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OPENSEQ.org
LSRK - Autoinducer 2 kinase LsrK
UniProt: P77432 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG13804
Length: 530 (506)
Sequences: 5457
Seq/Len: 10.78
LSRK
Paralog alert: 0.74 [within 20: 0.17] - ratio of genomes with paralogs
Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
205_P 215_A 5.067 1.00
30_D 34_N 4.687 1.00
119_E 156_H 4.171 1.00
406_A 410_Q 3.46 1.00
197_D 204_K 3.275 1.00
122_E 156_H 3.194 1.00
26_A 69_C 3.158 1.00
223_E 226_T 3.015 1.00
202_D 215_A 2.984 1.00
28_I 73_A 2.974 1.00
437_Q 441_D 2.943 1.00
378_F 393_L 2.933 1.00
351_V 392_T 2.744 1.00
100_N 164_Q 2.739 1.00
446_P 489_T 2.719 1.00
60_N 178_M 2.7 1.00
196_L 221_V 2.676 1.00
197_D 200_T 2.662 1.00
473_S 476_E 2.64 1.00
317_T 397_L 2.627 1.00
106_I 161_I 2.613 1.00
17_L 66_A 2.586 1.00
406_A 502_R 2.563 1.00
97_V 171_I 2.549 1.00
472_S 476_E 2.548 1.00
138_A 204_K 2.52 1.00
176_A 250_G 2.497 1.00
208_L 215_A 2.478 1.00
41_A 72_Q 2.455 1.00
180_S 247_V 2.429 1.00
39_G 72_Q 2.402 1.00
433_K 486_R 2.378 1.00
101_N 166_S 2.344 1.00
63_W 178_M 2.31 1.00
60_N 104_A 2.264 1.00
350_R 391_A 2.251 1.00
27_V 457_A 2.249 1.00
41_A 68_E 2.235 1.00
251_G 256_L 2.233 1.00
413_A 445_L 2.208 1.00
205_P 209_D 2.207 1.00
406_A 499_Q 2.164 1.00
23_S 40_Q 2.161 1.00
67_C 238_L 2.131 1.00
15_M 26_A 2.117 1.00
248_V 467_G 2.076 1.00
44_R 61_K 2.069 1.00
277_W 314_T 2.043 1.00
422_S 448_N 2.012 1.00
19_A 24_I 2.007 1.00
413_A 419_H 2 1.00
227_L 248_V 1.991 1.00
395_R 399_E 1.93 1.00
182_E 220_P 1.912 1.00
232_S 235_A 1.904 1.00
491_D 494_K 1.869 1.00
107_W 158_R 1.866 1.00
13_Y 36_I 1.863 1.00
343_L 346_E 1.855 1.00
434_L 438_I 1.853 1.00
15_M 70_M 1.807 1.00
72_Q 76_N 1.783 1.00
444_G 495_H 1.781 1.00
152_L 156_H 1.772 1.00
233_S 237_E 1.766 1.00
103_G 177_Y 1.762 1.00
222_K 226_T 1.756 1.00
356_W 392_T 1.729 1.00
180_S 229_G 1.719 1.00
118_R 122_E 1.702 1.00
138_A 206_A 1.702 1.00
425_F 436_S 1.687 1.00
134_E 138_A 1.68 1.00
167_T 183_L 1.677 1.00
433_K 488_H 1.672 1.00
176_A 184_A 1.669 1.00
502_R 506_Q 1.654 1.00
134_E 137_R 1.652 1.00
340_T 343_L 1.65 1.00
98_L 217_I 1.649 1.00
410_Q 413_A 1.648 1.00
134_E 206_A 1.622 1.00
14_L 465_G 1.597 1.00
121_S 125_E 1.593 1.00
433_K 449_I 1.583 1.00
451_V 483_R 1.571 1.00
268_Q 422_S 1.57 1.00
357_G 504_K 1.566 1.00
86_A 464_A 1.565 1.00
345_E 432_G 1.563 1.00
174_W 178_M 1.556 1.00
389_N 392_T 1.525 1.00
441_D 491_D 1.525 1.00
227_L 230_V 1.524 1.00
28_I 79_I 1.521 1.00
348_A 434_L 1.519 1.00
233_S 243_A 1.515 1.00
98_L 154_L 1.509 1.00
344_L 394_F 1.497 1.00
448_N 487_T 1.495 1.00
339_D 343_L 1.487 1.00
346_E 350_R 1.48 1.00
446_P 487_T 1.479 1.00
184_A 222_K 1.473 1.00
271_V 439_L 1.451 1.00
347_M 391_A 1.45 1.00
160_D 163_R 1.445 1.00
269_T 420_P 1.438 1.00
153_W 157_H 1.433 1.00
73_A 77_A 1.433 1.00
93_R 252_G 1.43 1.00
268_Q 424_V 1.43 1.00
58_D 61_K 1.424 1.00
449_I 488_H 1.417 1.00
251_G 463_A 1.415 1.00
24_I 66_A 1.414 1.00
347_M 350_R 1.404 0.99
495_H 499_Q 1.403 0.99
402_A 438_I 1.398 0.99
343_L 347_M 1.394 0.99
37_A 73_A 1.393 0.99
441_D 494_K 1.378 0.99
28_I 77_A 1.373 0.99
100_N 104_A 1.364 0.99
376_P 381_L 1.358 0.99
222_K 228_L 1.357 0.99
321_F 397_L 1.357 0.99
24_I 65_L 1.356 0.99
87_V 245_T 1.351 0.99
