May 4, 2021 - We are working on upgrading the webserver, some pages may not work.
OPENSEQ.org
INTF - Putative prophage CP4-6 integrase
UniProt: P71298 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13554
Length: 466 (390)
Sequences: 2155
Seq/Len: 5.53
INTF
Paralog alert: 0.71 [within 20: 0.06] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
199_L 208_Y 3.937 1.00
35_F 39_R 3.644 1.00
314_R 362_G 3.591 1.00
140_S 144_E 3.475 1.00
100_E 103_R 3.281 1.00
74_Q 81_T 3.17 1.00
41_F 52_L 2.919 1.00
304_G 402_F 2.804 1.00
441_R 445_E 2.685 1.00
313_L 318_V 2.673 1.00
319_D 322_W 2.518 1.00
403_G 416_V 2.487 1.00
216_E 227_A 2.367 1.00
205_T 249_P 2.357 1.00
323_S 341_P 2.235 1.00
36_E 39_R 2.235 1.00
403_G 407_E 2.204 1.00
402_F 406_A 2.19 1.00
315_W 364_V 2.163 1.00
302_L 444_H 2.147 1.00
313_L 325_M 2.145 1.00
320_F 344_S 2.102 1.00
299_V 343_V 2.082 1.00
411_V 442_K 2.068 1.00
70_A 88_N 2.037 1.00
163_S 166_Y 2.022 1.00
281_W 285_V 2.019 1.00
348_N 351_A 1.981 1.00
70_A 85_T 1.95 1.00
74_Q 83_R 1.93 1.00
107_L 112_I 1.921 1.00
313_L 364_V 1.917 1.00
54_D 98_R 1.9 1.00
400_R 434_R 1.865 1.00
295_A 346_L 1.849 1.00
82_L 113_D 1.839 1.00
46_G 50_T 1.831 1.00
305_A 310_I 1.827 1.00
311_A 376_E 1.789 1.00
140_S 198_N 1.787 1.00
241_Q 247_I 1.787 1.00
35_F 89_I 1.765 1.00
36_E 40_R 1.765 1.00
295_A 350_L 1.72 1.00
278_L 401_S 1.699 1.00
315_W 347_L 1.689 1.00
73_F 108_I 1.688 1.00
62_C 71_F 1.674 1.00
315_W 351_A 1.672 1.00
174_S 192_P 1.671 1.00
41_F 50_T 1.669 1.00
63_R 83_R 1.658 1.00
341_P 441_R 1.644 0.99
142_A 201_L 1.621 0.99
147_L 171_I 1.595 0.99
49_Q 63_R 1.591 0.99
196_L 212_W 1.567 0.99
204_L 235_I 1.557 0.99
407_E 416_V 1.556 0.99
209_I 253_A 1.553 0.99
139_F 231_L 1.551 0.99
144_E 193_L 1.541 0.99
93_K 96_D 1.531 0.99
192_P 231_L 1.521 0.99
171_I 175_S 1.513 0.99
342_Y 448_E 1.498 0.99
51_F 63_R 1.497 0.99
50_T 64_A 1.479 0.99
51_F 61_A 1.47 0.99
41_F 62_C 1.466 0.99
323_S 344_S 1.463 0.99
140_S 193_L 1.453 0.98
376_E 379_S 1.438 0.98
191_G 219_N 1.436 0.98
281_W 385_L 1.435 0.98
324_S 336_I 1.429 0.98
38_L 62_C 1.429 0.98
86_I 92_W 1.424 0.98
271_D 277_Q 1.424 0.98
320_F 323_S 1.41 0.98
404_T 433_R 1.41 0.98
272_C 434_R 1.41 0.98
342_Y 441_R 1.409 0.98
317_D 328_K 1.408 0.98
347_L 364_V 1.404 0.98
61_A 83_R 1.402 0.98
75_S 113_D 1.391 0.98
403_G 429_E 1.39 0.98
415_I 439_L 1.389 0.98
145_D 247_I 1.386 0.98
296_Y 310_I 1.384 0.98
76_V 81_T 1.377 0.98
369_S 372_G 1.373 0.98
73_F 105_Q 1.373 0.98
162_Y 166_Y 1.369 0.97
344_S 348_N 1.362 0.97
61_A 74_Q 1.36 0.97
173_L 230_L 1.351 0.97
117_A 121_K 1.343 0.97
383_R 387_L 1.341 0.97
112_I 117_A 1.339 0.97
195_S 215_T 1.335 0.97
200_P 203_E 1.332 0.97
117_A 120_V 1.332 0.97
326_R 336_I 1.331 0.97
144_E 171_I 1.328 0.97
166_Y 170_H 1.325 0.97
214_S 217_R 1.321 0.97
171_I 193_L 1.321 0.97
407_E 413_T 1.32 0.97
96_D 99_A 1.32 0.97
