| UniProt: | P22256 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10361 | ||
| Length: | 426 (419) | ||
| Sequences: | 9719 | ||
| Seq/Len: | 23.20 |
| GABT
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 67_E | 71_K | 4.678 | 1.00 | |
| 383_K | 419_Q | 4.39 | 1.00 | |
| 226_R | 230_D | 4.295 | 1.00 | |
| 34_R | 42_E | 3.909 | 1.00 | |
| 184_I | 224_R | 3.764 | 1.00 | |
| 330_K | 411_R | 3.746 | 1.00 | |
| 319_N | 322_Q | 3.436 | 1.00 | |
| 92_I | 313_K | 3.381 | 1.00 | |
| 29_R | 36_W | 3.247 | 1.00 | |
| 64_A | 68_A | 3.1 | 1.00 | |
| 250_T | 256_Q | 3.068 | 1.00 | |
| 330_K | 407_D | 2.967 | 1.00 | |
| 61_K | 317_Q | 2.909 | 1.00 | |
| 406_E | 409_Q | 2.869 | 1.00 | |
| 341_K | 418_S | 2.861 | 1.00 | |
| 323_K | 327_L | 2.742 | 1.00 | |
| 61_K | 310_E | 2.664 | 1.00 | |
| 326_D | 407_D | 2.587 | 1.00 | |
| 310_E | 313_K | 2.536 | 1.00 | |
| 227_A | 231_E | 2.459 | 1.00 | |
| 334_G | 414_L | 2.45 | 1.00 | |
| 92_I | 316_E | 2.437 | 1.00 | |
| 170_L | 186_S | 2.43 | 1.00 | |
| 224_R | 227_A | 2.41 | 1.00 | |
| 379_R | 382_D | 2.378 | 1.00 | |
| 188_H | 231_E | 2.349 | 1.00 | |
| 46_F | 413_G | 2.341 | 1.00 | |
| 28_D | 38_V | 2.322 | 1.00 | |
| 61_K | 314_V | 2.29 | 1.00 | |
| 59_H | 314_V | 2.288 | 1.00 | |
| 329_Q | 333_D | 2.214 | 1.00 | |
| 10_R | 91_E | 2.199 | 1.00 | |
| 383_K | 423_E | 2.171 | 1.00 | |
| 204_V | 237_I | 2.165 | 1.00 | |
| 34_R | 409_Q | 2.152 | 1.00 | |
| 385_L | 416_I | 2.143 | 1.00 | |
| 379_R | 423_E | 2 | 1.00 | |
| 36_W | 42_E | 1.999 | 1.00 | |
| 342_H | 418_S | 1.977 | 1.00 | |
| 84_E | 88_E | 1.937 | 1.00 | |
| 412_Q | 416_I | 1.934 | 1.00 | |
| 92_I | 309_L | 1.914 | 1.00 | |
| 28_D | 72_K | 1.914 | 1.00 | |
| 332_K | 336_L | 1.911 | 1.00 | |
| 379_R | 383_K | 1.909 | 1.00 | |
| 66_V | 307_A | 1.905 | 1.00 | |
| 334_G | 411_R | 1.9 | 1.00 | |
| 187_I | 225_L | 1.867 | 1.00 | |
| 334_G | 337_A | 1.867 | 1.00 | |
| 89_L | 308_A | 1.861 | 1.00 | |
| 63_V | 67_E | 1.861 | 1.00 | |
| 104_K | 283_A | 1.86 | 1.00 | |
| 91_E | 95_Q | 1.845 | 1.00 | |
| 334_G | 415_E | 1.84 | 1.00 | |
| 205_I | 225_L | 1.835 | 1.00 | |
| 130_G | 199_D | 1.813 | 1.00 | |
| 203_I | 229_C | 1.811 | 1.00 | |
| 108_V | 277_A | 1.81 | 1.00 | |
| 41_R | 384_G | 1.792 | 1.00 | |
| 134_F | 221_F | 1.783 | 1.00 | |
| 31_E | 60_P | 1.779 | 1.00 | |
| 37_D | 41_R | 1.77 | 1.00 | |
| 314_V | 318_E | 1.749 | 1.00 | |
| 283_A | 287_D | 1.736 | 1.00 | |
| 66_V | 70_L | 1.698 | 1.00 | |
| 169_A | 190_I | 1.659 | 1.00 | |
| 115_V | 265_T | 1.645 | 1.00 | |
| 42_E | 412_Q | 1.641 | 1.00 | |
| 34_R | 412_Q | 1.637 | 1.00 | |
| 90_C | 107_L | 1.636 | 1.00 | |
| 220_A | 223_Q | 1.634 | 1.00 | |
| 342_H | 422_D | 1.627 | 1.00 | |
| 103_K | 283_A | 1.621 | 1.00 | |
| 266_F | 278_G | 1.61 | 1.00 | |
| 323_K | 326_D | 1.607 | 1.00 | |
| 332_K | 350_G | 1.587 | 1.00 | |
