| UniProt: | P42588 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12718 | ||
| Length: | 459 (408) | ||
| Sequences: | 9541 | ||
| Seq/Len: | 23.38 |
| PAT
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 108_Q | 112_A | 4.785 | 1.00 | |
| 411_Q | 447_K | 4.439 | 1.00 | |
| 258_R | 262_D | 4.365 | 1.00 | |
| 75_T | 83_E | 3.934 | 1.00 | |
| 365_M | 439_E | 3.797 | 1.00 | |
| 354_N | 357_A | 3.495 | 1.00 | |
| 132_T | 348_N | 3.411 | 1.00 | |
| 69_Q | 77_V | 3.357 | 1.00 | |
| 215_I | 256_A | 3.299 | 1.00 | |
| 105_S | 109_N | 3.118 | 1.00 | |
| 282_K | 288_H | 3.078 | 1.00 | |
| 365_M | 435_I | 2.982 | 1.00 | |
| 102_V | 352_E | 2.922 | 1.00 | |
| 376_E | 446_R | 2.919 | 1.00 | |
| 434_T | 437_Q | 2.9 | 1.00 | |
| 358_Q | 362_K | 2.795 | 1.00 | |
| 102_V | 345_A | 2.614 | 1.00 | |
| 361_Q | 435_I | 2.609 | 1.00 | |
| 345_A | 348_N | 2.555 | 1.00 | |
| 256_A | 259_K | 2.482 | 1.00 | |
| 369_G | 442_I | 2.448 | 1.00 | |
| 259_K | 263_E | 2.426 | 1.00 | |
| 132_T | 351_L | 2.403 | 1.00 | |
| 87_C | 441_V | 2.362 | 1.00 | |
| 407_E | 410_R | 2.342 | 1.00 | |
| 102_V | 349_V | 2.325 | 1.00 | |
| 411_Q | 451_A | 2.282 | 1.00 | |
| 100_N | 349_V | 2.274 | 1.00 | |
| 364_D | 368_D | 2.258 | 1.00 | |
| 75_T | 437_Q | 2.229 | 1.00 | |
| 236_I | 269_I | 2.223 | 1.00 | |
| 413_V | 444_A | 2.089 | 1.00 | |
| 407_E | 451_A | 2.035 | 1.00 | |
| 77_V | 83_E | 2.017 | 1.00 | |
| 219_R | 263_E | 1.994 | 1.00 | |
| 377_Y | 446_R | 1.989 | 1.00 | |
| 124_P | 128_M | 1.982 | 1.00 | |
| 367_L | 371_R | 1.951 | 1.00 | |
| 369_G | 439_E | 1.947 | 1.00 | |
| 440_L | 444_A | 1.938 | 1.00 | |
| 407_E | 411_Q | 1.925 | 1.00 | |
| 131_K | 135_A | 1.919 | 1.00 | |
| 143_Y | 316_E | 1.91 | 1.00 | |
| 132_T | 344_L | 1.906 | 1.00 | |
| 107_V | 342_A | 1.906 | 1.00 | |
| 129_L | 343_A | 1.905 | 1.00 | |
| 104_V | 108_Q | 1.893 | 1.00 | |
| 369_G | 443_K | 1.893 | 1.00 | |
| 237_L | 257_V | 1.89 | 1.00 | |
| 71_G | 101_P | 1.845 | 1.00 | |
| 369_G | 372_Q | 1.839 | 1.00 | |
| 82_Q | 412_R | 1.834 | 1.00 | |
| 211_P | 217_A | 1.827 | 1.00 | |
| 78_D | 82_Q | 1.825 | 1.00 | |
| 147_C | 310_G | 1.817 | 1.00 | |
| 176_T | 253_Y | 1.808 | 1.00 | |
| 349_V | 353_Q | 1.803 | 1.00 | |
| 235_V | 261_C | 1.789 | 1.00 | |
| 107_V | 111_L | 1.747 | 1.00 | |
| 130_A | 146_F | 1.72 | 1.00 | |
| 218_M | 257_V | 1.685 | 1.00 | |
| 75_T | 440_L | 1.678 | 1.00 | |
| 298_L | 311_A | 1.676 | 1.00 | |
| 83_E | 440_L | 1.676 | 1.00 | |
| 316_E | 320_S | 1.668 | 1.00 | |
| 142_K | 316_E | 1.665 | 1.00 | |
| 164_Y | 318_V | 1.637 | 1.00 | |
| 252_G | 255_T | 1.636 | 1.00 | |
| 219_R | 223_N | 1.635 | 1.00 | |
| 154_V | 297_C | 1.635 | 1.00 | |
| 377_Y | 450_A | 1.633 | 1.00 | |
| 282_K | 360_E | 1.627 | 1.00 | |
