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OPENSEQ.org

FIMB - Type 1 fimbriae regulatory protein FimB
UniProt: P0ADH5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10309
Length: 200 (192)
Sequences: 14308
Seq/Len: 74.52

FIMB
Paralog alert: 0.88 [within 20: 0.28] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
148_G 165_L 4.02 1.00
77_T 166_G 2.718 1.00
56_I 93_L 2.68 1.00
55_R 115_P 2.555 1.00
139_H 142_M 2.437 1.00
147_C 164_Y 2.353 1.00
64_K 86_V 2.229 1.00
41_C 140_P 2.108 1.00
41_C 51_I 2.107 1.00
60_D 63_A 2.031 1.00
45_G 147_C 2.027 1.00
152_A 161_I 2.026 1.00
55_R 106_W 2.015 1.00
67_Y 78_T 1.947 1.00
159_R 162_Q 1.911 1.00
86_V 90_K 1.887 1.00
55_R 105_E 1.866 1.00
157_D 160_L 1.827 1.00
14_T 17_E 1.817 1.00
65_C 78_T 1.816 1.00
81_L 86_V 1.768 1.00
56_I 107_V 1.767 1.00
145_H 178_A 1.749 1.00
43_I 82_L 1.733 1.00
75_F 168_R 1.672 1.00
46_F 51_I 1.635 1.00
151_L 161_I 1.572 1.00
36_C 92_W 1.552 1.00
48_A 52_C 1.547 1.00
48_A 141_H 1.539 1.00
37_L 121_F 1.514 1.00
17_E 20_S 1.493 1.00
167_H 173_T 1.483 1.00
151_L 156_I 1.48 1.00
50_E 77_T 1.453 1.00
35_Y 39_L 1.444 1.00
129_G 138_I 1.437 1.00
118_R 122_Y 1.437 1.00
55_R 58_D 1.42 1.00
46_F 68_I 1.41 1.00
153_N 183_R 1.398 0.99
80_P 164_Y 1.391 0.99
37_L 51_I 1.39 0.99
172_H 175_W 1.384 0.99
58_D 69_H 1.381 0.99
42_F 150_A 1.361 0.99
69_H 76_S 1.359 0.99
159_R 163_D 1.343 0.99
60_D 65_C 1.341 0.99
49_S 53_R 1.329 0.99
147_C 151_L 1.324 0.99
39_L 88_A 1.309 0.99
18_I 42_F 1.296 0.99
61_L 90_K 1.296 0.99
149_F 178_A 1.287 0.99
48_A 118_R 1.284 0.99
64_K 83_N 1.284 0.99
152_A 177_T 1.284 0.99
165_L 173_T 1.279 0.99
15_H 154_M 1.263 0.99
13_L 138_I 1.256 0.99
106_W 115_P 1.256 0.99
171_R 174_V 1.255 0.99
17_E 136_L 1.253 0.99
61_L 86_V 1.253 0.99
54_L 66_I 1.241 0.98
13_L 17_E 1.238 0.98
162_Q 170_I 1.237 0.98
57_S 105_E 1.216 0.98
25_A 128_S 1.202 0.98
48_A 122_Y 1.2 0.98
153_N 180_N 1.196 0.98
117_S 120_Q 1.189 0.98
119_Q 122_Y 1.187 0.98
15_H 150_A 1.186 0.98
13_L 146_S 1.183 0.98
150_A 153_N 1.176 0.98
67_Y 76_S 1.159 0.97
42_F 143_L 1.147 0.97
20_S 24_A 1.139 0.97
82_L 85_E 1.129 0.97
186_G 190_R 1.127 0.97
24_A 131_N 1.123 0.97
34_N 124_I 1.121 0.97
43_I 85_E 1.12 0.96
160_L 187_I 1.12 0.96
120_Q 123_H 1.116 0.96
12_F 178_A 1.115 0.96
146_S 150_A 1.107 0.96
124_I 127_T 1.094 0.96
13_L 21_L 1.094 0.96
183_R 186_G 1.09 0.96
19_E 23_K 1.089 0.96
148_G 161_I 1.081 0.95
36_C 88_A 1.079 0.95
48_A 121_F 1.076 0.95
52_C 118_R 1.074 0.95
81_L 85_E 1.07 0.95
127_T 131_N 1.067 0.95
24_A 132_A 1.064 0.95
148_G 152_A 1.055 0.95
52_C 121_F 1.053 0.95
11_N 136_L 1.041 0.94
42_F 146_S 1.04 0.94
18_I 150_A 1.039 0.94
119_Q 126_S 1.027 0.94
11_N 142_M 1.021 0.93
12_F 146_S 1.01 0.93
22_L 39_L 1.007 0.93
26_N 35_Y 1.004 0.93
182_G 186_G 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2a3vA40.9451000.193Contact Map0.86
1a0pA10.941000.222Contact Map0.585
4a8eA10.951000.223Contact Map0.78
3nkhA20.9851000.23Contact Map0.806
1z1bA20.911000.259Contact Map0.561
1xo0A20.9651000.261Contact Map0.537
1z19A20.921000.271Contact Map0.564
1ae9A20.8651000.286Contact Map0.595
4e0gA10.9651000.343Contact Map0.393
1aihA40.8499.90.356Contact Map0.765

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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