| UniProt: | P25527 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11330 | ||
| Length: | 466 (445) | ||
| Sequences: | 10827 | ||
| Seq/Len: | 24.33 |
| GABP
Paralog alert: 0.82 [within 20: 0.38] - ratio of genomes with paralogs Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 324_V | 336_V | 4.175 | 1.00 | |
| 376_L | 411_I | 3.812 | 1.00 | |
| 138_T | 342_T | 3.447 | 1.00 | |
| 316_S | 326_G | 3.092 | 1.00 | |
| 15_K | 228_D | 3.054 | 1.00 | |
| 170_G | 255_V | 3.035 | 1.00 | |
| 327_K | 336_V | 2.964 | 1.00 | |
| 55_G | 246_S | 2.926 | 1.00 | |
| 229_T | 232_K | 2.828 | 1.00 | |
| 232_K | 236_R | 2.821 | 1.00 | |
| 131_L | 349_V | 2.744 | 1.00 | |
| 384_R | 388_I | 2.673 | 1.00 | |
| 408_W | 412_G | 2.465 | 1.00 | |
| 379_A | 410_V | 2.448 | 1.00 | |
| 284_H | 288_I | 2.431 | 1.00 | |
| 319_G | 323_A | 2.412 | 1.00 | |
| 339_L | 343_G | 2.381 | 1.00 | |
| 227_S | 233_H | 2.335 | 1.00 | |
| 324_V | 327_K | 2.274 | 1.00 | |
| 313_Y | 317_R | 2.233 | 1.00 | |
| 20_T | 240_S | 2.222 | 1.00 | |
| 95_G | 315_L | 2.219 | 1.00 | |
| 329_N | 335_Y | 2.199 | 1.00 | |
| 16_S | 240_S | 2.184 | 1.00 | |
| 56_L | 409_L | 2.151 | 1.00 | |
| 64_M | 379_A | 2.097 | 1.00 | |
| 79_S | 318_R | 2.095 | 1.00 | |
| 168_F | 172_V | 2.094 | 1.00 | |
| 16_S | 233_H | 2.062 | 1.00 | |
| 264_M | 279_L | 2.06 | 1.00 | |
| 46_A | 203_V | 2.057 | 1.00 | |
| 225_A | 317_R | 2.013 | 1.00 | |
| 325_M | 340_L | 2.006 | 1.00 | |
| 83_D | 88_R | 1.963 | 1.00 | |
| 15_K | 18_H | 1.962 | 1.00 | |
| 83_D | 91_G | 1.961 | 1.00 | |
| 10_L | 328_I | 1.954 | 1.00 | |
| 67_E | 386_R | 1.924 | 1.00 | |
| 86_I | 384_R | 1.914 | 1.00 | |
| 86_I | 380_V | 1.898 | 1.00 | |
| 226_E | 310_R | 1.861 | 1.00 | |
| 56_L | 60_M | 1.85 | 1.00 | |
| 236_R | 240_S | 1.848 | 1.00 | |
| 19_V | 227_S | 1.823 | 1.00 | |
| 142_L | 335_Y | 1.804 | 1.00 | |
| 142_L | 339_L | 1.799 | 1.00 | |
| 405_W | 409_L | 1.785 | 1.00 | |
| 146_K | 150_E | 1.78 | 1.00 | |
| 138_T | 338_V | 1.771 | 1.00 | |
| 139_G | 143_L | 1.744 | 1.00 | |
| 157_L | 161_I | 1.73 | 1.00 | |
| 16_S | 20_T | 1.73 | 1.00 | |
| 94_I | 377_V | 1.723 | 1.00 | |
| 380_V | 411_I | 1.722 | 1.00 | |
| 50_A | 206_A | 1.712 | 1.00 | |
| 189_L | 192_S | 1.708 | 1.00 | |
| 64_M | 407_T | 1.698 | 1.00 | |
| 412_G | 416_F | 1.696 | 1.00 | |
| 442_I | 446_P | 1.695 | 1.00 | |
| 261_P | 264_M | 1.693 | 1.00 | |
| 99_W | 341_S | 1.689 | 1.00 | |
| 89_W | 444_T | 1.682 | 1.00 | |
| 384_R | 387_K | 1.677 | 1.00 | |
| 229_T | 233_H | 1.676 | 1.00 | |
| 82_A | 94_I | 1.665 | 1.00 | |
| 160_V | 164_L | 1.656 | 1.00 | |
| 131_L | 346_F | 1.625 | 1.00 | |
| 39_A | 47_V | 1.622 | 1.00 | |
| 229_T | 236_R | 1.61 | 1.00 | |
| 243_W | 247_I | 1.61 | 1.00 | |
| 117_L | 129_F | 1.598 | 1.00 | |
| 239_N | 243_W | 1.592 | 1.00 | |
| 20_T | 244_R | 1.589 | 1.00 | |
| 52_L | 250_L | 1.577 | 1.00 | |
