| UniProt: | P75797 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13473 | ||
| Length: | 512 (485) | ||
| Sequences: | 9555 | ||
| Seq/Len: | 19.70 |
| GSIB
Paralog alert: 0.87 [within 20: 0.30] - ratio of genomes with paralogs Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 191_D | 202_K | 4.65 | 1.00 | |
| 284_K | 340_E | 3.996 | 1.00 | |
| 139_D | 142_T | 3.883 | 1.00 | |
| 296_P | 300_K | 3.868 | 1.00 | |
| 138_I | 144_K | 3.805 | 1.00 | |
| 333_K | 336_E | 3.756 | 1.00 | |
| 136_E | 144_K | 3.733 | 1.00 | |
| 94_E | 141_T | 3.542 | 1.00 | |
| 446_D | 450_Q | 3.343 | 1.00 | |
| 189_E | 202_K | 3.33 | 1.00 | |
| 454_T | 459_E | 3.251 | 1.00 | |
| 110_K | 114_D | 3.126 | 1.00 | |
| 439_Y | 474_E | 3.038 | 1.00 | |
| 110_K | 137_A | 2.997 | 1.00 | |
| 78_S | 91_K | 2.982 | 1.00 | |
| 426_S | 440_S | 2.925 | 1.00 | |
| 289_L | 371_L | 2.919 | 1.00 | |
| 443_Q | 446_D | 2.918 | 1.00 | |
| 294_N | 297_A | 2.916 | 1.00 | |
| 278_K | 281_D | 2.874 | 1.00 | |
| 336_E | 340_E | 2.861 | 1.00 | |
| 107_A | 137_A | 2.809 | 1.00 | |
| 80_T | 91_K | 2.79 | 1.00 | |
| 291_Y | 333_K | 2.781 | 1.00 | |
| 66_D | 70_K | 2.745 | 1.00 | |
| 348_S | 377_K | 2.744 | 1.00 | |
| 284_K | 337_L | 2.575 | 1.00 | |
| 63_F | 79_Y | 2.552 | 1.00 | |
| 283_P | 287_E | 2.552 | 1.00 | |
| 284_K | 287_E | 2.493 | 1.00 | |
| 459_E | 462_R | 2.493 | 1.00 | |
| 426_S | 445_D | 2.486 | 1.00 | |
| 104_F | 185_T | 2.485 | 1.00 | |
| 441_N | 474_E | 2.465 | 1.00 | |
| 372_A | 377_K | 2.444 | 1.00 | |
| 87_T | 144_K | 2.401 | 1.00 | |
| 441_N | 470_I | 2.399 | 1.00 | |
| 82_S | 86_I | 2.396 | 1.00 | |
| 136_E | 146_T | 2.349 | 1.00 | |
| 89_T | 144_K | 2.327 | 1.00 | |
| 87_T | 146_T | 2.268 | 1.00 | |
| 91_K | 142_T | 2.264 | 1.00 | |
| 456_D | 459_E | 2.258 | 1.00 | |
| 443_Q | 466_A | 2.246 | 1.00 | |
| 77_E | 94_E | 2.24 | 1.00 | |
| 189_E | 205_A | 2.219 | 1.00 | |
| 113_L | 145_I | 2.218 | 1.00 | |
| 99_Q | 204_F | 2.214 | 1.00 | |
| 97_K | 103_D | 2.211 | 1.00 | |
| 96_I | 104_F | 2.205 | 1.00 | |
| 81_V | 88_Y | 2.202 | 1.00 | |
| 97_K | 206_G | 2.195 | 1.00 | |
| 109_V | 143_V | 2.189 | 1.00 | |
| 66_D | 72_K | 2.179 | 1.00 | |
| 450_Q | 463_L | 2.168 | 1.00 | |
| 348_S | 379_Q | 2.151 | 1.00 | |
| 200_K | 217_S | 2.135 | 1.00 | |
| 133_A | 148_K | 2.108 | 1.00 | |
| 462_R | 466_A | 2.076 | 1.00 | |
