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OPENSEQ.org
ICLR - Acetate operon repressor
UniProt: P16528 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG10491
Length: 274 (249)
Sequences: 5152
Seq/Len: 20.69
ICLR
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs
Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
27_L 30_G 3.276 1.00
108_I 262_A 3.044 1.00
123_A 161_A 2.555 1.00
31_L 72_F 2.526 1.00
118_E 246_R 2.502 1.00
28_T 70_Q 2.424 1.00
115_E 258_M 2.402 1.00
175_T 198_K 2.395 1.00
35_E 87_H 2.371 1.00
203_Q 207_R 2.361 1.00
131_E 153_K 2.312 1.00
163_K 215_E 2.27 1.00
37_I 73_V 2.253 1.00
106_H 136_D 2.146 1.00
225_A 259_V 2.142 1.00
163_K 200_D 2.046 1.00
125_L 156_M 2.011 1.00
251_R 254_E 2.008 1.00
32_K 70_Q 2.004 1.00
212_D 222_C 1.999 1.00
64_L 73_V 1.956 1.00
33_L 49_L 1.949 1.00
213_D 221_R 1.915 1.00
36_W 53_A 1.842 1.00
187_T 190_T 1.801 1.00
111_N 265_E 1.785 1.00
36_W 49_L 1.738 1.00
169_L 173_Q 1.731 1.00
49_L 60_T 1.727 1.00
113_M 120_V 1.726 1.00
221_R 244_I 1.726 1.00
111_N 115_E 1.722 1.00
168_Q 228_F 1.685 1.00
35_E 70_Q 1.681 1.00
242_G 247_I 1.681 1.00
108_I 265_E 1.679 1.00
240_I 255_F 1.668 1.00
139_Q 145_R 1.628 1.00
108_I 269_A 1.618 1.00
44_V 52_Q 1.603 1.00
132_A 156_M 1.6 1.00
68_Q 73_V 1.579 1.00
110_R 138_V 1.546 1.00
45_A 48_E 1.532 1.00
174_V 198_K 1.526 1.00
76_V 79_L 1.522 1.00
35_E 72_F 1.513 1.00
225_A 263_A 1.511 1.00
37_I 44_V 1.508 1.00
256_G 260_I 1.503 1.00
214_E 244_I 1.495 1.00
109_L 120_V 1.472 1.00
267_T 272_G 1.439 1.00
214_E 219_G 1.426 1.00
193_S 196_H 1.42 1.00
74_R 83_A 1.415 1.00
105_V 266_V 1.412 1.00
157_H 190_T 1.407 0.99
102_L 136_D 1.407 0.99
46_L 61_H 1.406 0.99
112_L 262_A 1.397 0.99
168_Q 226_C 1.392 0.99
260_I 264_K 1.383 0.99
158_A 190_T 1.378 0.99
200_D 203_Q 1.363 0.99
170_S 173_Q 1.345 0.99
36_W 44_V 1.341 0.99
132_A 165_F 1.329 0.99
37_I 43_S 1.319 0.99
122_M 236_A 1.303 0.99
167_A 204_T 1.296 0.99
171_E 202_A 1.295 0.99
228_F 234_P 1.287 0.99
166_L 197_L 1.287 0.99
122_M 227_I 1.285 0.99
64_L 82_W 1.281 0.99
201_L 204_T 1.28 0.99
61_H 65_T 1.28 0.99
126_D 153_K 1.278 0.99
225_A 260_I 1.278 0.99
228_F 267_T 1.277 0.99
109_L 122_M 1.276 0.99
109_L 238_I 1.276 0.99
31_L 70_Q 1.27 0.99
130_H 180_R 1.266 0.99
204_T 207_R 1.257 0.99
116_S 258_M 1.256 0.99
159_S 162_G 1.254 0.99
194_P 198_K 1.248 0.99
49_L 64_L 1.244 0.98
108_I 111_N 1.242 0.98
123_A 132_A 1.236 0.98
105_V 122_M 1.236 0.98
225_A 256_G 1.229 0.98
50_A 60_T 1.22 0.98
113_M 138_V 1.218 0.98
261_K 265_E 1.213 0.98
112_L 258_M 1.209 0.98
263_A 267_T 1.2 0.98
209_Y 256_G 1.197 0.98
25_Q 29_R 1.188 0.98
43_S 83_A 1.188 0.98
56_P 59_T 1.185 0.98
204_T 210_S 1.184 0.98
229_D 233_E 1.182 0.98
55_L 60_T 1.179 0.98
36_W 52_Q 1.175 0.98
87_H 90_M 1.166 0.97
191_L 200_D 1.163 0.97
55_L 59_T 1.16 0.97
106_H 110_R 1.14 0.97
174_V 205_R 1.125 0.97
33_L 53_A 1.122 0.97
226_C 234_P 1.122 0.97
116_S 240_I 1.118 0.96
175_T 194_P 1.112 0.96
243_P 246_R 1.109 0.96
224_A 239_S 1.101 0.96
238_I 266_V 1.09 0.96
200_D 204_T 1.086 0.96
115_E 261_K 1.081 0.95
125_L 130_H 1.078 0.95
160_G 224_A 1.078 0.95
88_A 95_F 1.075 0.95
223_L 256_G 1.068 0.95
116_S 255_F 1.068 0.95
222_C 239_S 1.065 0.95
158_A 186_Y 1.056 0.95
185_A 192_V 1.048 0.94
40_S 52_Q 1.044 0.94
214_E 218_L 1.042 0.94
47_T 51_Q 1.041 0.94
34_L 88_A 1.034 0.94
189_A 214_E 1.028 0.94
222_C 241_S 1.026 0.94
68_Q 75_Q 1.022 0.93
133_I 153_K 1.01 0.93
171_E 198_K 1.007 0.93
168_Q 234_P 1.006 0.93
24_V 66_T 1.002 0.92
53_A 60_T 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
2ia2A40.95991000.173Contact Map0.841
3mq0A20.98181000.174Contact Map0.754
2g7uA40.93431000.174Contact Map0.811
3r4kA40.90881000.183Contact Map0.794
1mkmA20.90881000.184Contact Map0.88
2xrnA20.87961000.204Contact Map0.755
2o0yA40.9381000.228Contact Map0.786
1ysqA10.66061000.453Contact Map0.828
1tf1A40.71531000.457Contact Map0.879
1yspA10.64231000.459Contact Map0.895
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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