| UniProt: | P76268 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG14018 | ||
| Length: | 263 (251) | ||
| Sequences: | 5254 | ||
| Seq/Len: | 20.93 |
| KDGR
Paralog alert: 0.70 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: ALLR ICLR KDGR MHPR RHMR YAGI YIAJ YJHI |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 16_V | 19_V | 3.295 | 1.00 | |
| 96_Q | 248_A | 3.096 | 1.00 | |
| 111_G | 147_I | 2.549 | 1.00 | |
| 106_E | 232_R | 2.515 | 1.00 | |
| 20_F | 60_Y | 2.504 | 1.00 | |
| 103_L | 244_M | 2.488 | 1.00 | |
| 17_L | 58_L | 2.436 | 1.00 | |
| 161_K | 184_L | 2.389 | 1.00 | |
| 24_Q | 75_K | 2.363 | 1.00 | |
| 149_K | 201_E | 2.328 | 1.00 | |
| 189_Q | 193_Q | 2.324 | 1.00 | |
| 117_S | 139_R | 2.321 | 1.00 | |
| 26_L | 61_V | 2.288 | 1.00 | |
| 211_V | 245_L | 2.146 | 1.00 | |
| 94_D | 122_H | 2.103 | 1.00 | |
| 198_D | 208_C | 2.046 | 1.00 | |
| 113_L | 142_L | 2.044 | 1.00 | |
| 149_K | 186_V | 2.028 | 1.00 | |
| 21_G | 58_L | 2.001 | 1.00 | |
| 52_L | 61_V | 1.947 | 1.00 | |
| 22_I | 37_L | 1.947 | 1.00 | |
| 199_N | 207_R | 1.925 | 1.00 | |
| 173_T | 176_T | 1.858 | 1.00 | |
| 25_A | 41_V | 1.845 | 1.00 | |
| 99_E | 103_L | 1.802 | 1.00 | |
| 99_E | 251_K | 1.776 | 1.00 | |
| 207_R | 230_T | 1.773 | 1.00 | |
| 25_A | 37_L | 1.749 | 1.00 | |
| 237_R | 240_E | 1.747 | 1.00 | |
| 155_R | 159_E | 1.738 | 1.00 | |
| 37_L | 48_V | 1.734 | 1.00 | |
| 96_Q | 251_K | 1.733 | 1.00 | |
| 101_S | 108_I | 1.732 | 1.00 | |
| 226_I | 241_Y | 1.729 | 1.00 | |
| 154_W | 214_F | 1.717 | 1.00 | |
| 24_Q | 58_L | 1.712 | 1.00 | |
| 32_I | 40_R | 1.646 | 1.00 | |
| 118_I | 142_L | 1.633 | 1.00 | |
| 64_E | 67_S | 1.603 | 1.00 | |
| 228_F | 233_F | 1.599 | 1.00 | |
| 96_Q | 255_Q | 1.597 | 1.00 | |
| 26_L | 32_I | 1.592 | 1.00 | |
| 98_R | 124_I | 1.591 | 1.00 | |
| 242_V | 246_H | 1.585 | 1.00 | |
| 125_D | 131_R | 1.576 | 1.00 | |
| 24_Q | 60_Y | 1.549 | 1.00 | |
| 56_K | 61_V | 1.543 | 1.00 | |
| 160_V | 184_L | 1.525 | 1.00 | |
| 33_G | 36_E | 1.501 | 1.00 | |
| 211_V | 249_A | 1.499 | 1.00 | |
| 200_E | 230_T | 1.498 | 1.00 | |
| 97_M | 108_I | 1.489 | 1.00 | |
| 62_A | 71_S | 1.446 | 1.00 | |
| 93_A | 252_I | 1.435 | 1.00 | |
| 114_D | 139_R | 1.434 | 1.00 | |
| 200_E | 205_G | 1.425 | 1.00 | |
| 143_Y | 176_T | 1.412 | 1.00 | |
| 154_W | 212_P | 1.403 | 0.99 | |
| 100_L | 248_A | 1.402 | 0.99 | |
| 34_I | 49_Y | 1.392 | 0.99 | |
| 246_H | 250_R | 1.385 | 0.99 | |
| 90_I | 122_H | 1.377 | 0.99 | |
| 186_V | 189_Q | 1.373 | 0.99 | |
| 144_S | 176_T | 1.369 | 0.99 | |
| 25_A | 32_I | 1.367 | 0.99 | |
| 153_A | 190_V | 1.362 | 0.99 | |
| 179_S | 182_A | 1.359 | 0.99 | |
| 253_S | 258_Y | 1.342 | 0.99 | |
| 118_I | 151_L | 1.327 | 0.99 | |
| 52_L | 70_Y | 1.315 | 0.99 | |
| 214_F | 220_V | 1.305 | 0.99 | |
| 156_D | 159_E | 1.304 | 0.99 | |
| 20_F | 58_L | 1.303 | 0.99 | |
| 214_F | 253_S | 1.295 | 0.99 | |
| 187_L | 190_V | 1.289 | 0.99 | |
| 26_L | 31_E | 1.289 | 0.99 | |
