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NIKC - Nickel transport system permease protein NikC
UniProt: P0AFA9 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12077
Length: 277 (265)
Sequences: 11207
Seq/Len: 42.29
NIKC
Paralog alert: 0.90 [within 20: 0.63] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
104_D 154_R 2.857 1.00
207_V 223_E 2.663 1.00
157_V 184_L 2.628 1.00
92_I 107_T 2.549 1.00
170_R 176_H 2.545 1.00
71_T 224_W 2.449 1.00
178_R 182_D 2.412 1.00
160_L 165_F 2.395 1.00
164_E 167_L 2.36 1.00
73_V 212_F 2.227 1.00
177_V 181_V 2.198 1.00
160_L 163_R 2.152 1.00
224_W 252_S 2.144 1.00
40_D 43_S 2.133 1.00
174_A 178_R 2.122 1.00
166_V 184_L 2.107 1.00
80_A 138_I 2.085 1.00
84_L 142_A 2.072 1.00
99_I 176_H 2.07 1.00
197_T 260_G 2.063 1.00
175_G 178_R 2.016 1.00
66_R 227_M 2.009 1.00
94_G 157_V 1.948 1.00
57_D 61_R 1.915 1.00
226_V 230_D 1.911 1.00
25_A 71_T 1.91 1.00
50_A 53_W 1.909 1.00
97_G 157_V 1.884 1.00
64_F 68_M 1.863 1.00
54_L 244_W 1.845 1.00
102_R 106_A 1.831 1.00
165_F 187_A 1.819 1.00
149_Y 199_D 1.759 1.00
35_D 38_A 1.747 1.00
87_T 91_V 1.706 1.00
160_L 188_V 1.703 1.00
88_L 91_V 1.683 1.00
166_V 179_V 1.656 1.00
95_S 99_I 1.654 1.00
14_A 255_A 1.646 1.00
23_L 27_T 1.616 1.00
27_T 30_W 1.606 1.00
98_L 176_H 1.58 1.00
161_R 184_L 1.579 1.00
100_G 104_D 1.572 1.00
62_D 65_S 1.57 1.00
231_A 241_Q 1.534 1.00
160_L 184_L 1.533 1.00
99_I 103_V 1.533 1.00
264_R 268_D 1.531 1.00
32_L 65_S 1.519 1.00
97_G 161_R 1.515 1.00
194_V 264_R 1.514 1.00
132_T 136_N 1.511 1.00
86_L 196_A 1.498 1.00
54_L 67_L 1.496 1.00
21_L 252_S 1.486 1.00
109_R 112_D 1.469 1.00
58_H 230_D 1.466 1.00
63_I 244_W 1.443 1.00
103_V 107_T 1.436 1.00
138_I 142_A 1.402 0.99
69_A 72_R 1.399 0.99
107_T 150_A 1.398 0.99
52_H 62_D 1.395 0.99
108_M 150_A 1.387 0.99
93_G 153_V 1.387 0.99
89_G 149_Y 1.383 0.99
17_I 255_A 1.382 0.99
98_L 180_F 1.354 0.99
111_A 150_A 1.349 0.99
228_I 245_P 1.345 0.99
88_L 146_W 1.339 0.99
73_V 76_G 1.33 0.99
95_S 103_V 1.33 0.99
160_L 166_V 1.328 0.99
245_P 249_L 1.307 0.99
85_V 145_H 1.304 0.99
28_S 69_A 1.298 0.99
156_L 159_S 1.298 0.99
82_L 196_A 1.296 0.99
24_I 68_M 1.295 0.99
168_A 172_S 1.292 0.99
54_L 64_F 1.29 0.99
93_G 97_G 1.288 0.99
76_G 80_A 1.288 0.99
63_I 227_M 1.286 0.99
11_V 262_A 1.275 0.99
33_P 65_S 1.265 0.99
154_R 158_I 1.264 0.99
152_M 195_L 1.259 0.99
193_L 267_L 1.246 0.98
18_I 255_A 1.244 0.98
61_R 65_S 1.243 0.98
262_A 266_H 1.219 0.98
59_L 66_R 1.215 0.98
94_G 180_F 1.212 0.98
106_A 110_V 1.212 0.98
90_L 153_V 1.206 0.98
96_A 107_T 1.195 0.98
142_A 146_W 1.194 0.98
46_L 49_D 1.188 0.98
14_A 262_A 1.185 0.98
13_L 16_I 1.173 0.98
15_L 259_V 1.173 0.98
94_G 185_A 1.166 0.97
231_A 242_M 1.157 0.97
89_G 153_V 1.15 0.97
15_L 19_A 1.146 0.97
140_A 144_S 1.142 0.97
263_L 266_H 1.138 0.97
159_S 163_R 1.133 0.97
227_M 241_Q 1.123 0.97
153_V 157_V 1.119 0.96
74_S 78_V 1.095 0.96
77_S 207_V 1.09 0.96
133_G 136_N 1.09 0.96
105_Q 109_R 1.08 0.95
16_I 20_L 1.078 0.95
43_S 46_L 1.076 0.95
157_V 188_V 1.072 0.95
48_P 240_L 1.065 0.95
49_D 52_H 1.064 0.95
121_I 125_F 1.063 0.95
178_R 181_V 1.058 0.95
123_S 140_A 1.046 0.94
29_Q 72_R 1.044 0.94
114_F 147_A 1.038 0.94
224_W 248_A 1.036 0.94
117_F 122_L 1.035 0.94
61_R 69_A 1.035 0.94
92_I 150_A 1.028 0.94
126_M 140_A 1.027 0.94
256_F 260_G 1.022 0.93
255_A 259_V 1.014 0.93
67_L 248_A 1.008 0.93
18_I 259_V 1.007 0.93
239_P 243_F 1.003 0.93
14_A 258_L 1.002 0.92
34_Y 52_H 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.736599.90.65Contact Map0.785
3rlfG10.945899.90.665Contact Map0.495
3d31C20.906199.90.679Contact Map0.551
3rlfF10.960399.90.682Contact Map0.516
2onkC40.909799.80.695Contact Map0.576
2yevC20.115540.968Contact Map0.535
3hd7A20.11552.70.97Contact Map0.712
1kf6C20.37551.90.973Contact Map0.077
2kncA10.17691.70.973Contact Map0.097
3ffvA20.21661.60.974Contact Map0.178
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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