| UniProt: | P77581 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13999 | ||
| Length: | 406 (390) | ||
| Sequences: | 9666 | ||
| Seq/Len: | 24.78 |
| ASTC
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 65_N | 69_S | 4.607 | 1.00 | |
| 361_A | 395_A | 4.312 | 1.00 | |
| 210_R | 214_N | 4.189 | 1.00 | |
| 32_R | 40_E | 3.818 | 1.00 | |
| 314_W | 387_T | 3.629 | 1.00 | |
| 173_I | 208_G | 3.475 | 1.00 | |
| 303_E | 306_N | 3.343 | 1.00 | |
| 89_K | 297_E | 3.268 | 1.00 | |
| 27_R | 34_W | 3.187 | 1.00 | |
| 62_E | 66_E | 3.012 | 1.00 | |
| 234_E | 240_H | 2.998 | 1.00 | |
| 314_W | 383_E | 2.885 | 1.00 | |
| 382_S | 385_E | 2.86 | 1.00 | |
| 325_R | 394_A | 2.769 | 1.00 | |
| 59_E | 301_T | 2.756 | 1.00 | |
| 307_G | 311_R | 2.706 | 1.00 | |
| 59_E | 294_K | 2.559 | 1.00 | |
| 294_K | 297_E | 2.506 | 1.00 | |
| 310_Q | 383_E | 2.503 | 1.00 | |
| 211_E | 215_R | 2.415 | 1.00 | |
| 208_G | 211_E | 2.376 | 1.00 | |
| 318_R | 390_L | 2.346 | 1.00 | |
| 357_E | 360_K | 2.333 | 1.00 | |
| 44_F | 389_G | 2.303 | 1.00 | |
| 89_K | 300_N | 2.297 | 1.00 | |
| 26_V | 36_Q | 2.283 | 1.00 | |
| 59_E | 298_L | 2.261 | 1.00 | |
| 57_H | 298_L | 2.216 | 1.00 | |
| 313_D | 317_E | 2.211 | 1.00 | |
| 169_A | 175_S | 2.2 | 1.00 | |
| 361_A | 399_H | 2.148 | 1.00 | |
| 188_I | 221_I | 2.142 | 1.00 | |
| 32_R | 385_E | 2.139 | 1.00 | |
| 177_S | 215_R | 2.086 | 1.00 | |
| 363_V | 392_R | 2.04 | 1.00 | |
| 34_W | 40_E | 1.979 | 1.00 | |
| 357_E | 399_H | 1.977 | 1.00 | |
| 86_L | 292_A | 1.912 | 1.00 | |
| 81_E | 85_R | 1.902 | 1.00 | |
| 89_K | 293_G | 1.893 | 1.00 | |
| 316_V | 320_N | 1.887 | 1.00 | |
| 326_Y | 394_A | 1.877 | 1.00 | |
| 26_V | 70_K | 1.875 | 1.00 | |
| 388_T | 392_R | 1.873 | 1.00 | |
| 357_E | 361_A | 1.856 | 1.00 | |
| 88_K | 92_D | 1.855 | 1.00 | |
| 61_R | 65_N | 1.852 | 1.00 | |
| 64_L | 291_V | 1.85 | 1.00 | |
| 130_G | 183_S | 1.831 | 1.00 | |
| 318_R | 387_T | 1.829 | 1.00 | |
| 176_A | 209_L | 1.816 | 1.00 | |
| 98_R | 267_E | 1.808 | 1.00 | |
| 189_V | 209_L | 1.783 | 1.00 | |
| 35_D | 39_K | 1.776 | 1.00 | |
| 102_C | 261_G | 1.773 | 1.00 | |
| 318_R | 321_T | 1.772 | 1.00 | |
| 318_R | 391_D | 1.767 | 1.00 | |
| 29_E | 58_P | 1.743 | 1.00 | |
| 187_V | 213_C | 1.739 | 1.00 | |
| 267_E | 271_R | 1.722 | 1.00 | |
| 298_L | 302_P | 1.719 | 1.00 | |
| 134_F | 205_F | 1.711 | 1.00 | |
| 39_K | 362_G | 1.697 | 1.00 | |
| 64_L | 68_A | 1.684 | 1.00 | |
| 130_G | 166_R | 1.652 | 1.00 | |
| 87_A | 101_F | 1.6 | 1.00 | |
| 32_R | 388_T | 1.6 | 1.00 | |
| 40_E | 388_T | 1.594 | 1.00 | |
| 316_V | 334_G | 1.589 | 1.00 | |
| 109_N | 249_T | 1.586 | 1.00 | |
| 307_G | 310_Q | 1.575 | 1.00 | |
