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OPENSEQ.org
INTQ - Putative lambdoid prophage Qin defective integrase (Fragment)
UniProt: P76168 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13188
Length: 385 (327)
Sequences: 2990
Seq/Len: 9.14
INTQ
Paralog alert: 0.61 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
322_A 339_M 4.293 1.00
313_K 316_Q 3.592 1.00
321_Y 338_Q 3.434 1.00
230_R 340_G 3.252 1.00
198_W 246_M 3.192 1.00
56_A 221_V 2.953 1.00
83_I 129_F 2.942 1.00
202_D 205_N 2.852 1.00
188_V 210_I 2.739 1.00
77_K 87_K 2.731 1.00
183_S 193_L 2.575 1.00
44_A 128_V 2.574 1.00
319_H 353_K 2.498 1.00
343_D 349_Q 2.37 1.00
198_W 275_V 2.364 1.00
92_R 122_M 2.236 1.00
233_H 338_Q 2.227 1.00
206_G 239_I 2.217 1.00
163_E 310_R 2.216 1.00
45_E 71_L 2.204 1.00
183_S 314_S 2.191 1.00
332_P 348_F 2.108 1.00
84_N 87_K 2.108 1.00
346_M 350_V 2.097 1.00
160_S 163_E 2.095 1.00
190_P 315_Y 2.074 1.00
56_A 220_T 2.04 1.00
44_A 67_I 2.032 1.00
200_D 212_R 2.013 1.00
136_G 140_D 1.97 1.00
341_H 347_V 1.963 1.00
234_L 238_A 1.934 1.00
326_L 335_I 1.915 1.00
326_L 352_G 1.907 1.00
209_M 231_V 1.9 1.00
331_N 334_F 1.852 1.00
206_G 236_K 1.848 1.00
130_Q 144_K 1.84 1.00
224_T 227_G 1.835 1.00
333_A 336_A 1.827 1.00
159_L 167_L 1.823 1.00
129_F 143_F 1.818 1.00
208_M 234_L 1.759 1.00
43_L 80_A 1.739 1.00
43_L 131_F 1.738 1.00
167_L 180_W 1.73 1.00
59_S 63_Y 1.726 1.00
197_G 212_R 1.701 1.00
200_D 211_R 1.694 1.00
78_N 82_S 1.688 1.00
48_L 60_L 1.683 1.00
207_T 231_V 1.675 1.00
234_L 239_I 1.667 1.00
43_L 132_G 1.664 1.00
88_L 143_F 1.649 1.00
159_L 312_R 1.647 1.00
321_Y 325_S 1.645 1.00
133_V 138_L 1.644 1.00
222_P 229_N 1.608 1.00
40_I 83_I 1.597 1.00
134_D 147_S 1.584 1.00
179_L 193_L 1.579 1.00
235_I 238_A 1.556 1.00
39_T 42_E 1.546 1.00
49_A 52_E 1.517 1.00
41_K 71_L 1.504 1.00
164_F 184_V 1.495 1.00
199_E 273_T 1.494 1.00
345_Q 349_Q 1.485 1.00
239_I 243_R 1.471 1.00
74_I 91_V 1.468 1.00
198_W 242_L 1.444 1.00
178_N 245_Q 1.442 0.99
131_F 135_N 1.44 0.99
73_I 94_E 1.438 0.99
203_L 234_L 1.432 0.99
339_M 347_V 1.424 0.99
336_A 344_A 1.408 0.99
64_R 68_K 1.407 0.99
41_K 76_E 1.401 0.99
323_C 354_W 1.397 0.99
278_P 287_Y 1.38 0.99
236_K 240_D 1.37 0.99
301_D 311_H 1.368 0.99
182_V 238_A 1.357 0.99
343_D 346_M 1.341 0.99
114_S 117_T 1.34 0.99
89_L 135_N 1.315 0.99
325_S 335_I 1.305 0.99
171_C 303_A 1.301 0.99
203_L 239_I 1.295 0.99
185_Y 235_I 1.286 0.99
138_L 142_P 1.278 0.99
41_K 45_E 1.272 0.98
334_F 362_Q 1.272 0.98
184_V 317_S 1.264 0.98
116_V 120_N 1.261 0.98
40_I 125_L 1.26 0.98
182_V 208_M 1.259 0.98
192_E 230_R 1.255 0.98
197_G 274_F 1.245 0.98
338_Q 359_N 1.242 0.98
129_F 142_P 1.238 0.98
188_V 232_I 1.236 0.98
179_L 276_F 1.233 0.98
128_V 132_G 1.224 0.98
325_S 330_A 1.215 0.98
40_I 128_V 1.212 0.98
219_F 274_F 1.211 0.98
198_W 249_T 1.198 0.97
182_V 276_F 1.195 0.97
336_A 349_Q 1.186 0.97
69_N 72_S 1.184 0.97
312_R 316_Q 1.179 0.97
202_D 207_T 1.177 0.97
77_K 83_I 1.176 0.97
95_L 121_Y 1.175 0.97
130_Q 141_N 1.171 0.97
92_R 146_I 1.165 0.97
327_T 355_M 1.152 0.97
197_G 273_T 1.148 0.97
187_G 321_Y 1.148 0.97
157_D 310_R 1.139 0.96
89_L 93_K 1.134 0.96
185_Y 238_A 1.128 0.96
330_A 362_Q 1.125 0.96
66_V 124_N 1.123 0.96
336_A 347_V 1.116 0.96
37_D 81_S 1.102 0.95
191_G 222_P 1.094 0.95
337_N 359_N 1.094 0.95
178_N 241_A 1.093 0.95
178_N 276_F 1.087 0.95
159_L 163_E 1.063 0.94
344_A 348_F 1.063 0.94
113_R 117_T 1.062 0.94
122_M 146_I 1.061 0.94
57_K 61_N 1.058 0.94
52_E 60_L 1.057 0.94
170_A 307_A 1.051 0.94
91_V 95_L 1.047 0.93
177_K 181_C 1.046 0.93
55_V 59_S 1.046 0.93
69_N 121_Y 1.046 0.93
203_L 243_R 1.045 0.93
85_K 134_D 1.044 0.93
362_Q 365_L 1.042 0.93
45_E 49_A 1.041 0.93
237_P 367_N 1.04 0.93
223_K 227_G 1.039 0.93
188_V 208_M 1.037 0.93
156_P 313_K 1.036 0.93
236_K 367_N 1.034 0.93
326_L 355_M 1.03 0.93
297_R 314_S 1.028 0.93
181_C 241_A 1.026 0.92
322_A 326_L 1.024 0.92
233_H 359_N 1.02 0.92
188_V 193_L 1.018 0.92
323_C 327_T 1.017 0.92
190_P 194_C 1.014 0.92
213_N 222_P 1.011 0.92
136_G 145_G 1.01 0.92
348_F 352_G 1.004 0.91
164_F 168_I 1.004 0.91
83_I 142_P 1.004 0.91
333_A 349_Q 1.003 0.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1a0pA10.72471000.421Contact Map0.536
2a3vA40.78181000.427Contact Map0.764
1z1bA20.80261000.43Contact Map0.583
1z19A20.71691000.442Contact Map0.586
1xo0A20.74291000.46Contact Map0.5
4a8eA10.75581000.461Contact Map0.668
4e0gA10.87011000.537Contact Map0.352
3nkhA20.5741000.547Contact Map0.748
1ae9A20.44941000.625Contact Map0.577
1aihA40.42699.90.665Contact Map0.756
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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