| 350_T | 379_Q | 2.073 | 1.00 | |
| 188_Y | 215_L | 2.028 | 1.00 | |
| 273_M | 478_I | 2.012 | 1.00 | |
| 287_E | 333_K | 1.967 | 1.00 | |
| 444_V | 467_A | 1.966 | 1.00 | |
| 105_N | 108_A | 1.966 | 1.00 | |
| 60_Q | 74_V | 1.943 | 1.00 | |
| 42_D | 115_R | 1.923 | 1.00 | |
| 447_F | 466_A | 1.91 | 1.00 | |
| 168_P | 172_E | 1.908 | 1.00 | |
| 95_G | 103_D | 1.907 | 1.00 | |
| 277_Q | 403_R | 1.893 | 1.00 | |
| 469_D | 473_Q | 1.88 | 1.00 | |
| 451_A | 464_Y | 1.87 | 1.00 | |
| 273_M | 404_M | 1.869 | 1.00 | |
| 232_M | 237_E | 1.864 | 1.00 | |
| 107_A | 110_K | 1.859 | 1.00 | |
| 192_T | 200_K | 1.844 | 1.00 | |
| 194_N | 197_D | 1.834 | 1.00 | |
| 107_A | 140_P | 1.832 | 1.00 | |
| 289_L | 376_I | 1.83 | 1.00 | |
| 350_T | 381_T | 1.808 | 1.00 | |
| 310_A | 482_V | 1.807 | 1.00 | |
| 202_K | 217_S | 1.763 | 1.00 | |
| 463_L | 466_A | 1.745 | 1.00 | |
| 368_Q | 372_A | 1.744 | 1.00 | |
| 466_A | 469_D | 1.739 | 1.00 | |
| 290_N | 475_S | 1.734 | 1.00 | |
| 77_E | 91_K | 1.731 | 1.00 | |
| 293_I | 367_T | 1.726 | 1.00 | |
| 451_A | 463_L | 1.718 | 1.00 | |
| 442_K | 446_D | 1.713 | 1.00 | |
| 203_K | 216_D | 1.693 | 1.00 | |
| 100_D | 167_S | 1.692 | 1.00 | |
| 280_F | 289_L | 1.687 | 1.00 | |
| 234_Q | 251_L | 1.66 | 1.00 | |
| 283_P | 474_E | 1.658 | 1.00 | |
| 192_T | 198_F | 1.656 | 1.00 | |
| 330_D | 333_K | 1.65 | 1.00 | |
| 191_D | 217_S | 1.647 | 1.00 | |
| 335_R | 339_K | 1.644 | 1.00 | |
| 134_K | 146_T | 1.643 | 1.00 | |
| 79_Y | 90_V | 1.622 | 1.00 | |
| 450_Q | 459_E | 1.62 | 1.00 | |
| 63_F | 90_V | 1.609 | 1.00 | |
| 443_Q | 470_I | 1.608 | 1.00 | |
| 48_D | 51_S | 1.604 | 1.00 | |
| 82_S | 89_T | 1.597 | 1.00 | |
| 280_F | 349_T | 1.593 | 1.00 | |
| 102_T | 169_A | 1.575 | 1.00 | |
| 107_A | 168_P | 1.573 | 1.00 | |
| 447_F | 463_L | 1.569 | 1.00 | |
| 106_A | 137_A | 1.565 | 1.00 | |
| 194_N | 198_F | 1.564 | 1.00 | |
| 257_N | 491_K | 1.563 | 1.00 | |
| 105_N | 140_P | 1.56 | 1.00 | |
| 96_I | 185_T | 1.553 | 1.00 | |
| 82_S | 87_T | 1.551 | 1.00 | |
| 77_E | 93_R | 1.543 | 1.00 | |
| 332_V | 335_R | 1.541 | 1.00 | |
| 292_A | 374_V | 1.535 | 1.00 | |
| 462_R | 465_K | 1.532 | 1.00 | |
| 108_A | 168_P | 1.517 | 1.00 | |
| 415_E | 460_K | 1.514 | 1.00 | |
| 459_E | 463_L | 1.51 | 1.00 | |
| 285_V | 341_A | 1.507 | 1.00 | |
| 33_A | 238_A | 1.497 | 1.00 | |
| 198_F | 219_T | 1.488 | 1.00 | |