| 402_L | 406_L | 1.57 | 1.00 | |
| 60_M | 409_L | 1.563 | 1.00 | |
| 230_P | 235_V | 1.559 | 1.00 | |
| 18_H | 153_F | 1.558 | 1.00 | |
| 134_T | 345_A | 1.556 | 1.00 | |
| 434_T | 438_A | 1.548 | 1.00 | |
| 336_V | 340_L | 1.529 | 1.00 | |
| 441_I | 445_V | 1.528 | 1.00 | |
| 57_L | 413_F | 1.514 | 1.00 | |
| 312_L | 337_A | 1.512 | 1.00 | |
| 329_N | 333_T | 1.51 | 1.00 | |
| 14_L | 18_H | 1.51 | 1.00 | |
| 70_V | 397_R | 1.507 | 1.00 | |
| 383_L | 408_W | 1.497 | 1.00 | |
| 382_Q | 407_T | 1.485 | 1.00 | |
| 135_L | 346_F | 1.48 | 1.00 | |
| 308_A | 341_S | 1.468 | 1.00 | |
| 287_L | 291_C | 1.457 | 1.00 | |
| 309_S | 338_V | 1.446 | 1.00 | |
| 323_A | 327_K | 1.423 | 1.00 | |
| 331_S | 335_Y | 1.422 | 1.00 | |
| 343_G | 347_L | 1.406 | 0.99 | |
| 323_A | 326_G | 1.406 | 0.99 | |
| 82_A | 377_V | 1.403 | 0.99 | |
| 411_I | 415_T | 1.399 | 0.99 | |
| 171_A | 175_S | 1.395 | 0.99 | |
| 110_A | 134_T | 1.384 | 0.99 | |
| 275_S | 278_E | 1.377 | 0.99 | |
| 27_V | 245_I | 1.374 | 0.99 | |
| 135_L | 342_T | 1.365 | 0.99 | |
| 438_A | 442_I | 1.365 | 0.99 | |
| 131_L | 135_L | 1.358 | 0.99 | |
| 435_G | 438_A | 1.356 | 0.99 | |
| 46_A | 196_M | 1.354 | 0.99 | |
| 87_G | 90_A | 1.353 | 0.99 | |
| 16_S | 236_R | 1.352 | 0.99 | |
| 106_I | 345_A | 1.349 | 0.99 | |
| 223_A | 306_Y | 1.348 | 0.99 | |
| 40_I | 47_V | 1.342 | 0.99 | |
| 143_L | 331_S | 1.341 | 0.99 | |
| 86_I | 90_A | 1.337 | 0.99 | |
| 167_I | 251_C | 1.336 | 0.99 | |
| 404_P | 408_W | 1.333 | 0.99 | |
| 275_S | 279_L | 1.33 | 0.99 | |
| 23_S | 241_V | 1.327 | 0.99 | |
| 61_I | 379_A | 1.325 | 0.99 | |
| 389_L | 392_E | 1.315 | 0.99 | |
| 141_N | 302_N | 1.31 | 0.99 | |
| 72_T | 84_K | 1.31 | 0.99 | |
| 110_A | 301_L | 1.307 | 0.99 | |
| 134_T | 342_T | 1.306 | 0.99 | |
| 161_I | 165_A | 1.306 | 0.99 | |
| 62_M | 242_I | 1.302 | 0.99 | |
| 312_L | 321_A | 1.298 | 0.99 | |
| 85_A | 381_S | 1.295 | 0.99 | |
| 75_T | 225_A | 1.287 | 0.99 | |
| 138_T | 339_L | 1.285 | 0.99 | |
| 196_M | 203_V | 1.278 | 0.99 | |
| 11_G | 332_K | 1.276 | 0.99 | |
| 137_L | 301_L | 1.271 | 0.99 | |
| 233_H | 236_R | 1.271 | 0.99 | |
| 24_I | 244_R | 1.265 | 0.99 | |
| 14_L | 149_G | 1.255 | 0.99 | |
| 130_S | 349_V | 1.254 | 0.99 | |
| 80_T | 84_K | 1.25 | 0.99 | |
| 380_V | 384_R | 1.248 | 0.99 | |
| 69_A | 81_Y | 1.247 | 0.99 | |
| 446_P | 449_A | 1.245 | 0.98 | |
| 92_Y | 96_W | 1.23 | 0.98 | |
| 138_T | 142_L | 1.228 | 0.98 | |
| 10_L | 313_Y | 1.226 | 0.98 | |
| 49_L | 203_V | 1.222 | 0.98 | |
| 278_E | 283_P | 1.221 | 0.98 | |
| 172_V | 177_F | 1.218 | 0.98 | |
| 62_M | 238_T | 1.215 | 0.98 | |
| 113_A | 294_L | 1.211 | 0.98 | |
| 162_A | 292_V | 1.204 | 0.98 | |
| 376_L | 380_V | 1.203 | 0.98 | |
| 419_V | 423_F | 1.197 | 0.98 | |
| 54_A | 210_T | 1.19 | 0.98 | |
| 317_R | 326_G | 1.189 | 0.98 | |
| 328_I | 332_K | 1.189 | 0.98 | |
