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YGJI - Inner membrane transporter YgjI
UniProt: P42590 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12720
Length: 477 (419)
Sequences: 9830
Seq/Len: 23.46
YGJI
Paralog alert: 0.82 [within 20: 0.38] - ratio of genomes with paralogs
Cluster includes: ADIC ANSP ARCD AROP CADB CYCA FRLA GABP GADC LYSP MMUP PHEP PLAP POTE PROY PUUP YBAT YCAM YGJI YIFK YJEH YJEM
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
323_K 335_R 4.241 1.00
139_T 341_F 3.615 1.00
315_I 325_V 3.439 1.00
10_G 223_K 3.389 1.00
171_A 250_L 3.289 1.00
326_E 335_R 3.237 1.00
386_N 390_K 3.119 1.00
227_K 231_K 2.902 1.00
47_T 241_G 2.839 1.00
224_G 227_K 2.816 1.00
283_L 287_F 2.78 1.00
338_W 342_L 2.69 1.00
132_M 349_I 2.614 1.00
15_L 235_L 2.522 1.00
318_G 322_K 2.504 1.00
328_N 334_A 2.392 1.00
89_A 314_E 2.376 1.00
323_K 326_E 2.352 1.00
312_F 316_P 2.324 1.00
222_V 228_S 2.317 1.00
11_K 235_L 2.278 1.00
57_I 381_M 2.26 1.00
220_N 316_P 2.218 1.00
77_K 82_G 2.21 1.00
10_G 13_G 2.19 1.00
324_T 339_I 2.136 1.00
80_L 386_N 2.13 1.00
80_L 382_L 2.119 1.00
77_K 85_A 2.111 1.00
169_L 173_T 2.097 1.00
11_K 228_S 2.086 1.00
73_Y 317_E 2.077 1.00
386_N 389_A 2.053 1.00
60_E 388_R 2.046 1.00
143_T 338_W 2.018 1.00
221_D 309_K 1.948 1.00
139_T 337_A 1.927 1.00
93_W 340_Q 1.923 1.00
11_K 15_L 1.902 1.00
140_W 144_N 1.865 1.00
88_T 379_F 1.853 1.00
143_T 334_A 1.821 1.00
335_R 339_I 1.808 1.00
256_S 259_E 1.801 1.00
231_K 235_L 1.793 1.00
158_T 162_L 1.777 1.00
110_Y 113_Y 1.768 1.00
14_L 222_V 1.768 1.00
136_A 345_I 1.75 1.00
308_V 337_A 1.749 1.00
161_L 165_L 1.746 1.00
42_M 201_V 1.729 1.00
131_S 348_M 1.729 1.00
76_V 88_T 1.722 1.00
238_I 242_V 1.721 1.00
224_G 231_K 1.689 1.00
147_K 151_P 1.689 1.00
44_F 245_S 1.687 1.00
224_G 228_S 1.671 1.00
19_F 239_F 1.65 1.00
9_I 13_G 1.597 1.00
322_K 325_V 1.597 1.00
225_G 230_V 1.581 1.00
132_M 345_I 1.577 1.00
13_G 154_S 1.571 1.00
311_F 336_A 1.559 1.00
392_D 396_R 1.544 1.00
11_K 231_K 1.509 1.00
307_P 340_Q 1.5 1.00
63_S 397_D 1.498 1.00
9_I 150_G 1.493 1.00
234_I 238_I 1.493 1.00
322_K 326_E 1.487 1.00
162_L 166_S 1.482 1.00
80_L 84_W 1.474 1.00
90_Y 320_F 1.466 1.00
15_L 239_F 1.456 1.00
342_L 346_P 1.449 1.00
79_S 383_A 1.448 1.00
38_A 198_F 1.435 1.00
218_Y 305_A 1.431 1.00
172_G 176_V 1.425 1.00
226_S 397_D 1.424 1.00
259_E 276_Y 1.412 1.00
103_L 106_R 1.411 1.00
328_N 332_V 1.402 0.99
22_V 240_I 1.391 0.99
286_R 290_L 1.389 0.99
135_F 344_V 1.384 0.99
46_A 205_I 1.364 0.99
86_F 90_Y 1.355 0.99
69_E 220_N 1.355 0.99
38_A 190_M 1.352 0.99
18_T 236_A 1.347 0.99
111_A 114_A 1.347 0.99
210_G 373_S 1.334 0.99
138_S 300_L 1.329 0.99
62_V 75_W 1.325 0.99
311_F 320_F 1.324 0.99
382_L 386_N 1.316 0.99
357_T 360_D 1.313 0.99
191_I 198_F 1.309 0.99
128_T 132_M 1.306 0.99
168_I 246_V 1.289 0.99
9_I 14_L 1.289 0.99
378_L 382_L 1.287 0.99
129_I 133_V 1.284 0.99
38_A 191_I 1.284 0.99
76_V 379_F 1.28 0.99
