| UniProt: | P23893 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10432 | ||
| Length: | 426 (422) | ||
| Sequences: | 9800 | ||
| Seq/Len: | 23.22 |
| GSA
Paralog alert: 0.89 [within 20: 0.12] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 76_I | 80_E | 4.824 | 1.00 | |
| 389_E | 421_R | 4.472 | 1.00 | |
| 224_R | 228_D | 4.365 | 1.00 | |
| 43_Y | 51_A | 3.976 | 1.00 | |
| 330_R | 413_N | 3.824 | 1.00 | |
| 184_L | 222_G | 3.764 | 1.00 | |
| 319_G | 322_E | 3.565 | 1.00 | |
| 98_L | 313_N | 3.435 | 1.00 | |
| 38_K | 45_Y | 3.369 | 1.00 | |
| 73_N | 77_E | 3.137 | 1.00 | |
| 247_L | 253_Y | 3.065 | 1.00 | |
| 330_R | 409_M | 3.049 | 1.00 | |
| 70_A | 317_Q | 2.967 | 1.00 | |
| 408_S | 411_D | 2.931 | 1.00 | |
| 341_E | 420_R | 2.897 | 1.00 | |
| 323_T | 327_L | 2.809 | 1.00 | |
| 70_A | 310_A | 2.714 | 1.00 | |
| 310_A | 313_N | 2.632 | 1.00 | |
| 326_E | 409_M | 2.607 | 1.00 | |
| 222_G | 225_A | 2.493 | 1.00 | |
| 225_A | 229_E | 2.471 | 1.00 | |
| 98_L | 316_A | 2.466 | 1.00 | |
| 334_G | 416_I | 2.435 | 1.00 | |
| 37_E | 47_V | 2.415 | 1.00 | |
| 55_Y | 415_T | 2.372 | 1.00 | |
| 385_M | 388_D | 2.356 | 1.00 | |
| 70_A | 314_E | 2.355 | 1.00 | |
| 188_R | 229_E | 2.341 | 1.00 | |
| 68_H | 314_E | 2.321 | 1.00 | |
| 329_T | 333_E | 2.302 | 1.00 | |
| 202_I | 235_I | 2.284 | 1.00 | |
| 43_Y | 411_D | 2.276 | 1.00 | |
| 389_E | 425_K | 2.221 | 1.00 | |
| 10_A | 97_Q | 2.115 | 1.00 | |
| 391_V | 418_A | 2.098 | 1.00 | |
| 45_Y | 51_A | 2.051 | 1.00 | |
| 332_A | 336_L | 2.02 | 1.00 | |
| 37_E | 81_R | 2.006 | 1.00 | |
| 385_M | 389_E | 1.984 | 1.00 | |
| 75_V | 307_A | 1.968 | 1.00 | |
| 90_E | 94_K | 1.959 | 1.00 | |
| 98_L | 309_F | 1.957 | 1.00 | |
| 414_N | 418_A | 1.956 | 1.00 | |
| 342_A | 420_R | 1.931 | 1.00 | |
| 72_R | 76_I | 1.931 | 1.00 | |
| 203_V | 223_L | 1.931 | 1.00 | |
| 187_V | 223_L | 1.915 | 1.00 | |
| 112_V | 274_G | 1.908 | 1.00 | |
| 108_M | 280_R | 1.9 | 1.00 | |
| 334_G | 413_N | 1.894 | 1.00 | |
| 97_Q | 101_E | 1.89 | 1.00 | |
| 134_K | 197_E | 1.889 | 1.00 | |
| 95_M | 308_G | 1.887 | 1.00 | |
| 334_G | 417_D | 1.875 | 1.00 | |
| 385_M | 425_K | 1.873 | 1.00 | |
| 334_G | 337_E | 1.858 | 1.00 | |
| 201_I | 227_C | 1.856 | 1.00 | |
| 138_F | 219_F | 1.84 | 1.00 | |
| 96_A | 111_M | 1.84 | 1.00 | |
| 314_E | 318_P | 1.83 | 1.00 | |
| 46_D | 50_K | 1.828 | 1.00 | |
| 280_R | 284_D | 1.827 | 1.00 | |
| 75_V | 79_A | 1.811 | 1.00 | |
| 40_D | 69_P | 1.797 | 1.00 | |
| 50_K | 390_G | 1.793 | 1.00 | |
| 119_T | 262_C | 1.744 | 1.00 | |
| 51_A | 414_N | 1.707 | 1.00 | |
| 263_L | 275_A | 1.683 | 1.00 | |
| 107_D | 280_R | 1.682 | 1.00 | |
| 43_Y | 414_N | 1.67 | 1.00 | |
| 323_T | 326_E | 1.637 | 1.00 | |
| 332_A | 350_H | 1.631 | 1.00 | |
| 322_E | 326_E | 1.624 | 1.00 | |
| 218_E | 221_P | 1.61 | 1.00 | |
| 77_E | 81_R | 1.587 | 1.00 | |