| 52_L | 56_L | 1.183 | 0.98 | |
| 278_E | 286_K | 1.182 | 0.98 | |
| 48_L | 254_F | 1.18 | 0.98 | |
| 145_V | 306_Y | 1.175 | 0.98 | |
| 34_V | 112_I | 1.17 | 0.97 | |
| 432_I | 435_G | 1.169 | 0.97 | |
| 74_D | 80_T | 1.166 | 0.97 | |
| 327_K | 335_Y | 1.164 | 0.97 | |
| 215_M | 371_A | 1.164 | 0.97 | |
| 188_R | 192_S | 1.162 | 0.97 | |
| 175_S | 183_V | 1.161 | 0.97 | |
| 171_A | 255_V | 1.158 | 0.97 | |
| 87_G | 445_V | 1.152 | 0.97 | |
| 193_G | 196_M | 1.145 | 0.97 | |
| 247_I | 251_C | 1.144 | 0.97 | |
| 376_L | 415_T | 1.14 | 0.97 | |
| 224_A | 234_I | 1.139 | 0.97 | |
| 14_L | 19_V | 1.139 | 0.97 | |
| 231_E | 397_R | 1.134 | 0.97 | |
| 313_Y | 328_I | 1.132 | 0.97 | |
| 160_V | 248_F | 1.126 | 0.97 | |
| 82_A | 90_A | 1.125 | 0.97 | |
| 435_G | 439_I | 1.122 | 0.97 | |
| 336_V | 339_L | 1.117 | 0.96 | |
| 442_I | 445_V | 1.115 | 0.96 | |
| 204_L | 416_F | 1.111 | 0.96 | |
| 17_R | 150_E | 1.109 | 0.96 | |
| 17_R | 21_M | 1.103 | 0.96 | |
| 405_W | 408_W | 1.102 | 0.96 | |
| 65_L | 78_F | 1.098 | 0.96 | |
| 251_C | 255_V | 1.096 | 0.96 | |
| 142_L | 333_T | 1.089 | 0.96 | |
| 71_A | 397_R | 1.086 | 0.96 | |
| 436_L | 440_G | 1.085 | 0.96 | |
| 151_F | 155_L | 1.084 | 0.96 | |
| 29_G | 249_Y | 1.084 | 0.96 | |
| 19_V | 237_A | 1.082 | 0.96 | |
| 49_L | 52_L | 1.08 | 0.95 | |
| 142_L | 329_N | 1.078 | 0.95 | |
| 39_A | 43_A | 1.071 | 0.95 | |
| 139_G | 142_L | 1.068 | 0.95 | |
| 18_H | 150_E | 1.067 | 0.95 | |
| 170_G | 259_L | 1.064 | 0.95 | |
| 55_G | 214_F | 1.052 | 0.95 | |
| 218_E | 222_I | 1.048 | 0.94 | |
| 228_D | 233_H | 1.047 | 0.94 | |
| 96_W | 321_A | 1.044 | 0.94 | |
| 13_G | 146_K | 1.043 | 0.94 | |
| 383_L | 404_P | 1.043 | 0.94 | |
| 383_L | 407_T | 1.041 | 0.94 | |
| 136_A | 298_T | 1.038 | 0.94 | |
| 60_M | 406_L | 1.037 | 0.94 | |
| 150_E | 153_F | 1.029 | 0.94 | |
| 79_S | 314_S | 1.028 | 0.94 | |
| 444_T | 448_M | 1.021 | 0.93 | |
| 128_L | 132_V | 1.017 | 0.93 | |
| 305_L | 309_S | 1.017 | 0.93 | |
| 416_F | 420_V | 1.017 | 0.93 | |
| 152_E | 302_N | 1.013 | 0.93 | |
| 89_W | 441_I | 1.004 | 0.93 | |
| 124_I | 128_L | 1.004 | 0.93 | |
| 402_L | 405_W | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4djkA | 2 | 0.9657 | 100 | 0.331 | Contact Map | 0.599 |
| 3l1lA | 1 | 0.9399 | 100 | 0.358 | Contact Map | 0.685 |
| 3giaA | 1 | 0.9227 | 100 | 0.373 | Contact Map | 0.598 |
| 2xq2A | 1 | 0.97 | 98.1 | 0.895 | Contact Map | 0.49 |
| 3dh4A | 4 | 0.9421 | 98 | 0.897 | Contact Map | 0.39 |
| 2jlnA | 1 | 0.897 | 97.4 | 0.908 | Contact Map | 0.405 |
| 4m48A | 1 | 0.9464 | 94.6 | 0.93 | Contact Map | 0.368 |
| 2a65A | 1 | 0.9185 | 92.8 | 0.935 | Contact Map | 0.417 |
| 2wswA | 1 | 0.7897 | 49.6 | 0.957 | Contact Map | 0.321 |
| 1wazA | 1 | 0.0944 | 5.1 | 0.973 | Contact Map | 0.708 |
Sequence Conservation (Image Generated using WebLogo v3)