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OPENSEQ.org
INTA - Prophage CP4-57 integrase
UniProt: P32053 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11783
Length: 413 (393)
Sequences: 5199
Seq/Len: 13.23
INTA
Paralog alert: 0.68 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: FIMB FIME INTA INTB INTD INTE INTF INTQ INTR INTS INTZ XERC XERD
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
145_I 154_T 3.982 1.00
344_S 361_L 3.402 1.00
261_D 264_A 3.272 1.00
335_V 338_G 3.045 1.00
257_W 296_K 2.957 1.00
256_R 303_E 2.768 1.00
108_L 112_E 2.697 1.00
74_L 77_E 2.652 1.00
257_W 305_I 2.618 1.00
10_D 14_K 2.549 1.00
343_A 360_A 2.49 1.00
280_H 362_A 2.424 1.00
131_W 135_E 2.406 1.00
265_S 286_D 2.382 1.00
341_S 375_R 2.381 1.00
111_A 181_V 2.353 1.00
265_S 289_L 2.349 1.00
150_I 182_M 2.322 1.00
110_V 147_I 2.26 1.00
151_K 154_T 2.249 1.00
108_L 144_D 2.236 1.00
46_R 55_R 2.191 1.00
246_I 343_A 2.171 1.00
262_F 289_L 2.135 1.00
112_E 139_F 2.119 1.00
162_V 174_L 2.086 1.00
16_A 25_L 2.066 1.00
284_L 288_A 2.039 1.00
111_A 134_L 2.033 1.00
110_V 185_A 2.026 1.00
343_A 347_L 2.002 1.00
387_Q 391_D 1.982 1.00
348_N 357_I 1.968 1.00
354_P 370_R 1.967 1.00
268_K 281_T 1.94 1.00
108_L 139_F 1.901 1.00
68_L 72_R 1.891 1.00
266_E 281_T 1.885 1.00
48_Y 55_R 1.882 1.00
242_Q 252_A 1.878 1.00
255_A 260_I 1.877 1.00
259_E 270_P 1.873 1.00
67_S 70_D 1.867 1.00
237_C 295_M 1.851 1.00
155_L 196_S 1.824 1.00
77_E 81_L 1.81 1.00
141_A 161_P 1.786 1.00
242_Q 336_S 1.782 1.00
126_Y 130_I 1.775 1.00
257_W 292_L 1.753 1.00
241_W 288_A 1.752 1.00
365_D 371_R 1.73 1.00
183_I 197_V 1.716 1.00
259_E 273_R 1.709 1.00
249_P 337_H 1.681 1.00
159_V 175_C 1.676 1.00
344_S 357_I 1.674 1.00
142_I 158_A 1.672 1.00
146_S 149_E 1.654 1.00
46_R 57_K 1.652 1.00
11_T 14_K 1.652 1.00
19_K 23_Y 1.632 1.00
247_T 269_I 1.626 1.00
115_W 127_A 1.617 1.00
106_T 109_L 1.616 1.00
187_N 200_G 1.612 1.00
247_T 252_A 1.603 1.00
145_I 150_I 1.596 1.00
107_F 150_I 1.584 1.00
348_N 374_N 1.583 1.00
355_D 358_E 1.583 1.00
123_T 126_Y 1.575 1.00
255_A 267_W 1.536 1.00
353_P 356_V 1.527 1.00
289_L 293_E 1.524 1.00
283_P 360_A 1.515 1.00
134_L 139_F 1.513 1.00
238_L 252_A 1.506 1.00
285_S 288_A 1.502 1.00
186_Q 191_I 1.496 1.00
189_G 193_A 1.484 1.00
182_M 195_P 1.472 1.00
215_R 218_Q 1.468 1.00
261_D 266_E 1.467 1.00
236_R 240_M 1.46 1.00
107_F 178_I 1.459 1.00
145_I 149_E 1.457 1.00
169_E 173_R 1.448 1.00
11_T 15_A 1.442 1.00
73_K 77_E 1.427 1.00
352_F 388_W 1.417 1.00
184_Y 188_T 1.41 1.00
247_T 267_W 1.4 0.99
137_D 165_R 1.388 0.99
156_V 160_Q 1.388 0.99
356_V 385_M 1.379 0.99
108_L 143_G 1.374 0.99
284_L 289_L 1.367 0.99
151_K 192_D 1.365 0.99
368_E 372_A 1.354 0.99
344_S 348_N 1.35 0.99
380_E 383_R 1.342 0.99
77_E 80_V 1.332 0.99
218_Q 221_Q 1.33 0.99
16_A 23_Y 1.328 0.99
