| UniProt: | P12995 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10117 | ||
| Length: | 429 (415) | ||
| Sequences: | 9665 | ||
| Seq/Len: | 23.29 |
| BIOA
Paralog alert: 0.89 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ARGD ASTC BIOA GABT GSA PAT PUUE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 69_K | 73_D | 4.772 | 1.00 | |
| 386_Q | 419_R | 4.542 | 1.00 | |
| 232_R | 236_D | 4.374 | 1.00 | |
| 36_E | 44_R | 4.001 | 1.00 | |
| 191_M | 230_R | 3.987 | 1.00 | |
| 342_Q | 411_Q | 3.83 | 1.00 | |
| 94_K | 325_A | 3.483 | 1.00 | |
| 331_D | 334_Q | 3.455 | 1.00 | |
| 31_S | 38_I | 3.287 | 1.00 | |
| 66_A | 70_S | 3.174 | 1.00 | |
| 256_K | 262_H | 3.083 | 1.00 | |
| 342_Q | 407_P | 2.997 | 1.00 | |
| 406_L | 409_Q | 2.927 | 1.00 | |
| 63_Q | 329_S | 2.909 | 1.00 | |
| 335_Q | 339_I | 2.842 | 1.00 | |
| 63_Q | 322_A | 2.737 | 1.00 | |
| 338_D | 407_P | 2.663 | 1.00 | |
| 322_A | 325_A | 2.587 | 1.00 | |
| 346_Q | 414_T | 2.487 | 1.00 | |
| 233_K | 237_R | 2.482 | 1.00 | |
| 195_A | 237_R | 2.456 | 1.00 | |
| 230_R | 233_K | 2.439 | 1.00 | |
| 94_K | 328_E | 2.417 | 1.00 | |
| 382_F | 385_E | 2.403 | 1.00 | |
| 30_V | 40_S | 2.392 | 1.00 | |
| 61_H | 326_I | 2.361 | 1.00 | |
| 48_G | 413_L | 2.352 | 1.00 | |
| 63_Q | 326_I | 2.338 | 1.00 | |
| 341_V | 345_E | 2.266 | 1.00 | |
| 209_I | 243_I | 2.25 | 1.00 | |
| 388_V | 416_A | 2.184 | 1.00 | |
| 36_E | 409_Q | 2.183 | 1.00 | |
| 38_I | 44_R | 1.987 | 1.00 | |
| 86_A | 90_E | 1.979 | 1.00 | |
| 194_F | 231_I | 1.973 | 1.00 | |
| 382_F | 386_Q | 1.959 | 1.00 | |
| 210_I | 231_I | 1.945 | 1.00 | |
| 68_M | 319_A | 1.941 | 1.00 | |
| 93_R | 97_A | 1.932 | 1.00 | |
| 412_R | 416_A | 1.93 | 1.00 | |
| 346_Q | 411_Q | 1.924 | 1.00 | |
| 94_K | 321_N | 1.923 | 1.00 | |
| 30_V | 74_A | 1.92 | 1.00 | |
| 105_C | 290_R | 1.917 | 1.00 | |
| 91_L | 320_A | 1.914 | 1.00 | |
| 346_Q | 415_A | 1.902 | 1.00 | |
| 65_N | 69_K | 1.895 | 1.00 | |
| 353_A | 418_N | 1.891 | 1.00 | |
| 344_R | 348_A | 1.881 | 1.00 | |
| 208_V | 235_C | 1.872 | 1.00 | |
| 136_R | 204_E | 1.865 | 1.00 | |
| 109_A | 284_S | 1.859 | 1.00 | |
| 140_F | 227_W | 1.832 | 1.00 | |
| 39_L | 43_R | 1.823 | 1.00 | |
| 326_I | 330_G | 1.79 | 1.00 | |
| 176_P | 193_G | 1.784 | 1.00 | |
| 33_E | 62_P | 1.782 | 1.00 | |
| 346_Q | 349_P | 1.776 | 1.00 | |
| 43_R | 387_G | 1.755 | 1.00 | |
| 68_M | 72_I | 1.754 | 1.00 | |
| 92_C | 108_L | 1.726 | 1.00 | |
| 290_R | 294_E | 1.725 | 1.00 | |
| 386_Q | 423_D | 1.709 | 1.00 | |
| 44_R | 412_R | 1.708 | 1.00 | |
| 116_V | 271_C | 1.663 | 1.00 | |
| 226_E | 229_K | 1.655 | 1.00 | |
| 36_E | 412_R | 1.649 | 1.00 | |
| 272_L | 285_A | 1.632 | 1.00 | |
| 104_E | 290_R | 1.63 | 1.00 | |
| 256_K | 337_A | 1.624 | 1.00 | |
| 195_A | 199_A | 1.624 | 1.00 | |
| 339_I | 410_L | 1.595 | 1.00 | |
