| UniProt: | P18335 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10066 | ||
| Length: | 406 (391) | ||
| Sequences: | 9680 | ||
| Seq/Len: | 24.76 |
| ARGD
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 68_K | 72_E | 4.574 | 1.00 | |
| 364_A | 398_H | 4.217 | 1.00 | |
| 213_R | 217_D | 4.209 | 1.00 | |
| 35_R | 43_E | 3.805 | 1.00 | |
| 317_R | 390_D | 3.629 | 1.00 | |
| 176_L | 211_G | 3.504 | 1.00 | |
| 306_E | 309_E | 3.299 | 1.00 | |
| 92_K | 300_D | 3.264 | 1.00 | |
| 30_K | 37_W | 3.187 | 1.00 | |
| 237_D | 243_H | 2.987 | 1.00 | |
| 65_N | 69_T | 2.978 | 1.00 | |
| 317_R | 386_D | 2.898 | 1.00 | |
| 385_E | 388_D | 2.846 | 1.00 | |
| 62_A | 304_T | 2.781 | 1.00 | |
| 310_G | 314_K | 2.704 | 1.00 | |
| 328_Q | 397_A | 2.7 | 1.00 | |
| 62_A | 297_A | 2.571 | 1.00 | |
| 297_A | 300_D | 2.495 | 1.00 | |
| 313_A | 386_D | 2.482 | 1.00 | |
| 211_G | 214_E | 2.372 | 1.00 | |
| 214_E | 218_Q | 2.366 | 1.00 | |
| 321_H | 393_M | 2.334 | 1.00 | |
| 29_V | 39_Q | 2.303 | 1.00 | |
| 47_F | 392_G | 2.294 | 1.00 | |
| 92_K | 303_N | 2.273 | 1.00 | |
| 62_A | 301_I | 2.249 | 1.00 | |
| 360_A | 363_E | 2.241 | 1.00 | |
| 60_H | 301_I | 2.225 | 1.00 | |
| 172_P | 178_A | 2.212 | 1.00 | |
| 364_A | 402_K | 2.196 | 1.00 | |
| 316_Q | 320_D | 2.193 | 1.00 | |
| 191_V | 224_V | 2.145 | 1.00 | |
| 35_R | 388_D | 2.113 | 1.00 | |
| 180_K | 218_Q | 2.106 | 1.00 | |
| 366_V | 395_R | 2.03 | 1.00 | |
| 37_W | 43_E | 1.953 | 1.00 | |
| 360_A | 402_K | 1.947 | 1.00 | |
| 84_E | 88_R | 1.907 | 1.00 | |
| 319_V | 323_Q | 1.891 | 1.00 | |
| 329_Y | 397_A | 1.882 | 1.00 | |
| 179_V | 212_L | 1.874 | 1.00 | |
| 133_K | 186_H | 1.87 | 1.00 | |
| 92_K | 296_G | 1.87 | 1.00 | |
| 29_V | 73_T | 1.864 | 1.00 | |
| 360_A | 364_A | 1.863 | 1.00 | |
| 89_L | 295_A | 1.861 | 1.00 | |
| 67_L | 294_V | 1.859 | 1.00 | |
| 64_V | 68_K | 1.853 | 1.00 | |
| 391_E | 395_R | 1.847 | 1.00 | |
| 91_R | 95_E | 1.841 | 1.00 | |
| 101_R | 270_A | 1.825 | 1.00 | |
| 321_H | 390_D | 1.821 | 1.00 | |
| 192_V | 212_L | 1.817 | 1.00 | |
| 105_M | 264_S | 1.806 | 1.00 | |
| 38_D | 42_K | 1.768 | 1.00 | |
| 137_F | 208_F | 1.764 | 1.00 | |
| 321_H | 324_K | 1.759 | 1.00 | |
| 321_H | 394_Q | 1.744 | 1.00 | |
| 270_A | 274_S | 1.726 | 1.00 | |
| 301_I | 305_P | 1.723 | 1.00 | |
| 32_Q | 61_P | 1.72 | 1.00 | |
| 190_V | 216_C | 1.716 | 1.00 | |
| 42_K | 365_G | 1.695 | 1.00 | |
| 67_L | 71_G | 1.68 | 1.00 | |
| 90_G | 104_F | 1.648 | 1.00 | |
| 43_E | 391_E | 1.592 | 1.00 | |
| 237_D | 312_Q | 1.59 | 1.00 | |
| 133_K | 169_I | 1.587 | 1.00 | |
| 35_R | 391_E | 1.579 | 1.00 | |
| 207_E | 210_Q | 1.574 | 1.00 | |
| 310_G | 313_A | 1.564 | 1.00 | |