132_R 136_R 1.328 0.99
60_F 74_L 1.324 0.99
183_I 194_V 1.313 0.99
286_D 290_A 1.313 0.99
214_I 222_L 1.311 0.99
249_P 253_A 1.307 0.99
133_S 177_R 1.298 0.99
110_V 184_Y 1.289 0.99
293_E 296_K 1.28 0.99
107_F 181_V 1.277 0.99
347_L 357_I 1.277 0.99
147_I 182_M 1.276 0.99
81_L 86_I 1.273 0.99
262_F 293_E 1.265 0.99
267_W 284_L 1.261 0.99
119_K 127_A 1.257 0.99
80_V 84_K 1.241 0.98
255_A 305_I 1.241 0.98
130_I 177_R 1.233 0.98
175_C 179_N 1.229 0.98
237_C 291_I 1.228 0.98
256_R 304_F 1.226 0.98
262_F 305_I 1.22 0.98
129_D 132_R 1.22 0.98
116_N 119_K 1.217 0.98
243_L 339_L 1.216 0.98
345_T 376_S 1.214 0.98
119_K 131_W 1.193 0.98
75_R 79_K 1.189 0.98
244_L 285_S 1.185 0.98
278_R 364_V 1.185 0.98
286_D 387_Q 1.183 0.98
212_P 218_Q 1.183 0.98
182_M 196_S 1.174 0.98
112_E 135_E 1.171 0.98
22_D 34_L 1.166 0.97
122_V 126_Y 1.164 0.97
24_Q 32_T 1.162 0.97
238_L 306_F 1.157 0.97
74_L 78_S 1.154 0.97
179_N 183_I 1.149 0.97
262_F 284_L 1.148 0.97
42_L 62_A 1.147 0.97
42_L 59_S 1.147 0.97
115_W 131_W 1.146 0.97
138_I 178_I 1.139 0.97
258_D 303_E 1.135 0.97
137_D 140_P 1.131 0.97
345_T 374_N 1.119 0.96
22_D 37_S 1.117 0.96
182_M 191_I 1.116 0.96
214_I 334_L 1.116 0.96
263_N 293_E 1.114 0.96
112_E 131_W 1.111 0.96
219_L 243_L 1.109 0.96
221_Q 225_T 1.106 0.96
358_E 371_R 1.099 0.96
285_S 390_A 1.098 0.96
222_L 325_L 1.098 0.96
160_Q 188_T 1.092 0.96
73_K 80_V 1.091 0.96
244_L 390_A 1.091 0.96
260_I 267_W 1.09 0.96
107_F 142_I 1.09 0.96
140_P 143_G 1.086 0.96
251_E 280_H 1.086 0.96
134_L 138_I 1.083 0.96
244_L 288_A 1.083 0.96
241_W 306_F 1.081 0.95
134_L 181_V 1.077 0.95
181_V 185_A 1.076 0.95
127_A 131_W 1.075 0.95
334_L 338_G 1.073 0.95
240_M 287_G 1.066 0.95
49_R 52_T 1.065 0.95
107_F 111_A 1.065 0.95
10_D 63_Y 1.063 0.95
262_F 265_S 1.062 0.95
111_A 139_F 1.061 0.95
241_W 292_L 1.059 0.95
308_S 314_Q 1.057 0.95
352_F 356_V 1.054 0.95
27_D 72_R 1.054 0.95
112_E 116_N 1.053 0.95
247_T 282_V 1.049 0.94
367_N 371_R 1.049 0.94
253_A 318_S 1.044 0.94
288_A 291_I 1.041 0.94
113_R 117_V 1.04 0.94
26_Y 32_T 1.034 0.94
24_Q 34_L 1.033 0.94
250_A 254_E 1.03 0.94
10_D 13_I 1.023 0.93
44_Q 59_S 1.023 0.93
227_R 240_M 1.02 0.93
114_W 180_E 1.018 0.93
113_R 190_L 1.016 0.93
355_D 370_R 1.01 0.93
353_P 381_Q 1.008 0.93
222_L 239_F 1.007 0.93
256_R 259_E 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1z1bA20.82081000.446Contact Map0.604
1z19A20.65131000.505Contact Map0.596
1a0pA10.65861000.506Contact Map0.578
2a3vA40.6611000.512Contact Map0.722
4a8eA10.68771000.551Contact Map0.667
1xo0A20.6781000.553Contact Map0.505
4e0gA10.89831000.612Contact Map0.402
3nkhA20.49391000.624Contact Map0.78
1ae9A20.39951000.675Contact Map0.614
1aihA40.40681000.683Contact Map0.733
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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