| 335_Q | 338_D | 1.588 | 1.00 | |
| 192_V | 195_A | 1.561 | 1.00 | |
| 29_V | 37_L | 1.558 | 1.00 | |
| 66_A | 69_K | 1.556 | 1.00 | |
| 70_S | 74_A | 1.543 | 1.00 | |
| 90_E | 321_N | 1.539 | 1.00 | |
| 198_M | 240_I | 1.538 | 1.00 | |
| 277_T | 283_L | 1.53 | 1.00 | |
| 94_K | 97_A | 1.528 | 1.00 | |
| 123_A | 243_I | 1.526 | 1.00 | |
| 334_Q | 338_D | 1.525 | 1.00 | |
| 272_L | 287_L | 1.521 | 1.00 | |
| 339_I | 342_Q | 1.511 | 1.00 | |
| 39_L | 45_L | 1.507 | 1.00 | |
| 119_A | 271_C | 1.496 | 1.00 | |
| 322_A | 326_I | 1.485 | 1.00 | |
| 232_R | 242_L | 1.483 | 1.00 | |
| 244_A | 260_C | 1.477 | 1.00 | |
| 67_A | 322_A | 1.475 | 1.00 | |
| 276_L | 283_L | 1.458 | 1.00 | |
| 382_F | 423_D | 1.454 | 1.00 | |
| 232_R | 235_C | 1.449 | 1.00 | |
| 62_P | 66_A | 1.446 | 1.00 | |
| 244_A | 265_I | 1.446 | 1.00 | |
| 31_S | 74_A | 1.438 | 1.00 | |
| 35_C | 409_Q | 1.434 | 1.00 | |
| 256_K | 261_E | 1.43 | 1.00 | |
| 99_T | 287_L | 1.428 | 1.00 | |
| 386_Q | 420_A | 1.427 | 1.00 | |
| 383_F | 390_I | 1.426 | 1.00 | |
| 35_C | 404_I | 1.412 | 1.00 | |
| 154_V | 172_N | 1.411 | 1.00 | |
| 339_I | 407_P | 1.407 | 0.99 | |
| 353_A | 422_Q | 1.407 | 0.99 | |
| 210_I | 228_L | 1.401 | 0.99 | |
| 60_N | 65_N | 1.401 | 0.99 | |
| 61_H | 330_G | 1.4 | 0.99 | |
| 118_V | 286_T | 1.398 | 0.99 | |
| 90_E | 325_A | 1.396 | 0.99 | |
| 136_R | 173_L | 1.387 | 0.99 | |
| 382_F | 420_A | 1.386 | 0.99 | |
| 350_A | 414_T | 1.379 | 0.99 | |
| 68_M | 315_L | 1.376 | 0.99 | |
| 33_E | 44_R | 1.373 | 0.99 | |
| 283_L | 317_C | 1.364 | 0.99 | |
| 98_M | 328_E | 1.36 | 0.99 | |
| 352_D | 418_N | 1.359 | 0.99 | |
| 269_I | 288_T | 1.357 | 0.99 | |
| 96_V | 106_V | 1.355 | 0.99 | |
| 208_V | 231_I | 1.355 | 0.99 | |
| 405_I | 410_L | 1.354 | 0.99 | |
| 138_L | 205_I | 1.352 | 0.99 | |
| 407_P | 411_Q | 1.35 | 0.99 | |
| 196_R | 200_A | 1.349 | 0.99 | |
| 226_E | 263_A | 1.347 | 0.99 | |
| 231_I | 242_L | 1.342 | 0.99 | |
| 195_A | 230_R | 1.339 | 0.99 | |
| 120_M | 137_F | 1.33 | 0.99 | |
| 33_E | 60_N | 1.329 | 0.99 | |
| 105_C | 294_E | 1.321 | 0.99 | |
| 134_R | 239_G | 1.32 | 0.99 | |
| 321_N | 325_A | 1.317 | 0.99 | |
| 106_V | 287_L | 1.311 | 0.99 | |
| 192_V | 196_R | 1.308 | 0.99 | |
| 346_Q | 418_N | 1.308 | 0.99 | |
| 342_Q | 346_Q | 1.305 | 0.99 | |
| 36_E | 46_V | 1.304 | 0.99 | |
| 229_K | 233_K | 1.302 | 0.99 | |
| 344_R | 361_V | 1.284 | 0.99 | |
| 344_R | 366_G | 1.283 | 0.99 | |
| 70_S | 73_D | 1.28 | 0.99 | |
| 283_L | 320_A | 1.279 | 0.99 | |
| 260_C | 270_L | 1.278 | 0.99 | |
| 116_V | 209_I | 1.274 | 0.99 | |
| 418_N | 422_Q | 1.272 | 0.99 | |
| 69_K | 72_I | 1.262 | 0.99 | |
| 57_H | 326_I | 1.257 | 0.99 | |
| 97_A | 328_E | 1.249 | 0.99 | |
| 241_L | 292_V | 1.247 | 0.99 | |
| 266_A | 289_T | 1.243 | 0.98 | |
| 257_L | 261_E | 1.238 | 0.98 | |
| 325_A | 329_S | 1.236 | 0.98 | |
