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RUTR - HTH-type transcriptional regulator RutR
UniProt: P0ACU2 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12301
Length: 212 (200)
Sequences: 12948
Seq/Len: 64.74

RUTR
Paralog alert: 0.77 [within 20: 0.18] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
29_D 47_L 3.938 1.00
34_F 43_Q 3.799 1.00
42_E 52_K 3.556 1.00
30_T 39_T 2.773 1.00
60_P 64_A 2.754 1.00
33_Q 47_L 2.575 1.00
93_A 147_G 2.494 1.00
89_A 92_A 2.386 1.00
146_A 150_K 2.377 1.00
31_F 39_T 2.329 1.00
21_K 72_Q 2.291 1.00
142_S 160_Q 2.232 1.00
61_S 64_A 2.211 1.00
45_A 55_L 2.047 1.00
30_T 47_L 2.023 1.00
51_S 54_N 2.011 1.00
95_K 199_E 1.942 1.00
148_W 154_L 1.942 1.00
19_K 22_A 1.89 1.00
20_K 68_A 1.859 1.00
21_K 25_S 1.838 1.00
68_A 71_R 1.811 1.00
26_A 47_L 1.807 1.00
30_T 43_Q 1.796 1.00
89_A 153_K 1.782 1.00
27_A 31_F 1.772 1.00
25_S 72_Q 1.741 1.00
22_A 26_A 1.728 1.00
142_S 146_A 1.726 1.00
146_A 159_P 1.721 1.00
146_A 149_V 1.7 1.00
39_T 44_I 1.665 1.00
30_T 34_F 1.665 1.00
28_L 72_Q 1.654 1.00
42_E 46_E 1.64 1.00
82_K 140_E 1.633 1.00
148_W 153_K 1.591 1.00
41_L 56_L 1.571 1.00
31_F 36_F 1.563 1.00
99_R 199_E 1.525 1.00
204_I 208_G 1.502 1.00
64_A 68_A 1.494 1.00
91_L 95_K 1.48 1.00
41_L 55_L 1.464 1.00
147_G 151_S 1.442 1.00
99_R 195_N 1.437 1.00
90_P 151_S 1.419 1.00
59_F 68_A 1.392 0.99
20_K 58_Y 1.384 0.99
95_K 99_R 1.373 0.99
207_E 210_R 1.342 0.99
72_Q 76_I 1.34 0.99
71_R 129_E 1.34 0.99
40_R 43_Q 1.338 0.99
168_A 172_H 1.326 0.99
41_L 52_K 1.323 0.99
193_F 196_Q 1.312 0.99
71_R 75_D 1.306 0.99
145_I 159_P 1.299 0.99
161_H 200_N 1.297 0.99
25_S 29_D 1.294 0.99
24_L 68_A 1.28 0.99
35_G 39_T 1.27 0.99
50_V 54_N 1.269 0.99
24_L 69_V 1.263 0.99
63_E 123_A 1.258 0.99
24_L 59_F 1.255 0.99
13_S 16_V 1.25 0.99
35_G 38_G 1.243 0.98
54_N 57_Y 1.236 0.98
149_V 159_P 1.228 0.98
43_Q 47_L 1.227 0.98
26_A 29_D 1.225 0.98
203_R 207_E 1.221 0.98
43_Q 46_E 1.22 0.98
91_L 210_R 1.219 0.98
142_S 159_P 1.206 0.98
165_M 169_S 1.202 0.98
19_K 58_Y 1.195 0.98
149_V 156_P 1.193 0.98
34_F 39_T 1.171 0.98
29_D 33_Q 1.166 0.97
27_A 65_L 1.152 0.97
51_S 57_Y 1.15 0.97
144_L 148_W 1.142 0.97
28_L 69_V 1.136 0.97
147_G 150_K 1.133 0.97
26_A 48_A 1.128 0.97
67_I 129_E 1.127 0.97
28_L 32_S 1.127 0.97
190_D 193_F 1.113 0.96
44_I 65_L 1.105 0.96
96_E 99_R 1.101 0.96
93_A 144_L 1.097 0.96
139_D 143_A 1.076 0.95
158_D 161_H 1.063 0.95
91_L 203_R 1.056 0.95
67_I 71_R 1.047 0.94
56_L 61_S 1.044 0.94
75_D 79_A 1.043 0.94
34_F 38_G 1.042 0.94
103_E 107_D 1.041 0.94
92_A 96_E 1.036 0.94
149_V 157_I 1.034 0.94
54_N 58_Y 1.029 0.94
138_I 160_Q 1.016 0.93
90_P 153_K 1.012 0.93
28_L 73_I 1.008 0.93
91_L 206_I 1.005 0.93
138_I 142_S 1.004 0.93
80_P 100_L 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4jykA211000.154Contact Map0.71
1pb6A411000.154Contact Map0.707
3npiA20.98581000.212Contact Map0.569
2ibdA20.93871000.214Contact Map0.74
2qtqA40.98581000.228Contact Map0.686
3gziA10.97641000.241Contact Map0.525
3f0cA10.94811000.245Contact Map0.671
3dcfA20.94811000.246Contact Map0.602
3nrgA50.97171000.248Contact Map0.692
3himA20.94811000.249Contact Map0.645

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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