| UniProt: | P50457 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13187 | ||
| Length: | 421 (417) | ||
| Sequences: | 9700 | ||
| Seq/Len: | 23.26 |
| PUUE
Paralog alert: 0.89 [within 20: 0.12] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 66_E | 70_Q | 4.711 | 1.00 | |
| 381_Q | 417_D | 4.423 | 1.00 | |
| 225_R | 229_D | 4.332 | 1.00 | |
| 33_T | 41_E | 3.937 | 1.00 | |
| 183_L | 223_A | 3.84 | 1.00 | |
| 329_R | 409_D | 3.764 | 1.00 | |
| 318_S | 321_E | 3.451 | 1.00 | |
| 91_K | 312_N | 3.39 | 1.00 | |
| 28_S | 35_K | 3.272 | 1.00 | |
| 63_A | 67_Q | 3.08 | 1.00 | |
| 249_K | 255_H | 3.027 | 1.00 | |
| 329_R | 405_D | 2.977 | 1.00 | |
| 404_P | 407_Q | 2.94 | 1.00 | |
| 340_S | 416_Q | 2.901 | 1.00 | |
| 60_D | 316_K | 2.894 | 1.00 | |
| 322_R | 326_L | 2.777 | 1.00 | |
| 60_D | 309_A | 2.685 | 1.00 | |
| 325_Q | 405_D | 2.574 | 1.00 | |
| 309_A | 312_N | 2.549 | 1.00 | |
| 169_P | 185_A | 2.458 | 1.00 | |
| 226_R | 230_E | 2.44 | 1.00 | |
| 333_T | 412_M | 2.425 | 1.00 | |
| 223_A | 226_R | 2.419 | 1.00 | |
| 91_K | 315_D | 2.383 | 1.00 | |
| 187_E | 230_E | 2.375 | 1.00 | |
| 377_R | 380_A | 2.331 | 1.00 | |
| 27_Q | 37_V | 2.331 | 1.00 | |
| 45_F | 411_A | 2.328 | 1.00 | |
| 60_D | 313_I | 2.278 | 1.00 | |
| 58_H | 313_I | 2.277 | 1.00 | |
| 328_Q | 332_N | 2.243 | 1.00 | |
| 203_I | 236_I | 2.175 | 1.00 | |
| 33_T | 407_Q | 2.16 | 1.00 | |
| 383_L | 414_I | 2.129 | 1.00 | |
| 9_R | 90_E | 2.001 | 1.00 | |
| 35_K | 41_E | 1.991 | 1.00 | |
| 377_R | 381_Q | 1.964 | 1.00 | |
| 341_V | 416_Q | 1.955 | 1.00 | |
| 83_E | 87_T | 1.951 | 1.00 | |
| 331_K | 335_I | 1.943 | 1.00 | |
| 129_G | 198_Q | 1.941 | 1.00 | |
| 410_A | 414_I | 1.933 | 1.00 | |
| 91_K | 308_H | 1.923 | 1.00 | |
| 27_Q | 71_Q | 1.902 | 1.00 | |
| 186_I | 224_I | 1.893 | 1.00 | |
| 65_V | 306_A | 1.891 | 1.00 | |
| 204_F | 224_I | 1.881 | 1.00 | |
| 333_T | 409_D | 1.877 | 1.00 | |
| 88_L | 307_A | 1.873 | 1.00 | |
| 90_E | 94_A | 1.857 | 1.00 | |
| 103_K | 282_A | 1.856 | 1.00 | |
| 333_T | 336_D | 1.855 | 1.00 | |
| 62_V | 66_E | 1.844 | 1.00 | |
| 333_T | 413_K | 1.821 | 1.00 | |
| 30_E | 59_P | 1.817 | 1.00 | |
| 36_D | 40_N | 1.801 | 1.00 | |
| 313_I | 317_E | 1.799 | 1.00 | |
| 107_F | 276_S | 1.796 | 1.00 | |
| 40_N | 382_G | 1.791 | 1.00 | |
| 133_F | 220_L | 1.789 | 1.00 | |
| 202_I | 228_C | 1.783 | 1.00 | |
| 282_A | 286_D | 1.767 | 1.00 | |
| 65_V | 69_L | 1.706 | 1.00 | |
| 89_A | 106_F | 1.675 | 1.00 | |
| 41_E | 410_A | 1.67 | 1.00 | |
| 129_G | 166_Y | 1.658 | 1.00 | |
| 114_V | 264_T | 1.651 | 1.00 | |
| 102_A | 282_A | 1.647 | 1.00 | |
| 219_E | 222_A | 1.632 | 1.00 | |
| 33_T | 410_A | 1.631 | 1.00 | |
| 265_M | 277_G | 1.614 | 1.00 | |
| 331_K | 349_G | 1.609 | 1.00 | |
| 341_V | 420_S | 1.606 | 1.00 | |
| 322_R | 325_Q | 1.595 | 1.00 | |