| 112_N | 252_T | 1.564 | 1.00 | |
| 319_V | 337_G | 1.562 | 1.00 | |
| 253_S | 265_A | 1.558 | 1.00 | |
| 92_K | 95_E | 1.555 | 1.00 | |
| 314_K | 389_I | 1.531 | 1.00 | |
| 177_H | 180_K | 1.501 | 1.00 | |
| 309_E | 313_A | 1.494 | 1.00 | |
| 258_G | 263_I | 1.48 | 1.00 | |
| 253_S | 267_L | 1.467 | 1.00 | |
| 100_E | 270_A | 1.458 | 1.00 | |
| 65_N | 68_K | 1.454 | 1.00 | |
| 314_K | 317_R | 1.452 | 1.00 | |
| 180_K | 184_D | 1.451 | 1.00 | |
| 183_M | 221_A | 1.448 | 1.00 | |
| 88_R | 296_G | 1.447 | 1.00 | |
| 69_T | 73_T | 1.447 | 1.00 | |
| 28_P | 36_I | 1.444 | 1.00 | |
| 225_F | 241_Y | 1.442 | 1.00 | |
| 119_A | 224_V | 1.428 | 1.00 | |
| 329_Y | 401_A | 1.425 | 1.00 | |
| 360_A | 399_A | 1.425 | 1.00 | |
| 115_A | 252_T | 1.422 | 1.00 | |
| 213_R | 223_L | 1.416 | 1.00 | |
| 171_V | 182_V | 1.414 | 1.00 | |
| 38_D | 44_Y | 1.407 | 0.99 | |
| 61_P | 65_N | 1.406 | 0.99 | |
| 174_N | 205_T | 1.403 | 0.99 | |
| 257_L | 263_I | 1.4 | 0.99 | |
| 213_R | 216_C | 1.4 | 0.99 | |
| 30_K | 73_T | 1.379 | 0.99 | |
| 237_D | 242_M | 1.375 | 0.99 | |
| 151_V | 168_I | 1.37 | 0.99 | |
| 66_A | 297_A | 1.368 | 0.99 | |
| 297_A | 301_I | 1.366 | 0.99 | |
| 34_S | 388_D | 1.363 | 0.99 | |
| 192_V | 209_L | 1.36 | 0.99 | |
| 114_T | 266_M | 1.357 | 0.99 | |
| 333_S | 347_K | 1.357 | 0.99 | |
| 122_Y | 272_I | 1.356 | 0.99 | |
| 361_G | 368_V | 1.349 | 0.99 | |
| 177_H | 181_A | 1.345 | 0.99 | |
| 314_K | 386_D | 1.343 | 0.99 | |
| 60_H | 305_P | 1.343 | 0.99 | |
| 59_C | 64_V | 1.34 | 0.99 | |
| 102_V | 267_L | 1.34 | 0.99 | |
| 250_I | 268_T | 1.339 | 0.99 | |
| 94_I | 102_V | 1.335 | 0.99 | |
| 88_R | 300_D | 1.33 | 0.99 | |
| 263_I | 292_C | 1.33 | 0.99 | |
| 116_F | 134_I | 1.328 | 0.99 | |
| 138_H | 172_P | 1.325 | 0.99 | |
| 67_L | 290_L | 1.324 | 0.99 | |
| 384_V | 389_I | 1.318 | 0.99 | |
| 34_S | 383_V | 1.314 | 0.99 | |
| 364_A | 399_A | 1.31 | 0.99 | |
| 319_V | 342_I | 1.31 | 0.99 | |
| 32_Q | 59_C | 1.307 | 0.99 | |
| 325_I | 393_M | 1.306 | 0.99 | |
| 96_A | 303_N | 1.297 | 0.99 | |
| 136_A | 170_H | 1.295 | 0.99 | |
| 210_Q | 214_E | 1.292 | 0.99 | |
| 190_V | 212_L | 1.292 | 0.99 | |
| 135_I | 187_T | 1.291 | 0.99 | |
| 386_D | 390_D | 1.288 | 0.99 | |
| 32_Q | 43_E | 1.286 | 0.99 | |
| 207_E | 244_Y | 1.286 | 0.99 | |
| 225_F | 246_V | 1.28 | 0.99 | |
| 296_G | 300_D | 1.268 | 0.99 | |
| 317_R | 321_H | 1.258 | 0.99 | |
| 112_N | 191_V | 1.256 | 0.99 | |
| 241_Y | 251_L | 1.253 | 0.99 | |
| 97_T | 267_L | 1.243 | 0.98 | |
| 35_R | 45_V | 1.242 | 0.98 | |
| 172_P | 175_D | 1.241 | 0.98 | |
| 180_K | 211_G | 1.231 | 0.98 | |
| 244_Y | 338_M | 1.221 | 0.98 | |
