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OPENSEQ.org
GSIC - Glutathione transport system permease protein GsiC
UniProt: P75798 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13474
Length: 306 (305)
Sequences: 7334
Seq/Len: 24.05
GSIC
Paralog alert: 0.82 [within 20: 0.35] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
59_Q 63_H 3.622 1.00
53_Q 58_D 3.52 1.00
28_H 64_Q 3.441 1.00
59_Q 67_H 3.382 1.00
20_S 65_F 3.232 1.00
45_A 49_E 3.161 1.00
70_S 74_Q 3.161 1.00
33_D 52_R 3.094 1.00
66_W 70_S 3.027 1.00
21_V 65_F 2.735 1.00
209_R 215_E 2.726 1.00
217_W 221_K 2.651 1.00
196_F 223_G 2.626 1.00
97_P 255_W 2.565 1.00
205_M 223_G 2.553 1.00
104_T 177_S 2.453 1.00
62_Y 66_W 2.448 1.00
162_L 174_I 2.263 1.00
260_R 264_D 2.222 1.00
232_V 299_I 2.219 1.00
90_E 261_L 2.174 1.00
236_G 292_V 2.072 1.00
199_V 204_Y 2.062 1.00
108_W 181_G 2.02 1.00
129_D 193_R 1.976 1.00
127_W 131_L 1.94 1.00
207_T 211_K 1.912 1.00
19_V 282_S 1.908 1.00
200_L 223_G 1.905 1.00
3_N 7_K 1.897 1.00
47_V 50_L 1.861 1.00
214_S 217_W 1.857 1.00
233_T 296_Y 1.857 1.00
50_L 54_Q 1.845 1.00
71_N 76_D 1.811 1.00
86_P 89_D 1.805 1.00
63_H 67_H 1.803 1.00
48_I 52_R 1.793 1.00
72_A 77_F 1.771 1.00
123_W 126_R 1.761 1.00
49_E 53_Q 1.748 1.00
199_V 202_E 1.746 1.00
116_A 132_S 1.74 1.00
111_I 115_A 1.727 1.00
216_T 220_L 1.721 1.00
20_S 68_Y 1.705 1.00
16_L 283_L 1.703 1.00
295_L 298_A 1.695 1.00
17_F 21_V 1.689 1.00
83_S 90_E 1.686 1.00
88_A 92_A 1.654 1.00
44_D 47_V 1.649 1.00
85_R 89_D 1.631 1.00
10_L 14_P 1.63 1.00
162_L 171_Q 1.629 1.00
112_F 115_A 1.629 1.00
49_E 52_R 1.588 1.00
77_F 276_A 1.57 1.00
156_S 164_T 1.545 1.00
12_L 286_I 1.542 1.00
63_H 66_W 1.538 1.00
177_S 181_G 1.512 1.00
146_A 150_L 1.509 1.00
67_H 70_S 1.507 1.00
153_Q 158_E 1.498 1.00
203_D 206_R 1.491 1.00
265_S 273_V 1.483 1.00
125_N 129_D 1.482 1.00
199_V 205_M 1.48 1.00
128_P 132_S 1.47 1.00
204_Y 226_N 1.467 1.00
154_V 158_E 1.462 1.00
205_M 218_V 1.458 1.00
151_L 179_T 1.457 1.00
85_R 93_S 1.455 1.00
119_I 123_W 1.454 1.00
87_V 276_A 1.443 1.00
122_V 219_V 1.434 1.00
181_G 185_A 1.431 1.00
110_V 235_M 1.423 1.00
35_A 48_I 1.409 1.00
17_F 69_I 1.407 0.99
17_F 65_F 1.397 0.99
112_F 185_A 1.395 0.99
162_L 175_L 1.394 0.99
121_A 196_F 1.37 0.99
262_L 277_E 1.368 0.99
139_G 186_A 1.362 0.99
118_I 196_F 1.362 0.99
119_I 128_P 1.361 0.99
109_A 184_V 1.36 0.99
121_A 197_V 1.357 0.99
97_P 100_W 1.339 0.99
261_L 273_V 1.328 0.99
113_G 188_M 1.328 0.99
56_G 59_Q 1.325 0.99
199_V 227_A 1.323 0.99
117_G 192_T 1.319 0.99
211_K 222_H 1.311 0.99
21_V 61_L 1.301 0.99
132_S 189_A 1.299 0.99
123_W 128_P 1.294 0.99
60_P 63_H 1.291 0.99
90_E 273_V 1.287 0.99
213_V 217_W 1.284 0.99
142_F 147_L 1.279 0.99
67_H 71_N 1.277 0.99
154_V 159_L 1.277 0.99
51_V 55_L 1.268 0.99
277_E 281_F 1.257 0.99
6_I 10_L 1.253 0.99
12_L 290_L 1.229 0.98
32_G 269_R 1.224 0.98
155_F 159_L 1.208 0.98
77_F 88_A 1.196 0.98
294_V 298_A 1.19 0.98
229_I 296_Y 1.187 0.98
117_G 121_A 1.164 0.97
150_L 154_V 1.156 0.97
16_L 286_I 1.153 0.97
56_G 67_H 1.146 0.97
28_H 61_L 1.131 0.97
113_G 192_T 1.127 0.97
151_L 175_L 1.123 0.97
103_I 107_V 1.121 0.97
108_W 177_S 1.117 0.96
131_L 135_I 1.117 0.96
291_V 295_L 1.117 0.96
51_V 54_Q 1.105 0.96
93_S 96_M 1.103 0.96
125_N 130_R 1.102 0.96
20_S 279_L 1.101 0.96
188_M 238_Q 1.097 0.96
106_M 235_M 1.097 0.96
100_W 173_Y 1.097 0.96
120_A 132_S 1.097 0.96
148_G 179_T 1.084 0.96
121_A 200_L 1.084 0.96
4_Y 8_R 1.074 0.95
85_R 90_E 1.065 0.95
147_L 182_A 1.06 0.95
148_G 252_V 1.059 0.95
5_V 294_V 1.055 0.95
65_F 69_I 1.052 0.95
89_D 92_A 1.049 0.94
4_Y 305_Y 1.049 0.94
144_A 249_V 1.044 0.94
59_Q 62_Y 1.042 0.94
246_S 249_V 1.041 0.94
174_I 178_L 1.04 0.94
100_W 104_T 1.033 0.94
191_F 234_M 1.033 0.94
100_W 167_A 1.029 0.94
21_V 25_L 1.027 0.94
2_L 6_I 1.024 0.93
199_V 223_G 1.02 0.93
53_Q 59_Q 1.015 0.93
193_R 197_V 1.008 0.93
25_L 61_L 1.007 0.93
33_D 36_R 1.007 0.93
167_A 255_W 1.005 0.93
80_S 270_D 1.004 0.93
133_M 189_A 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.686399.90.698Contact Map0.74
3rlfF10.911899.80.732Contact Map0.563
2onkC40.862799.80.737Contact Map0.583
3d31C20.862799.80.747Contact Map0.565
3rlfG10.91599.70.773Contact Map0.431
3aqpA20.839960.969Contact Map0.343
2p02A10.27125.60.969Contact Map0.295
2jlnA10.82685.60.969Contact Map0.197
1n0uA10.20264.40.971Contact Map0.33
4humA10.32353.50.972Contact Map0.126
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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