| 250_T | 325_N | 1.572 | 1.00 | |
| 92_I | 95_Q | 1.541 | 1.00 | |
| 327_L | 410_I | 1.538 | 1.00 | |
| 130_G | 167_Y | 1.535 | 1.00 | |
| 68_A | 72_K | 1.523 | 1.00 | |
| 185_A | 188_H | 1.514 | 1.00 | |
| 88_E | 309_L | 1.501 | 1.00 | |
| 266_F | 280_T | 1.499 | 1.00 | |
| 64_A | 67_E | 1.497 | 1.00 | |
| 322_Q | 326_D | 1.494 | 1.00 | |
| 118_A | 265_T | 1.488 | 1.00 | |
| 327_L | 330_K | 1.487 | 1.00 | |
| 271_A | 276_L | 1.487 | 1.00 | |
| 250_T | 255_E | 1.48 | 1.00 | |
| 122_A | 237_I | 1.469 | 1.00 | |
| 135_S | 170_L | 1.463 | 1.00 | |
| 226_R | 236_L | 1.456 | 1.00 | |
| 188_H | 192_K | 1.456 | 1.00 | |
| 27_A | 35_V | 1.453 | 1.00 | |
| 310_E | 314_V | 1.449 | 1.00 | |
| 238_A | 254_M | 1.445 | 1.00 | |
| 125_A | 285_V | 1.443 | 1.00 | |
| 379_R | 420_C | 1.439 | 1.00 | |
| 97_V | 280_T | 1.43 | 1.00 | |
| 60_P | 64_A | 1.429 | 1.00 | |
| 226_R | 229_C | 1.425 | 1.00 | |
| 33_C | 409_Q | 1.419 | 1.00 | |
| 65_A | 310_E | 1.417 | 1.00 | |
| 37_D | 43_Y | 1.414 | 1.00 | |
| 270_I | 276_L | 1.41 | 1.00 | |
| 170_L | 183_A | 1.402 | 0.99 | |
| 380_A | 387_L | 1.395 | 0.99 | |
| 29_R | 72_K | 1.392 | 0.99 | |
| 191_F | 234_I | 1.389 | 0.99 | |
| 59_H | 318_E | 1.387 | 0.99 | |
| 33_C | 404_T | 1.377 | 0.99 | |
| 88_E | 313_K | 1.375 | 0.99 | |
| 327_L | 407_D | 1.374 | 0.99 | |
| 185_A | 189_R | 1.368 | 0.99 | |
| 383_K | 420_C | 1.368 | 0.99 | |
| 338_I | 414_L | 1.367 | 0.99 | |
| 223_Q | 227_A | 1.359 | 0.99 | |
| 332_K | 355_I | 1.357 | 0.99 | |
| 205_I | 222_M | 1.355 | 0.99 | |
| 58_L | 63_V | 1.351 | 0.99 | |
| 117_N | 279_V | 1.347 | 0.99 | |
| 263_L | 281_G | 1.343 | 0.99 | |
| 203_I | 225_L | 1.341 | 0.99 | |
| 105_T | 280_T | 1.341 | 0.99 | |
| 119_V | 131_T | 1.337 | 0.99 | |
| 148_L | 166_V | 1.336 | 0.99 | |
| 276_L | 305_C | 1.324 | 0.99 | |
| 96_K | 316_E | 1.324 | 0.99 | |
| 405_I | 410_I | 1.322 | 0.99 | |
| 220_A | 257_M | 1.32 | 0.99 | |
| 66_V | 303_I | 1.318 | 0.99 | |
| 407_D | 411_R | 1.317 | 0.99 | |
| 418_S | 422_D | 1.316 | 0.99 | |
| 31_E | 42_E | 1.316 | 0.99 | |
| 330_K | 334_G | 1.313 | 0.99 | |
| 94_N | 105_T | 1.312 | 0.99 | |
| 31_E | 58_L | 1.31 | 0.99 | |
| 238_A | 259_V | 1.307 | 0.99 | |
| 132_I | 200_I | 1.3 | 0.99 | |
| 34_R | 44_L | 1.295 | 0.99 | |
| 309_L | 313_K | 1.291 | 0.99 | |
| 188_H | 224_R | 1.285 | 0.99 | |
| 128_R | 233_G | 1.28 | 0.99 | |
| 115_V | 204_V | 1.279 | 0.99 | |
| 276_L | 308_A | 1.272 | 0.99 | |
| 67_E | 70_L | 1.271 | 0.99 | |
| 104_K | 287_D | 1.26 | 0.99 | |
| 133_A | 168_R | 1.251 | 0.99 | |
| 254_M | 264_T | 1.248 | 0.99 | |
| 257_M | 351_L | 1.244 | 0.98 | |
| 333_D | 337_A | 1.236 | 0.98 | |
| 251_L | 255_E | 1.235 | 0.98 | |
| 336_L | 339_A | 1.232 | 0.98 | |
| 225_L | 236_L | 1.232 | 0.98 | |
| 235_M | 285_V | 1.226 | 0.98 | |
| 260_A | 282_R | 1.222 | 0.98 | |
| 95_Q | 316_E | 1.22 | 0.98 | |
