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YBIH - Uncharacterized HTH-type transcriptional regulator YbiH
UniProt: P0ACU0 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12406
Length: 223 (208)
Sequences: 8393
Seq/Len: 40.35

YBIH
Paralog alert: 0.73 [within 20: 0.12] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
23_A 40_Q 4.228 1.00
28_Y 36_E 3.982 1.00
35_R 45_I 3.452 1.00
53_G 57_D 3.07 1.00
27_E 40_Q 2.918 1.00
94_A 154_A 2.684 1.00
90_P 93_A 2.593 1.00
96_R 205_Q 2.58 1.00
54_S 57_D 2.457 1.00
24_Q 33_T 2.397 1.00
15_K 65_W 2.224 1.00
14_K 61_A 2.196 1.00
44_N 47_A 2.182 1.00
149_T 166_I 2.161 1.00
13_A 16_Q 2.123 1.00
24_Q 40_Q 2.088 1.00
24_Q 36_E 2.067 1.00
21_A 25_F 2.059 1.00
61_A 64_Q 2.033 1.00
19_A 65_W 2.005 1.00
34_T 45_I 1.974 1.00
90_P 158_C 1.941 1.00
38_A 48_I 1.921 1.00
15_K 19_A 1.842 1.00
174_G 178_A 1.825 1.00
153_A 165_M 1.798 1.00
100_L 205_Q 1.797 1.00
20_A 40_Q 1.791 1.00
149_T 153_A 1.788 1.00
16_Q 20_A 1.78 1.00
199_K 202_L 1.718 1.00
213_L 217_G 1.7 1.00
52_F 61_A 1.698 1.00
155_W 159_D 1.694 1.00
100_L 201_E 1.69 1.00
25_F 30_M 1.673 1.00
92_R 96_R 1.64 1.00
216_Q 219_S 1.634 1.00
34_T 48_I 1.63 1.00
34_T 49_T 1.57 1.00
96_R 100_L 1.566 1.00
212_D 216_Q 1.56 1.00
57_D 61_A 1.554 1.00
22_L 65_W 1.554 1.00
75_R 147_H 1.506 1.00
155_W 158_C 1.494 1.00
49_T 54_S 1.487 1.00
92_R 219_S 1.48 1.00
24_Q 28_Y 1.465 1.00
171_A 175_E 1.463 1.00
152_I 165_M 1.425 1.00
92_R 212_D 1.401 0.99
43_Q 47_A 1.4 0.99
47_A 51_Y 1.387 0.99
35_R 39_A 1.384 0.99
25_F 29_G 1.376 0.99
18_I 62_C 1.371 0.99
151_L 155_W 1.368 0.99
22_L 62_C 1.352 0.99
160_A 163_T 1.345 0.99
20_A 41_A 1.319 0.99
91_D 158_C 1.315 0.99
64_Q 136_V 1.293 0.99
153_A 156_T 1.283 0.99
12_Q 15_K 1.272 0.99
44_N 50_Y 1.27 0.99
14_K 51_Y 1.262 0.99
20_A 24_Q 1.255 0.99
20_A 23_A 1.25 0.99
37_I 58_L 1.24 0.98
17_L 41_A 1.237 0.98
18_I 52_F 1.229 0.98
65_W 69_F 1.216 0.98
19_A 23_A 1.207 0.98
33_T 37_I 1.206 0.98
18_I 61_A 1.183 0.98
24_Q 32_A 1.171 0.98
25_F 33_T 1.166 0.97
36_E 39_A 1.166 0.97
99_I 172_L 1.165 0.97
93_A 97_E 1.16 0.97
23_A 27_E 1.151 0.97
96_R 212_D 1.148 0.97
13_A 43_Q 1.131 0.97
30_M 56_E 1.128 0.97
92_R 215_L 1.126 0.97
97_E 100_L 1.125 0.97
89_Q 93_A 1.122 0.97
36_E 40_Q 1.114 0.96
68_D 72_E 1.106 0.96
22_L 66_I 1.103 0.96
149_T 165_M 1.092 0.96
201_E 205_Q 1.086 0.96
156_T 162_D 1.083 0.96
64_Q 68_D 1.081 0.95
25_F 59_Y 1.072 0.95
100_L 204_N 1.068 0.95
31_N 125_E 1.067 0.95
146_S 150_R 1.06 0.95
30_M 59_Y 1.048 0.94
13_A 51_Y 1.046 0.94
196_D 199_K 1.044 0.94
172_L 214_I 1.031 0.94
45_I 49_T 1.026 0.94
134_H 138_E 1.023 0.93
22_L 26_G 1.023 0.93
18_I 22_L 1.019 0.93
145_H 166_I 1.016 0.93
164_R 167_L 1.006 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1t33A20.98211000.229Contact Map0.65
3npiA20.92831000.232Contact Map0.576
4jykA20.91031000.244Contact Map0.717
1pb6A40.91031000.244Contact Map0.717
2ibdA20.88791000.254Contact Map0.728
3nrgA50.923899.90.257Contact Map0.647
2qtqA40.914899.90.26Contact Map0.687
3dcfA20.874499.90.265Contact Map0.614
3dewA10.887999.90.268Contact Map0.624
3himA20.883499.90.268Contact Map0.595

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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