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XERC - Tyrosine recombinase XerC
UniProt: P0A8P6 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11069
Length: 298 (290)
Sequences: 15557
Seq/Len: 53.64
XERC
Paralog alert: 0.88 [within 20: 0.25] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
247_A 264_L 4.113 1.00
177_R 265_G 3.048 1.00
52_D 55_M 2.906 1.00
157_I 193_L 2.705 1.00
156_D 214_R 2.639 1.00
46_Q 55_M 2.601 1.00
238_H 241_K 2.416 1.00
246_F 263_L 2.355 1.00
142_M 239_P 2.33 1.00
165_G 186_V 2.244 1.00
32_Q 75_L 2.181 1.00
161_D 164_S 2.178 1.00
149_L 240_H 2.068 1.00
142_M 152_L 2.067 1.00
156_D 205_A 2.067 1.00
115_D 118_D 2.051 1.00
251_L 260_V 2.035 1.00
63_S 76_R 2.033 1.00
146_G 246_F 2.028 1.00
157_I 206_L 1.969 1.00
256_D 259_G 1.958 1.00
156_D 204_D 1.938 1.00
168_W 178_R 1.923 1.00
30_Q 34_E 1.919 1.00
244_H 277_H 1.918 1.00
186_V 190_E 1.831 1.00
266_H 272_T 1.817 1.00
175_K 267_A 1.782 1.00
51_C 84_F 1.769 1.00
258_R 261_Q 1.755 1.00
181_I 186_V 1.676 1.00
12_L 30_Q 1.666 1.00
25_T 29_Y 1.665 1.00
151_E 177_R 1.658 1.00
144_G 182_G 1.639 1.00
35_A 76_R 1.637 1.00
166_E 178_R 1.624 1.00
47_S 50_Q 1.59 1.00
250_M 255_G 1.581 1.00
60_A 77_L 1.578 1.00
56_V 98_A 1.577 1.00
74_A 104_P 1.56 1.00
250_M 260_V 1.554 1.00
143_Y 249_H 1.539 1.00
246_F 250_M 1.527 1.00
147_L 152_L 1.526 1.00
118_D 121_R 1.512 1.00
180_P 263_L 1.482 1.00
32_Q 79_A 1.472 1.00
271_T 274_I 1.458 1.00
86_W 90_Q 1.455 1.00
138_M 220_V 1.451 1.00
8_V 83_F 1.439 1.00
138_M 152_L 1.432 1.00
137_A 192_W 1.427 1.00
8_V 33_L 1.427 1.00
149_L 153_V 1.4 0.99
147_L 169_V 1.397 0.99
88_V 93_L 1.394 0.99
83_F 87_L 1.393 0.99
24_I 27_L 1.393 0.99
23_P 27_L 1.392 0.99
156_D 159_H 1.389 0.99
252_E 282_H 1.384 0.99
11_Y 82_S 1.382 0.99
162_L 190_E 1.379 0.99
251_L 276_T 1.377 0.99
118_D 235_N 1.376 0.99
59_F 76_R 1.368 0.99
5_H 9_E 1.359 0.99
150_S 154_G 1.346 0.99
270_S 273_Q 1.342 0.99
264_L 272_T 1.336 0.99
228_G 237_V 1.333 0.99
205_A 214_R 1.333 0.99
161_D 166_E 1.33 0.99
165_G 183_R 1.315 0.99
136_R 140_E 1.314 0.99
114_I 118_D 1.301 0.99
149_L 221_Q 1.293 0.99
114_I 237_V 1.291 0.99
170_M 176_E 1.288 0.99
158_K 204_D 1.28 0.99
149_L 217_A 1.255 0.99
120_N 124_D 1.254 0.99
258_R 262_E 1.252 0.99
282_H 285_S 1.249 0.99
261_Q 272_T 1.248 0.99
181_I 185_A 1.237 0.98
217_A 221_Q 1.229 0.98
248_T 277_H 1.224 0.98
89_S 102_S 1.222 0.98
261_Q 269_L 1.219 0.98
116_V 249_H 1.216 0.98
71_A 75_L 1.213 0.98
140_E 188_W 1.211 0.98
216_S 219_N 1.204 0.98
39_F 62_R 1.204 0.98
137_A 188_W 1.196 0.98
144_G 185_A 1.187 0.98
162_L 186_V 1.183 0.98
85_D 99_K 1.177 0.98
27_L 31_R 1.171 0.98
72_S 76_R 1.169 0.97
155_L 167_V 1.164 0.97
153_V 217_A 1.162 0.97
114_I 245_S 1.155 0.97
153_V 220_V 1.147 0.97
113_N 277_H 1.145 0.97
84_F 98_A 1.138 0.97
7_D 87_L 1.137 0.97
182_G 185_A 1.133 0.97
10_R 92_E 1.133 0.97
39_F 58_N 1.128 0.97
125_I 231_Q 1.125 0.97
183_R 187_A 1.119 0.96
168_W 176_E 1.117 0.96
77_L 81_R 1.116 0.96
116_V 253_S 1.115 0.96
245_S 249_H 1.114 0.96
249_H 252_E 1.107 0.96
119_M 143_Y 1.106 0.96
223_R 226_E 1.105 0.96
252_E 279_D 1.096 0.96
57_R 61_V 1.094 0.96
268_N 273_Q 1.091 0.96
12_L 26_L 1.076 0.95
125_I 230_K 1.076 0.95
281_Q 285_S 1.074 0.95
246_F 264_L 1.071 0.95
39_F 59_F 1.071 0.95
127_I 136_R 1.067 0.95
46_Q 50_Q 1.065 0.95
143_Y 245_S 1.064 0.95
225_A 236_H 1.059 0.95
84_F 97_P 1.056 0.95
7_D 48_W 1.048 0.94
140_E 184_N 1.047 0.94
247_A 251_L 1.046 0.94
59_F 63_S 1.046 0.94
247_A 260_V 1.044 0.94
85_D 96_N 1.041 0.94
5_H 45_L 1.038 0.94
138_M 207_F 1.038 0.94
268_N 271_T 1.037 0.94
141_V 167_V 1.035 0.94
143_Y 242_L 1.029 0.94
259_G 286_V 1.025 0.93
218_R 221_Q 1.024 0.93
91_N 95_A 1.016 0.93
285_S 289_A 1.015 0.93
114_I 122_L 1.013 0.93
158_K 203_D 1.013 0.93
63_S 73_L 1.012 0.93
135_D 223_R 1.006 0.93
22_S 25_T 1.004 0.93
9_E 13_R 1.001 0.92
141_V 207_F 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a0pA10.95641000.186Contact Map0.594
1z1bA20.92951000.224Contact Map0.587
2a3vA40.93291000.231Contact Map0.812
1z19A20.92951000.231Contact Map0.598
1xo0A20.96641000.238Contact Map0.568
4a8eA10.92281000.257Contact Map0.728
4e0gA10.95971000.384Contact Map0.389
3nkhA20.6981000.434Contact Map0.793
1ae9A20.57381000.489Contact Map0.619
1aihA40.560499.90.528Contact Map0.726
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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