| 223_V | 232_M | 1.484 | 1.00 | |
| 339_K | 344_P | 1.48 | 1.00 | |
| 337_L | 340_E | 1.48 | 1.00 | |
| 285_V | 338_L | 1.471 | 1.00 | |
| 167_S | 170_A | 1.467 | 1.00 | |
| 89_T | 142_T | 1.455 | 1.00 | |
| 29_D | 217_S | 1.455 | 1.00 | |
| 31_V | 219_T | 1.45 | 1.00 | |
| 102_T | 167_S | 1.441 | 1.00 | |
| 299_V | 309_P | 1.438 | 1.00 | |
| 461_T | 465_K | 1.436 | 1.00 | |
| 133_A | 146_T | 1.421 | 1.00 | |
| 145_I | 154_F | 1.419 | 1.00 | |
| 287_E | 475_S | 1.416 | 1.00 | |
| 250_T | 253_E | 1.415 | 1.00 | |
| 99_Q | 189_E | 1.413 | 1.00 | |
| 138_I | 142_T | 1.406 | 0.99 | |
| 103_D | 141_T | 1.396 | 0.99 | |
| 440_S | 445_D | 1.396 | 0.99 | |
| 276_T | 438_F | 1.396 | 0.99 | |
| 93_R | 96_I | 1.389 | 0.99 | |
| 296_P | 309_P | 1.384 | 0.99 | |
| 200_K | 219_T | 1.378 | 0.99 | |
| 283_P | 473_Q | 1.365 | 0.99 | |
| 29_D | 219_T | 1.36 | 0.99 | |
| 91_K | 141_T | 1.36 | 0.99 | |
| 60_Q | 185_T | 1.357 | 0.99 | |
| 447_F | 470_I | 1.353 | 0.99 | |
| 470_I | 474_E | 1.352 | 0.99 | |
| 137_A | 140_P | 1.348 | 0.99 | |
| 336_E | 339_K | 1.336 | 0.99 | |
| 259_E | 491_K | 1.328 | 0.99 | |
| 361_Q | 365_Q | 1.312 | 0.99 | |
| 439_Y | 444_V | 1.31 | 0.99 | |
| 232_M | 238_A | 1.31 | 0.99 | |
| 331_P | 374_V | 1.31 | 0.99 | |
| 201_V | 220_W | 1.3 | 0.99 | |
| 60_Q | 208_W | 1.299 | 0.99 | |
| 97_K | 204_F | 1.293 | 0.99 | |
| 203_K | 213_P | 1.284 | 0.99 | |
| 370_Q | 373_Q | 1.281 | 0.99 | |
| 384_D | 387_Q | 1.277 | 0.99 | |
| 88_Y | 154_F | 1.276 | 0.99 | |
| 454_T | 463_L | 1.264 | 0.99 | |
| 239_Q | 490_S | 1.26 | 0.99 | |
| 425_A | 449_A | 1.257 | 0.99 | |
| 91_K | 94_E | 1.251 | 0.99 | |
| 106_A | 138_I | 1.242 | 0.98 | |
| 287_E | 337_L | 1.238 | 0.98 | |
| 99_Q | 190_L | 1.237 | 0.98 | |
| 73_N | 79_Y | 1.235 | 0.98 | |
| 443_Q | 447_F | 1.235 | 0.98 | |
| 202_K | 205_A | 1.227 | 0.98 | |
| 259_E | 489_H | 1.223 | 0.98 | |
| 277_Q | 281_D | 1.211 | 0.98 | |
| 385_A | 389_A | 1.211 | 0.98 | |
| 110_K | 135_T | 1.204 | 0.98 | |
| 99_Q | 206_G | 1.203 | 0.98 | |
| 446_D | 449_A | 1.202 | 0.98 | |
| 228_T | 232_M | 1.201 | 0.98 | |
| 291_Y | 327_W | 1.196 | 0.98 | |
| 191_D | 200_K | 1.185 | 0.98 | |
| 366_F | 370_Q | 1.176 | 0.98 | |
| 331_P | 335_R | 1.176 | 0.98 | |
| 332_V | 336_E | 1.166 | 0.97 | |
| 75_L | 185_T | 1.152 | 0.97 | |
| 316_P | 482_V | 1.151 | 0.97 | |
