| UniProt: | P09099 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11075 | ||
| Length: | 484 (481) | ||
| Sequences: | 5519 | ||
| Seq/Len: | 11.47 |
| XYLB
Paralog alert: 0.75 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 186_D | 196_R | 4.903 | 1.00 | |
| 18_N | 22_E | 4.41 | 1.00 | |
| 104_E | 137_R | 3.89 | 1.00 | |
| 374_A | 378_D | 3.167 | 1.00 | |
| 107_L | 137_R | 3.124 | 1.00 | |
| 178_D | 185_S | 3.099 | 1.00 | |
| 349_F | 361_L | 3.012 | 1.00 | |
| 374_A | 469_R | 3 | 1.00 | |
| 14_V | 55_A | 2.937 | 1.00 | |
| 204_E | 207_E | 2.828 | 1.00 | |
| 404_Q | 408_D | 2.824 | 1.00 | |
| 16_L | 59_L | 2.802 | 1.00 | |
| 90_L | 142_I | 2.799 | 1.00 | |
| 177_L | 202_L | 2.664 | 1.00 | |
| 183_D | 196_R | 2.662 | 1.00 | |
| 178_D | 181_K | 2.62 | 1.00 | |
| 46_E | 159_R | 2.582 | 1.00 | |
| 413_Q | 456_L | 2.581 | 1.00 | |
| 381_H | 412_Q | 2.566 | 1.00 | |
| 84_D | 145_Q | 2.503 | 1.00 | |
| 118_I | 185_S | 2.493 | 1.00 | |
| 440_K | 444_E | 2.467 | 1.00 | |
| 441_S | 444_E | 2.464 | 1.00 | |
| 297_C | 365_V | 2.461 | 1.00 | |
| 91_R | 139_E | 2.419 | 1.00 | |
| 5_I | 52_T | 2.418 | 1.00 | |
| 29_E | 58_A | 2.376 | 1.00 | |
| 34_S | 92_P | 2.37 | 1.00 | |
| 189_L | 196_R | 2.36 | 1.00 | |
| 49_W | 159_R | 2.335 | 1.00 | |
| 157_R | 230_G | 2.3 | 1.00 | |
| 27_Q | 58_A | 2.287 | 1.00 | |
| 161_T | 227_V | 2.269 | 1.00 | |
| 400_E | 453_Q | 2.264 | 1.00 | |
| 186_D | 190_Q | 2.199 | 1.00 | |
| 231_G | 236_A | 2.199 | 1.00 | |
| 85_A | 147_D | 2.177 | 1.00 | |
| 374_A | 466_Q | 2.147 | 1.00 | |
| 29_E | 54_R | 2.145 | 1.00 | |
| 11_G | 28_T | 2.134 | 1.00 | |
| 46_E | 88_R | 2.122 | 1.00 | |
| 15_I | 425_A | 2.112 | 1.00 | |
| 257_G | 294_A | 2.076 | 1.00 | |
| 53_D | 219_A | 2.058 | 1.00 | |
| 32_T | 47_Q | 2.024 | 1.00 | |
| 381_H | 386_K | 2.011 | 1.00 | |
| 389_S | 415_D | 1.969 | 1.00 | |
| 228_V | 435_A | 1.95 | 1.00 | |
| 329_F | 349_F | 1.941 | 1.00 | |
| 458_D | 461_R | 1.895 | 1.00 | |
| 342_N | 480_L | 1.893 | 1.00 | |
| 7_L | 12_V | 1.889 | 1.00 | |
| 3_I | 14_V | 1.882 | 1.00 | |
| 325_E | 360_E | 1.852 | 1.00 | |
| 208_I | 228_V | 1.85 | 1.00 | |
| 86_Q | 150_L | 1.848 | 1.00 | |
| 469_R | 473_R | 1.817 | 1.00 | |
| 118_I | 187_V | 1.778 | 1.00 | |
| 163_E | 201_A | 1.768 | 1.00 | |
| 328_W | 471_T | 1.747 | 1.00 | |
| 411_G | 462_Y | 1.742 | 1.00 | |
| 213_L | 216_V | 1.734 | 1.00 | |
| 401_Y | 405_M | 1.723 | 1.00 | |
| 363_R | 367_E | 1.718 | 1.00 | |
