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DDPC - Probable D,D-dipeptide transport system permease protein DdpC
UniProt: P77463 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13788
Length: 298 (273)
Sequences: 6322
Seq/Len: 23.16
DDPC
Paralog alert: 0.75 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
229_A 245_E 3.463 1.00
93_S 246_W 3.244 1.00
114_L 129_I 3.109 1.00
126_D 176_R 2.919 1.00
121_L 198_R 2.784 1.00
246_W 274_T 2.758 1.00
186_T 189_Q 2.596 1.00
76_F 89_V 2.529 1.00
47_M 93_S 2.448 1.00
62_D 65_A 2.435 1.00
79_D 83_R 2.407 1.00
72_A 75_W 2.332 1.00
196_A 200_H 2.224 1.00
182_V 187_Y 2.162 1.00
106_I 164_A 2.13 1.00
36_S 277_G 2.104 1.00
80_E 252_N 2.098 1.00
54_A 87_S 2.097 1.00
116_C 179_A 2.072 1.00
131_R 134_D 2.049 1.00
286_R 290_D 2.044 1.00
119_G 179_A 2.019 1.00
199_W 203_N 2.013 1.00
74_H 84_D 1.99 1.00
57_D 60_A 1.983 1.00
43_M 274_T 1.973 1.00
76_F 266_F 1.892 1.00
45_L 49_F 1.841 1.00
86_F 90_L 1.831 1.00
49_F 52_W 1.804 1.00
50_S 91_V 1.78 1.00
120_V 198_R 1.763 1.00
55_T 87_S 1.754 1.00
39_I 277_G 1.747 1.00
46_M 90_L 1.733 1.00
85_L 249_M 1.708 1.00
24_V 28_K 1.701 1.00
33_T 284_G 1.699 1.00
40_I 277_G 1.667 1.00
182_V 206_I 1.63 1.00
89_V 270_A 1.622 1.00
178_Q 181_V 1.61 1.00
116_C 202_I 1.606 1.00
102_V 160_M 1.6 1.00
179_A 206_I 1.591 1.00
171_Y 221_D 1.572 1.00
76_F 86_F 1.551 1.00
182_V 185_Y 1.542 1.00
121_L 125_A 1.527 1.00
128_I 132_I 1.506 1.00
130_M 172_V 1.471 1.00
197_S 200_H 1.465 1.00
99_A 229_A 1.45 1.00
117_L 121_L 1.444 1.00
182_V 210_S 1.431 1.00
37_A 281_F 1.43 1.00
55_T 86_F 1.42 1.00
91_V 94_Q 1.42 1.00
51_P 94_Q 1.419 1.00
36_S 284_G 1.409 1.00
124_R 128_I 1.408 1.00
122_G 183_R 1.395 0.99
108_G 218_A 1.385 0.99
187_Y 209_N 1.375 0.99
192_K 198_R 1.366 0.99
56_H 87_S 1.362 0.99
181_V 185_Y 1.356 0.99
36_S 280_L 1.353 0.99
246_W 270_A 1.353 0.99
116_C 207_L 1.353 0.99
219_S 282_G 1.34 0.99
119_G 183_R 1.339 0.99
37_A 41_V 1.327 0.99
104_V 218_A 1.324 0.99
68_L 71_S 1.322 0.99
130_M 134_D 1.317 0.99
71_S 74_H 1.305 0.99
121_L 202_I 1.305 0.99
127_A 131_R 1.305 0.99
157_F 161_L 1.301 0.99
35_T 38_V 1.299 0.99
118_S 130_M 1.295 0.99
130_M 133_M 1.292 0.99
39_I 273_L 1.286 0.99
261_W 265_A 1.278 0.99
70_P 262_W 1.275 0.99
253_G 264_C 1.27 0.99
266_F 269_A 1.261 0.99
28_K 34_V 1.258 0.99
133_M 172_V 1.252 0.99
200_H 204_W 1.234 0.98
85_L 263_Y 1.232 0.98
262_W 266_F 1.226 0.98
75_W 86_F 1.216 0.98
163_I 228_M 1.215 0.98
189_Q 192_K 1.21 0.98
223_G 275_A 1.205 0.98
253_G 263_Y 1.203 0.98
120_V 201_L 1.202 0.98
168_I 172_V 1.193 0.98
40_I 281_F 1.192 0.98
112_S 214_L 1.188 0.98
118_S 129_I 1.186 0.98
65_A 68_L 1.184 0.98
122_G 126_D 1.183 0.98
234_F 254_R 1.172 0.98
103_V 163_I 1.168 0.97
38_V 42_L 1.15 0.97
179_A 210_S 1.147 0.97
265_A 269_A 1.146 0.97
74_H 78_T 1.145 0.97
62_D 74_H 1.143 0.97
68_L 78_T 1.132 0.97
129_I 172_V 1.114 0.96
56_H 73_A 1.112 0.96
50_S 53_L 1.11 0.96
191_A 205_H 1.109 0.96
31_P 34_V 1.109 0.96
136_M 168_I 1.089 0.96
59_N 244_A 1.086 0.96
188_V 201_L 1.079 0.95
155_S 158_N 1.078 0.95
43_M 273_L 1.076 0.95
176_R 180_L 1.071 0.95
110_I 113_L 1.066 0.95
56_H 74_H 1.065 0.95
41_V 45_L 1.058 0.95
112_S 175_A 1.057 0.95
98_L 102_V 1.041 0.94
71_S 75_W 1.041 0.94
114_L 172_V 1.037 0.94
103_V 225_A 1.037 0.94
40_I 278_F 1.027 0.94
133_M 169_P 1.025 0.93
110_I 168_I 1.024 0.93
36_S 39_I 1.017 0.93
49_F 53_L 1.011 0.93
233_G 245_E 1.005 0.93
89_V 249_M 1.005 0.93
227_L 268_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.684699.90.704Contact Map0.777
3rlfG10.899399.90.714Contact Map0.546
3d31C20.916199.90.715Contact Map0.566
2onkC40.902799.90.729Contact Map0.573
3rlfF10.959799.90.73Contact Map0.476
2kogA10.174512.50.966Contact Map0.331
3hd7A20.164460.971Contact Map0.461
3o7qA10.687940.973Contact Map0.222
3tdsE50.34563.70.974Contact Map0.514
4fc4A100.32553.70.974Contact Map0.49
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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