| 323_Q | 326_D | 1.214 | 0.98 | |
| 263_I | 295_A | 1.213 | 0.98 | |
| 68_K | 71_G | 1.209 | 0.98 | |
| 131_K | 220_Q | 1.209 | 0.98 | |
| 397_A | 401_A | 1.209 | 0.98 | |
| 56_L | 301_I | 1.207 | 0.98 | |
| 238_L | 242_M | 1.201 | 0.98 | |
| 222_L | 272_I | 1.194 | 0.98 | |
| 212_L | 223_L | 1.194 | 0.98 | |
| 320_D | 324_K | 1.187 | 0.98 | |
| 101_R | 274_S | 1.186 | 0.98 | |
| 95_E | 303_N | 1.186 | 0.98 | |
| 247_T | 269_T | 1.18 | 0.98 | |
| 151_V | 191_V | 1.177 | 0.98 | |
| 394_Q | 398_H | 1.175 | 0.98 | |
| 69_T | 72_E | 1.175 | 0.98 | |
| 321_H | 397_A | 1.174 | 0.98 | |
| 257_L | 265_A | 1.162 | 0.97 | |
| 300_D | 304_T | 1.148 | 0.97 | |
| 388_D | 391_E | 1.147 | 0.97 | |
| 364_A | 395_R | 1.143 | 0.97 | |
| 64_V | 72_E | 1.137 | 0.97 | |
| 64_V | 71_G | 1.137 | 0.97 | |
| 29_V | 41_G | 1.127 | 0.97 | |
| 214_E | 217_D | 1.122 | 0.97 | |
| 390_D | 394_Q | 1.104 | 0.96 | |
| 302_I | 308_L | 1.101 | 0.96 | |
| 134_I | 189_A | 1.094 | 0.96 | |
| 243_H | 338_M | 1.093 | 0.96 | |
| 302_I | 307_V | 1.093 | 0.96 | |
| 233_G | 308_L | 1.086 | 0.96 | |
| 308_L | 311_I | 1.084 | 0.96 | |
| 361_G | 366_V | 1.084 | 0.96 | |
| 250_I | 266_M | 1.079 | 0.95 | |
| 361_G | 399_A | 1.079 | 0.95 | |
| 236_G | 242_M | 1.075 | 0.95 | |
| 63_L | 294_V | 1.073 | 0.95 | |
| 105_M | 266_M | 1.07 | 0.95 | |
| 104_F | 292_C | 1.07 | 0.95 | |
| 210_Q | 245_G | 1.067 | 0.95 | |
| 89_L | 296_G | 1.049 | 0.94 | |
| 183_M | 187_T | 1.049 | 0.94 | |
| 195_I | 338_M | 1.047 | 0.94 | |
| 361_G | 395_R | 1.04 | 0.94 | |
| 150_S | 165_P | 1.039 | 0.94 | |
| 259_G | 298_A | 1.036 | 0.94 | |
| 391_E | 394_Q | 1.035 | 0.94 | |
| 109_T | 148_T | 1.03 | 0.94 | |
| 325_I | 397_A | 1.027 | 0.94 | |
| 180_K | 219_H | 1.023 | 0.93 | |
| 215_L | 219_H | 1.021 | 0.93 | |
| 366_V | 392_G | 1.019 | 0.93 | |
| 387_A | 390_D | 1.019 | 0.93 | |
| 309_E | 312_Q | 1.016 | 0.93 | |
| 239_F | 253_S | 1.014 | 0.93 | |
| 34_S | 45_V | 1.012 | 0.93 | |
| 312_Q | 316_Q | 1.008 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9975 | 100 | 0.324 | Contact Map | 0.572 |
| 3tfuA | 2 | 0.9901 | 100 | 0.366 | Contact Map | 0.716 |
| 2epjA | 1 | 0.9729 | 100 | 0.388 | Contact Map | 0.706 |
| 4e3qA | 4 | 0.9901 | 100 | 0.39 | Contact Map | 0.785 |
| 3nx3A | 2 | 0.968 | 100 | 0.394 | Contact Map | 0.769 |
| 4ffcA | 4 | 0.9852 | 100 | 0.396 | Contact Map | 0.653 |
| 1z7dA | 6 | 0.9975 | 100 | 0.396 | Contact Map | 0.85 |
| 4atqA | 12 | 0.9803 | 100 | 0.398 | Contact Map | 0.715 |
| 3hmuA | 2 | 0.9926 | 100 | 0.399 | Contact Map | 0.81 |
| 3oksA | 4 | 0.9778 | 100 | 0.399 | Contact Map | 0.733 |
Sequence Conservation (Image Generated using WebLogo v3)