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INTZ - Putative prophage CPZ-55 integrase
UniProt: P76542 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14172
Length: 402 (385)
Sequences: 5683
Seq/Len: 14.76
INTZ
Paralog alert: 0.71 [within 20: 0.10] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
143_R 152_D 3.968 1.00
339_S 357_L 3.578 1.00
257_N 260_D 3.218 1.00
330_T 333_G 3.033 1.00
253_W 292_F 2.941 1.00
252_R 299_A 2.701 1.00
253_W 301_V 2.619 1.00
72_R 75_E 2.592 1.00
106_K 110_E 2.539 1.00
129_R 133_E 2.52 1.00
338_F 356_Q 2.473 1.00
8_A 12_D 2.437 1.00
148_I 179_F 2.419 1.00
109_A 178_I 2.398 1.00
276_H 358_A 2.394 1.00
149_T 152_D 2.384 1.00
261_A 285_V 2.377 1.00
46_R 53_E 2.327 1.00
108_V 145_I 2.225 1.00
261_A 282_R 2.188 1.00
336_T 370_Q 2.176 1.00
106_K 142_K 2.128 1.00
343_N 353_I 2.12 1.00
242_A 338_F 2.118 1.00
109_A 132_L 2.07 1.00
262_T 277_V 2.053 1.00
108_V 182_A 2.04 1.00
264_T 277_V 2.003 1.00
258_L 285_V 1.987 1.00
14_A 23_L 1.98 1.00
233_T 291_Q 1.979 1.00
338_F 342_L 1.976 1.00
110_E 137_Y 1.972 1.00
238_L 331_G 1.958 1.00
65_T 68_E 1.946 1.00
350_P 365_R 1.93 1.00
75_E 79_L 1.903 1.00
255_W 266_P 1.898 1.00
280_L 284_A 1.895 1.00
106_K 137_Y 1.887 1.00
66_L 70_R 1.886 1.00
382_Q 386_D 1.884 1.00
238_L 248_L 1.872 1.00
153_V 193_V 1.796 1.00
184_I 197_D 1.788 1.00
279_P 356_Q 1.772 1.00
124_Y 128_V 1.771 1.00
251_C 256_I 1.757 1.00
253_W 288_L 1.743 1.00
144_S 147_D 1.723 1.00
48_W 53_E 1.718 1.00
237_L 284_A 1.708 1.00
139_V 159_K 1.701 1.00
245_T 332_H 1.671 1.00
180_K 194_A 1.666 1.00
361_P 366_G 1.655 1.00
349_S 352_W 1.654 1.00
255_W 269_V 1.627 1.00
157_L 172_R 1.627 1.00
234_A 248_L 1.624 1.00
46_R 55_L 1.617 1.00
243_L 265_L 1.608 1.00
140_L 156_L 1.604 1.00
9_K 12_D 1.6 1.00
343_N 369_N 1.588 1.00
104_G 107_K 1.586 1.00
243_L 248_L 1.584 1.00
339_S 353_I 1.582 1.00
166_E 170_K 1.577 1.00
17_Q 21_Y 1.577 1.00
351_D 354_E 1.57 1.00
183_V 188_V 1.565 1.00
257_N 262_T 1.561 1.00
212_P 215_E 1.555 1.00
143_R 147_D 1.554 1.00
232_Q 236_R 1.551 1.00
105_F 148_I 1.521 1.00
215_E 218_A 1.496 1.00
251_C 263_I 1.49 1.00
179_F 192_P 1.485 1.00
181_F 185_T 1.484 1.00
186_E 190_R 1.482 1.00
285_V 289_Q 1.482 1.00
121_S 124_Y 1.48 1.00
113_F 125_A 1.457 1.00
132_L 137_Y 1.457 1.00
211_I 219_F 1.442 1.00
143_R 148_I 1.404 0.99
108_V 181_F 1.397 0.99
71_R 75_E 1.396 0.99
274_R 360_V 1.391 0.99
281_S 284_A 1.382 0.99
105_F 175_I 1.367 0.99
9_K 13_A 1.36 0.99
263_I 280_L 1.36 0.99
245_T 249_R 1.356 0.99
26_S 29_P 1.353 0.99
215_E 326_K 1.352 0.99
154_L 158_Q 1.347 0.99
106_K 141_G 1.347 0.99
58_I 72_R 1.345 0.99
180_K 191_N 1.344 0.99
14_A 21_Y 1.336 0.99
348_Y 383_D 1.327 0.99
130_S 134_K 1.323 0.99
