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OPENSEQ.org

UIDR - HTH-type transcriptional regulator UidR
UniProt: P0ACT6 Sequence
Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12667
Length: 196 (189)
Sequences: 17316
Seq/Len: 91.62

UIDR
Paralog alert: 0.80 [within 20: 0.20] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_N 36_A 3.941 1.00
22_E 40_S 3.8 1.00
35_K 45_P 3.457 1.00
53_I 57_A 2.793 1.00
134_A 153_A 2.552 1.00
26_E 40_S 2.304 1.00
14_T 65_Q 2.301 1.00
12_T 15_R 2.277 1.00
83_F 139_D 2.22 1.00
23_I 32_A 2.195 1.00
24_F 32_A 2.163 1.00
54_S 57_A 2.1 1.00
138_R 142_Q 2.07 1.00
44_S 47_T 2.069 1.00
79_E 82_H 2.062 1.00
13_R 61_A 1.986 1.00
38_C 48_L 1.981 1.00
134_A 138_R 1.869 1.00
23_I 40_S 1.857 1.00
19_A 40_S 1.855 1.00
20_A 24_F 1.842 1.00
138_R 152_T 1.839 1.00
14_T 18_N 1.795 1.00
23_I 36_A 1.792 1.00
15_R 19_A 1.771 1.00
61_A 64_L 1.77 1.00
35_K 39_K 1.766 1.00
177_R 180_S 1.694 1.00
18_N 65_Q 1.668 1.00
64_L 121_M 1.655 1.00
23_I 27_N 1.651 1.00
85_D 186_R 1.65 1.00
140_A 146_I 1.632 1.00
138_R 141_Q 1.595 1.00
21_R 65_Q 1.577 1.00
140_A 145_E 1.573 1.00
89_E 182_A 1.565 1.00
32_A 37_I 1.529 1.00
34_M 48_L 1.503 1.00
28_G 32_A 1.502 1.00
17_L 61_A 1.496 1.00
34_M 49_Y 1.49 1.00
79_E 145_E 1.481 1.00
24_F 29_F 1.479 1.00
28_G 31_S 1.478 1.00
130_T 157_R 1.453 1.00
20_A 58_L 1.448 1.00
57_A 61_A 1.442 1.00
56_E 115_N 1.425 1.00
60_Q 121_M 1.386 0.99
141_Q 152_T 1.357 0.99
22_E 26_E 1.356 0.99
65_Q 69_R 1.345 0.99
13_R 51_H 1.339 0.99
33_S 36_A 1.333 0.99
19_A 41_C 1.306 0.99
139_D 143_K 1.303 0.99
37_I 58_L 1.292 0.99
52_F 61_A 1.289 0.99
120_A 124_N 1.282 0.99
80_G 143_K 1.277 0.99
36_A 39_K 1.27 0.99
19_A 22_E 1.264 0.99
161_D 165_G 1.263 0.99
141_Q 148_P 1.25 0.99
34_M 45_P 1.248 0.99
137_M 152_T 1.248 0.99
158_L 162_L 1.244 0.98
85_D 89_E 1.238 0.98
17_L 62_I 1.225 0.98
43_I 47_T 1.225 0.98
21_R 62_I 1.218 0.98
81_I 85_D 1.203 0.98
81_I 190_G 1.199 0.98
82_H 86_Y 1.191 0.98
134_A 152_T 1.182 0.98
36_A 40_S 1.182 0.98
83_F 136_R 1.176 0.98
56_E 117_Q 1.176 0.98
147_S 150_I 1.17 0.97
130_T 153_A 1.167 0.97
29_F 59_I 1.162 0.97
151_N 154_M 1.157 0.97
49_Y 54_S 1.149 0.97
11_P 14_T 1.148 0.97
21_R 25_S 1.145 0.97
47_T 50_H 1.138 0.97
18_N 22_E 1.136 0.97
12_T 51_H 1.13 0.97
6_Q 9_A 1.122 0.97
21_R 66_D 1.116 0.96
75_R 132_F 1.113 0.96
19_A 23_I 1.11 0.96
17_L 52_F 1.107 0.96
27_N 32_A 1.105 0.96
60_Q 64_L 1.096 0.96
29_F 55_K 1.076 0.95
57_A 60_Q 1.073 0.95
187_A 191_G 1.065 0.95
86_Y 89_E 1.059 0.95
136_R 140_A 1.054 0.95
64_L 68_E 1.045 0.94
47_T 51_H 1.042 0.94
44_S 50_H 1.039 0.94
130_T 134_A 1.039 0.94
11_P 15_R 1.019 0.93
127_M 131_E 1.011 0.93
27_N 31_S 1.003 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2xdnA411000.168Contact Map0.737
2gfnA20.98981000.183Contact Map0.758
3crjA40.98471000.186Contact Map0.815
2wuiA111000.194Contact Map0.615
2nx4A40.96941000.197Contact Map0.773
3e7qA20.99491000.2Contact Map0.683
3eupA20.99491000.201Contact Map0.758
2w53A211000.202Contact Map0.787
3vibA40.99491000.206Contact Map0.757
2hyjA10.979699.90.209Contact Map0.632

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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