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YEJE - Inner membrane ABC transporter permease protein YejE
UniProt: P33915 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12040
Length: 341 (295)
Sequences: 4608
Seq/Len: 15.62
YEJE
Paralog alert: 0.74 [within 20: 0.09] - ratio of genomes with paralogs
Cluster includes: DDPB DDPC DPPB DPPC GSIC GSID NIKB NIKC OPPB OPPC SAPB SAPC YEJB YEJE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
161_A 176_G 3.684 1.00
276_L 292_S 3.482 1.00
168_Y 245_D 3.34 1.00
123_L 136_I 3.288 1.00
140_T 293_L 3.277 1.00
173_D 223_R 2.781 1.00
35_S 140_T 2.678 1.00
233_D 236_R 2.654 1.00
126_D 130_G 2.424 1.00
243_V 247_S 2.339 1.00
229_T 234_Y 2.274 1.00
332_R 336_D 2.267 1.00
42_A 134_A 2.18 1.00
119_R 122_W 2.179 1.00
12_W 16_R 2.157 1.00
178_R 181_E 2.129 1.00
21_G 330_A 2.096 1.00
121_N 131_D 2.064 1.00
167_Y 245_D 2.056 1.00
163_A 226_F 2.051 1.00
38_S 138_Y 2.047 1.00
127_A 299_Q 2.035 1.00
153_C 211_V 1.994 1.00
166_G 226_F 1.991 1.00
106_N 109_T 1.982 1.00
133_L 137_L 1.982 1.00
246_R 250_L 1.965 1.00
37_C 40_L 1.956 1.00
293_L 320_L 1.929 1.00
229_T 253_M 1.859 1.00
34_L 137_L 1.809 1.00
218_L 268_I 1.807 1.00
123_L 312_T 1.773 1.00
132_V 296_L 1.755 1.00
149_M 207_L 1.741 1.00
33_G 37_C 1.734 1.00
123_L 133_L 1.719 1.00
177_Q 219_V 1.657 1.00
101_G 104_S 1.651 1.00
226_F 253_M 1.623 1.00
225_E 228_R 1.62 1.00
175_W 179_F 1.581 1.00
163_A 249_I 1.559 1.00
24_S 330_A 1.546 1.00
266_P 328_G 1.536 1.00
146_F 276_L 1.518 1.00
25_L 29_L 1.515 1.00
168_Y 249_I 1.513 1.00
25_L 327_I 1.503 1.00
228_R 232_F 1.49 1.00
155_S 265_L 1.481 1.00
229_T 232_F 1.48 1.00
138_Y 141_R 1.478 1.00
39_E 141_R 1.475 1.00
171_K 175_W 1.471 1.00
26_W 30_V 1.469 1.00
16_R 22_Y 1.464 1.00
122_W 133_L 1.464 1.00
244_S 247_S 1.461 1.00
307_P 311_I 1.461 1.00
168_Y 172_V 1.459 1.00
115_S 118_S 1.452 1.00
229_T 257_A 1.444 1.00
177_Q 180_I 1.44 1.00
132_V 309_L 1.422 1.00
313_A 316_S 1.416 1.00
164_L 168_Y 1.414 1.00
24_S 326_F 1.406 0.99
165_Q 177_Q 1.39 0.99
159_V 261_T 1.377 0.99
167_Y 248_I 1.373 0.99
118_S 121_N 1.357 0.99
177_Q 181_E 1.356 0.99
28_F 327_I 1.35 0.99
315_L 323_L 1.335 0.99
234_Y 256_N 1.334 0.99
150_L 210_T 1.331 0.99
174_L 178_R 1.328 0.99
163_A 254_L 1.325 0.99
24_S 27_I 1.324 0.99
117_P 308_W 1.314 0.99
239_Q 245_D 1.302 0.99
23_W 26_W 1.301 0.99
99_R 134_A 1.296 0.99
204_W 208_A 1.287 0.99
313_A 323_L 1.281 0.99
169_G 230_R 1.277 0.99
300_G 310_G 1.277 0.99
210_T 275_T 1.271 0.99
169_G 173_D 1.267 0.99
100_F 121_N 1.263 0.99
180_I 219_V 1.262 0.99
281_F 301_K 1.246 0.98
145_L 149_M 1.236 0.98
300_G 309_L 1.232 0.98
247_S 251_R 1.223 0.98
15_F 327_I 1.215 0.98
135_R 289_G 1.204 0.98
151_T 265_L 1.192 0.98
116_P 308_W 1.19 0.98
176_G 219_V 1.187 0.98
121_N 125_T 1.185 0.98
161_A 219_V 1.183 0.98
315_L 319_I 1.176 0.98
166_G 230_R 1.171 0.98
99_R 133_L 1.168 0.97
106_N 121_N 1.162 0.97
280_D 292_S 1.159 0.97
180_I 216_M 1.155 0.97
236_R 239_Q 1.149 0.97
24_S 323_L 1.145 0.97
313_A 322_S 1.144 0.97
22_Y 26_W 1.142 0.97
21_G 334_A 1.142 0.97
312_T 315_L 1.139 0.97
293_L 322_S 1.139 0.97
314_F 323_L 1.136 0.97
159_V 222_V 1.133 0.97
314_F 317_V 1.125 0.97
165_Q 176_G 1.124 0.97
215_W 219_V 1.12 0.96
209_I 213_F 1.119 0.96
257_A 260_A 1.119 0.96
150_L 211_V 1.118 0.96
150_L 272_S 1.106 0.96
333_D 337_P 1.103 0.96
43_N 134_A 1.089 0.96
183_W 215_W 1.088 0.96
136_I 296_L 1.085 0.96
226_F 257_A 1.078 0.95
18_N 21_G 1.066 0.95
147_G 272_S 1.063 0.95
37_C 41_I 1.06 0.95
222_V 257_A 1.059 0.95
34_L 140_T 1.048 0.94
316_S 323_L 1.042 0.94
42_A 137_L 1.041 0.94
157_M 160_L 1.041 0.94
156_V 160_L 1.041 0.94
143_S 147_G 1.038 0.94
29_L 33_G 1.036 0.94
105_I 128_N 1.027 0.94
316_S 319_I 1.025 0.93
207_L 211_V 1.022 0.93
245_D 249_I 1.017 0.93
239_Q 248_I 1.015 0.93
38_S 41_I 1.013 0.93
130_G 135_R 1.01 0.93
313_A 321_L 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3tuiA40.595399.90.729Contact Map0.713
3rlfG10.78399.90.737Contact Map0.51
3d31C20.771399.90.747Contact Map0.549
3rlfF10.818299.90.763Contact Map0.479
2onkC40.765499.80.771Contact Map0.572
3ixzA10.25515.60.975Contact Map0.032
2m8rA10.12324.20.976Contact Map0.182
3hd7B20.12324.20.976Contact Map0.336
2kbcB10.07043.70.977Contact Map0.583
2zxeA10.24933.60.977Contact Map0.386
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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