280_L 285_V 1.323 0.99
282_R 286_E 1.321 0.99
131_A 174_R 1.315 0.99
252_R 300_F 1.31 0.99
339_S 343_N 1.308 0.99
342_L 353_I 1.302 0.99
128_V 174_R 1.301 0.99
149_T 189_T 1.294 0.99
172_R 176_G 1.282 0.99
233_T 287_L 1.274 0.99
113_F 129_R 1.268 0.99
243_L 263_I 1.268 0.99
211_I 329_A 1.261 0.99
78_S 82_N 1.257 0.99
352_W 380_M 1.255 0.99
73_A 77_R 1.253 0.99
258_L 289_Q 1.251 0.99
145_I 179_F 1.25 0.99
79_L 84_I 1.247 0.99
289_Q 292_F 1.244 0.98
247_E 276_H 1.242 0.98
251_C 301_V 1.242 0.98
239_I 334_W 1.239 0.98
110_E 114_A 1.237 0.98
209_A 215_E 1.236 0.98
75_E 78_S 1.232 0.98
216_I 239_I 1.227 0.98
179_F 193_V 1.219 0.98
364_I 367_V 1.216 0.98
176_G 180_K 1.213 0.98
240_L 281_S 1.208 0.98
254_E 299_A 1.208 0.98
105_F 178_I 1.207 0.98
375_K 378_R 1.206 0.98
252_R 255_W 1.204 0.98
218_A 222_A 1.188 0.98
240_L 284_A 1.171 0.98
42_Y 57_A 1.164 0.97
110_E 133_E 1.158 0.97
135_D 138_P 1.153 0.97
44_R 57_A 1.15 0.97
117_V 125_A 1.149 0.97
135_D 162_R 1.147 0.97
340_T 369_N 1.147 0.97
42_Y 60_V 1.145 0.97
219_F 235_I 1.14 0.97
111_D 115_T 1.139 0.97
20_P 37_P 1.135 0.97
258_L 280_L 1.128 0.97
234_A 302_F 1.128 0.97
237_L 302_F 1.127 0.97
127_Q 130_S 1.122 0.97
112_W 177_E 1.119 0.96
178_I 182_A 1.111 0.96
34_L 44_R 1.11 0.96
22_K 32_F 1.107 0.96
246_A 250_L 1.106 0.96
354_E 366_G 1.105 0.96
258_L 301_V 1.104 0.96
342_L 348_Y 1.103 0.96
179_F 188_V 1.1 0.96
329_A 333_G 1.1 0.96
282_R 382_Q 1.098 0.96
20_P 34_L 1.098 0.96
120_W 124_Y 1.096 0.96
224_E 232_Q 1.094 0.96
156_L 171_L 1.093 0.96
45_F 72_R 1.093 0.96
132_L 178_I 1.088 0.96
105_F 140_L 1.075 0.95
72_R 76_S 1.074 0.95
258_L 261_A 1.07 0.95
363_G 366_G 1.069 0.95
348_Y 352_W 1.066 0.95
224_E 236_R 1.052 0.95
151_R 155_A 1.051 0.94
132_L 136_V 1.05 0.94
256_I 263_I 1.049 0.94
237_L 288_L 1.048 0.94
233_T 290_D 1.046 0.94
117_V 129_R 1.045 0.94
354_E 364_I 1.045 0.94
154_L 185_T 1.042 0.94
109_A 137_Y 1.038 0.94
114_A 117_V 1.035 0.94
158_Q 185_T 1.032 0.94
71_R 78_S 1.019 0.93
110_E 129_R 1.019 0.93
281_S 385_A 1.018 0.93
25_D 70_R 1.013 0.93
24_T 32_F 1.006 0.93
351_D 365_R 1.004 0.93
45_F 76_S 1.004 0.93
179_F 183_V 1.003 0.93
150_A 184_I 1.002 0.92
125_A 129_R 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.84081000.42Contact Map0.595
1a0pA10.67161000.478Contact Map0.568
1z19A20.66671000.48Contact Map0.588
2a3vA40.67411000.487Contact Map0.728
1xo0A20.69151000.525Contact Map0.489
4a8eA10.69151000.526Contact Map0.674
4e0gA10.9031000.59Contact Map0.393
3nkhA20.50251000.609Contact Map0.788
1ae9A20.41041000.656Contact Map0.614
1aihA40.41791000.662Contact Map0.739
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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