| UniProt: | P37671 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12278 | ||
| Length: | 282 (253) | ||
| Sequences: | 5062 | ||
| Seq/Len: | 20.01 |
| YIAJ
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 26_L | 29_G | 3.269 | 1.00 | |
| 107_H | 262_T | 3.033 | 1.00 | |
| 117_E | 246_R | 2.572 | 1.00 | |
| 122_S | 159_M | 2.562 | 1.00 | |
| 30_L | 71_Y | 2.561 | 1.00 | |
| 27_F | 69_C | 2.456 | 1.00 | |
| 114_A | 258_P | 2.426 | 1.00 | |
| 173_K | 198_F | 2.412 | 1.00 | |
| 34_E | 86_K | 2.369 | 1.00 | |
| 203_H | 207_S | 2.335 | 1.00 | |
| 128_H | 151_H | 2.328 | 1.00 | |
| 36_L | 72_V | 2.305 | 1.00 | |
| 161_K | 215_E | 2.282 | 1.00 | |
| 105_A | 133_Y | 2.17 | 1.00 | |
| 225_V | 259_L | 2.158 | 1.00 | |
| 124_R | 154_L | 2.078 | 1.00 | |
| 251_G | 254_N | 2.054 | 1.00 | |
| 161_K | 200_E | 2.047 | 1.00 | |
| 212_D | 222_C | 2.042 | 1.00 | |
| 31_M | 69_C | 2.017 | 1.00 | |
| 63_L | 72_V | 1.951 | 1.00 | |
| 32_L | 48_L | 1.926 | 1.00 | |
| 187_T | 190_T | 1.891 | 1.00 | |
| 213_R | 221_S | 1.884 | 1.00 | |
| 35_I | 52_A | 1.821 | 1.00 | |
| 110_A | 265_A | 1.788 | 1.00 | |
| 35_I | 48_L | 1.783 | 1.00 | |
| 48_L | 59_V | 1.759 | 1.00 | |
| 167_G | 171_Y | 1.749 | 1.00 | |
| 166_F | 228_F | 1.748 | 1.00 | |
| 110_A | 114_A | 1.745 | 1.00 | |
| 221_S | 244_T | 1.742 | 1.00 | |
| 34_E | 69_C | 1.72 | 1.00 | |
| 107_H | 265_A | 1.704 | 1.00 | |
| 242_L | 247_L | 1.698 | 1.00 | |
| 112_N | 119_I | 1.685 | 1.00 | |
| 240_I | 255_L | 1.683 | 1.00 | |
| 136_E | 143_R | 1.666 | 1.00 | |
| 43_C | 51_L | 1.632 | 1.00 | |
| 256_L | 260_R | 1.595 | 1.00 | |
| 129_A | 154_L | 1.592 | 1.00 | |
| 107_H | 269_E | 1.59 | 1.00 | |
| 67_Q | 72_V | 1.558 | 1.00 | |
| 225_V | 263_A | 1.554 | 1.00 | |
| 36_L | 43_C | 1.536 | 1.00 | |
| 44_P | 47_H | 1.532 | 1.00 | |
| 172_V | 198_F | 1.53 | 1.00 | |
| 75_A | 78_A | 1.529 | 1.00 | |
| 214_E | 244_T | 1.527 | 1.00 | |
| 34_E | 71_Y | 1.524 | 1.00 | |
| 109_E | 135_L | 1.518 | 1.00 | |
| 104_A | 266_I | 1.493 | 1.00 | |
| 108_L | 119_I | 1.489 | 1.00 | |
| 73_T | 82_R | 1.481 | 1.00 | |
| 214_E | 219_G | 1.462 | 1.00 | |
| 45_L | 60_H | 1.42 | 1.00 | |
| 125_E | 151_H | 1.404 | 0.99 | |
| 111_L | 262_T | 1.401 | 0.99 | |
| 155_Y | 190_T | 1.401 | 0.99 | |
| 193_E | 196_A | 1.394 | 0.99 | |
| 101_I | 133_Y | 1.394 | 0.99 | |
| 156_C | 190_T | 1.387 | 0.99 | |
| 260_R | 264_Q | 1.367 | 0.99 | |
| 200_E | 203_H | 1.364 | 0.99 | |
| 35_I | 43_C | 1.359 | 0.99 | |
| 127_D | 178_S | 1.355 | 0.99 | |
| 166_F | 226_P | 1.351 | 0.99 | |
| 36_L | 42_G | 1.345 | 0.99 | |
| 267_S | 272_F | 1.329 | 0.99 | |
| 129_A | 163_Y | 1.325 | 0.99 | |
| 201_L | 204_I | 1.315 | 0.99 | |
| 164_M | 197_M | 1.312 | 0.99 | |
| 168_H | 171_Y | 1.309 | 0.99 | |
| 42_G | 82_R | 1.308 | 0.99 | |
| 228_F | 234_V | 1.308 | 0.99 | |
| 115_T | 258_P | 1.306 | 0.99 | |
| 63_L | 81_Y | 1.305 | 0.99 | |
| 121_F | 227_V | 1.302 | 0.99 | |