438_I 442_V 1.342 0.99
39_G 69_C 1.341 0.99
375_A 382_S 1.326 0.99
313_F 316_L 1.325 0.99
60_N 64_Q 1.324 0.99
63_W 67_C 1.322 0.99
493_E 496_E 1.317 0.99
119_E 152_L 1.311 0.99
319_R 323_D 1.31 0.99
17_L 70_M 1.306 0.99
451_V 485_E 1.301 0.99
368_F 371_W 1.3 0.99
14_L 470_I 1.296 0.99
17_L 26_A 1.292 0.99
273_G 439_L 1.291 0.99
37_A 77_A 1.291 0.99
381_L 388_C 1.286 0.99
98_L 151_L 1.286 0.99
345_E 349_S 1.285 0.99
507_A 511_D 1.284 0.99
242_K 245_T 1.281 0.99
161_I 164_Q 1.281 0.99
403_I 501_S 1.278 0.99
13_Y 28_I 1.278 0.99
187_P 201_R 1.278 0.99
266_P 284_A 1.269 0.99
39_G 73_A 1.261 0.99
422_S 446_P 1.259 0.99
227_L 246_P 1.253 0.99
74_L 84_I 1.245 0.98
465_G 471_F 1.243 0.98
354_G 357_G 1.243 0.98
378_F 397_L 1.241 0.98
155_A 162_Y 1.237 0.98
99_Y 169_T 1.235 0.98
94_E 192_T 1.235 0.98
64_Q 68_E 1.234 0.98
133_N 137_R 1.229 0.98
62_N 171_I 1.221 0.98
311_S 404_V 1.22 0.98
134_E 210_M 1.216 0.98
45_H 57_F 1.215 0.98
227_L 467_G 1.213 0.98
31_L 470_I 1.211 0.98
160_D 164_Q 1.208 0.98
345_E 433_K 1.203 0.98
117_A 121_S 1.203 0.98
115_R 153_W 1.202 0.98
214_R 217_I 1.201 0.98
29_F 35_Q 1.2 0.98
230_V 244_G 1.199 0.98
196_L 200_T 1.195 0.98
66_A 175_L 1.183 0.98
206_A 209_D 1.182 0.98
436_S 488_H 1.181 0.98
199_T 286_P 1.178 0.98
165_A 217_I 1.177 0.98
28_I 84_I 1.175 0.98
410_Q 506_Q 1.169 0.97
348_A 395_R 1.165 0.97
406_A 443_S 1.163 0.97
43_W 65_L 1.158 0.97
187_P 196_L 1.151 0.97
124_K 132_E 1.149 0.97
401_A 429_G 1.149 0.97
13_Y 83_Y 1.139 0.97
162_Y 165_A 1.13 0.97
51_V 54_S 1.129 0.97
484_W 487_T 1.127 0.97
135_V 194_G 1.127 0.97
402_A 442_V 1.126 0.97
131_F 210_M 1.125 0.97
68_E 72_Q 1.123 0.97
395_R 434_L 1.123 0.97
402_A 439_L 1.12 0.96
202_D 220_P 1.118 0.96
403_I 442_V 1.117 0.96
66_A 70_M 1.117 0.96
265_R 421_S 1.116 0.96
176_A 228_L 1.114 0.96
208_L 218_L 1.11 0.96
154_L 161_I 1.1 0.96
15_M 28_I 1.096 0.96
431_K 453_K 1.095 0.96
230_V 246_P 1.095 0.96
187_P 221_V 1.095 0.96
346_E 349_S 1.085 0.96
71_R 238_L 1.083 0.96
204_K 207_L 1.082 0.96
158_R 161_I 1.08 0.95
12_Y 85_A 1.075 0.95
72_Q 75_H 1.074 0.95
74_L 77_A 1.074 0.95
202_D 205_P 1.067 0.95
13_Y 79_I 1.064 0.95
89_A 175_L 1.054 0.95
118_R 121_S 1.048 0.94
119_E 157_H 1.045 0.94
103_G 183_L 1.044 0.94
279_Q 409_L 1.043 0.94
152_L 162_Y 1.042 0.94
358_V 397_L 1.041 0.94
86_A 248_V 1.038 0.94
19_A 66_A 1.037 0.94
120_V 149_P 1.036 0.94
347_M 394_F 1.034 0.94
71_R 75_H 1.03 0.94
12_Y 83_Y 1.029 0.94
231_V 245_T 1.028 0.94
265_R 268_Q 1.025 0.93
96_I 168_I 1.023 0.93
93_R 308_E 1.021 0.93
19_A 65_L 1.021 0.93
38_V 454_E 1.018 0.93
313_F 317_T 1.016 0.93
392_T 395_R 1.014 0.93
248_V 468_A 1.014 0.93
37_A 76_N 1.013 0.93
55_M 112_V 1.012 0.93
80_A 83_Y 1.008 0.93
74_L 81_P 1.006 0.93
169_T 183_L 1.003 0.93
43_W 57_F 1.002 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3ifrA20.94721000.16Contact Map0.736
3hz6A10.93581000.164Contact Map0.624
3ll3A20.93771000.169Contact Map0.752
3jvpA40.97171000.175Contact Map0.747
2itmA20.90191000.186Contact Map0.788
3g25A40.9171000.204Contact Map0.864
3l0qA20.95851000.209Contact Map0.737
3h3nX20.92831000.209Contact Map0.803
2zf5O20.91511000.21Contact Map0.834
2p3rA80.93021000.212Contact Map0.87
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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