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OPENSEQ.org
MMUP - Probable S-methylmethionine permease
UniProt: Q47689 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13342
Length: 467 (448)
Sequences: 10823
Seq/Len: 24.16
MMUP
Paralog alert: 0.81 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
326_C 338_T 4.196 1.00
378_L 416_F 3.679 1.00
139_F 344_M 3.428 1.00
171_G 258_V 3.22 1.00
318_S 328_A 3.08 1.00
15_K 231_E 3.052 1.00
329_R 338_T 3.018 1.00
56_A 249_I 2.903 1.00
232_N 235_K 2.886 1.00
235_K 239_V 2.853 1.00
381_C 415_G 2.485 1.00
321_R 325_A 2.427 1.00
413_V 417_V 2.401 1.00
326_C 329_R 2.35 1.00
20_I 243_T 2.329 1.00
16_T 243_T 2.306 1.00
286_Y 290_I 2.305 1.00
341_S 345_L 2.28 1.00
230_T 236_V 2.255 1.00
331_T 337_L 2.242 1.00
315_W 319_N 2.24 1.00
267_Q 281_K 2.232 1.00
96_A 317_L 2.221 1.00
386_V 390_R 2.149 1.00
169_I 173_A 2.134 1.00
65_C 381_C 2.126 1.00
57_L 414_L 2.117 1.00
80_H 320_E 2.088 1.00
47_G 206_I 2.075 1.00
16_T 236_V 2.064 1.00
228_G 319_N 2.02 1.00
84_A 92_G 2.014 1.00
327_F 342_V 1.969 1.00
90_A 450_Y 1.957 1.00
84_A 89_P 1.942 1.00
10_L 330_V 1.915 1.00
15_K 18_H 1.906 1.00
264_P 267_Q 1.893 1.00
87_L 382_A 1.882 1.00
16_T 20_I 1.879 1.00
229_E 312_R 1.863 1.00
57_L 61_L 1.826 1.00
147_R 151_E 1.824 1.00
139_F 340_L 1.809 1.00
410_L 414_L 1.806 1.00
87_L 386_V 1.801 1.00
239_V 243_T 1.785 1.00
51_A 209_T 1.78 1.00
19_L 230_T 1.779 1.00
68_E 388_R 1.772 1.00
143_V 337_L 1.766 1.00
417_V 421_V 1.759 1.00
382_A 416_F 1.751 1.00
100_W 343_S 1.744 1.00
161_V 165_I 1.726 1.00
140_G 144_I 1.724 1.00
386_V 389_R 1.709 1.00
158_L 162_V 1.703 1.00
143_V 341_S 1.694 1.00
39_I 48_T 1.684 1.00
132_V 352_F 1.676 1.00
246_A 250_I 1.674 1.00
65_C 412_P 1.666 1.00
232_N 236_V 1.661 1.00
18_H 154_F 1.647 1.00
20_I 247_R 1.639 1.00
242_R 246_A 1.634 1.00
53_L 253_I 1.63 1.00
95_V 379_S 1.614 1.00
83_A 95_V 1.61 1.00
14_M 18_H 1.603 1.00
407_W 411_V 1.601 1.00
233_P 238_P 1.593 1.00
232_N 239_V 1.573 1.00
58_V 418_L 1.562 1.00
385_F 413_V 1.536 1.00
384_H 412_P 1.516 1.00
448_G 452_L 1.515 1.00
314_L 339_A 1.508 1.00
135_C 347_G 1.497 1.00
132_V 348_V 1.483 1.00
311_G 340_L 1.481 1.00
338_T 342_V 1.48 1.00
444_A 448_G 1.468 1.00
83_A 379_S 1.466 1.00
310_S 343_S 1.466 1.00
61_L 414_L 1.463 1.00
331_T 335_V 1.461 1.00
289_D 293_F 1.457 1.00
325_A 328_A 1.432 1.00
226_A 308_Y 1.432 1.00
277_L 280_E 1.431 1.00
136_A 348_V 1.431 1.00
168_I 254_G 1.421 1.00
132_V 136_A 1.418 1.00
277_L 281_K 1.413 1.00
118_M 130_W 1.405 0.99
447_Y 451_F 1.397 0.99
136_A 344_M 1.391 0.99
27_V 248_L 1.388 0.99
142_N 304_N 1.387 0.99
111_F 303_A 1.384 0.99
111_F 135_C 1.381 0.99
416_F 420_L 1.376 0.99
47_G 199_F 1.374 0.99
40_I 48_T 1.369 0.99
88_G 91_T 1.363 0.99
16_T 239_V 1.363 0.99
24_L 247_R 1.362 0.99
162_V 166_A 1.352 0.99
87_L 91_T 1.35 0.99
325_A 329_R 1.348 0.99
280_E 288_A 1.346 0.99
73_M 85_R 1.343 0.99
63_M 245_I 1.341 0.99
107_L 347_G 1.321 0.99
345_L 349_L 1.315 0.99
62_V 381_C 1.31 0.99
93_Y 97_W 1.308 0.99