143_T 332_V 1.276 0.99
335_R 338_W 1.274 0.99
12_F 151_P 1.272 0.99
48_I 52_I 1.27 0.99
55_C 237_G 1.269 0.99
163_L 291_V 1.26 0.99
12_F 16_S 1.26 0.99
132_M 136_A 1.257 0.99
391_L 394_L 1.257 0.99
316_P 325_V 1.256 0.99
330_N 334_A 1.248 0.99
140_W 143_T 1.238 0.98
228_S 231_K 1.236 0.98
242_V 246_V 1.235 0.98
54_F 381_M 1.225 0.98
326_E 334_A 1.224 0.98
81_G 84_W 1.218 0.98
176_V 184_A 1.216 0.98
135_F 341_F 1.215 0.98
142_S 301_L 1.204 0.98
139_T 338_W 1.203 0.98
327_L 331_G 1.196 0.98
74_A 78_S 1.195 0.98
213_E 217_V 1.19 0.98
76_V 383_A 1.178 0.98
144_N 330_N 1.176 0.98
173_T 178_G 1.176 0.98
20_A 157_S 1.171 0.98
13_G 151_P 1.168 0.97
106_R 114_A 1.165 0.97
73_Y 313_S 1.164 0.97
152_I 156_T 1.155 0.97
136_A 341_F 1.154 0.97
111_A 115_F 1.152 0.97
6_R 331_G 1.152 0.97
139_T 143_T 1.152 0.97
47_T 50_Y 1.151 0.97
73_Y 89_A 1.149 0.97
5_K 327_L 1.137 0.97
312_F 327_L 1.131 0.97
385_L 389_A 1.131 0.97
141_V 152_I 1.13 0.97
143_T 328_N 1.128 0.97
34_E 200_G 1.125 0.97
101_T 104_L 1.125 0.97
106_R 110_Y 1.125 0.97
10_G 147_K 1.124 0.97
108_I 111_A 1.123 0.97
44_F 48_I 1.123 0.97
64_L 396_R 1.122 0.97
304_T 308_V 1.12 0.96
126_A 129_I 1.118 0.96
146_A 305_A 1.118 0.96
41_P 198_F 1.116 0.96
15_L 18_T 1.114 0.96
151_P 154_S 1.11 0.96
123_T 126_A 1.109 0.96
171_A 254_F 1.108 0.96
246_V 250_L 1.105 0.96
18_T 215_V 1.096 0.96
65_N 78_S 1.094 0.96
241_G 245_S 1.09 0.96
411_S 414_I 1.089 0.96
68_S 74_A 1.089 0.96
64_L 394_L 1.084 0.96
320_F 324_T 1.081 0.95
137_F 297_F 1.081 0.95
106_R 109_A 1.08 0.95
55_C 233_I 1.08 0.95
8_T 147_K 1.077 0.95
56_L 234_I 1.075 0.95
151_P 155_V 1.073 0.95
64_L 397_D 1.071 0.95
368_M 372_A 1.066 0.95
328_N 331_G 1.065 0.95
136_A 140_W 1.064 0.95
223_K 228_S 1.063 0.95
393_H 396_R 1.062 0.95
172_G 250_L 1.059 0.95
165_L 169_L 1.059 0.95
40_A 249_V 1.056 0.95
57_I 400_M 1.052 0.95
280_P 283_L 1.05 0.94
95_V 373_S 1.046 0.94
14_L 232_V 1.044 0.94
76_V 84_W 1.044 0.94
419_V 423_A 1.043 0.94
28_V 31_N 1.042 0.94
107_V 110_Y 1.042 0.94
134_L 138_S 1.038 0.94
24_S 244_Y 1.024 0.93
58_I 72_V 1.022 0.93
47_T 51_F 1.02 0.93
8_T 223_K 1.02 0.93
219_V 229_F 1.02 0.93
156_T 298_G 1.018 0.93
410_V 414_I 1.014 0.93
419_V 422_V 1.012 0.93
22_V 236_A 1.011 0.93
272_G 275_A 1.011 0.93
70_A 73_Y 1.008 0.93
161_L 243_L 1.008 0.93
77_K 317_E 1.007 0.93
17_L 218_Y 1.006 0.93
59_A 63_S 1.004 0.93
304_T 341_F 1.003 0.93
184_A 187_V 1 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
4djkA20.98531000.282Contact Map0.591
3l1lA10.92661000.414Contact Map0.682
3giaA10.9141000.424Contact Map0.56
2jlnA10.876398.30.891Contact Map0.439
2a65A10.930897.80.906Contact Map0.54
4m48A10.932997.20.916Contact Map0.453
3dh4A40.905797.10.916Contact Map0.386
2xq2A10.905796.50.923Contact Map0.472
4ainA30.178222.60.966Contact Map0.368
2wswA10.176119.50.967Contact Map0.431
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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