| 139_T | 174_F | 1.224 | 0.98 | |
| 383_F | 388_V | 1.221 | 0.98 | |
| 386_Q | 416_A | 1.221 | 0.98 | |
| 154_V | 209_I | 1.22 | 0.98 | |
| 415_A | 419_R | 1.214 | 0.98 | |
| 276_L | 285_A | 1.2 | 0.98 | |
| 409_Q | 412_R | 1.188 | 0.98 | |
| 141_R | 176_P | 1.182 | 0.98 | |
| 30_V | 42_G | 1.18 | 0.98 | |
| 65_N | 72_I | 1.174 | 0.98 | |
| 195_A | 238_E | 1.174 | 0.98 | |
| 191_M | 234_I | 1.172 | 0.98 | |
| 65_N | 73_D | 1.165 | 0.97 | |
| 137_F | 207_A | 1.161 | 0.97 | |
| 383_F | 420_A | 1.159 | 0.97 | |
| 345_E | 349_P | 1.159 | 0.97 | |
| 175_A | 197_L | 1.156 | 0.97 | |
| 411_Q | 415_A | 1.156 | 0.97 | |
| 233_K | 236_D | 1.155 | 0.97 | |
| 333_Q | 336_V | 1.154 | 0.97 | |
| 263_A | 362_L | 1.147 | 0.97 | |
| 252_G | 333_Q | 1.144 | 0.97 | |
| 199_A | 238_E | 1.134 | 0.97 | |
| 327_L | 332_W | 1.13 | 0.97 | |
| 327_L | 333_Q | 1.128 | 0.97 | |
| 281_M | 316_A | 1.124 | 0.97 | |
| 108_L | 317_C | 1.123 | 0.97 | |
| 255_G | 261_E | 1.118 | 0.96 | |
| 269_I | 286_T | 1.111 | 0.96 | |
| 383_F | 416_A | 1.11 | 0.96 | |
| 113_S | 151_A | 1.101 | 0.96 | |
| 412_R | 415_A | 1.096 | 0.96 | |
| 262_H | 362_L | 1.093 | 0.96 | |
| 64_L | 319_A | 1.089 | 0.96 | |
| 348_A | 351_R | 1.085 | 0.96 | |
| 109_A | 286_T | 1.077 | 0.95 | |
| 153_S | 169_L | 1.068 | 0.95 | |
| 388_V | 413_L | 1.062 | 0.95 | |
| 234_I | 238_E | 1.06 | 0.95 | |
| 195_A | 233_K | 1.06 | 0.95 | |
| 198_M | 205_I | 1.059 | 0.95 | |
| 229_K | 264_E | 1.056 | 0.95 | |
| 195_A | 234_I | 1.055 | 0.95 | |
| 91_L | 321_N | 1.053 | 0.95 | |
| 278_G | 323_S | 1.051 | 0.94 | |
| 98_M | 257_L | 1.05 | 0.94 | |
| 120_M | 154_V | 1.049 | 0.94 | |
| 115_A | 271_C | 1.047 | 0.94 | |
| 113_S | 148_T | 1.045 | 0.94 | |
| 408_Q | 411_Q | 1.04 | 0.94 | |
| 251_F | 327_L | 1.039 | 0.94 | |
| 57_H | 323_S | 1.037 | 0.94 | |
| 337_A | 341_V | 1.036 | 0.94 | |
| 35_C | 46_V | 1.036 | 0.94 | |
| 258_F | 272_L | 1.035 | 0.94 | |
| 126_Y | 295_T | 1.031 | 0.94 | |
| 350_A | 418_N | 1.028 | 0.94 | |
| 358_D | 369_E | 1.027 | 0.94 | |
| 29_V | 32_A | 1.02 | 0.93 | |
| 326_I | 329_S | 1.01 | 0.93 | |
| 378_A | 382_F | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 4a0gA | 4 | 0.993 | 100 | 0.319 | Contact Map | 0.581 |
| 3tfuA | 2 | 0.986 | 100 | 0.357 | Contact Map | 0.713 |
| 4e3qA | 4 | 0.993 | 100 | 0.398 | Contact Map | 0.786 |
| 3hmuA | 2 | 0.986 | 100 | 0.399 | Contact Map | 0.813 |
| 3i5tA | 2 | 0.9953 | 100 | 0.413 | Contact Map | 0.75 |
| 3oksA | 4 | 0.951 | 100 | 0.421 | Contact Map | 0.737 |
| 4atqA | 12 | 0.9487 | 100 | 0.424 | Contact Map | 0.724 |
| 2epjA | 1 | 0.9394 | 100 | 0.424 | Contact Map | 0.697 |
| 4ffcA | 4 | 0.9557 | 100 | 0.425 | Contact Map | 0.66 |
| 1sffA | 4 | 0.9534 | 100 | 0.434 | Contact Map | 0.768 |
Sequence Conservation (Image Generated using WebLogo v3)