49_L 257_F 1.303 0.99
132_V 351_L 1.301 0.99
409_P 413_V 1.294 0.99
163_T 294_V 1.292 0.99
14_M 150_A 1.29 0.99
138_I 303_A 1.285 0.99
23_S 244_T 1.283 0.99
441_P 444_A 1.279 0.99
333_N 337_L 1.276 0.99
407_W 410_L 1.274 0.99
236_V 239_V 1.273 0.99
314_L 323_L 1.268 0.99
424_V 428_F 1.257 0.99
11_K 334_G 1.257 0.99
199_F 206_I 1.249 0.99
280_E 285_P 1.249 0.99
234_R 402_H 1.247 0.99
76_T 228_G 1.244 0.98
284_I 287_A 1.243 0.98
114_A 296_L 1.242 0.98
71_V 402_H 1.241 0.98
271_E 277_L 1.24 0.98
131_C 351_L 1.237 0.98
144_I 333_N 1.236 0.98
172_G 176_F 1.236 0.98
55_G 213_V 1.234 0.98
450_Y 454_Q 1.234 0.98
378_L 420_L 1.232 0.98
146_T 308_Y 1.225 0.98
139_F 143_V 1.224 0.98
445_L 449_A 1.223 0.98
118_M 296_L 1.221 0.98
250_I 254_G 1.214 0.98
10_L 315_W 1.204 0.98
202_G 431_A 1.203 0.98
139_F 341_S 1.197 0.98
70_S 82_Y 1.195 0.98
86_Y 383_S 1.193 0.98
14_M 19_L 1.186 0.98
176_F 187_A 1.184 0.98
50_L 206_I 1.183 0.98
440_L 444_A 1.182 0.98
448_G 451_F 1.181 0.98
315_W 330_V 1.179 0.98
382_A 386_V 1.177 0.98
63_M 241_I 1.175 0.98
61_L 411_V 1.174 0.98
378_L 382_A 1.173 0.98
452_L 455_P 1.168 0.97
172_G 258_V 1.163 0.97
173_A 178_F 1.16 0.97
319_N 328_A 1.156 0.97
81_V 85_R 1.156 0.97
17_R 151_E 1.155 0.97
385_F 412_P 1.146 0.97
338_T 341_S 1.145 0.97
17_R 21_M 1.145 0.97
75_E 81_V 1.143 0.97
171_G 262_L 1.141 0.97
330_V 334_G 1.135 0.97
39_I 43_T 1.13 0.97
218_S 373_V 1.129 0.97
186_P 191_S 1.122 0.97
410_L 413_V 1.122 0.97
128_W 132_V 1.117 0.96
227_A 237_I 1.116 0.96
97_W 323_L 1.112 0.96
396_K 399_S 1.112 0.96
34_F 113_A 1.11 0.96
77_G 80_H 1.11 0.96
143_V 331_T 1.105 0.96
329_R 337_L 1.104 0.96
135_C 344_M 1.104 0.96
221_E 225_I 1.1 0.96
140_G 143_V 1.096 0.96
152_G 156_F 1.095 0.96
66_L 79_F 1.089 0.96
13_T 147_R 1.071 0.95
203_G 206_I 1.068 0.95
56_A 217_F 1.061 0.95
190_L 261_A 1.057 0.95
385_F 409_P 1.056 0.95
80_H 316_S 1.051 0.94
153_E 304_N 1.05 0.94
19_L 240_A 1.047 0.94
83_A 91_T 1.046 0.94
88_G 451_F 1.044 0.94
254_G 258_V 1.042 0.94
307_L 311_G 1.042 0.94
207_L 421_V 1.042 0.94
32_L 255_T 1.041 0.94
69_L 384_H 1.041 0.94
18_H 151_E 1.037 0.94
137_I 300_L 1.037 0.94
438_C 441_P 1.027 0.94
50_L 53_L 1.022 0.93
231_E 236_V 1.021 0.93
23_S 223_I 1.021 0.93
143_V 335_V 1.021 0.93
72_A 401_L 1.02 0.93
165_I 169_I 1.016 0.93
151_E 154_F 1.014 0.93
161_V 251_F 1.013 0.93
151_E 155_W 1.012 0.93
421_V 425_G 1.01 0.93
64_Q 242_R 1.01 0.93
409_P 412_P 1.01 0.93
100_W 314_L 1.004 0.93
53_L 57_L 1.003 0.93
389_R 392_L 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.95071000.323Contact Map0.605
3l1lA10.93151000.333Contact Map0.675
3giaA10.90791000.371Contact Map0.609
3dh4A40.933698.30.887Contact Map0.411
2jlnA10.895198.10.892Contact Map0.433
2xq2A10.9315980.895Contact Map0.506
4m48A10.927294.40.93Contact Map0.368
2a65A10.920890.90.938Contact Map0.416
3j1zP20.286914.30.967Contact Map0.392
2kluA10.09858.90.97Contact Map0.456
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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