| UniProt: | P77569 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG20276 | ||
| Length: | 277 (253) | ||
| Sequences: | 5146 | ||
| Seq/Len: | 20.34 |
| MHPR
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 15_L | 18_G | 3.349 | 1.00 | |
| 96_L | 252_V | 3.112 | 1.00 | |
| 111_S | 148_S | 2.616 | 1.00 | |
| 106_W | 235_A | 2.571 | 1.00 | |
| 19_L | 60_Y | 2.561 | 1.00 | |
| 103_E | 248_A | 2.517 | 1.00 | |
| 16_T | 58_E | 2.455 | 1.00 | |
| 162_K | 186_E | 2.437 | 1.00 | |
| 117_A | 140_R | 2.372 | 1.00 | |
| 23_N | 75_K | 2.364 | 1.00 | |
| 191_R | 195_E | 2.352 | 1.00 | |
| 25_L | 61_V | 2.352 | 1.00 | |
| 150_L | 203_G | 2.328 | 1.00 | |
| 215_V | 249_L | 2.171 | 1.00 | |
| 94_A | 122_E | 2.159 | 1.00 | |
| 150_L | 188_I | 2.079 | 1.00 | |
| 113_L | 143_L | 2.057 | 1.00 | |
| 20_M | 58_E | 2.044 | 1.00 | |
| 200_N | 212_S | 2.037 | 1.00 | |
| 52_L | 61_V | 1.971 | 1.00 | |
| 21_L | 37_L | 1.949 | 1.00 | |
| 201_Y | 211_A | 1.939 | 1.00 | |
| 24_M | 41_S | 1.876 | 1.00 | |
| 240_Q | 244_K | 1.844 | 1.00 | |
| 99_D | 255_Q | 1.809 | 1.00 | |
| 99_D | 103_E | 1.776 | 1.00 | |
| 37_L | 48_V | 1.772 | 1.00 | |
| 24_M | 37_L | 1.757 | 1.00 | |
| 156_C | 160_D | 1.745 | 1.00 | |
| 211_A | 233_A | 1.744 | 1.00 | |
| 229_L | 245_H | 1.74 | 1.00 | |
| 101_L | 108_T | 1.729 | 1.00 | |
| 96_L | 255_Q | 1.718 | 1.00 | |
| 23_N | 58_E | 1.716 | 1.00 | |
| 155_F | 218_R | 1.715 | 1.00 | |
| 32_A | 40_L | 1.664 | 1.00 | |
| 125_H | 131_S | 1.659 | 1.00 | |
| 118_M | 143_L | 1.641 | 1.00 | |
| 231_Y | 236_M | 1.64 | 1.00 | |
| 96_L | 259_G | 1.595 | 1.00 | |
| 56_Q | 61_V | 1.576 | 1.00 | |
| 33_S | 36_L | 1.566 | 1.00 | |
| 246_L | 250_Q | 1.564 | 1.00 | |
| 215_V | 253_A | 1.551 | 1.00 | |
| 64_S | 67_D | 1.55 | 1.00 | |
| 202_R | 233_A | 1.541 | 1.00 | |
| 23_N | 60_Y | 1.538 | 1.00 | |
| 98_G | 124_T | 1.534 | 1.00 | |
| 62_R | 71_R | 1.529 | 1.00 | |
| 161_R | 186_E | 1.526 | 1.00 | |
| 97_L | 108_T | 1.524 | 1.00 | |
| 25_L | 32_A | 1.516 | 1.00 | |
| 145_K | 178_L | 1.438 | 1.00 | |
| 93_A | 256_I | 1.434 | 1.00 | |
| 114_D | 140_R | 1.43 | 1.00 | |
| 181_E | 184_K | 1.43 | 1.00 | |
| 202_R | 209_K | 1.427 | 1.00 | |
| 100_L | 252_V | 1.427 | 1.00 | |
| 155_F | 216_P | 1.418 | 1.00 | |
| 34_V | 49_R | 1.416 | 1.00 | |
| 144_L | 178_L | 1.41 | 1.00 | |
| 24_M | 32_A | 1.388 | 0.99 | |
| 175_D | 178_L | 1.375 | 0.99 | |
| 188_I | 191_R | 1.367 | 0.99 | |
| 250_Q | 254_K | 1.364 | 0.99 | |
| 90_S | 122_E | 1.358 | 0.99 | |
| 157_P | 160_D | 1.346 | 0.99 | |
| 154_A | 192_A | 1.332 | 0.99 | |
| 189_L | 192_A | 1.332 | 0.99 | |
| 215_V | 250_Q | 1.315 | 0.99 | |
| 19_L | 58_E | 1.312 | 0.99 | |
| 118_M | 152_W | 1.309 | 0.99 | |
| 31_G | 71_R | 1.308 | 0.99 | |
| 192_A | 195_E | 1.306 | 0.99 | |
| 25_L | 31_G | 1.303 | 0.99 | |
| 110_V | 225_G | 1.301 | 0.99 | |
| 116_D | 167_M | 1.291 | 0.99 | |
| 153_L | 185_L | 1.288 | 0.99 | |
| 158_E | 190_A | 1.287 | 0.99 | |