| 234_E | 309_K | 1.57 | 1.00 | |
| 204_A | 207_Q | 1.562 | 1.00 | |
| 89_K | 92_D | 1.559 | 1.00 | |
| 250_T | 262_A | 1.544 | 1.00 | |
| 306_N | 310_Q | 1.527 | 1.00 | |
| 174_N | 177_S | 1.522 | 1.00 | |
| 326_Y | 398_E | 1.52 | 1.00 | |
| 311_R | 386_V | 1.508 | 1.00 | |
| 85_R | 293_G | 1.479 | 1.00 | |
| 250_T | 264_L | 1.476 | 1.00 | |
| 255_G | 260_V | 1.469 | 1.00 | |
| 311_R | 314_W | 1.465 | 1.00 | |
| 62_E | 65_N | 1.458 | 1.00 | |
| 222_F | 238_Y | 1.457 | 1.00 | |
| 66_E | 70_K | 1.454 | 1.00 | |
| 112_A | 249_T | 1.452 | 1.00 | |
| 116_A | 221_I | 1.447 | 1.00 | |
| 177_S | 181_D | 1.443 | 1.00 | |
| 97_D | 267_E | 1.442 | 1.00 | |
| 25_P | 33_L | 1.434 | 1.00 | |
| 58_P | 62_E | 1.43 | 1.00 | |
| 180_I | 218_A | 1.423 | 1.00 | |
| 210_R | 220_L | 1.417 | 1.00 | |
| 357_E | 396_A | 1.414 | 1.00 | |
| 330_S | 344_N | 1.407 | 0.99 | |
| 210_R | 213_C | 1.402 | 0.99 | |
| 35_D | 41_Y | 1.393 | 0.99 | |
| 31_S | 385_E | 1.384 | 0.99 | |
| 63_A | 294_K | 1.383 | 0.99 | |
| 168_A | 179_L | 1.382 | 0.99 | |
| 254_L | 260_V | 1.38 | 0.99 | |
| 189_V | 206_L | 1.378 | 0.99 | |
| 234_E | 239_M | 1.372 | 0.99 | |
| 111_A | 263_L | 1.368 | 0.99 | |
| 27_R | 70_K | 1.365 | 0.99 | |
| 311_R | 383_E | 1.361 | 0.99 | |
| 57_H | 302_P | 1.359 | 0.99 | |
| 322_I | 390_L | 1.359 | 0.99 | |
| 294_K | 298_L | 1.354 | 0.99 | |
| 99_V | 264_L | 1.354 | 0.99 | |
| 85_R | 297_E | 1.352 | 0.99 | |
| 247_L | 265_A | 1.349 | 0.99 | |
| 56_A | 61_R | 1.348 | 0.99 | |
| 113_L | 131_I | 1.347 | 0.99 | |
| 132_V | 184_T | 1.346 | 0.99 | |
| 174_N | 178_A | 1.345 | 0.99 | |
| 361_A | 396_A | 1.335 | 0.99 | |
| 31_S | 380_N | 1.335 | 0.99 | |
| 93_A | 300_N | 1.331 | 0.99 | |
| 358_A | 365_V | 1.327 | 0.99 | |
| 135_K | 169_A | 1.327 | 0.99 | |
| 316_V | 339_I | 1.324 | 0.99 | |
| 381_V | 386_V | 1.318 | 0.99 | |
| 260_V | 289_S | 1.318 | 0.99 | |
| 91_I | 99_V | 1.317 | 0.99 | |
| 29_E | 56_A | 1.316 | 0.99 | |
| 94_T | 264_L | 1.311 | 0.99 | |
| 148_A | 165_I | 1.3 | 0.99 | |
| 171_N | 202_S | 1.296 | 0.99 | |
| 394_A | 398_E | 1.296 | 0.99 | |
| 383_E | 387_T | 1.293 | 0.99 | |
| 207_Q | 211_E | 1.287 | 0.99 | |
| 64_L | 287_L | 1.282 | 0.99 | |
| 187_V | 209_L | 1.28 | 0.99 | |
| 293_G | 297_E | 1.276 | 0.99 | |
| 204_A | 241_Y | 1.267 | 0.99 | |
| 169_A | 172_D | 1.267 | 0.99 | |
| 109_N | 188_I | 1.265 | 0.99 | |
| 133_A | 167_H | 1.259 | 0.99 | |
| 29_E | 40_E | 1.259 | 0.99 | |
| 177_S | 208_G | 1.254 | 0.99 | |
| 238_Y | 248_L | 1.249 | 0.99 | |
| 32_R | 42_I | 1.24 | 0.98 | |
| 53_L | 298_L | 1.236 | 0.98 | |
| 125_G | 269_C | 1.236 | 0.98 | |
| 314_W | 318_R | 1.232 | 0.98 | |