340_T 343_V 1.311 0.96
413_T 429_E 1.311 0.96
144_E 175_S 1.306 0.96
100_E 104_L 1.298 0.96
340_T 444_H 1.296 0.96
335_R 421_G 1.291 0.96
140_S 197_L 1.289 0.96
73_F 101_A 1.284 0.96
320_F 348_N 1.266 0.95
427_L 430_K 1.263 0.95
214_S 241_Q 1.263 0.95
53_W 61_A 1.262 0.95
174_S 193_L 1.262 0.95
142_A 238_S 1.256 0.95
403_G 424_P 1.238 0.95
317_D 325_M 1.238 0.95
294_S 298_Q 1.235 0.95
407_E 414_G 1.233 0.95
280_S 284_A 1.233 0.95
96_D 110_T 1.231 0.94
99_A 103_R 1.23 0.94
308_E 312_S 1.225 0.94
318_V 364_V 1.225 0.94
411_V 415_I 1.224 0.94
99_A 106_T 1.218 0.94
71_F 89_I 1.207 0.94
235_I 252_L 1.207 0.94
397_G 400_R 1.204 0.94
35_F 38_L 1.2 0.93
301_L 398_L 1.197 0.93
407_E 429_E 1.196 0.93
72_V 85_T 1.195 0.93
85_T 88_N 1.195 0.93
205_T 208_Y 1.194 0.93
86_I 100_E 1.19 0.93
73_F 86_I 1.188 0.93
63_R 72_V 1.187 0.93
73_F 104_L 1.184 0.93
424_P 429_E 1.182 0.93
53_W 74_Q 1.175 0.93
91_D 105_Q 1.174 0.92
286_R 298_Q 1.172 0.92
403_G 420_M 1.171 0.92
419_I 440_L 1.168 0.92
400_R 431_H 1.166 0.92
326_R 334_E 1.162 0.92
170_H 230_L 1.16 0.92
272_C 400_R 1.159 0.92
305_A 325_M 1.158 0.92
71_F 90_N 1.156 0.92
302_L 340_T 1.151 0.91
340_T 441_R 1.15 0.91
381_H 395_L 1.138 0.91
209_I 231_L 1.137 0.91
431_H 434_R 1.136 0.91
339_L 343_V 1.128 0.90
96_D 106_T 1.126 0.90
42_T 45_E 1.122 0.90
143_W 234_F 1.121 0.90
199_L 204_L 1.117 0.90
72_V 83_R 1.116 0.90
51_F 83_R 1.114 0.90
291_P 295_A 1.112 0.90
84_M 115_R 1.112 0.90
285_V 297_L 1.111 0.89
174_S 234_F 1.107 0.89
309_E 335_R 1.106 0.89
318_V 325_M 1.103 0.89
75_S 84_M 1.095 0.89
403_G 433_R 1.095 0.89
49_Q 65_T 1.088 0.88
39_R 89_I 1.088 0.88
82_L 115_R 1.088 0.88
320_F 364_V 1.087 0.88
107_L 117_A 1.085 0.88
438_D 442_K 1.084 0.88
84_M 104_L 1.077 0.87
228_Y 253_A 1.073 0.87
411_V 439_L 1.067 0.87
77_Y 108_I 1.065 0.87
51_F 74_Q 1.062 0.86
146_Y 233_A 1.06 0.86
222_T 226_H 1.058 0.86
194_A 197_L 1.056 0.86
116_I 119_A 1.05 0.86
145_D 241_Q 1.047 0.85
331_I 421_G 1.046 0.85
103_R 106_T 1.046 0.85
419_I 439_L 1.036 0.85
284_A 390_L 1.031 0.84
33_F 54_D 1.031 0.84
305_A 313_L 1.03 0.84
33_F 38_L 1.025 0.84
230_L 233_A 1.022 0.83
216_E 224_T 1.021 0.83
177_G 220_R 1.02 0.83
111_G 114_P 1.018 0.83
321_K 348_N 1.015 0.83
312_S 317_D 1.014 0.83
172_N 176_R 1.009 0.82
99_A 102_R 1.009 0.82
38_L 41_F 1.007 0.82
342_Y 445_E 1.006 0.82
424_P 430_K 1.006 0.82
311_A 373_K 1 0.82
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.72531000.596Contact Map0.515
1a0pA10.59441000.66Contact Map0.504
1z19A20.58581000.662Contact Map0.467
2a3vA40.59011000.67Contact Map0.613
4a8eA10.61161000.692Contact Map0.609
1xo0A20.61161000.697Contact Map0.49
4e0gA10.84121000.726Contact Map0.326
3nkhA20.43991000.748Contact Map0.672
1ae9A20.354199.90.773Contact Map0.4
1aihA40.356299.90.781Contact Map0.633
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
Page generated in 0.0137 seconds.