| 228_F | 267_S | 1.296 | 0.99 | |
| 30_L | 69_C | 1.291 | 0.99 | |
| 263_A | 267_S | 1.291 | 0.99 | |
| 122_S | 129_A | 1.276 | 0.99 | |
| 48_L | 63_L | 1.274 | 0.99 | |
| 124_R | 127_D | 1.271 | 0.99 | |
| 169_P | 202_A | 1.27 | 0.99 | |
| 209_A | 256_L | 1.266 | 0.99 | |
| 104_A | 121_F | 1.265 | 0.99 | |
| 121_F | 236_Y | 1.261 | 0.99 | |
| 261_E | 265_A | 1.255 | 0.99 | |
| 60_H | 64_Q | 1.254 | 0.99 | |
| 165_A | 204_I | 1.252 | 0.99 | |
| 157_S | 160_G | 1.252 | 0.99 | |
| 107_H | 110_A | 1.251 | 0.99 | |
| 225_V | 260_R | 1.249 | 0.99 | |
| 204_I | 207_S | 1.236 | 0.98 | |
| 49_S | 59_V | 1.235 | 0.98 | |
| 108_L | 121_F | 1.235 | 0.98 | |
| 108_L | 238_V | 1.234 | 0.98 | |
| 194_L | 198_F | 1.233 | 0.98 | |
| 204_I | 210_A | 1.232 | 0.98 | |
| 225_V | 256_L | 1.227 | 0.98 | |
| 24_Q | 28_R | 1.226 | 0.98 | |
| 112_N | 135_L | 1.205 | 0.98 | |
| 172_V | 205_R | 1.202 | 0.98 | |
| 111_L | 258_P | 1.179 | 0.98 | |
| 229_D | 233_R | 1.179 | 0.98 | |
| 54_L | 59_V | 1.174 | 0.98 | |
| 35_I | 51_L | 1.157 | 0.97 | |
| 32_L | 52_A | 1.154 | 0.97 | |
| 86_K | 89_A | 1.153 | 0.97 | |
| 105_A | 109_E | 1.15 | 0.97 | |
| 55_N | 58_T | 1.144 | 0.97 | |
| 243_S | 246_R | 1.143 | 0.97 | |
| 54_L | 58_T | 1.142 | 0.97 | |
| 191_I | 200_E | 1.14 | 0.97 | |
| 173_K | 194_L | 1.126 | 0.97 | |
| 223_I | 256_L | 1.12 | 0.96 | |
| 115_T | 255_L | 1.104 | 0.96 | |
| 115_T | 240_I | 1.104 | 0.96 | |
| 224_A | 239_S | 1.098 | 0.96 | |
| 200_E | 204_I | 1.097 | 0.96 | |
| 156_C | 186_L | 1.091 | 0.96 | |
| 226_P | 234_V | 1.084 | 0.96 | |
| 123_S | 236_Y | 1.073 | 0.95 | |
| 169_P | 198_F | 1.07 | 0.95 | |
| 158_A | 224_A | 1.068 | 0.95 | |
| 114_A | 261_E | 1.062 | 0.95 | |
| 87_F | 94_A | 1.052 | 0.95 | |
| 189_N | 214_E | 1.05 | 0.94 | |
| 238_V | 266_I | 1.047 | 0.94 | |
| 222_C | 239_S | 1.046 | 0.94 | |
| 214_E | 218_L | 1.046 | 0.94 | |
| 185_P | 192_T | 1.039 | 0.94 | |
| 23_S | 65_G | 1.027 | 0.94 | |
| 39_Y | 51_L | 1.027 | 0.94 | |
| 107_H | 266_I | 1.023 | 0.93 | |
| 120_N | 146_A | 1.022 | 0.93 | |
| 163_Y | 236_Y | 1.02 | 0.93 | |
| 46_A | 56_K | 1.016 | 0.93 | |
| 158_A | 222_C | 1.008 | 0.93 | |
| 166_F | 234_V | 1.007 | 0.93 | |
| 46_A | 50_E | 1.004 | 0.93 | |
| 33_I | 87_F | 1.003 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2ia2A | 4 | 0.9326 | 100 | 0.19 | Contact Map | 0.842 |
| 3mq0A | 2 | 0.961 | 100 | 0.191 | Contact Map | 0.751 |
| 2g7uA | 4 | 0.9078 | 100 | 0.197 | Contact Map | 0.807 |
| 3r4kA | 4 | 0.9113 | 100 | 0.208 | Contact Map | 0.795 |
| 1mkmA | 2 | 0.883 | 100 | 0.209 | Contact Map | 0.884 |
| 2xrnA | 2 | 0.8546 | 100 | 0.225 | Contact Map | 0.764 |
| 2o0yA | 4 | 0.9184 | 100 | 0.246 | Contact Map | 0.787 |
| 1ysqA | 1 | 0.6773 | 100 | 0.45 | Contact Map | 0.831 |
| 1tf1A | 4 | 0.7021 | 100 | 0.473 | Contact Map | 0.876 |
| 3obfA | 2 | 0.6241 | 100 | 0.476 | Contact Map | 0.725 |
Sequence Conservation (Image Generated using WebLogo v3)