| 218_R | 223_V | 1.279 | 0.99 | |
| 218_R | 257_E | 1.279 | 0.99 | |
| 113_L | 116_D | 1.274 | 0.99 | |
| 197_Y | 246_L | 1.272 | 0.99 | |
| 37_L | 52_L | 1.272 | 0.99 | |
| 101_L | 124_T | 1.267 | 0.99 | |
| 97_L | 227_L | 1.266 | 0.99 | |
| 251_R | 255_Q | 1.264 | 0.99 | |
| 52_L | 70_F | 1.263 | 0.99 | |
| 49_R | 53_E | 1.261 | 0.99 | |
| 253_A | 257_E | 1.26 | 0.99 | |
| 104_V | 248_A | 1.257 | 0.99 | |
| 93_A | 110_V | 1.255 | 0.99 | |
| 215_V | 246_L | 1.247 | 0.99 | |
| 146_T | 149_G | 1.246 | 0.98 | |
| 111_S | 118_M | 1.246 | 0.98 | |
| 96_L | 99_D | 1.245 | 0.98 | |
| 38_A | 48_V | 1.243 | 0.98 | |
| 182_P | 186_E | 1.242 | 0.98 | |
| 110_V | 217_L | 1.236 | 0.98 | |
| 192_A | 198_G | 1.221 | 0.98 | |
| 97_L | 110_V | 1.217 | 0.98 | |
| 161_R | 193_R | 1.209 | 0.98 | |
| 13_R | 17_R | 1.199 | 0.98 | |
| 75_K | 78_Q | 1.184 | 0.98 | |
| 44_H | 47_T | 1.183 | 0.98 | |
| 24_M | 40_L | 1.182 | 0.98 | |
| 100_L | 248_A | 1.181 | 0.98 | |
| 21_L | 41_S | 1.178 | 0.98 | |
| 43_L | 48_V | 1.171 | 0.98 | |
| 43_L | 47_T | 1.17 | 0.97 | |
| 257_E | 262_S | 1.149 | 0.97 | |
| 227_L | 256_I | 1.148 | 0.97 | |
| 216_P | 223_V | 1.148 | 0.97 | |
| 232_M | 235_A | 1.143 | 0.97 | |
| 94_A | 98_G | 1.134 | 0.97 | |
| 213_I | 246_L | 1.131 | 0.97 | |
| 214_A | 228_N | 1.12 | 0.96 | |
| 147_A | 214_A | 1.109 | 0.96 | |
| 179_A | 188_I | 1.102 | 0.96 | |
| 104_V | 229_L | 1.102 | 0.96 | |
| 162_K | 182_P | 1.099 | 0.96 | |
| 219_S | 222_R | 1.09 | 0.96 | |
| 202_R | 208_E | 1.085 | 0.96 | |
| 166_E | 182_P | 1.077 | 0.95 | |
| 152_W | 225_G | 1.071 | 0.95 | |
| 188_I | 192_A | 1.07 | 0.95 | |
| 76_V | 83_F | 1.069 | 0.95 | |
| 104_V | 245_H | 1.067 | 0.95 | |
| 158_E | 186_E | 1.06 | 0.95 | |
| 103_E | 251_R | 1.054 | 0.95 | |
| 155_F | 223_V | 1.046 | 0.94 | |
| 212_S | 228_N | 1.043 | 0.94 | |
| 41_S | 48_V | 1.038 | 0.94 | |
| 12_V | 54_T | 1.035 | 0.94 | |
| 28_L | 40_L | 1.033 | 0.94 | |
| 119_V | 140_R | 1.03 | 0.94 | |
| 22_L | 76_V | 1.028 | 0.94 | |
| 109_D | 134_R | 1.028 | 0.94 | |
| 177_Q | 202_R | 1.026 | 0.94 | |
| 35_G | 39_E | 1.026 | 0.94 | |
| 162_K | 166_E | 1.018 | 0.93 | |
| 96_L | 256_I | 1.012 | 0.93 | |
| 56_Q | 63_R | 1.008 | 0.93 | |
| 147_A | 212_S | 1.003 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2ia2A | 4 | 0.935 | 100 | 0.162 | Contact Map | 0.833 |
| 2g7uA | 4 | 0.9206 | 100 | 0.169 | Contact Map | 0.803 |
| 3mq0A | 2 | 0.9386 | 100 | 0.171 | Contact Map | 0.751 |
| 1mkmA | 2 | 0.8953 | 100 | 0.181 | Contact Map | 0.876 |
| 3r4kA | 4 | 0.9278 | 100 | 0.183 | Contact Map | 0.79 |
| 2xrnA | 2 | 0.8664 | 100 | 0.198 | Contact Map | 0.754 |
| 2o0yA | 4 | 0.9097 | 100 | 0.217 | Contact Map | 0.787 |
| 1ysqA | 1 | 0.6823 | 100 | 0.453 | Contact Map | 0.822 |
| 1tf1A | 4 | 0.7112 | 100 | 0.461 | Contact Map | 0.87 |
| 3obfA | 2 | 0.6318 | 100 | 0.462 | Contact Map | 0.729 |
Sequence Conservation (Image Generated using WebLogo v3)