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OPENSEQ.org
YBAE - Uncharacterized protein YbaE
UniProt: P46890 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13217
Length: 566 (443)
Sequences: 3979
Seq/Len: 8.98
YBAE
Paralog alert: 0.72 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
368_S 372_Q 4.667 1.00
230_H 233_C 4.499 1.00
272_T 282_E 4.246 1.00
357_Q 401_E 4.199 1.00
188_S 232_Q 4.186 1.00
229_T 235_T 4.109 1.00
486_F 524_D 3.97 1.00
504_M 509_N 3.848 1.00
227_E 235_T 3.712 1.00
270_R 282_E 3.563 1.00
174_E 185_Y 3.381 1.00
172_H 185_Y 3.137 1.00
204_H 228_V 3.122 1.00
269_F 294_L 3.059 1.00
159_D 164_R 3.027 1.00
407_T 435_E 2.986 1.00
357_Q 360_K 2.932 1.00
181_R 237_F 2.923 1.00
509_N 512_N 2.917 1.00
204_H 208_L 2.917 1.00
270_R 285_D 2.757 1.00
207_L 236_F 2.753 1.00
496_S 500_A 2.667 1.00
159_D 166_I 2.659 1.00
506_D 509_N 2.629 1.00
351_P 354_S 2.627 1.00
176_S 180_L 2.611 1.00
488_A 524_D 2.611 1.00
201_S 228_V 2.592 1.00
356_W 360_K 2.579 1.00
544_N 562_P 2.566 1.00
366_H 369_G 2.531 1.00
171_H 188_S 2.53 1.00
156_T 173_W 2.514 1.00
198_V 266_T 2.496 1.00
430_A 435_E 2.46 1.00
190_L 198_V 2.437 1.00
478_C 487_D 2.421 1.00
407_T 437_T 2.359 1.00
141_G 144_E 2.352 1.00
512_N 516_A 2.346 1.00
409_T 437_T 2.345 1.00
175_T 182_W 2.333 1.00
185_Y 233_C 2.314 1.00
181_R 235_T 2.305 1.00
135_Q 209_M 2.304 1.00
544_N 560_W 2.247 1.00
203_L 234_L 2.242 1.00
488_A 520_Q 2.201 1.00
227_E 237_F 2.176 1.00
353_L 408_L 2.168 1.00
512_N 515_K 2.124 1.00
362_I 525_A 2.12 1.00
201_S 231_P 2.118 1.00
280_R 296_A 2.072 1.00
501_V 513_A 2.066 1.00
500_A 513_A 2.041 1.00
191_H 197_A 2.033 1.00
189_T 197_A 1.972 1.00
224_K 239_H 1.971 1.00
122_T 296_A 1.956 1.00
191_H 286_Y 1.904 1.00
199_K 202_H 1.875 1.00
153_S 168_D 1.87 1.00
202_H 259_P 1.86 1.00
200_A 228_V 1.859 1.00
513_A 516_A 1.836 1.00
124_R 298_E 1.816 1.00
293_L 560_W 1.814 1.00
193_H 284_H 1.793 1.00
350_S 456_D 1.789 1.00
493_H 496_S 1.779 1.00
173_W 184_F 1.772 1.00
121_P 295_K 1.765 1.00
122_T 298_E 1.757 1.00
224_K 237_F 1.747 1.00
194_N 258_H 1.739 1.00
384_S 532_N 1.711 1.00
159_D 162_T 1.704 1.00
519_S 523_T 1.687 1.00
190_L 266_T 1.68 1.00
516_A 519_S 1.659 1.00
201_S 204_H 1.654 1.00
282_E 296_A 1.653 1.00
236_F 245_L 1.642 1.00
365_I 425_L 1.635 1.00
344_Y 347_L 1.631 1.00
500_A 509_N 1.628 1.00
273_Q 278_L 1.61 1.00
171_H 185_Y 1.609 1.00
358_A 402_V 1.591 1.00
176_S 183_D 1.588 1.00
169_L 203_L 1.556 1.00
345_L 348_R 1.555 1.00
509_N 513_A 1.542 1.00
426_Q 430_A 1.525 1.00
156_T 184_F 1.524 1.00
153_S 288_H 1.521 1.00
449_T 454_H 1.519 1.00
273_Q 280_R 1.508 1.00
182_W 245_L 1.501 1.00
497_T 516_A 1.498 1.00
501_V 514_L 1.498 1.00
183_D 235_T 1.485 1.00
448_D 452_Q 1.485 1.00
171_H 187_R 1.478 1.00
409_T 439_I 1.47 1.00
412_Y 438_I 1.46 1.00
187_R 288_H 1.459 1.00
