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FRLA - Putative fructoselysine transporter FrlA
UniProt: P45539 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12908
Length: 445 (435)
Sequences: 10509
Seq/Len: 24.16
FRLA
Paralog alert: 0.81 [within 20: 0.31] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
319_C 332_V 4.247 1.00
139_M 338_G 3.379 1.00
171_G 249_V 3.237 1.00
11_G 222_K 3.165 1.00
311_A 321_G 3.121 1.00
366_T 398_I 3.077 1.00
322_H 332_V 2.998 1.00
223_N 226_K 2.968 1.00
226_K 230_R 2.902 1.00
53_G 240_L 2.791 1.00
335_I 339_A 2.669 1.00
374_W 378_R 2.594 1.00
324_H 327_Y 2.566 1.00
132_A 345_I 2.544 1.00
314_N 318_K 2.512 1.00
279_T 283_F 2.485 1.00
395_T 399_A 2.375 1.00
16_L 234_G 2.336 1.00
93_G 310_M 2.329 1.00
169_G 173_F 2.315 1.00
221_I 227_T 2.301 1.00
308_Y 312_K 2.253 1.00
12_F 234_G 2.167 1.00
324_H 331_D 2.148 1.00
319_C 322_H 2.134 1.00
77_Y 313_D 2.104 1.00
54_L 396_L 2.098 1.00
12_F 227_T 2.079 1.00
81_K 86_R 2.046 1.00
81_K 89_A 2.028 1.00
11_G 14_A 2.006 1.00
219_G 312_K 1.993 1.00
374_W 377_K 1.984 1.00
320_F 336_L 1.979 1.00
258_K 272_W 1.967 1.00
6_L 323_V 1.96 1.00
15_V 221_I 1.948 1.00
389_A 393_M 1.904 1.00
255_P 258_K 1.888 1.00
12_F 16_L 1.854 1.00
392_L 396_L 1.849 1.00
54_L 58_P 1.846 1.00
223_N 230_R 1.846 1.00
220_E 305_R 1.832 1.00
143_L 331_D 1.825 1.00
44_L 197_L 1.824 1.00
399_A 403_I 1.822 1.00
230_R 234_G 1.808 1.00
143_L 335_I 1.807 1.00
161_I 165_T 1.802 1.00
158_I 162_I 1.791 1.00
140_L 144_R 1.762 1.00
369_F 397_A 1.761 1.00
139_M 334_I 1.739 1.00
223_N 227_T 1.728 1.00
62_V 369_F 1.714 1.00
50_V 244_T 1.647 1.00
14_A 154_T 1.646 1.00
237_L 241_V 1.643 1.00
147_E 151_A 1.603 1.00
84_G 374_W 1.59 1.00
132_A 342_I 1.588 1.00
233_I 237_L 1.577 1.00
10_L 14_A 1.565 1.00
362_C 365_N 1.562 1.00
398_I 402_L 1.558 1.00
48_A 200_G 1.557 1.00
168_I 245_L 1.546 1.00
35_V 45_T 1.517 1.00
16_L 238_L 1.517 1.00
84_G 370_G 1.508 1.00
224_P 229_P 1.505 1.00
327_Y 331_D 1.497 1.00
304_P 334_I 1.487 1.00
307_E 333_S 1.476 1.00
85_S 88_L 1.47 1.00
62_V 394_T 1.469 1.00
372_I 394_T 1.469 1.00
373_I 395_T 1.466 1.00
371_S 375_C 1.465 1.00
92_S 367_L 1.463 1.00
282_I 286_I 1.462 1.00
355_G 358_T 1.459 1.00
332_V 336_L 1.45 1.00
97_F 337_Q 1.439 1.00
80_L 92_S 1.435 1.00
303_Q 337_Q 1.434 1.00
391_G 394_T 1.433 1.00
84_G 88_L 1.425 1.00
171_G 253_L 1.424 1.00
65_E 376_R 1.415 1.00
135_I 341_G 1.415 1.00
70_Y 82_N 1.405 0.99
68_T 384_L 1.4 0.99
391_G 395_T 1.386 0.99
20_V 238_L 1.386 0.99
268_D 271_T 1.384 0.99
162_I 166_I 1.382 0.99
268_D 272_W 1.376 0.99
370_G 398_I 1.376 0.99
217_M 301_M 1.375 0.99
370_G 374_W 1.365 0.99
131_A 345_I 1.362 0.99
23_T 239_V 1.357 0.99
144_R 327_Y 1.355 0.99
10_L 150_A 1.353 0.99
139_M 335_I 1.343 0.99
318_K 321_G 1.342 0.99
94_W 427_G 1.338 0.99
318_K 322_H 1.334 0.99
55_I 400_S 1.316 0.99
136_I 342_I 1.314 0.99
425_A 429_P 1.314 0.99
421_V 425_A 1.313 0.99