| 68_A | 71_K | 1.219 | 0.98 | |
| 313_K | 317_Q | 1.214 | 0.98 | |
| 383_K | 416_I | 1.2 | 0.98 | |
| 55_T | 314_V | 1.197 | 0.98 | |
| 415_E | 419_Q | 1.196 | 0.98 | |
| 148_L | 204_V | 1.192 | 0.98 | |
| 334_G | 418_S | 1.191 | 0.98 | |
| 63_V | 71_K | 1.181 | 0.98 | |
| 270_I | 278_G | 1.172 | 0.98 | |
| 131_T | 202_A | 1.17 | 0.97 | |
| 184_I | 228_L | 1.165 | 0.97 | |
| 361_E | 367_K | 1.155 | 0.97 | |
| 63_V | 70_L | 1.152 | 0.97 | |
| 10_R | 14_A | 1.15 | 0.97 | |
| 409_Q | 412_Q | 1.149 | 0.97 | |
| 380_A | 385_L | 1.145 | 0.97 | |
| 246_G | 321_L | 1.141 | 0.97 | |
| 256_Q | 351_L | 1.138 | 0.97 | |
| 189_R | 193_N | 1.134 | 0.97 | |
| 28_D | 40_G | 1.131 | 0.97 | |
| 315_F | 320_L | 1.131 | 0.97 | |
| 263_L | 279_V | 1.126 | 0.97 | |
| 188_H | 232_H | 1.117 | 0.96 | |
| 227_A | 230_D | 1.115 | 0.96 | |
| 380_A | 420_C | 1.111 | 0.96 | |
| 182_D | 218_S | 1.109 | 0.96 | |
| 223_Q | 258_G | 1.108 | 0.96 | |
| 321_L | 324_A | 1.103 | 0.96 | |
| 147_A | 163_P | 1.1 | 0.96 | |
| 108_V | 279_V | 1.094 | 0.96 | |
| 112_S | 145_T | 1.094 | 0.96 | |
| 411_R | 415_E | 1.092 | 0.96 | |
| 338_I | 418_S | 1.087 | 0.96 | |
| 380_A | 416_I | 1.086 | 0.96 | |
| 346_G | 360_F | 1.083 | 0.96 | |
| 412_Q | 415_E | 1.076 | 0.95 | |
| 249_G | 255_E | 1.071 | 0.95 | |
| 385_L | 413_G | 1.07 | 0.95 | |
| 325_N | 329_Q | 1.067 | 0.95 | |
| 315_F | 321_L | 1.062 | 0.95 | |
| 119_V | 148_L | 1.062 | 0.95 | |
| 322_Q | 325_N | 1.057 | 0.95 | |
| 62_V | 307_A | 1.055 | 0.95 | |
| 208_V | 351_L | 1.054 | 0.95 | |
| 9_Q | 13_Q | 1.052 | 0.95 | |
| 107_L | 305_C | 1.049 | 0.94 | |
| 274_F | 304_A | 1.046 | 0.94 | |
| 89_L | 309_L | 1.037 | 0.94 | |
| 33_C | 44_L | 1.034 | 0.94 | |
| 336_L | 340_E | 1.025 | 0.93 | |
| 375_E | 379_R | 1.024 | 0.93 | |
| 114_A | 265_T | 1.024 | 0.93 | |
| 188_H | 228_L | 1.023 | 0.93 | |
| 408_A | 411_R | 1.019 | 0.93 | |
| 272_G | 311_V | 1.018 | 0.93 | |
| 228_L | 232_H | 1.017 | 0.93 | |
| 252_F | 266_F | 1.009 | 0.93 | |
| 55_T | 311_V | 1.009 | 0.93 | |
| 188_H | 227_A | 1.007 | 0.93 | |
| 112_S | 142_T | 1.005 | 0.93 | |
| 245_A | 315_F | 1.005 | 0.93 | |
| 191_F | 200_I | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9906 | 100 | 0.316 | Contact Map | 0.577 |
| 1sffA | 4 | 1 | 100 | 0.369 | Contact Map | 0.771 |
| 3tfuA | 2 | 0.9577 | 100 | 0.373 | Contact Map | 0.711 |
| 4ffcA | 4 | 0.9883 | 100 | 0.373 | Contact Map | 0.656 |
| 3oksA | 4 | 0.993 | 100 | 0.373 | Contact Map | 0.726 |
| 4atqA | 12 | 0.9859 | 100 | 0.374 | Contact Map | 0.714 |
| 2epjA | 1 | 0.946 | 100 | 0.381 | Contact Map | 0.693 |
| 4e3qA | 4 | 0.9812 | 100 | 0.394 | Contact Map | 0.784 |
| 3dxvA | 2 | 0.9883 | 100 | 0.396 | Contact Map | 0.759 |
| 3hmuA | 2 | 0.9789 | 100 | 0.406 | Contact Map | 0.817 |
Sequence Conservation (Image Generated using WebLogo v3)