400_D 405_P 1.458 1.00
185_Y 188_S 1.453 1.00
176_S 181_R 1.443 0.99
193_H 271_L 1.424 0.99
272_T 296_A 1.413 0.99
123_L 543_V 1.398 0.99
360_K 525_A 1.39 0.99
356_W 524_D 1.383 0.99
225_R 237_F 1.378 0.99
370_L 421_M 1.37 0.99
364_I 429_L 1.367 0.99
204_H 234_L 1.362 0.99
185_Y 230_H 1.356 0.99
368_S 383_A 1.348 0.99
429_L 434_C 1.344 0.99
185_Y 232_Q 1.335 0.99
187_R 190_L 1.334 0.99
283_S 295_K 1.325 0.99
371_L 383_A 1.324 0.99
450_T 458_M 1.324 0.99
238_L 245_L 1.312 0.99
283_S 292_P 1.308 0.99
453_A 485_V 1.306 0.99
511_F 515_K 1.296 0.99
419_H 423_E 1.292 0.99
350_S 354_S 1.292 0.99
169_L 266_T 1.278 0.98
176_S 179_G 1.272 0.98
424_R 428_T 1.269 0.98
281_L 299_Y 1.267 0.98
199_K 231_P 1.257 0.98
468_P 510_R 1.257 0.98
229_T 233_C 1.254 0.98
201_S 259_P 1.246 0.98
183_D 233_C 1.243 0.98
196_D 258_H 1.236 0.98
356_W 523_T 1.232 0.98
154_G 255_H 1.226 0.98
543_V 561_L 1.221 0.98
429_L 457_L 1.206 0.98
497_T 500_A 1.203 0.97
490_A 493_H 1.203 0.97
497_T 513_A 1.194 0.97
542_G 561_L 1.193 0.97
344_Y 348_R 1.188 0.97
422_A 438_I 1.183 0.97
202_H 206_R 1.176 0.97
520_Q 524_D 1.175 0.97
200_A 229_T 1.171 0.97
489_P 493_H 1.17 0.97
137_G 210_L 1.167 0.97
203_L 256_L 1.161 0.97
353_L 457_L 1.16 0.97
362_I 367_Q 1.158 0.97
289_L 557_T 1.157 0.97
364_I 432_E 1.156 0.97
124_R 300_W 1.151 0.96
280_R 298_E 1.15 0.96
439_I 449_T 1.146 0.96
147_L 281_L 1.144 0.96
311_G 314_C 1.131 0.96
204_H 226_I 1.126 0.96
494_L 497_T 1.126 0.96
197_A 232_Q 1.122 0.96
358_A 399_P 1.121 0.96
173_W 246_A 1.12 0.96
182_W 246_A 1.117 0.96
493_H 516_A 1.116 0.96
153_S 266_T 1.116 0.96
202_H 205_Q 1.115 0.96
504_M 513_A 1.114 0.96
500_A 504_M 1.108 0.95
184_F 236_F 1.09 0.95
228_V 231_P 1.083 0.95
167_G 173_W 1.082 0.95
198_V 206_R 1.081 0.94
169_L 198_V 1.081 0.94
123_L 294_L 1.068 0.94
236_F 249_L 1.063 0.94
157_R 168_D 1.061 0.94
442_N 445_N 1.061 0.94
443_A 446_W 1.06 0.94
500_A 516_A 1.054 0.93
462_R 465_G 1.049 0.93
489_P 496_S 1.049 0.93
184_F 246_A 1.048 0.93
443_A 447_D 1.041 0.93
157_R 166_I 1.031 0.92
125_I 556_F 1.024 0.92
425_L 429_L 1.02 0.92
346_T 528_T 1.018 0.92
363_S 396_W 1.015 0.92
226_I 236_F 1.012 0.92
360_K 523_T 1.012 0.92
272_T 280_R 1.009 0.91
278_L 298_E 1.007 0.91
208_L 228_V 1.006 0.91
139_L 148_A 1.005 0.91
270_R 284_H 1 0.91
390_G 532_N 1 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3m8uA10.77921000.405Contact Map0.81
3zs6A10.77391000.406Contact Map0.773
1dpeA10.76861000.407Contact Map0.807
1uqwA20.80571000.407Contact Map0.773
4gl8A20.81451000.408Contact Map0.782
3o9pA10.79681000.41Contact Map0.769
3tpaA10.7881000.412Contact Map0.783
1jetA10.78981000.413Contact Map0.82
1xocA10.79861000.421Contact Map0.761
2wolA10.82331000.429Contact Map0.732
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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