46_V 248_L 1.306 0.99
139_M 143_L 1.301 0.99
227_T 230_R 1.294 0.99
36_A 45_T 1.289 0.99
12_F 230_R 1.283 0.99
307_E 316_F 1.271 0.99
389_A 392_L 1.27 0.99
60_M 236_C 1.27 0.99
90_F 94_W 1.261 0.99
323_V 328_N 1.26 0.99
7_Q 328_N 1.248 0.99
58_P 396_L 1.246 0.98
19_A 235_S 1.242 0.98
142_H 297_S 1.24 0.98
177_A 184_T 1.239 0.98
80_L 88_L 1.237 0.98
429_P 433_F 1.237 0.98
339_A 343_F 1.233 0.98
73_N 219_G 1.228 0.98
67_S 79_Y 1.227 0.98
369_F 398_I 1.223 0.98
74_G 77_Y 1.222 0.98
379_D 383_P 1.218 0.98
13_W 151_A 1.218 0.98
349_D 352_S 1.203 0.98
373_I 377_K 1.202 0.98
136_I 338_G 1.202 0.98
241_V 245_L 1.197 0.98
116_L 130_I 1.196 0.98
78_V 82_N 1.196 0.98
190_A 193_S 1.194 0.98
132_A 136_I 1.193 0.98
94_W 316_F 1.189 0.98
128_K 132_A 1.178 0.98
146_V 301_M 1.171 0.98
14_A 151_A 1.17 0.97
72_E 78_V 1.164 0.97
312_K 321_G 1.163 0.97
262_S 268_D 1.163 0.97
358_T 361_M 1.162 0.97
28_I 246_L 1.159 0.97
9_K 147_E 1.159 0.97
138_F 296_L 1.158 0.97
175_F 252_G 1.157 0.97
352_S 355_G 1.146 0.97
429_P 432_A 1.145 0.97
324_H 329_T 1.142 0.97
53_G 208_Y 1.138 0.97
172_I 249_V 1.137 0.97
308_Y 323_V 1.137 0.97
422_I 426_T 1.136 0.97
322_H 331_D 1.133 0.97
352_S 360_V 1.13 0.97
212_A 216_Y 1.128 0.97
105_L 341_G 1.128 0.97
50_V 54_L 1.109 0.96
10_L 15_V 1.109 0.96
380_D 383_P 1.104 0.96
140_L 143_L 1.103 0.96
135_I 338_G 1.098 0.96
60_M 232_L 1.096 0.96
77_Y 309_A 1.09 0.96
47_L 197_L 1.085 0.96
35_V 39_A 1.084 0.96
428_L 432_A 1.078 0.95
172_I 176_K 1.077 0.95
225_G 384_L 1.076 0.95
165_T 169_G 1.076 0.95
245_L 249_V 1.074 0.95
18_I 217_M 1.072 0.95
161_I 242_L 1.068 0.95
222_K 227_T 1.067 0.95
253_L 269_A 1.064 0.95
166_I 170_L 1.062 0.95
240_L 244_T 1.055 0.95
13_W 17_A 1.055 0.95
198_L 403_I 1.05 0.94
367_L 371_S 1.047 0.94
15_V 231_A 1.047 0.94
300_V 304_P 1.046 0.94
143_L 324_H 1.044 0.94
52_G 204_T 1.044 0.94
109_A 296_L 1.044 0.94
194_F 197_L 1.043 0.94
58_P 393_M 1.04 0.94
419_C 422_I 1.038 0.94
61_C 233_I 1.037 0.94
69_A 384_L 1.036 0.94
152_F 156_I 1.033 0.94
151_A 155_L 1.031 0.94
47_L 50_V 1.029 0.94
59_Q 369_F 1.028 0.94
57_I 61_C 1.028 0.94
366_T 370_G 1.026 0.94
14_A 150_A 1.025 0.93
190_A 197_L 1.024 0.93
65_E 68_T 1.024 0.93
80_L 371_S 1.018 0.93
9_K 222_K 1.018 0.93
19_A 214_I 1.018 0.93
87_P 428_L 1.016 0.93
392_L 395_T 1.013 0.93
104_S 107_I 1.009 0.93
21_G 157_T 1.007 0.93
11_G 147_E 1.004 0.93
366_T 402_L 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3l1lA10.9641000.333Contact Map0.673
4djkA20.9641000.354Contact Map0.582
3giaA10.95061000.355Contact Map0.585
2jlnA10.903497.90.896Contact Map0.426
3dh4A40.948397.80.897Contact Map0.439
2xq2A10.946197.40.905Contact Map0.515
2a65A10.9416960.921Contact Map0.464
4m48A10.955195.20.925Contact Map0.395
2wswA10.797868.80.95Contact Map0.307
3j1zP20.274228.30.961Contact Map0.319
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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