 355_D | 358_K | 1.655 | 1.00 | |
| 217_Q | 223_R | 1.649 | 1.00 | |
| 82_W | 93_F | 1.643 | 1.00 | |
| 85_S | 92_T | 1.643 | 1.00 | |
| 65_V | 93_F | 1.64 | 1.00 | |
| 216_Q | 241_T | 1.637 | 1.00 | |
| 465_K | 469_D | 1.633 | 1.00 | |
| 360_K | 364_K | 1.624 | 1.00 | |
| 103_D | 187_S | 1.62 | 1.00 | |
| 115_A | 157_K | 1.618 | 1.00 | |
| 258_Q | 275_R | 1.612 | 1.00 | |
| 473_P | 482_K | 1.606 | 1.00 | |
| 32_V | 243_V | 1.597 | 1.00 | |
| 466_P | 493_V | 1.583 | 1.00 | |
| 219_Q | 223_R | 1.57 | 1.00 | |
| 470_L | 486_L | 1.57 | 1.00 | |
| 85_S | 90_T | 1.557 | 1.00 | |
| 316_A | 403_V | 1.546 | 1.00 | |
| 111_R | 187_S | 1.544 | 1.00 | |
| 114_N | 160_D | 1.535 | 1.00 | |
| 99_V | 210_T | 1.532 | 1.00 | |
| 364_K | 369_E | 1.529 | 1.00 | |
| 309_V | 366_A | 1.526 | 1.00 | |
| 517_K | 533_S | 1.526 | 1.00 | |
| 80_E | 96_R | 1.516 | 1.00 | |
| 375_D | 410_V | 1.514 | 1.00 | |
| 357_E | 360_K | 1.513 | 1.00 | |
| 419_K | 423_D | 1.506 | 1.00 | |
| 309_V | 363_L | 1.502 | 1.00 | |
| 485_E | 488_K | 1.5 | 1.00 | |
| 482_K | 486_L | 1.499 | 1.00 | |
| 247_T | 256_K | 1.496 | 1.00 | |
| 420_R | 425_E | 1.496 | 1.00 | |
| 362_L | 365_E | 1.493 | 1.00 | |
| 439_D | 483_R | 1.477 | 1.00 | |
| 323_I | 333_S | 1.468 | 1.00 | |
| 102_H | 214_Q | 1.458 | 1.00 | |
| 92_T | 162_T | 1.452 | 1.00 | |
| 283_N | 514_K | 1.45 | 1.00 | |
| 413_E | 416_E | 1.448 | 1.00 | |
| 158_V | 162_T | 1.445 | 1.00 | |
| 223_R | 243_V | 1.432 | 1.00 | |
| 49_S | 52_T | 1.428 | 1.00 | |
| 165_F | 174_F | 1.418 | 1.00 | |
| 463_C | 468_E | 1.414 | 1.00 | |
| 320_D | 333_S | 1.401 | 0.99 | |
| 300_Q | 461_K | 1.398 | 0.99 | |
| 238_Q | 533_S | 1.396 | 0.99 | |
| 484_V | 488_K | 1.392 | 0.99 | |
| 62_N | 210_T | 1.387 | 0.99 | |
| 274_A | 277_K | 1.384 | 0.99 | |
| 62_N | 233_W | 1.374 | 0.99 | |
| 304_L | 374_I | 1.368 | 0.99 | |
| 307_V | 496_D | 1.364 | 0.99 | |
| 311_Q | 498_A | 1.363 | 0.99 | |
| 96_R | 99_V | 1.363 | 0.99 | |
| 225_R | 243_V | 1.361 | 0.99 | |
| 112_E | 161_N | 1.355 | 0.99 | |
| 94_H | 161_N | 1.348 | 0.99 | |
| 477_T | 486_L | 1.344 | 0.99 | |
| 115_A | 158_V | 1.342 | 0.99 | |
| 493_V | 497_Q | 1.341 | 0.99 | |
| 361_A | 364_K | 1.338 | 0.99 | |
| 157_K | 160_D | 1.333 | 0.99 | |
| 390_R | 394_E | 1.328 | 0.99 | |
| 228_A | 237_P | 1.321 | 0.99 | |
| 263_Q | 513_R | 1.303 | 0.99 | |
| 470_L | 493_V | 1.302 | 0.99 | |
| 356_P | 403_V | 1.298 | 0.99 | |
| 256_K | 262_C | 1.297 | 0.99 | |
| 187_S | 190_Y | 1.293 | 0.99 | |
| 100_K | 229_F | 1.287 | 0.99 | |
| 91_Y | 174_F | 1.286 | 0.99 | |
| 449_S | 472_Q | 1.277 | 0.99 | |
| 226_Y | 244_F | 1.271 | 0.99 | |
| 283_N | 512_V | 1.246 | 0.98 | |
| 462_W | 467_F | 1.244 | 0.98 | |
| 399_D | 402_K | 1.24 | 0.98 | |
| 227_K | 230_D | 1.236 | 0.98 | |
| 94_H | 97_K | 1.229 | 0.98 | |
| 102_H | 215_L | 1.228 | 0.98 | |
| 311_Q | 362_L | 1.215 | 0.98 | |