| 367_L | 386_G | 1.62 | 1.00 | |
| 362_K | 438_C | 1.608 | 1.00 | |
| 358_Q | 361_Q | 1.576 | 1.00 | |
| 128_M | 344_L | 1.564 | 1.00 | |
| 132_T | 135_A | 1.558 | 1.00 | |
| 109_N | 113_K | 1.534 | 1.00 | |
| 357_A | 361_Q | 1.531 | 1.00 | |
| 362_K | 365_M | 1.531 | 1.00 | |
| 105_S | 108_Q | 1.527 | 1.00 | |
| 157_A | 297_C | 1.513 | 1.00 | |
| 303_G | 309_I | 1.506 | 1.00 | |
| 298_L | 313_I | 1.499 | 1.00 | |
| 270_L | 286_C | 1.493 | 1.00 | |
| 216_E | 219_R | 1.492 | 1.00 | |
| 161_A | 269_I | 1.476 | 1.00 | |
| 101_P | 105_S | 1.469 | 1.00 | |
| 407_E | 448_A | 1.468 | 1.00 | |
| 219_R | 256_A | 1.46 | 1.00 | |
| 302_L | 309_I | 1.454 | 1.00 | |
| 69_Q | 113_K | 1.451 | 1.00 | |
| 78_D | 84_F | 1.442 | 1.00 | |
| 282_K | 287_E | 1.438 | 1.00 | |
| 362_K | 435_I | 1.43 | 1.00 | |
| 408_M | 415_V | 1.423 | 1.00 | |
| 106_A | 345_A | 1.423 | 1.00 | |
| 137_T | 313_I | 1.42 | 1.00 | |
| 345_A | 349_V | 1.418 | 1.00 | |
| 213_G | 250_P | 1.417 | 1.00 | |
| 258_R | 268_M | 1.413 | 1.00 | |
| 258_R | 261_C | 1.409 | 1.00 | |
| 74_N | 437_Q | 1.409 | 1.00 | |
| 373_L | 442_I | 1.404 | 0.99 | |
| 156_A | 312_T | 1.401 | 0.99 | |
| 237_L | 254_L | 1.398 | 0.99 | |
| 211_P | 214_N | 1.392 | 0.99 | |
| 382_Q | 396_V | 1.392 | 0.99 | |
| 174_I | 232_V | 1.391 | 0.99 | |
| 177_S | 211_P | 1.387 | 0.99 | |
| 100_N | 353_Q | 1.386 | 0.99 | |
| 433_L | 438_C | 1.385 | 0.99 | |
| 74_N | 432_T | 1.378 | 0.99 | |
| 295_I | 314_A | 1.373 | 0.99 | |
| 446_R | 450_A | 1.37 | 0.99 | |
| 367_L | 391_M | 1.368 | 0.99 | |
| 158_L | 173_F | 1.367 | 0.99 | |
| 136_L | 351_L | 1.366 | 0.99 | |
| 235_V | 257_V | 1.364 | 0.99 | |
| 252_G | 289_E | 1.364 | 0.99 | |
| 270_L | 291_V | 1.363 | 0.99 | |
| 144_S | 313_I | 1.361 | 0.99 | |
| 411_Q | 448_A | 1.354 | 0.99 | |
| 99_R | 104_V | 1.353 | 0.99 | |
| 134_A | 144_S | 1.351 | 0.99 | |
| 128_M | 348_N | 1.346 | 0.99 | |
| 71_G | 99_R | 1.336 | 0.99 | |
| 309_I | 340_C | 1.334 | 0.99 | |
| 107_V | 338_L | 1.33 | 0.99 | |
| 71_G | 83_E | 1.325 | 0.99 | |
| 435_I | 439_E | 1.324 | 0.99 | |
| 255_T | 259_K | 1.319 | 0.99 | |
| 257_V | 268_M | 1.312 | 0.99 | |
| 75_T | 85_I | 1.308 | 0.99 | |
| 154_V | 236_I | 1.304 | 0.99 | |
| 365_M | 369_G | 1.299 | 0.99 | |
| 344_L | 348_N | 1.296 | 0.99 | |
| 143_Y | 320_S | 1.288 | 0.99 | |
| 108_Q | 111_L | 1.278 | 0.99 | |
| 289_E | 387_K | 1.277 | 0.99 | |
| 190_A | 207_F | 1.272 | 0.99 | |
| 135_A | 351_L | 1.271 | 0.99 | |
| 109_N | 112_A | 1.271 | 0.99 | |
| 371_R | 374_A | 1.27 | 0.99 | |
| 369_G | 446_R | 1.267 | 0.99 | |
| 267_L | 318_V | 1.265 | 0.99 | |
| 96_V | 349_V | 1.264 | 0.99 | |
| 348_N | 352_E | 1.262 | 0.99 | |
| 292_Q | 315_T | 1.259 | 0.99 | |
| 286_C | 296_L | 1.25 | 0.99 | |
| 222_L | 266_A | 1.246 | 0.98 | |