| 188_R | 192_E | 1.584 | 1.00 | |
| 263_L | 277_G | 1.583 | 1.00 | |
| 129_F | 282_V | 1.579 | 1.00 | |
| 247_L | 325_D | 1.576 | 1.00 | |
| 94_K | 309_F | 1.567 | 1.00 | |
| 180_T | 186_S | 1.567 | 1.00 | |
| 98_L | 101_E | 1.557 | 1.00 | |
| 73_N | 76_I | 1.55 | 1.00 | |
| 268_G | 273_V | 1.548 | 1.00 | |
| 122_A | 262_C | 1.538 | 1.00 | |
| 69_P | 73_N | 1.538 | 1.00 | |
| 247_L | 252_D | 1.528 | 1.00 | |
| 327_L | 412_I | 1.522 | 1.00 | |
| 327_L | 330_R | 1.522 | 1.00 | |
| 191_F | 232_A | 1.52 | 1.00 | |
| 342_A | 424_A | 1.519 | 1.00 | |
| 236_I | 251_Q | 1.519 | 1.00 | |
| 36_I | 44_L | 1.504 | 1.00 | |
| 74_A | 310_A | 1.492 | 1.00 | |
| 224_R | 234_L | 1.491 | 1.00 | |
| 267_I | 273_V | 1.482 | 1.00 | |
| 103_V | 277_G | 1.479 | 1.00 | |
| 126_A | 235_I | 1.473 | 1.00 | |
| 310_A | 314_E | 1.471 | 1.00 | |
| 38_K | 81_R | 1.468 | 1.00 | |
| 46_D | 52_Y | 1.462 | 1.00 | |
| 42_A | 411_D | 1.46 | 1.00 | |
| 185_A | 188_R | 1.453 | 1.00 | |
| 121_S | 276_F | 1.453 | 1.00 | |
| 224_R | 227_C | 1.436 | 1.00 | |
| 182_N | 216_L | 1.434 | 1.00 | |
| 67_N | 72_R | 1.427 | 1.00 | |
| 385_M | 422_V | 1.424 | 1.00 | |
| 180_T | 183_D | 1.414 | 1.00 | |
| 68_H | 318_P | 1.41 | 1.00 | |
| 201_I | 223_L | 1.404 | 0.99 | |
| 102_L | 316_A | 1.403 | 0.99 | |
| 123_I | 135_I | 1.389 | 0.99 | |
| 327_L | 409_M | 1.385 | 0.99 | |
| 203_V | 220_L | 1.385 | 0.99 | |
| 188_R | 222_G | 1.384 | 0.99 | |
| 260_L | 278_G | 1.382 | 0.99 | |
| 40_D | 67_N | 1.382 | 0.99 | |
| 409_M | 413_N | 1.38 | 0.99 | |
| 338_A | 416_I | 1.378 | 0.99 | |
| 75_V | 303_I | 1.374 | 0.99 | |
| 273_V | 305_M | 1.369 | 0.99 | |
| 42_A | 406_A | 1.368 | 0.99 | |
| 40_D | 51_A | 1.368 | 0.99 | |
| 109_V | 277_G | 1.367 | 0.99 | |
| 407_H | 412_I | 1.366 | 0.99 | |
| 218_E | 254_Y | 1.365 | 0.99 | |
| 94_K | 313_N | 1.363 | 0.99 | |
| 389_E | 422_V | 1.355 | 0.99 | |
| 100_T | 109_V | 1.348 | 0.99 | |
| 236_I | 256_V | 1.348 | 0.99 | |
| 332_A | 355_F | 1.345 | 0.99 | |
| 136_I | 198_I | 1.338 | 0.99 | |
| 309_F | 313_N | 1.337 | 0.99 | |
| 221_P | 225_A | 1.337 | 0.99 | |
| 132_R | 231_G | 1.328 | 0.99 | |
| 386_M | 393_L | 1.328 | 0.99 | |
| 330_R | 334_G | 1.324 | 0.99 | |
| 336_L | 339_A | 1.32 | 0.99 | |
| 43_Y | 53_I | 1.319 | 0.99 | |
| 254_Y | 351_V | 1.318 | 0.99 | |
| 119_T | 202_I | 1.316 | 0.99 | |
| 77_E | 80_E | 1.307 | 0.99 | |
| 420_R | 424_A | 1.292 | 0.99 | |
| 273_V | 308_G | 1.285 | 0.99 | |
| 233_L | 282_V | 1.271 | 0.99 | |
| 334_G | 420_R | 1.269 | 0.99 | |
| 185_A | 189_A | 1.268 | 0.99 | |
| 76_I | 79_A | 1.268 | 0.99 | |
| 257_V | 279_R | 1.268 | 0.99 | |
| 108_M | 284_D | 1.261 | 0.99 | |
| 129_F | 285_A | 1.254 | 0.99 | |
| 223_L | 234_L | 1.245 | 0.98 | |
| 72_R | 79_A | 1.239 | 0.98 | |
| 189_A | 193_Q | 1.238 | 0.98 | |
| 134_K | 177_L | 1.236 | 0.98 | |