| 469_D | 472_Q | 1.208 | 0.98 | |
| 76_P | 82_W | 1.202 | 0.98 | |
| 119_V | 155_V | 1.2 | 0.98 | |
| 466_P | 470_L | 1.199 | 0.98 | |
| 29_K | 240_D | 1.199 | 0.98 | |
| 102_H | 231_G | 1.196 | 0.98 | |
| 263_Q | 515_E | 1.195 | 0.98 | |
| 252_V | 256_K | 1.191 | 0.98 | |
| 153_S | 166_V | 1.191 | 0.98 | |
| 216_Q | 225_R | 1.19 | 0.98 | |
| 323_I | 331_G | 1.182 | 0.98 | |
| 410_V | 420_R | 1.176 | 0.98 | |
| 470_L | 473_P | 1.176 | 0.98 | |
| 103_D | 189_E | 1.172 | 0.98 | |
| 118_V | 185_I | 1.171 | 0.98 | |
| 357_E | 361_A | 1.16 | 0.97 | |
| 473_P | 477_T | 1.156 | 0.97 | |
| 424_G | 461_K | 1.153 | 0.97 | |
| 301_K | 305_D | 1.153 | 0.97 | |
| 80_E | 161_N | 1.151 | 0.97 | |
| 395_M | 399_D | 1.15 | 0.97 | |
| 356_P | 360_K | 1.14 | 0.97 | |
| 327_Y | 331_G | 1.136 | 0.97 | |
| 169_R | 476_A | 1.135 | 0.97 | |
| 78_L | 210_T | 1.135 | 0.97 | |
| 228_A | 236_K | 1.132 | 0.97 | |
| 414_W | 418_L | 1.13 | 0.97 | |
| 315_Y | 352_Y | 1.128 | 0.97 | |
| 340_P | 505_H | 1.128 | 0.97 | |
| 94_H | 159_D | 1.128 | 0.97 | |
| 32_V | 245_S | 1.125 | 0.97 | |
| 85_S | 88_G | 1.123 | 0.97 | |
| 473_P | 489_Q | 1.106 | 0.96 | |
| 296_S | 429_V | 1.103 | 0.96 | |
| 400_W | 407_A | 1.102 | 0.96 | |
| 112_E | 160_D | 1.101 | 0.96 | |
| 321_A | 399_D | 1.098 | 0.96 | |
| 31_L | 516_V | 1.093 | 0.96 | |
| 92_T | 158_V | 1.092 | 0.96 | |
| 322_I | 392_M | 1.092 | 0.96 | |
| 93_F | 165_F | 1.091 | 0.96 | |
| 257_L | 511_P | 1.089 | 0.96 | |
| 66_E | 75_I | 1.088 | 0.96 | |
| 297_Y | 313_L | 1.088 | 0.96 | |
| 316_A | 400_W | 1.087 | 0.96 | |
| 155_V | 163_V | 1.085 | 0.96 | |
| 34_C | 253_R | 1.083 | 0.96 | |
| 397_Q | 409_I | 1.071 | 0.95 | |
| 286_E | 507_T | 1.058 | 0.95 | |
| 38_S | 218_Y | 1.056 | 0.95 | |
| 63_R | 77_G | 1.05 | 0.94 | |
| 123_D | 157_K | 1.046 | 0.94 | |
| 282_I | 511_P | 1.045 | 0.94 | |
| 96_R | 233_W | 1.038 | 0.94 | |
| 481_N | 485_E | 1.037 | 0.94 | |
| 307_V | 498_A | 1.035 | 0.94 | |
| 66_E | 77_G | 1.03 | 0.94 | |
| 314_T | 319_K | 1.024 | 0.93 | |
| 91_Y | 175_L | 1.019 | 0.93 | |
| 83_E | 92_T | 1.019 | 0.93 | |
| 398_A | 402_K | 1.013 | 0.93 | |
| 167_L | 174_F | 1.005 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1dpeA | 1 | 0.9346 | 100 | 0.132 | Contact Map | 0.79 |
| 3m8uA | 1 | 0.9364 | 100 | 0.136 | Contact Map | 0.785 |
| 3tpaA | 1 | 0.9458 | 100 | 0.137 | Contact Map | 0.756 |
| 1uqwA | 2 | 0.9327 | 100 | 0.158 | Contact Map | 0.787 |
| 3zs6A | 1 | 0.9084 | 100 | 0.167 | Contact Map | 0.752 |
| 3o9pA | 1 | 0.9215 | 100 | 0.168 | Contact Map | 0.733 |
| 1xocA | 1 | 0.929 | 100 | 0.17 | Contact Map | 0.759 |
| 4fajA | 1 | 0.9383 | 100 | 0.174 | Contact Map | 0.726 |
| 4gl8A | 2 | 0.9514 | 100 | 0.175 | Contact Map | 0.799 |
| 1jetA | 1 | 0.9234 | 100 | 0.176 | Contact Map | 0.796 |
Sequence Conservation (Image Generated using WebLogo v3)