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NEMR - HTH-type transcriptional repressor NemR
UniProt: P67430 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13947
Length: 199 (190)
Sequences: 17332
Seq/Len: 91.22

NEMR
Paralog alert: 0.81 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
24_R 33_E 3.973 1.00
19_Q 37_T 3.664 1.00
32_S 42_K 3.468 1.00
50_R 54_A 2.884 1.00
138_S 157_L 2.512 1.00
85_R 143_N 2.359 1.00
20_L 29_M 2.338 1.00
23_Q 37_T 2.291 1.00
11_E 62_R 2.278 1.00
51_S 54_A 2.157 1.00
21_C 29_M 2.136 1.00
81_N 84_D 2.094 1.00
9_T 12_H 2.093 1.00
17_G 21_C 1.981 1.00
10_R 58_A 1.978 1.00
41_P 44_S 1.955 1.00
35_L 45_F 1.949 1.00
142_E 146_E 1.944 1.00
16_T 37_T 1.935 1.00
142_E 156_P 1.932 1.00
138_S 142_E 1.887 1.00
11_E 15_A 1.872 1.00
32_S 36_K 1.846 1.00
12_H 16_T 1.835 1.00
58_A 61_E 1.814 1.00
61_E 125_A 1.72 1.00
72_T 136_L 1.717 1.00
20_L 37_T 1.692 1.00
29_M 34_L 1.626 1.00
20_L 33_E 1.617 1.00
18_E 62_R 1.572 1.00
142_E 145_R 1.563 1.00
144_G 150_L 1.558 1.00
15_A 62_R 1.547 1.00
20_L 24_R 1.544 1.00
14_L 58_A 1.539 1.00
31_L 45_F 1.528 1.00
54_A 58_A 1.519 1.00
134_I 161_Q 1.513 1.00
81_N 149_C 1.487 1.00
21_C 26_F 1.476 1.00
53_E 119_S 1.47 1.00
16_T 19_Q 1.457 1.00
17_G 55_F 1.456 1.00
25_G 29_M 1.449 1.00
62_R 66_A 1.411 1.00
10_R 48_Y 1.389 0.99
31_L 46_Y 1.381 0.99
49_F 58_A 1.37 0.99
144_G 149_C 1.368 0.99
165_A 169_G 1.338 0.99
143_N 147_N 1.333 0.99
25_G 28_G 1.331 0.99
145_R 156_P 1.328 0.99
18_E 59_M 1.322 0.99
19_Q 23_Q 1.31 0.99
162_V 166_L 1.309 0.99
16_T 38_A 1.302 0.99
30_G 33_E 1.293 0.99
26_F 56_G 1.269 0.99
31_L 42_K 1.264 0.99
34_L 55_F 1.263 0.99
33_E 36_K 1.253 0.99
82_Y 147_N 1.245 0.98
33_E 37_T 1.245 0.98
85_R 140_A 1.234 0.98
57_V 125_A 1.232 0.98
57_V 61_E 1.231 0.98
141_L 156_P 1.225 0.98
155_E 158_Q 1.223 0.98
87_L 91_Q 1.22 0.98
134_I 157_L 1.213 0.98
46_Y 51_S 1.197 0.98
84_D 88_A 1.187 0.98
40_V 44_S 1.184 0.98
14_L 59_M 1.162 0.97
44_S 47_H 1.162 0.97
8_D 11_E 1.144 0.97
138_S 156_P 1.142 0.97
83_R 87_L 1.128 0.97
8_D 12_H 1.128 0.97
145_R 152_F 1.127 0.97
87_L 191_K 1.121 0.97
91_Q 187_L 1.12 0.96
53_E 121_D 1.116 0.96
14_L 49_F 1.092 0.96
140_A 144_G 1.087 0.96
9_T 48_Y 1.083 0.96
15_A 19_Q 1.081 0.95
26_F 52_K 1.077 0.95
24_R 28_G 1.062 0.95
151_T 154_G 1.061 0.95
16_T 20_L 1.058 0.95
45_F 55_F 1.054 0.95
18_E 22_L 1.051 0.94
18_E 63_H 1.047 0.94
54_A 57_V 1.043 0.94
43_G 47_H 1.042 0.94
88_A 91_Q 1.037 0.94
41_P 47_H 1.036 0.94
61_E 65_A 1.023 0.93
44_S 48_Y 1.021 0.93
24_R 29_M 1.021 0.93
141_L 163_L 1.018 0.93
65_A 69_Q 1.013 0.93
131_R 135_A 1.004 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bruA211000.17Contact Map0.733
2hyjA10.98491000.182Contact Map0.629
3qbmA20.98991000.182Contact Map0.663
3knwA20.9951000.187Contact Map0.769
3rd3A20.97491000.189Contact Map0.707
3eupA20.9951000.191Contact Map0.75
2g7sA10.96481000.197Contact Map0.643
2xdnA40.9951000.201Contact Map0.72
1vi0A20.97491000.203Contact Map0.79
2i10A20.98991000.204Contact Map0.72

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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