| 187_E | 191_K | 1.585 | 1.00 | |
| 249_K | 324_N | 1.582 | 1.00 | |
| 91_K | 94_A | 1.571 | 1.00 | |
| 168_V | 189_L | 1.567 | 1.00 | |
| 124_H | 284_I | 1.555 | 1.00 | |
| 326_L | 408_F | 1.544 | 1.00 | |
| 87_T | 308_H | 1.526 | 1.00 | |
| 63_A | 66_E | 1.523 | 1.00 | |
| 321_E | 325_Q | 1.517 | 1.00 | |
| 184_D | 187_E | 1.515 | 1.00 | |
| 265_M | 279_V | 1.498 | 1.00 | |
| 270_A | 275_L | 1.496 | 1.00 | |
| 249_K | 254_D | 1.487 | 1.00 | |
| 326_L | 329_R | 1.485 | 1.00 | |
| 121_A | 236_I | 1.485 | 1.00 | |
| 67_Q | 71_Q | 1.483 | 1.00 | |
| 117_A | 264_T | 1.467 | 1.00 | |
| 26_A | 34_L | 1.466 | 1.00 | |
| 225_R | 235_M | 1.462 | 1.00 | |
| 237_A | 253_M | 1.452 | 1.00 | |
| 377_R | 418_A | 1.447 | 1.00 | |
| 59_P | 63_A | 1.445 | 1.00 | |
| 225_R | 228_C | 1.436 | 1.00 | |
| 32_A | 407_Q | 1.435 | 1.00 | |
| 184_D | 188_R | 1.434 | 1.00 | |
| 36_D | 42_Y | 1.433 | 1.00 | |
| 309_A | 313_I | 1.432 | 1.00 | |
| 190_F | 233_I | 1.432 | 1.00 | |
| 269_L | 275_L | 1.421 | 1.00 | |
| 378_A | 385_L | 1.415 | 1.00 | |
| 28_S | 71_Q | 1.405 | 0.99 | |
| 32_A | 402_T | 1.403 | 0.99 | |
| 96_A | 279_V | 1.4 | 0.99 | |
| 64_A | 309_A | 1.4 | 0.99 | |
| 134_S | 169_P | 1.391 | 0.99 | |
| 116_N | 278_V | 1.388 | 0.99 | |
| 204_F | 221_V | 1.388 | 0.99 | |
| 87_T | 312_N | 1.387 | 0.99 | |
| 337_A | 412_M | 1.381 | 0.99 | |
| 381_Q | 418_A | 1.38 | 0.99 | |
| 187_E | 223_A | 1.375 | 0.99 | |
| 57_R | 62_V | 1.374 | 0.99 | |
| 58_H | 317_E | 1.368 | 0.99 | |
| 104_T | 279_V | 1.363 | 0.99 | |
| 118_V | 130_V | 1.361 | 0.99 | |
| 262_L | 280_G | 1.361 | 0.99 | |
| 188_R | 192_S | 1.357 | 0.99 | |
| 331_K | 354_I | 1.357 | 0.99 | |
| 202_I | 224_I | 1.353 | 0.99 | |
| 326_L | 405_D | 1.353 | 0.99 | |
| 275_L | 304_V | 1.351 | 0.99 | |
| 403_I | 408_F | 1.348 | 0.99 | |
| 65_V | 302_L | 1.333 | 0.99 | |
| 222_A | 226_R | 1.332 | 0.99 | |
| 405_D | 409_D | 1.33 | 0.99 | |
| 131_I | 199_V | 1.329 | 0.99 | |
| 219_E | 256_Y | 1.329 | 0.99 | |
| 147_L | 165_V | 1.326 | 0.99 | |
| 169_P | 182_S | 1.321 | 0.99 | |
| 30_E | 57_R | 1.309 | 0.99 | |
| 95_L | 315_D | 1.308 | 0.99 | |
| 416_Q | 420_S | 1.306 | 0.99 | |
| 329_R | 333_T | 1.305 | 0.99 | |
| 308_H | 312_N | 1.298 | 0.99 | |
| 275_L | 307_A | 1.296 | 0.99 | |
| 30_E | 41_E | 1.296 | 0.99 | |
| 93_N | 104_T | 1.295 | 0.99 | |
| 237_A | 258_D | 1.294 | 0.99 | |
| 33_T | 43_I | 1.292 | 0.99 | |
| 66_E | 69_L | 1.284 | 0.99 | |
| 103_K | 286_D | 1.275 | 0.99 | |
| 256_Y | 350_L | 1.27 | 0.99 | |
| 114_V | 203_I | 1.267 | 0.99 | |
| 67_Q | 70_Q | 1.26 | 0.99 | |
| 132_A | 167_H | 1.259 | 0.99 | |
| 127_R | 232_G | 1.247 | 0.99 | |
| 253_M | 263_M | 1.243 | 0.98 | |
| 54_T | 313_I | 1.235 | 0.98 | |
| 312_N | 316_K | 1.234 | 0.98 | |
| 335_I | 338_K | 1.226 | 0.98 | |
| 224_I | 235_M | 1.221 | 0.98 | |
| 333_T | 416_Q | 1.216 | 0.98 | |
