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OPENSEQ.org
BDCR - HTH-type transcriptional repressor BdcR
UniProt: P39334 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12529
Length: 197 (183)
Sequences: 16400
Seq/Len: 89.62
BDCR
Paralog alert: 0.79 [within 20: 0.21] - ratio of genomes with paralogs
Cluster includes: ACRR BDCR BETI COMR ENVR NEMR RUTR SLMA UIDR YBIH YBJK YJDC
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
32_K 41_E 4.015 1.00
27_V 45_Y 3.686 1.00
40_A 50_P 3.366 1.00
58_G 62_G 2.889 1.00
28_L 37_V 2.358 1.00
19_E 70_E 2.336 1.00
29_F 37_V 2.318 1.00
31_Q 45_Y 2.317 1.00
17_A 20_Q 2.205 1.00
88_P 91_E 2.151 1.00
142_Y 154_Q 2.088 1.00
49_N 52_S 2.051 1.00
59_S 62_G 2.039 1.00
92_C 147_R 2.004 1.00
43_T 53_L 1.945 1.00
142_Y 146_A 1.94 1.00
18_P 66_R 1.937 1.00
24_A 45_Y 1.904 1.00
19_E 23_S 1.875 1.00
25_A 29_F 1.87 1.00
40_A 44_D 1.829 1.00
66_R 69_N 1.825 1.00
20_Q 24_A 1.819 1.00
69_N 129_I 1.81 1.00
28_L 45_Y 1.79 1.00
26_K 70_E 1.671 1.00
80_A 140_T 1.667 1.00
23_S 70_E 1.618 1.00
146_A 150_P 1.547 1.00
61_A 123_D 1.542 1.00
37_V 42_V 1.525 1.00
28_L 32_K 1.512 1.00
29_F 34_F 1.508 1.00
24_A 27_V 1.502 1.00
70_E 74_T 1.491 1.00
22_I 66_R 1.479 1.00
28_L 41_E 1.478 1.00
62_G 66_R 1.473 1.00
34_F 64_F 1.47 1.00
25_A 63_L 1.466 1.00
138_E 158_D 1.465 1.00
27_V 31_Q 1.446 1.00
39_V 53_L 1.444 1.00
39_V 54_Y 1.436 1.00
146_A 153_A 1.419 1.00
33_G 37_V 1.415 1.00
57_F 66_R 1.395 0.99
94_V 185_A 1.372 0.99
159_F 163_V 1.35 0.99
33_G 36_A 1.344 0.99
24_A 46_L 1.324 0.99
94_V 98_K 1.32 0.99
41_E 45_Y 1.302 0.99
92_C 144_Y 1.285 0.99
41_E 44_D 1.285 0.99
65_S 129_I 1.275 0.99
39_V 50_P 1.274 0.99
91_E 95_E 1.274 0.99
98_K 184_A 1.269 0.99
18_P 56_A 1.256 0.99
26_K 67_V 1.246 0.98
38_S 41_E 1.245 0.98
162_T 166_G 1.241 0.98
22_I 67_V 1.231 0.98
65_S 69_N 1.221 0.98
146_A 149_H 1.215 0.98
98_K 181_C 1.214 0.98
69_N 73_G 1.214 0.98
48_I 52_S 1.203 0.98
94_V 188_G 1.201 0.98
52_S 56_A 1.192 0.98
138_E 154_Q 1.189 0.98
149_H 153_A 1.189 0.98
61_A 125_Q 1.176 0.98
54_Y 59_S 1.143 0.97
17_A 56_A 1.135 0.97
61_A 65_S 1.13 0.97
152_R 155_C 1.114 0.96
23_S 27_V 1.106 0.96
22_I 57_F 1.105 0.96
52_S 55_A 1.102 0.96
16_F 19_E 1.093 0.96
32_K 36_A 1.093 0.96
24_A 28_L 1.09 0.96
78_P 99_E 1.082 0.96
53_L 63_L 1.079 0.95
32_K 37_V 1.072 0.95
135_H 139_T 1.07 0.95
139_T 143_D 1.07 0.95
42_V 63_L 1.065 0.95
90_G 94_V 1.063 0.95
144_Y 148_R 1.019 0.93
73_G 77_I 1.017 0.93
26_K 30_H 1.014 0.93
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3bruA211000.239Contact Map0.693
2ibdA20.97971000.241Contact Map0.769
3kz9A40.994999.90.251Contact Map0.816
4gckA40.994999.90.252Contact Map0.755
2i10A20.969599.90.254Contact Map0.704
4gfkA20.949299.90.254Contact Map0.719
3g1oA10.989899.90.259Contact Map0.688
3dcfA20.989899.90.261Contact Map0.668
3himA20.989899.90.262Contact Map0.643
3npiA20.994999.90.265Contact Map0.582
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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