May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
YEJA - Uncharacterized protein YejA
UniProt: P33913 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12037
Length: 604 (541)
Sequences: 4905
Seq/Len: 9.07
YEJA
Paralog alert: 0.78 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: DDPA DPPA GSIB MPPA NIKA OPPA SAPA SGRR YBAE YEJA YGIS
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
216_T 227_S 4.98 1.00
323_R 412_E 4.907 1.00
164_A 167_T 4.887 1.00
335_E 339_K 4.753 1.00
405_K 408_K 4.292 1.00
514_V 550_N 4.009 1.00
162_A 169_R 3.992 1.00
121_P 166_L 3.844 1.00
502_S 520_D 3.696 1.00
529_A 535_K 3.661 1.00
521_S 525_Q 3.619 1.00
137_E 163_I 3.548 1.00
214_R 227_S 3.541 1.00
408_K 412_E 3.399 1.00
137_E 141_Q 3.292 1.00
323_R 409_L 3.264 1.00
191_E 195_K 3.231 1.00
518_V 521_S 3.218 1.00
333_D 336_W 3.148 1.00
323_R 326_E 3.103 1.00
105_S 118_A 2.992 1.00
109_A 113_S 2.981 1.00
328_I 453_L 2.979 1.00
330_L 405_K 2.934 1.00
214_R 230_K 2.933 1.00
131_I 210_S 2.923 1.00
213_Y 246_F 2.903 1.00
502_S 515_Q 2.862 1.00
432_S 459_N 2.851 1.00
134_R 163_I 2.843 1.00
317_P 320_S 2.811 1.00
55_Q 248_T 2.78 1.00
129_S 192_K 2.706 1.00
322_R 326_E 2.703 1.00
516_S 550_N 2.664 1.00
454_Q 459_N 2.664 1.00
134_R 191_E 2.632 1.00
532_N 535_K 2.629 1.00
535_K 538_P 2.612 1.00
88_F 106_A 2.55 1.00
319_F 433_F 2.502 1.00
114_W 171_E 2.485 1.00
162_A 171_E 2.47 1.00
518_V 542_A 2.468 1.00
123_A 131_I 2.467 1.00
118_A 167_T 2.466 1.00
107_R 118_A 2.454 1.00
516_S 546_V 2.443 1.00
126_H 229_V 2.41 1.00
434_E 463_R 2.404 1.00
140_F 170_I 2.37 1.00
432_S 461_D 2.359 1.00
450_Q 454_Q 2.284 1.00
104_E 121_P 2.28 1.00
326_E 405_K 2.269 1.00
68_N 142_K 2.263 1.00
525_Q 539_L 2.222 1.00
134_R 165_P 2.216 1.00
316_R 480_D 2.215 1.00
91_S 97_S 2.176 1.00
124_R 231_D 2.154 1.00
114_W 169_R 2.112 1.00
127_D 190_P 2.106 1.00
132_T 135_D 2.094 1.00
434_E 461_D 2.076 1.00
225_V 248_T 2.072 1.00
136_V 168_V 2.06 1.00
312_F 554_L 2.044 1.00
538_P 542_A 2.044 1.00
91_S 99_Y 2.035 1.00
134_R 137_E 2.035 1.00
55_Q 250_R 2.01 1.00
402_N 405_K 1.996 1.00
123_A 210_S 1.993 1.00
133_A 163_I 1.969 1.00
409_L 412_E 1.965 1.00
129_S 190_P 1.959 1.00
106_A 117_V 1.933 1.00
349_T 558_Y 1.927 1.00
108_Y 115_V 1.911 1.00
116_E 169_R 1.905 1.00
104_E 118_A 1.895 1.00
407_D 411_N 1.89 1.00
124_R 130_P 1.89 1.00
228_R 247_D 1.888 1.00
522_L 542_A 1.878 1.00
57_T 250_R 1.865 1.00
526_I 539_L 1.863 1.00
135_D 191_E 1.861 1.00
53_G 247_D 1.857 1.00
85_D 101_L 1.855 1.00
529_A 532_N 1.85 1.00
324_V 413_A 1.845 1.00
526_I 540_G 1.839 1.00
312_F 481_M 1.836 1.00
539_L 542_A 1.828 1.00
217_S 225_V 1.827 1.00
116_E 167_T 1.807 1.00
109_A 114_W 1.796 1.00
88_F 117_V 1.793 1.00
59_S 269_F 1.789 1.00
519_I 543_L 1.785 1.00
127_D 192_K 1.783 1.00
332_F 449_F 1.779 1.00
404_L 407_D 1.778 1.00
54_G 247_D 1.772 1.00
219_K 222_Q 1.771 1.00
319_F 328_I 1.768 1.00
227_S 248_T 1.758 1.00
322_R 550_N 1.753 1.00
159_T 173_A 1.738 1.00
216_T 248_T 1.731 1.00
326_E 409_L 1.717 1.00
542_A 545_R 1.71 1.00
338_N 348_R 1.706 1.00
122_R 130_P 1.705 1.00
136_V 188_V 1.692 1.00
74_G 77_G 1.684 1.00
328_I 458_I 1.673 1.00
126_H 214_R 1.662 1.00
263_A 268_A 1.637 1.00
130_P 166_L 1.635 1.00
433_F 481_M 1.625 1.00
515_Q 520_D 1.6 1.00
472_N 476_S 1.597 1.00
430_P 459_N 1.591 1.00
411_N 423_V 1.589 1.00
56_I 570_F 1.58 1.00
522_L 539_L 1.565 1.00
473_R 478_D 1.562 1.00