| 94_A | 315_D | 1.215 | 0.98 | |
| 381_Q | 414_I | 1.214 | 0.98 | |
| 332_N | 336_D | 1.212 | 0.98 | |
| 259_K | 281_N | 1.202 | 0.98 | |
| 250_L | 254_D | 1.201 | 0.98 | |
| 183_L | 227_L | 1.198 | 0.98 | |
| 234_V | 284_I | 1.197 | 0.98 | |
| 413_K | 417_D | 1.196 | 0.98 | |
| 269_L | 277_G | 1.194 | 0.98 | |
| 147_L | 203_I | 1.185 | 0.98 | |
| 407_Q | 410_A | 1.184 | 0.98 | |
| 62_V | 70_Q | 1.18 | 0.98 | |
| 146_A | 162_P | 1.164 | 0.97 | |
| 226_R | 229_D | 1.16 | 0.97 | |
| 359_N | 365_E | 1.156 | 0.97 | |
| 130_V | 201_A | 1.153 | 0.97 | |
| 381_Q | 421_D | 1.153 | 0.97 | |
| 27_Q | 39_G | 1.149 | 0.97 | |
| 245_A | 320_C | 1.147 | 0.97 | |
| 9_R | 13_A | 1.145 | 0.97 | |
| 62_V | 69_L | 1.139 | 0.97 | |
| 378_A | 418_A | 1.138 | 0.97 | |
| 124_H | 287_A | 1.135 | 0.97 | |
| 409_D | 413_K | 1.133 | 0.97 | |
| 378_A | 383_L | 1.131 | 0.97 | |
| 314_I | 319_L | 1.124 | 0.97 | |
| 255_H | 350_L | 1.124 | 0.97 | |
| 262_L | 278_V | 1.122 | 0.97 | |
| 222_A | 257_A | 1.122 | 0.97 | |
| 187_E | 231_H | 1.119 | 0.96 | |
| 314_I | 320_C | 1.107 | 0.96 | |
| 320_C | 323_A | 1.105 | 0.96 | |
| 176_G | 217_P | 1.1 | 0.96 | |
| 191_K | 231_H | 1.091 | 0.96 | |
| 324_N | 328_Q | 1.09 | 0.96 | |
| 187_E | 226_R | 1.085 | 0.96 | |
| 61_L | 306_A | 1.081 | 0.95 | |
| 111_A | 144_T | 1.081 | 0.95 | |
| 190_F | 199_V | 1.078 | 0.95 | |
| 107_F | 278_V | 1.073 | 0.95 | |
| 248_G | 254_D | 1.072 | 0.95 | |
| 106_F | 304_V | 1.066 | 0.95 | |
| 378_A | 414_I | 1.063 | 0.95 | |
| 207_V | 350_L | 1.06 | 0.95 | |
| 383_L | 411_A | 1.06 | 0.95 | |
| 337_A | 416_Q | 1.059 | 0.95 | |
| 410_A | 413_K | 1.057 | 0.95 | |
| 88_L | 308_H | 1.056 | 0.95 | |
| 271_G | 310_V | 1.045 | 0.94 | |
| 373_K | 377_R | 1.039 | 0.94 | |
| 118_V | 147_L | 1.034 | 0.94 | |
| 95_L | 250_L | 1.033 | 0.94 | |
| 406_A | 409_D | 1.033 | 0.94 | |
| 54_T | 310_V | 1.028 | 0.94 | |
| 32_A | 43_I | 1.025 | 0.93 | |
| 113_A | 264_T | 1.023 | 0.93 | |
| 321_E | 324_N | 1.022 | 0.93 | |
| 111_A | 141_T | 1.019 | 0.93 | |
| 187_E | 227_L | 1.015 | 0.93 | |
| 313_I | 316_K | 1.006 | 0.93 | |
| 251_F | 265_M | 1.005 | 0.93 | |
| 227_L | 231_H | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.9881 | 100 | 0.302 | Contact Map | 0.577 |
| 3tfuA | 2 | 0.9596 | 100 | 0.348 | Contact Map | 0.713 |
| 4atqA | 12 | 0.9881 | 100 | 0.353 | Contact Map | 0.721 |
| 3oksA | 4 | 0.9976 | 100 | 0.354 | Contact Map | 0.733 |
| 4ffcA | 4 | 0.9881 | 100 | 0.354 | Contact Map | 0.663 |
| 1sffA | 4 | 1 | 100 | 0.36 | Contact Map | 0.77 |
| 2epjA | 1 | 0.9477 | 100 | 0.368 | Contact Map | 0.693 |
| 4e3qA | 4 | 0.981 | 100 | 0.379 | Contact Map | 0.78 |
| 3dxvA | 2 | 0.9952 | 100 | 0.379 | Contact Map | 0.762 |
| 3hmuA | 2 | 0.981 | 100 | 0.386 | Contact Map | 0.814 |
Sequence Conservation (Image Generated using WebLogo v3)