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OPENSEQ.org
INTD - Prophage DLP12 integrase
UniProt: P24218 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10507
Length: 387 (341)
Sequences: 5711
Seq/Len: 16.75
INTD
Paralog alert: 0.70 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
93_I 102_K 4.005 1.00
321_A 338_G 3.647 1.00
228_D 231_R 3.028 1.00
312_R 315_D 2.955 1.00
224_W 263_I 2.89 1.00
247_I 339_G 2.704 1.00
223_E 268_K 2.565 1.00
320_W 337_M 2.495 1.00
232_R 256_C 2.481 1.00
80_K 84_E 2.481 1.00
37_L 40_K 2.436 1.00
224_W 270_V 2.412 1.00
99_S 102_K 2.399 1.00
13_S 21_R 2.392 1.00
63_C 156_I 2.364 1.00
98_I 157_L 2.304 1.00
318_H 351_H 2.274 1.00
60_E 64_L 2.261 1.00
62_A 95_L 2.207 1.00
209_A 219_I 2.197 1.00
31_K 35_Q 2.196 1.00
325_I 334_L 2.147 1.00
63_C 83_I 2.143 1.00
209_A 313_F 2.118 1.00
204_S 262_Q 2.072 1.00
62_A 160_A 2.048 1.00
232_R 253_D 2.04 1.00
110_M 149_H 2.023 1.00
60_E 92_G 1.995 1.00
213_G 320_W 1.967 1.00
40_K 44_E 1.967 1.00
103_I 172_V 1.959 1.00
233_V 248_G 1.956 1.00
216_K 314_H 1.935 1.00
64_L 87_L 1.917 1.00
330_P 333_V 1.891 1.00
235_W 248_G 1.889 1.00
251_L 255_A 1.86 1.00
320_W 324_L 1.834 1.00
229_M 256_C 1.83 1.00
15_S 21_R 1.82 1.00
13_S 23_K 1.795 1.00
30_D 33_Q 1.791 1.00
161_E 167_L 1.738 1.00
75_S 79_D 1.724 1.00
340_W 346_V 1.71 1.00
250_A 337_M 1.695 1.00
224_W 259_L 1.678 1.00
94_R 97_D 1.654 1.00
93_I 97_D 1.641 1.00
144_Q 148_K 1.636 1.00
60_E 87_L 1.619 1.00
187_E 190_E 1.615 1.00
107_V 150_L 1.6 1.00
89_H 109_R 1.594 1.00
214_L 236_V 1.59 1.00
345_M 348_R 1.574 1.00
256_C 260_R 1.562 1.00
208_F 255_A 1.552 1.00
325_I 350_A 1.548 1.00
190_E 309_E 1.547 1.00
163_D 174_K 1.546 1.00
58_T 61_E 1.546 1.00
332_S 335_Q 1.539 1.00
211_A 252_N 1.539 1.00
205_V 219_I 1.528 1.00
245_R 341_E 1.52 1.00
226_Q 237_N 1.519 1.00
165_K 169_K 1.499 1.00
59_F 98_I 1.492 1.00
190_E 193_R 1.488 1.00
82_R 152_M 1.483 1.00
62_A 159_A 1.476 1.00
210_L 316_L 1.475 1.00
157_L 171_P 1.458 1.00
186_L 194_L 1.438 1.00
186_L 311_F 1.435 1.00
228_D 233_V 1.423 1.00
191_A 210_L 1.422 1.00
203_K 207_K 1.421 1.00
251_L 256_C 1.418 1.00
157_L 172_V 1.414 1.00
64_L 68_E 1.406 0.99
90_F 106_A 1.403 0.99
222_L 227_I 1.402 0.99
216_K 220_I 1.376 0.99
36_E 40_K 1.375 0.99
159_A 164_W 1.372 0.99
223_E 269_W 1.37 0.99
322_S 352_L 1.369 0.99
158_R 173_I 1.366 0.99
342_S 345_M 1.358 0.99
214_L 219_I 1.356 0.99
218_N 247_I 1.343 0.99