| 98_R | 271_R | 1.231 | 0.98 | |
| 241_Y | 335_L | 1.228 | 0.98 | |
| 235_L | 239_M | 1.223 | 0.98 | |
| 222_F | 243_V | 1.218 | 0.98 | |
| 317_E | 321_T | 1.213 | 0.98 | |
| 260_V | 292_A | 1.211 | 0.98 | |
| 244_T | 266_T | 1.206 | 0.98 | |
| 209_L | 220_L | 1.195 | 0.98 | |
| 66_E | 69_S | 1.195 | 0.98 | |
| 320_N | 323_N | 1.194 | 0.98 | |
| 219_L | 269_C | 1.193 | 0.98 | |
| 65_N | 68_A | 1.192 | 0.98 | |
| 128_K | 217_N | 1.19 | 0.98 | |
| 92_D | 300_N | 1.186 | 0.98 | |
| 318_R | 394_A | 1.171 | 0.98 | |
| 391_D | 395_A | 1.169 | 0.97 | |
| 385_E | 388_T | 1.167 | 0.97 | |
| 361_A | 392_R | 1.163 | 0.97 | |
| 297_E | 301_T | 1.156 | 0.97 | |
| 148_A | 188_I | 1.15 | 0.97 | |
| 61_R | 68_A | 1.143 | 0.97 | |
| 61_R | 69_S | 1.133 | 0.97 | |
| 26_V | 38_G | 1.124 | 0.97 | |
| 254_L | 262_A | 1.123 | 0.97 | |
| 240_H | 335_L | 1.117 | 0.96 | |
| 387_T | 391_D | 1.108 | 0.96 | |
| 131_I | 186_A | 1.106 | 0.96 | |
| 247_L | 263_L | 1.099 | 0.96 | |
| 230_G | 305_L | 1.097 | 0.96 | |
| 211_E | 214_N | 1.093 | 0.96 | |
| 207_Q | 242_G | 1.092 | 0.96 | |
| 299_I | 305_L | 1.091 | 0.96 | |
| 233_G | 239_M | 1.09 | 0.96 | |
| 180_I | 184_T | 1.087 | 0.96 | |
| 299_I | 304_M | 1.079 | 0.95 | |
| 305_L | 308_V | 1.07 | 0.95 | |
| 102_C | 263_L | 1.068 | 0.95 | |
| 358_A | 363_V | 1.067 | 0.95 | |
| 101_F | 289_S | 1.065 | 0.95 | |
| 358_A | 396_A | 1.064 | 0.95 | |
| 60_L | 291_V | 1.063 | 0.95 | |
| 322_I | 394_A | 1.06 | 0.95 | |
| 388_T | 391_D | 1.052 | 0.95 | |
| 175_S | 178_A | 1.046 | 0.94 | |
| 309_K | 313_D | 1.033 | 0.94 | |
| 358_A | 392_R | 1.031 | 0.94 | |
| 192_I | 335_L | 1.026 | 0.94 | |
| 86_L | 293_G | 1.025 | 0.93 | |
| 106_A | 145_T | 1.02 | 0.93 | |
| 108_A | 249_T | 1.013 | 0.93 | |
| 31_S | 42_I | 1.013 | 0.93 | |
| 363_V | 389_G | 1.011 | 0.93 | |
| 256_G | 295_V | 1.01 | 0.93 | |
| 236_Y | 250_T | 1.008 | 0.93 | |
| 177_S | 216_H | 1.007 | 0.93 | |
| 212_L | 216_H | 1.004 | 0.93 | |
| 229_V | 299_I | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9901 | 100 | 0.317 | Contact Map | 0.574 |
| 3tfuA | 2 | 0.9852 | 100 | 0.37 | Contact Map | 0.714 |
| 4e3qA | 4 | 0.9901 | 100 | 0.387 | Contact Map | 0.78 |
| 2epjA | 1 | 0.9631 | 100 | 0.39 | Contact Map | 0.706 |
| 4ffcA | 4 | 0.9803 | 100 | 0.393 | Contact Map | 0.652 |
| 4atqA | 12 | 0.9729 | 100 | 0.394 | Contact Map | 0.715 |
| 3nx3A | 2 | 0.9704 | 100 | 0.395 | Contact Map | 0.768 |
| 1z7dA | 6 | 0.9926 | 100 | 0.395 | Contact Map | 0.848 |
| 3hmuA | 2 | 0.9926 | 100 | 0.396 | Contact Map | 0.808 |
| 3oksA | 4 | 0.9704 | 100 | 0.396 | Contact Map | 0.731 |
Sequence Conservation (Image Generated using WebLogo v3)