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OPENSEQ.org
YCAM - Inner membrane transporter YcaM
UniProt: P75835 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13697
Length: 476 (446)
Sequences: 10100
Seq/Len: 22.65
YCAM
Paralog alert: 0.81 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
331_S 343_N 4.359 1.00
143_M 349_L 3.556 1.00
323_A 333_C 3.507 1.00
11_R 229_R 3.316 1.00
48_F 247_A 3.138 1.00
334_R 343_N 3.07 1.00
230_N 233_K 3.016 1.00
233_K 237_K 3.016 1.00
394_A 398_L 2.986 1.00
291_T 295_I 2.901 1.00
175_A 256_A 2.782 1.00
346_F 350_V 2.663 1.00
16_A 241_C 2.542 1.00
336_N 342_V 2.469 1.00
326_K 330_A 2.463 1.00
228_T 234_E 2.419 1.00
136_L 357_M 2.415 1.00
331_S 334_R 2.352 1.00
90_A 322_D 2.279 1.00
78_K 83_P 2.269 1.00
320_L 324_D 2.267 1.00
262_D 265_N 2.246 1.00
74_S 325_S 2.209 1.00
12_W 241_C 2.205 1.00
78_K 86_A 2.198 1.00
226_N 324_D 2.187 1.00
81_M 394_A 2.167 1.00
332_L 347_L 2.119 1.00
58_I 389_F 2.116 1.00
61_Q 396_V 2.108 1.00
12_W 234_E 2.1 1.00
11_R 14_N 2.088 1.00
81_M 390_V 2.081 1.00
394_A 397_R 2.047 1.00
227_Q 317_K 1.961 1.00
173_A 177_T 1.944 1.00
12_W 16_A 1.937 1.00
165_F 169_L 1.935 1.00
147_S 346_F 1.914 1.00
94_W 348_T 1.886 1.00
144_W 148_R 1.852 1.00
237_K 241_C 1.824 1.00
15_I 228_T 1.816 1.00
343_N 347_L 1.815 1.00
143_M 345_Y 1.806 1.00
89_A 387_W 1.804 1.00
140_I 353_A 1.801 1.00
230_N 237_K 1.797 1.00
39_V 204_Y 1.778 1.00
6_Q 335_T 1.747 1.00
147_S 342_V 1.743 1.00
230_N 234_E 1.733 1.00
77_I 89_A 1.726 1.00
136_L 353_A 1.719 1.00
316_L 345_Y 1.718 1.00
244_V 248_V 1.716 1.00
45_V 251_I 1.707 1.00
386_L 423_F 1.689 1.00
294_V 298_I 1.684 1.00
14_N 158_S 1.68 1.00
164_M 168_S 1.655 1.00
32_N 40_V 1.646 1.00
10_L 14_N 1.633 1.00
49_A 53_T 1.612 1.00
151_K 155_I 1.608 1.00
20_F 245_M 1.587 1.00
162_I 166_V 1.581 1.00
330_A 334_R 1.576 1.00
330_A 333_C 1.575 1.00
43_S 207_T 1.569 1.00
231_P 236_P 1.568 1.00
350_V 354_I 1.552 1.00
41_V 255_L 1.54 1.00
319_L 344_G 1.532 1.00
139_F 352_V 1.528 1.00
16_A 245_M 1.524 1.00
315_P 348_T 1.524 1.00
23_V 246_V 1.513 1.00
132_Q 136_L 1.51 1.00
401_K 405_E 1.497 1.00
66_F 79_H 1.489 1.00
224_Y 313_D 1.48 1.00
12_W 237_K 1.479 1.00
80_T 391_A 1.477 1.00
47_I 211_L 1.457 1.00
135_T 356_I 1.432 1.00
58_I 415_A 1.431 1.00
240_L 244_V 1.43 1.00
69_G 226_N 1.429 1.00
166_V 170_L 1.417 1.00
416_M 420_I 1.415 1.00
49_A 417_T 1.411 1.00
91_W 328_I 1.41 1.00
19_S 242_L 1.407 0.99
336_N 340_T 1.404 0.99
10_L 15_I 1.397 0.99
39_V 197_I 1.395 0.99
81_M 85_L 1.381 0.99
420_I 424_A 1.371 0.99
403_K 406_Y 1.364 0.99
111_A 114_W 1.361 0.99
400_Q 403_K 1.358 0.99
216_G 381_M 1.347 0.99
281_K 284_E 1.346 0.99
63_G 76_W 1.343 0.99
82_G 85_L 1.334 0.99
405_E 408_F 1.334 0.99
147_S 340_T 1.333 0.99
10_L 154_K 1.331 0.99
386_L 390_V 1.323 0.99
281_K 285_Y 1.315 0.99
207_T 211_L 1.314 0.99
144_W 147_S 1.312 0.99
77_I 387_W 1.311 0.99
142_F 308_L 1.31 0.99
334_R 342_V 1.307 0.99
423_F 427_A 1.3 0.99