| 96_Q | 99_E | 1.287 | 0.99 | |
| 211_V | 246_H | 1.286 | 0.99 | |
| 110_L | 213_V | 1.282 | 0.99 | |
| 195_Y | 242_V | 1.282 | 0.99 | |
| 113_L | 116_D | 1.279 | 0.99 | |
| 97_M | 110_L | 1.276 | 0.99 | |
| 110_L | 222_A | 1.276 | 0.99 | |
| 152_L | 183_L | 1.272 | 0.99 | |
| 180_T | 184_L | 1.272 | 0.99 | |
| 116_D | 166_G | 1.269 | 0.99 | |
| 31_E | 71_S | 1.267 | 0.99 | |
| 111_G | 118_I | 1.263 | 0.99 | |
| 145_T | 148_G | 1.263 | 0.99 | |
| 190_V | 193_Q | 1.258 | 0.99 | |
| 93_A | 110_L | 1.258 | 0.99 | |
| 157_R | 188_D | 1.251 | 0.99 | |
| 44_S | 47_T | 1.251 | 0.99 | |
| 104_T | 244_M | 1.25 | 0.99 | |
| 49_Y | 53_Q | 1.248 | 0.99 | |
| 37_L | 52_L | 1.239 | 0.98 | |
| 97_M | 224_L | 1.229 | 0.98 | |
| 247_T | 251_K | 1.227 | 0.98 | |
| 190_V | 196_G | 1.216 | 0.98 | |
| 211_V | 242_V | 1.211 | 0.98 | |
| 14_S | 18_K | 1.208 | 0.98 | |
| 101_S | 124_I | 1.206 | 0.98 | |
| 215_D | 219_V | 1.203 | 0.98 | |
| 38_S | 48_V | 1.197 | 0.98 | |
| 25_A | 40_R | 1.196 | 0.98 | |
| 75_K | 78_E | 1.192 | 0.98 | |
| 249_A | 253_S | 1.189 | 0.98 | |
| 100_L | 244_M | 1.184 | 0.98 | |
| 43_M | 47_T | 1.174 | 0.98 | |
| 229_P | 232_R | 1.168 | 0.97 | |
| 43_M | 48_V | 1.167 | 0.97 | |
| 160_V | 191_R | 1.165 | 0.97 | |
| 104_T | 226_I | 1.148 | 0.97 | |
| 212_P | 220_V | 1.128 | 0.97 | |
| 161_K | 180_T | 1.117 | 0.96 | |
| 209_I | 242_V | 1.116 | 0.96 | |
| 94_D | 98_R | 1.116 | 0.96 | |
| 76_L | 83_A | 1.115 | 0.96 | |
| 22_I | 41_V | 1.103 | 0.96 | |
| 186_V | 190_V | 1.102 | 0.96 | |
| 146_A | 210_A | 1.1 | 0.96 | |
| 177_I | 186_V | 1.099 | 0.96 | |
| 35_T | 39_Q | 1.089 | 0.96 | |
| 144_S | 172_S | 1.085 | 0.96 | |
| 175_R | 200_E | 1.081 | 0.95 | |
| 103_L | 247_T | 1.08 | 0.95 | |
| 224_L | 252_I | 1.079 | 0.95 | |
| 208_C | 225_S | 1.078 | 0.95 | |
| 200_E | 204_E | 1.075 | 0.95 | |
| 104_T | 241_Y | 1.072 | 0.95 | |
| 210_A | 225_S | 1.067 | 0.95 | |
| 171_R | 178_T | 1.049 | 0.94 | |
| 35_T | 45_K | 1.026 | 0.94 | |
| 119_V | 139_R | 1.024 | 0.93 | |
| 56_K | 63_Q | 1.022 | 0.93 | |
| 23_L | 76_L | 1.019 | 0.93 | |
| 157_R | 184_L | 1.011 | 0.93 | |
| 208_C | 227_S | 1.01 | 0.93 | |
| 146_A | 208_C | 1.008 | 0.93 | |
| 96_Q | 252_I | 1.005 | 0.93 | |
| 41_V | 48_V | 1.001 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3mq0A | 2 | 0.9924 | 100 | 0.098 | Contact Map | 0.753 |
| 2g7uA | 4 | 0.9658 | 100 | 0.103 | Contact Map | 0.815 |
| 2ia2A | 4 | 0.9848 | 100 | 0.109 | Contact Map | 0.845 |
| 1mkmA | 2 | 0.943 | 100 | 0.115 | Contact Map | 0.888 |
| 3r4kA | 4 | 0.9544 | 100 | 0.116 | Contact Map | 0.802 |
| 2xrnA | 2 | 0.9125 | 100 | 0.138 | Contact Map | 0.755 |
| 2o0yA | 4 | 0.962 | 100 | 0.157 | Contact Map | 0.787 |
| 1yspA | 1 | 0.6806 | 100 | 0.402 | Contact Map | 0.895 |
| 1tf1A | 4 | 0.7529 | 100 | 0.409 | Contact Map | 0.882 |
| 1ysqA | 1 | 0.6958 | 100 | 0.411 | Contact Map | 0.83 |
Sequence Conservation (Image Generated using WebLogo v3)