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SAPC - Peptide transport system permease protein SapC
UniProt: P0AGH5 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG20256
Length: 296 (280)
Sequences: 6453
Seq/Len: 23.05

SAPC
Paralog alert: 0.77 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
231_I 247_E 3.434 1.00
95_A 248_W 3.209 1.00
116_L 131_L 3.136 1.00
128_S 178_Y 2.961 1.00
123_T 200_T 2.865 1.00
248_W 276_S 2.725 1.00
78_L 91_L 2.618 1.00
188_E 191_I 2.616 1.00
58_F 61_Y 2.571 1.00
81_D 85_R 2.442 1.00
43_C 95_A 2.432 1.00
198_A 202_N 2.245 1.00
50_A 89_S 2.139 1.00
184_E 189_Y 2.137 1.00
118_T 181_V 2.126 1.00
133_H 136_D 2.121 1.00
82_D 254_D 2.11 1.00
76_F 86_D 2.108 1.00
32_G 279_L 2.101 1.00
53_G 56_Q 2.073 1.00
108_A 166_W 2.038 1.00
39_L 276_S 2.031 1.00
201_L 205_W 2.027 1.00
121_G 181_V 2.024 1.00
288_R 292_I 2.022 1.00
78_L 268_L 1.915 1.00
122_A 200_T 1.896 1.00
20_W 24_Y 1.855 1.00
88_L 92_L 1.85 1.00
41_V 45_F 1.823 1.00
45_F 48_W 1.818 1.00
46_G 93_S 1.785 1.00
87_V 251_M 1.773 1.00
35_G 279_L 1.756 1.00
51_P 89_S 1.725 1.00
29_A 286_G 1.715 1.00
68_W 77_F 1.71 1.00
42_L 92_L 1.707 1.00
36_C 279_L 1.676 1.00
184_E 208_V 1.673 1.00
91_L 272_A 1.67 1.00
181_V 208_V 1.659 1.00
180_M 183_D 1.654 1.00
104_V 162_M 1.627 1.00
123_T 127_R 1.623 1.00
173_M 223_A 1.59 1.00
78_L 88_L 1.587 1.00
184_E 187_K 1.582 1.00
119_F 123_T 1.547 1.00
33_L 283_L 1.527 1.00
118_T 204_L 1.511 1.00
199_S 202_N 1.498 1.00
51_P 88_L 1.492 1.00
184_E 212_I 1.465 1.00
130_V 134_I 1.454 1.00
132_N 174_V 1.454 1.00
101_G 231_I 1.442 1.00
32_G 286_G 1.439 1.00
47_G 96_A 1.434 1.00
189_Y 211_N 1.427 1.00
67_S 75_S 1.419 1.00
110_T 220_I 1.403 0.99
124_H 185_L 1.4 0.99
118_T 209_M 1.397 0.99
52_Y 89_S 1.39 0.99
93_S 96_A 1.381 0.99
194_R 200_T 1.38 0.99
183_D 187_K 1.372 0.99
248_W 272_A 1.365 0.99
121_G 185_L 1.356 0.99
126_L 130_V 1.34 0.99
159_S 163_F 1.336 0.99
24_Y 30_M 1.334 0.99
33_L 37_A 1.328 0.99
221_T 284_G 1.328 0.99
129_A 133_H 1.325 0.99
106_T 220_I 1.324 0.99
32_G 282_L 1.323 0.99
64_L 67_S 1.317 0.99
170_L 174_V 1.316 0.99
132_N 135_L 1.306 0.99
66_P 264_W 1.3 0.99
132_N 136_D 1.292 0.99
263_P 267_M 1.29 0.99
35_G 275_I 1.284 0.99
135_L 174_V 1.284 0.99
123_T 204_L 1.281 0.99
202_N 206_F 1.277 0.99
255_A 266_V 1.276 0.99
76_F 80_T 1.272 0.99
122_A 203_I 1.263 0.99
268_L 271_A 1.259 0.99
87_V 265_T 1.259 0.99
31_V 34_Y 1.256 0.99
264_W 268_L 1.25 0.99
77_F 88_L 1.25 0.99
191_I 194_R 1.243 0.98
255_A 265_T 1.241 0.98
267_M 271_A 1.239 0.98
61_Y 64_L 1.236 0.98
120_A 131_L 1.227 0.98
120_A 132_N 1.213 0.98
114_L 216_L 1.208 0.98
36_C 283_L 1.206 0.98
58_F 76_F 1.206 0.98
124_H 128_S 1.204 0.98
165_V 230_D 1.203 0.98
34_Y 38_G 1.198 0.98
181_V 212_I 1.174 0.98
225_S 277_V 1.167 0.97
236_F 256_L 1.138 0.97
157_S 160_H 1.134 0.97
131_L 174_V 1.115 0.96
112_C 115_V 1.112 0.96
193_A 207_A 1.1 0.96
55_D 246_P 1.097 0.96
114_L 177_I 1.09 0.96
135_L 171_P 1.089 0.96
39_L 275_I 1.083 0.96
64_L 80_T 1.072 0.95
105_V 165_V 1.07 0.95
178_Y 182_H 1.068 0.95
27_A 30_M 1.067 0.95
100_G 104_V 1.066 0.95
138_L 170_L 1.066 0.95
105_V 227_A 1.053 0.95
46_G 49_F 1.046 0.94
190_V 203_I 1.046 0.94
42_L 95_A 1.037 0.94
112_C 170_L 1.036 0.94
116_L 174_V 1.033 0.94
32_G 35_G 1.032 0.94
45_F 49_F 1.032 0.94
36_C 280_V 1.029 0.94
235_G 247_E 1.024 0.93
105_V 166_W 1.024 0.93
191_I 195_L 1.017 0.93
37_A 41_V 1.01 0.93
111_I 115_V 1.008 0.93
91_L 251_M 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.689299.90.683Contact Map0.787
3d31C20.912299.90.699Contact Map0.559
3rlfG10.895399.90.701Contact Map0.556
3rlfF10.949399.90.713Contact Map0.479
2onkC40.898699.80.724Contact Map0.562
2fotC10.09124.10.971Contact Map0
4azxD30.14863.40.972Contact Map0.15
3j27B30.14863.40.973Contact Map0.593
2m8rA10.15882.80.974Contact Map0.158
3hd7B20.15882.80.974Contact Map0.313

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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