393_I 416_M 1.3 0.99
56_A 243_A 1.297 0.99
74_S 321_G 1.295 0.99
234_E 237_K 1.294 0.99
413_P 417_T 1.292 0.99
68_D 75_T 1.291 0.99
180_A 190_N 1.286 0.99
324_D 333_C 1.279 0.99
109_L 112_L 1.277 0.99
140_I 144_W 1.273 0.99
143_M 346_F 1.273 0.99
140_I 349_L 1.269 0.99
104_K 107_A 1.268 0.99
146_A 309_V 1.266 0.99
155_I 159_V 1.265 0.99
335_T 339_G 1.258 0.99
189_T 194_E 1.255 0.99
319_L 328_I 1.254 0.99
277_Y 280_Q 1.245 0.98
252_L 256_A 1.244 0.98
197_I 200_I 1.23 0.98
75_T 79_H 1.227 0.98
424_A 428_F 1.222 0.98
11_R 151_K 1.22 0.98
197_I 204_Y 1.219 0.98
343_N 346_F 1.208 0.98
7_E 339_G 1.205 0.98
87_Y 91_W 1.203 0.98
13_Y 17_L 1.202 0.98
390_V 394_A 1.201 0.98
143_M 147_S 1.195 0.98
56_A 239_M 1.194 0.98
139_F 349_L 1.192 0.98
338_S 342_V 1.189 0.98
133_G 137_V 1.188 0.98
219_E 223_P 1.186 0.98
55_Y 389_F 1.185 0.98
42_F 204_Y 1.177 0.98
136_L 140_I 1.171 0.98
74_S 90_A 1.158 0.97
156_V 160_A 1.151 0.97
77_I 85_L 1.15 0.97
407_V 410_R 1.15 0.97
45_V 49_A 1.15 0.97
248_V 252_L 1.148 0.97
155_I 158_S 1.147 0.97
206_T 210_M 1.143 0.97
312_I 316_L 1.139 0.97
411_N 414_L 1.137 0.97
170_L 174_M 1.132 0.97
150_M 313_D 1.131 0.97
14_N 155_I 1.129 0.97
275_Q 278_A 1.124 0.97
19_S 221_I 1.124 0.97
13_Y 155_I 1.123 0.97
265_N 268_D 1.115 0.96
278_A 283_G 1.096 0.96
393_I 419_G 1.095 0.96
77_I 391_A 1.093 0.96
96_V 381_M 1.091 0.96
268_D 271_M 1.09 0.96
147_S 336_N 1.09 0.96
85_L 387_W 1.089 0.96
417_T 421_W 1.088 0.96
392_F 396_V 1.087 0.96
59_V 73_V 1.083 0.96
417_T 420_I 1.08 0.95
148_R 338_S 1.079 0.95
320_L 335_T 1.077 0.95
92_T 384_R 1.075 0.95
167_M 299_A 1.075 0.95
165_F 249_C 1.069 0.95
32_N 36_Q 1.068 0.95
9_Q 229_R 1.066 0.95
16_A 19_S 1.063 0.95
141_F 305_V 1.063 0.95
71_G 74_S 1.06 0.95
33_Y 40_V 1.06 0.95
225_V 235_F 1.059 0.95
15_I 238_G 1.054 0.95
78_K 325_S 1.053 0.95
172_V 252_L 1.051 0.94
9_Q 151_K 1.05 0.94
138_L 142_F 1.049 0.94
336_N 339_G 1.049 0.94
57_L 240_L 1.046 0.94
247_A 251_I 1.045 0.94
97_H 311_S 1.04 0.94
177_T 184_V 1.038 0.94
376_L 380_V 1.038 0.94
108_I 112_L 1.036 0.94
29_V 32_N 1.035 0.94
229_R 234_E 1.03 0.94
192_T 195_T 1.029 0.94
402_Y 405_E 1.025 0.93
107_A 110_I 1.021 0.93
195_T 200_I 1.018 0.93
110_I 114_W 1.018 0.93
14_N 154_K 1.017 0.93
62_L 392_F 1.014 0.93
60_G 64_S 1.011 0.93
48_F 215_V 1.005 0.93
176_V 180_A 1.004 0.93
160_A 306_A 1.003 0.93
169_L 173_A 1.003 0.93
418_V 422_C 1.003 0.93
25_G 250_A 1.002 0.92
200_I 203_T 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.96431000.273Contact Map0.602
3l1lA10.89921000.348Contact Map0.684
3giaA10.88241000.381Contact Map0.572
2jlnA10.865597.70.898Contact Map0.459
4m48A10.918195.90.921Contact Map0.417
2a65A10.911894.80.926Contact Map0.519
3dh4A40.884593.70.93Contact Map0.413
2xq2A10.888787.60.939Contact Map0.502
3j1zP20.27115.60.965Contact Map0.232
2wswA10.76899.60.968Contact Map0.386
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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