535_K 539_L 1.562 1.00
545_R 549_W 1.562 1.00
217_S 223_N 1.553 1.00
477_R 513_G 1.552 1.00
254_Y 263_A 1.544 1.00
118_A 166_L 1.538 1.00
219_K 223_N 1.528 1.00
329_T 551_Y 1.52 1.00
259_V 263_A 1.509 1.00
322_R 549_W 1.474 1.00
315_Q 513_G 1.471 1.00
331_A 456_L 1.464 1.00
437_L 462_I 1.46 1.00
517_P 521_S 1.443 0.99
226_Y 251_Y 1.427 0.99
118_A 164_A 1.426 0.99
160_V 171_E 1.425 0.99
85_D 210_S 1.424 0.99
104_E 120_N 1.421 0.99
525_Q 542_A 1.417 0.99
109_A 116_E 1.413 0.99
546_V 550_N 1.411 0.99
407_D 417_L 1.405 0.99
525_Q 535_K 1.4 0.99
163_I 169_R 1.392 0.99
324_V 410_L 1.388 0.99
331_A 453_L 1.387 0.99
522_L 525_Q 1.376 0.99
225_V 250_R 1.375 0.99
518_V 546_V 1.367 0.99
326_E 551_Y 1.367 0.99
190_P 193_Y 1.365 0.99
342_F 346_W 1.361 0.99
102_I 210_S 1.353 0.99
529_A 539_L 1.349 0.99
501_S 524_N 1.346 0.99
85_D 233_W 1.346 0.99
216_T 225_V 1.338 0.99
223_N 250_R 1.333 0.99
138_F 191_E 1.327 0.99
514_V 519_I 1.327 0.99
139_T 188_V 1.326 0.99
443_S 447_L 1.32 0.99
126_H 231_D 1.317 0.99
227_S 230_K 1.313 0.99
193_Y 208_L 1.309 0.99
408_K 411_N 1.308 0.99
403_L 407_D 1.299 0.99
102_I 136_V 1.298 0.99
335_E 348_R 1.293 0.99
312_F 328_I 1.285 0.99
328_I 433_F 1.28 0.99
451_H 455_R 1.277 0.98
537_L 541_R 1.275 0.98
120_N 123_A 1.275 0.98
120_N 233_W 1.261 0.98
435_L 460_M 1.258 0.98
448_P 452_S 1.24 0.98
104_E 166_L 1.238 0.98
270_D 569_K 1.235 0.98
518_V 522_L 1.231 0.98
491_W 536_L 1.227 0.98
214_R 229_V 1.224 0.98
117_V 170_I 1.224 0.98
433_F 460_M 1.218 0.98
263_A 269_F 1.208 0.98
521_S 524_N 1.204 0.98
538_P 541_R 1.2 0.97
198_K 201_D 1.199 0.97
323_R 413_A 1.19 0.97
449_F 453_L 1.19 0.97
270_D 567_W 1.188 0.97
141_Q 163_I 1.184 0.97
91_S 95_P 1.18 0.97
522_L 546_V 1.179 0.97
411_N 416_V 1.177 0.97
124_R 229_V 1.176 0.97
109_A 112_Y 1.173 0.97
133_A 137_E 1.17 0.97
466_D 469_Q 1.167 0.97
59_S 260_A 1.166 0.97
132_T 191_E 1.166 0.97
137_E 168_V 1.155 0.97
450_Q 462_I 1.151 0.97
126_H 215_V 1.144 0.96
463_R 473_R 1.138 0.96
125_F 192_K 1.13 0.96
526_I 543_L 1.128 0.96
163_I 168_V 1.127 0.96
125_F 135_D 1.119 0.96
338_N 346_W 1.108 0.95
404_L 408_K 1.1 0.95
121_P 130_P 1.096 0.95
355_N 558_Y 1.096 0.95
319_F 481_M 1.086 0.95
135_D 138_F 1.086 0.95
100_P 106_A 1.085 0.95
57_T 270_D 1.085 0.95
403_L 456_L 1.078 0.94
329_T 334_F 1.074 0.94
118_A 121_P 1.07 0.94
170_I 179_D 1.068 0.94
467_N 471_T 1.068 0.94
132_T 165_P 1.062 0.94
137_E 161_K 1.061 0.94
446_V 462_I 1.055 0.94
534_E 538_P 1.052 0.93
271_L 570_F 1.05 0.93
337_M 445_W 1.041 0.93
223_N 252_D 1.039 0.93
418_K 421_Q 1.039 0.93
327_A 410_L 1.036 0.93
117_V 183_L 1.032 0.93
329_T 554_L 1.032 0.93
63_T 218_W 1.03 0.93
70_Y 143_F 1.022 0.92
85_D 232_Y 1.022 0.92
431_L 458_I 1.022 0.92
287_K 290_D 1.022 0.92
115_V 172_L 1.02 0.92
316_R 320_S 1.015 0.92
254_Y 269_F 1.015 0.92
57_T 252_D 1.01 0.92
310_L 556_M 1.008 0.91
126_H 209_A 1.008 0.91
265_K 288_N 1.004 0.91
56_I 271_L 1.002 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1xocA10.83441000.337Contact Map0.761
1uqwA20.81461000.368Contact Map0.764
3drfA10.86421000.368Contact Map0.71
3zs6A10.79471000.373Contact Map0.767
3m8uA10.81291000.374Contact Map0.783
3o9pA10.81461000.376Contact Map0.741
1dpeA10.78811000.376Contact Map0.787
4gl8A20.82621000.376Contact Map0.805
3tpaA10.80961000.379Contact Map0.754
4fajA10.83611000.38Contact Map0.747
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0268 seconds.