| 91_K | 139_D | 1.149 | 0.97 | |
| 239_Q | 492_N | 1.147 | 0.97 | |
| 447_F | 450_Q | 1.145 | 0.97 | |
| 303_F | 307_A | 1.139 | 0.97 | |
| 450_Q | 454_T | 1.132 | 0.97 | |
| 82_S | 85_G | 1.132 | 0.97 | |
| 149_Q | 453_K | 1.127 | 0.97 | |
| 77_E | 141_T | 1.126 | 0.97 | |
| 292_A | 371_L | 1.123 | 0.97 | |
| 203_K | 212_L | 1.121 | 0.97 | |
| 371_L | 378_A | 1.12 | 0.96 | |
| 90_V | 145_I | 1.119 | 0.96 | |
| 297_A | 370_Q | 1.117 | 0.96 | |
| 209_Q | 212_L | 1.113 | 0.96 | |
| 450_Q | 466_A | 1.11 | 0.96 | |
| 64_G | 72_K | 1.11 | 0.96 | |
| 299_V | 307_A | 1.108 | 0.96 | |
| 368_Q | 380_V | 1.105 | 0.96 | |
| 64_G | 74_V | 1.103 | 0.96 | |
| 103_D | 140_P | 1.096 | 0.96 | |
| 135_T | 143_V | 1.095 | 0.96 | |
| 89_T | 138_I | 1.086 | 0.96 | |
| 298_L | 363_V | 1.075 | 0.95 | |
| 290_N | 295_R | 1.07 | 0.95 | |
| 234_Q | 255_N | 1.066 | 0.95 | |
| 169_A | 173_K | 1.064 | 0.95 | |
| 283_P | 475_S | 1.055 | 0.95 | |
| 272_S | 405_F | 1.054 | 0.95 | |
| 273_M | 289_L | 1.054 | 0.95 | |
| 258_I | 488_A | 1.037 | 0.94 | |
| 93_R | 208_W | 1.037 | 0.94 | |
| 458_A | 461_T | 1.034 | 0.94 | |
| 367_T | 371_L | 1.032 | 0.94 | |
| 458_A | 462_R | 1.027 | 0.94 | |
| 198_F | 221_R | 1.026 | 0.94 | |
| 369_Q | 373_Q | 1.022 | 0.93 | |
| 262_A | 484_K | 1.02 | 0.93 | |
| 80_T | 89_T | 1.019 | 0.93 | |
| 284_K | 341_A | 1.019 | 0.93 | |
| 61_G | 74_V | 1.017 | 0.93 | |
| 439_Y | 476_P | 1.015 | 0.93 | |
| 114_D | 137_A | 1.014 | 0.93 | |
| 88_Y | 155_I | 1.013 | 0.93 | |
| 233_L | 488_A | 1.011 | 0.93 | |
| 189_E | 204_F | 1.01 | 0.93 | |
| 381_T | 391_E | 1.008 | 0.93 | |
| 28_K | 216_D | 1.001 | 0.92 | |
| 424_F | 471_I | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 1uqwA | 2 | 0.9902 | 100 | 0.105 | Contact Map | 0.789 |
| 4fajA | 1 | 0.9629 | 100 | 0.139 | Contact Map | 0.732 |
| 4gl8A | 2 | 0.9648 | 100 | 0.142 | Contact Map | 0.805 |
| 3m8uA | 1 | 0.9355 | 100 | 0.147 | Contact Map | 0.797 |
| 1dpeA | 1 | 0.9336 | 100 | 0.147 | Contact Map | 0.8 |
| 3zs6A | 1 | 0.9316 | 100 | 0.148 | Contact Map | 0.762 |
| 3tpaA | 1 | 0.9453 | 100 | 0.148 | Contact Map | 0.763 |
| 3o9pA | 1 | 0.9492 | 100 | 0.15 | Contact Map | 0.742 |
| 1xocA | 1 | 0.9668 | 100 | 0.159 | Contact Map | 0.764 |
| 1jetA | 1 | 0.9453 | 100 | 0.159 | Contact Map | 0.797 |
Sequence Conservation (Image Generated using WebLogo v3)