| 283_M | 287_E | 1.242 | 0.98 | |
| 190_A | 236_I | 1.237 | 0.98 | |
| 309_I | 343_A | 1.237 | 0.98 | |
| 210_V | 221_A | 1.234 | 0.98 | |
| 169_G | 231_D | 1.219 | 0.98 | |
| 175_A | 209_H | 1.218 | 0.98 | |
| 443_K | 447_K | 1.208 | 0.98 | |
| 164_Y | 321_V | 1.188 | 0.98 | |
| 302_L | 311_A | 1.186 | 0.98 | |
| 259_K | 262_D | 1.185 | 0.98 | |
| 437_Q | 440_L | 1.18 | 0.98 | |
| 368_D | 372_Q | 1.177 | 0.98 | |
| 411_Q | 444_A | 1.176 | 0.98 | |
| 307_M | 339_A | 1.167 | 0.97 | |
| 278_G | 356_P | 1.167 | 0.97 | |
| 167_P | 170_K | 1.167 | 0.97 | |
| 288_H | 387_K | 1.156 | 0.97 | |
| 173_F | 234_A | 1.147 | 0.97 | |
| 104_V | 112_A | 1.146 | 0.97 | |
| 104_V | 111_L | 1.142 | 0.97 | |
| 151_T | 187_A | 1.14 | 0.97 | |
| 350_L | 356_P | 1.139 | 0.97 | |
| 295_I | 312_T | 1.131 | 0.97 | |
| 408_M | 413_V | 1.123 | 0.97 | |
| 439_E | 443_K | 1.111 | 0.96 | |
| 240_I | 387_K | 1.11 | 0.96 | |
| 147_C | 312_T | 1.105 | 0.96 | |
| 255_T | 290_N | 1.103 | 0.96 | |
| 350_L | 355_L | 1.103 | 0.96 | |
| 103_V | 342_A | 1.101 | 0.96 | |
| 170_K | 265_G | 1.1 | 0.96 | |
| 440_L | 443_K | 1.1 | 0.96 | |
| 146_F | 340_C | 1.099 | 0.96 | |
| 172_T | 231_D | 1.098 | 0.96 | |
| 74_N | 85_I | 1.089 | 0.96 | |
| 356_P | 359_A | 1.087 | 0.96 | |
| 373_L | 446_R | 1.082 | 0.96 | |
| 360_E | 364_D | 1.074 | 0.95 | |
| 408_M | 448_A | 1.067 | 0.95 | |
| 281_G | 287_E | 1.067 | 0.95 | |
| 153_S | 297_C | 1.052 | 0.95 | |
| 158_L | 190_A | 1.048 | 0.94 | |
| 413_V | 441_V | 1.044 | 0.94 | |
| 136_L | 283_M | 1.039 | 0.94 | |
| 408_M | 444_A | 1.036 | 0.94 | |
| 189_S | 204_L | 1.032 | 0.94 | |
| 216_E | 220_T | 1.031 | 0.94 | |
| 304_G | 346_T | 1.029 | 0.94 | |
| 96_V | 346_T | 1.028 | 0.94 | |
| 371_R | 375_R | 1.023 | 0.93 | |
| 260_L | 264_F | 1.023 | 0.93 | |
| 403_N | 407_E | 1.018 | 0.93 | |
| 167_P | 265_G | 1.012 | 0.93 | |
| 254_L | 289_E | 1.01 | 0.93 | |
| 129_L | 344_L | 1.009 | 0.93 | |
| 277_M | 350_L | 1.006 | 0.93 | |
| 284_F | 298_L | 1.006 | 0.93 | |
| 219_R | 264_F | 1.002 | 0.92 | |
| 71_G | 77_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9739 | 100 | 0.395 | Contact Map | 0.577 |
| 3tfuA | 2 | 0.9434 | 100 | 0.449 | Contact Map | 0.72 |
| 2epjA | 1 | 0.8998 | 100 | 0.454 | Contact Map | 0.703 |
| 3hmuA | 2 | 0.9216 | 100 | 0.47 | Contact Map | 0.816 |
| 4e3qA | 4 | 0.9325 | 100 | 0.471 | Contact Map | 0.781 |
| 4ffcA | 4 | 0.9259 | 100 | 0.471 | Contact Map | 0.66 |
| 4atqA | 12 | 0.915 | 100 | 0.474 | Contact Map | 0.722 |
| 3oksA | 4 | 0.9129 | 100 | 0.475 | Contact Map | 0.739 |
| 4ao9A | 2 | 0.9259 | 100 | 0.475 | Contact Map | 0.626 |
| 2ykyA | 3 | 0.9216 | 100 | 0.476 | Contact Map | 0.642 |
Sequence Conservation (Image Generated using WebLogo v3)