184_R 190_E 1.335 0.99
158_R 170_A 1.327 0.99
324_L 334_L 1.312 0.99
65_R 69_E 1.31 0.99
253_D 257_K 1.308 0.99
59_F 153_I 1.303 0.99
67_L 80_K 1.291 0.99
335_Q 346_V 1.284 0.99
12_A 37_L 1.281 0.99
229_M 251_L 1.268 0.99
234_A 251_L 1.263 0.99
204_S 258_V 1.252 0.99
59_F 156_I 1.249 0.99
93_I 98_I 1.247 0.99
9_I 25_S 1.245 0.98
222_L 234_A 1.243 0.98
324_L 329_V 1.242 0.98
38_H 42_K 1.236 0.98
229_M 260_R 1.231 0.98
342_S 347_R 1.231 0.98
154_K 158_R 1.219 0.98
79_D 152_M 1.218 0.98
37_L 41_R 1.215 0.98
95_L 157_L 1.207 0.98
223_E 226_Q 1.199 0.98
252_N 255_A 1.195 0.98
214_L 234_A 1.192 0.98
225_Q 268_K 1.191 0.98
205_V 271_F 1.187 0.98
104_Y 108_S 1.181 0.98
193_R 197_E 1.181 0.98
67_L 76_L 1.176 0.98
60_E 91_E 1.175 0.98
338_G 346_V 1.17 0.97
321_A 325_I 1.169 0.97
223_E 238_P 1.168 0.97
204_S 261_D 1.166 0.97
250_A 357_L 1.16 0.97
226_Q 238_P 1.154 0.97
157_L 167_L 1.152 0.97
211_A 255_A 1.149 0.97
129_K 142_S 1.143 0.97
39_D 46_W 1.136 0.97
9_I 28_T 1.136 0.97
99_S 168_E 1.131 0.97
150_L 154_K 1.128 0.97
194_L 206_V 1.122 0.97
321_A 334_L 1.122 0.97
83_I 87_L 1.115 0.96
222_L 270_V 1.109 0.96
156_I 160_A 1.1 0.96
243_S 246_A 1.094 0.96
4_F 11_Y 1.093 0.96
191_A 323_W 1.093 0.96
217_S 221_N 1.092 0.96
59_F 63_C 1.091 0.96
40_K 43_A 1.09 0.96
260_R 263_I 1.09 0.96
85_F 88_E 1.087 0.96
332_S 347_R 1.083 0.96
333_V 360_H 1.082 0.96
227_I 234_A 1.079 0.95
319_T 323_W 1.074 0.95
10_W 31_K 1.073 0.95
84_E 87_L 1.07 0.95
35_Q 39_D 1.062 0.95
311_F 315_D 1.058 0.95
28_T 37_L 1.052 0.95
26_L 37_L 1.051 0.94
106_A 149_H 1.05 0.94
226_Q 240_E 1.043 0.94
86_W 153_I 1.04 0.94
11_Y 25_S 1.035 0.94
332_S 336_E 1.027 0.94
296_K 300_L 1.021 0.93
208_F 271_F 1.02 0.93
41_R 44_E 1.018 0.93
39_D 43_A 1.014 0.93
186_L 319_T 1.011 0.93
359_E 362_R 1.009 0.93
83_I 156_I 1.006 0.93
229_M 232_R 1.005 0.93
216_K 313_F 1.004 0.93
342_S 348_R 1.001 0.92
157_L 161_E 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.81141000.381Contact Map0.61
2a3vA40.71581000.436Contact Map0.765
1a0pA10.68221000.442Contact Map0.583
1z19A20.6771000.446Contact Map0.601
4a8eA10.73641000.481Contact Map0.68
1xo0A20.70541000.49Contact Map0.519
4e0gA10.87081000.556Contact Map0.407
3nkhA20.5091000.574Contact Map0.788
1ae9A20.42381000.615Contact Map0.594
1aihA40.42121000.646Contact Map0.753
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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