| 313_N | 317_Q | 1.234 | 0.98 | |
| 417_D | 421_R | 1.23 | 0.98 | |
| 64_L | 314_E | 1.23 | 0.98 | |
| 248_A | 252_D | 1.229 | 0.98 | |
| 251_Q | 261_T | 1.218 | 0.98 | |
| 386_M | 391_V | 1.216 | 0.98 | |
| 72_R | 80_E | 1.214 | 0.98 | |
| 267_I | 275_A | 1.21 | 0.98 | |
| 101_E | 316_A | 1.207 | 0.98 | |
| 411_D | 414_N | 1.206 | 0.98 | |
| 333_E | 337_E | 1.196 | 0.98 | |
| 135_I | 200_C | 1.18 | 0.98 | |
| 389_E | 418_A | 1.179 | 0.98 | |
| 315_V | 321_H | 1.171 | 0.98 | |
| 367_C | 370_D | 1.169 | 0.97 | |
| 346_L | 360_T | 1.166 | 0.97 | |
| 225_A | 228_D | 1.163 | 0.97 | |
| 413_N | 417_D | 1.145 | 0.97 | |
| 253_Y | 351_V | 1.142 | 0.97 | |
| 260_L | 276_F | 1.141 | 0.97 | |
| 386_M | 422_V | 1.14 | 0.97 | |
| 315_V | 320_V | 1.14 | 0.97 | |
| 112_V | 276_F | 1.136 | 0.97 | |
| 37_E | 49_G | 1.132 | 0.97 | |
| 321_H | 324_L | 1.124 | 0.97 | |
| 338_A | 420_R | 1.122 | 0.97 | |
| 188_R | 230_F | 1.115 | 0.96 | |
| 221_P | 255_G | 1.113 | 0.96 | |
| 206_V | 351_V | 1.105 | 0.96 | |
| 71_I | 307_A | 1.102 | 0.96 | |
| 386_M | 418_A | 1.093 | 0.96 | |
| 246_A | 252_D | 1.091 | 0.96 | |
| 414_N | 417_D | 1.088 | 0.96 | |
| 179_C | 190_A | 1.079 | 0.95 | |
| 10_A | 14_L | 1.079 | 0.95 | |
| 184_L | 226_L | 1.075 | 0.95 | |
| 42_A | 53_I | 1.074 | 0.95 | |
| 111_M | 305_M | 1.073 | 0.95 | |
| 325_D | 329_T | 1.071 | 0.95 | |
| 116_T | 146_A | 1.07 | 0.95 | |
| 118_A | 262_C | 1.065 | 0.95 | |
| 271_M | 304_A | 1.064 | 0.95 | |
| 243_F | 315_V | 1.058 | 0.95 | |
| 95_M | 309_F | 1.056 | 0.95 | |
| 188_R | 226_L | 1.056 | 0.95 | |
| 64_L | 311_C | 1.054 | 0.95 | |
| 191_F | 198_I | 1.054 | 0.95 | |
| 391_V | 415_T | 1.053 | 0.95 | |
| 269_G | 311_C | 1.051 | 0.94 | |
| 226_L | 230_F | 1.048 | 0.94 | |
| 125_L | 276_F | 1.045 | 0.94 | |
| 314_E | 317_Q | 1.038 | 0.94 | |
| 188_R | 225_A | 1.036 | 0.94 | |
| 109_V | 275_A | 1.028 | 0.94 | |
| 381_R | 385_M | 1.025 | 0.93 | |
| 192_E | 230_F | 1.024 | 0.93 | |
| 207_A | 210_M | 1.021 | 0.93 | |
| 186_S | 189_A | 1.018 | 0.93 | |
| 410_E | 413_N | 1.018 | 0.93 | |
| 102_L | 248_A | 1.018 | 0.93 | |
| 322_E | 325_D | 1.014 | 0.93 | |
| 36_I | 39_A | 1.003 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9789 | 100 | 0.335 | Contact Map | 0.583 |
| 2epjA | 1 | 0.9906 | 100 | 0.336 | Contact Map | 0.706 |
| 4e77A | 1 | 1 | 100 | 0.356 | Contact Map | 0.696 |
| 4ao9A | 2 | 0.9484 | 100 | 0.379 | Contact Map | 0.628 |
| 2ykyA | 3 | 0.9484 | 100 | 0.386 | Contact Map | 0.649 |
| 3tfuA | 2 | 0.9437 | 100 | 0.398 | Contact Map | 0.708 |
| 3k28A | 4 | 0.9953 | 100 | 0.401 | Contact Map | 0.787 |
| 2e7uA | 1 | 0.9883 | 100 | 0.403 | Contact Map | 0.709 |
| 2cy8A | 1 | 0.9812 | 100 | 0.412 | Contact Map | 0.648 |
| 3oksA | 4 | 0.9554 | 100 | 0.412 | Contact Map | 0.721 |
Sequence Conservation (Image Generated using WebLogo v3)