| 82_L | 198_Q | 1.673 | 1.00 | |
| 145_Q | 150_L | 1.664 | 1.00 | |
| 87_Q | 158_L | 1.663 | 1.00 | |
| 203_Y | 207_E | 1.663 | 1.00 | |
| 37_H | 40_W | 1.658 | 1.00 | |
| 3_I | 56_M | 1.641 | 1.00 | |
| 58_A | 62_Q | 1.64 | 1.00 | |
| 133_L | 137_R | 1.638 | 1.00 | |
| 400_E | 455_H | 1.628 | 1.00 | |
| 214_P | 218_K | 1.624 | 1.00 | |
| 357_G | 360_E | 1.618 | 1.00 | |
| 320_A | 360_E | 1.616 | 1.00 | |
| 392_L | 403_R | 1.615 | 1.00 | |
| 157_R | 165_A | 1.577 | 1.00 | |
| 400_E | 416_Y | 1.559 | 1.00 | |
| 103_Q | 107_L | 1.557 | 1.00 | |
| 320_A | 359_N | 1.526 | 1.00 | |
| 315_A | 319_Q | 1.519 | 1.00 | |
| 148_K | 164_F | 1.518 | 1.00 | |
| 114_Q | 187_V | 1.513 | 1.00 | |
| 378_D | 381_H | 1.513 | 1.00 | |
| 477_Q | 480_L | 1.506 | 1.00 | |
| 329_F | 333_L | 1.505 | 1.00 | |
| 161_T | 210_G | 1.5 | 1.00 | |
| 248_Q | 389_S | 1.491 | 1.00 | |
| 16_L | 63_H | 1.483 | 1.00 | |
| 77_M | 232_G | 1.479 | 1.00 | |
| 418_T | 450_P | 1.476 | 1.00 | |
| 114_Q | 117_V | 1.47 | 1.00 | |
| 114_Q | 118_I | 1.468 | 1.00 | |
| 59_L | 63_H | 1.465 | 1.00 | |
| 70_A | 432_A | 1.463 | 1.00 | |
| 16_L | 65_L | 1.461 | 1.00 | |
| 460_Q | 463_A | 1.454 | 1.00 | |
| 141_E | 144_R | 1.45 | 1.00 | |
| 408_D | 458_D | 1.445 | 1.00 | |
| 106_T | 110_A | 1.443 | 1.00 | |
| 352_L | 356_H | 1.44 | 1.00 | |
| 85_A | 152_P | 1.437 | 1.00 | |
| 208_I | 211_A | 1.435 | 1.00 | |
| 413_Q | 454_S | 1.433 | 1.00 | |
| 165_A | 203_Y | 1.429 | 1.00 | |
| 415_D | 454_S | 1.425 | 1.00 | |
| 27_Q | 55_A | 1.424 | 1.00 | |
| 82_L | 135_V | 1.424 | 1.00 | |
| 155_Y | 159_R | 1.42 | 1.00 | |
| 2_Y | 433_Q | 1.418 | 1.00 | |
| 134_W | 138_H | 1.416 | 1.00 | |
| 251_L | 406_L | 1.4 | 0.99 | |
| 249_A | 387_P | 1.389 | 0.99 | |
| 25_A | 59_L | 1.38 | 0.99 | |
| 301_A | 365_V | 1.377 | 0.99 | |
| 49_W | 53_D | 1.375 | 0.99 | |
| 299_D | 303_K | 1.371 | 0.99 | |
| 371_Y | 468_R | 1.361 | 0.99 | |
| 12_V | 51_A | 1.358 | 0.99 | |
| 327_V | 356_H | 1.353 | 0.99 | |
| 44_D | 47_Q | 1.345 | 0.99 | |
| 329_F | 365_V | 1.328 | 0.99 | |
| 346_K | 353_T | 1.317 | 0.99 | |
| 248_Q | 391_T | 1.316 | 0.99 | |
| 12_V | 52_T | 1.314 | 0.99 | |
| 416_Y | 455_H | 1.314 | 0.99 | |
| 291_M | 372_A | 1.313 | 0.99 | |
| 231_G | 431_L | 1.309 | 0.99 | |
| 462_Y | 466_Q | 1.307 | 0.99 | |
| 323_S | 326_P | 1.306 | 0.99 | |
| 27_Q | 59_L | 1.305 | 0.99 | |
| 370_G | 405_M | 1.304 | 0.99 | |
| 79_G | 93_A | 1.304 | 0.99 | |
| 348_V | 479_L | 1.3 | 0.99 | |
| 474_R | 478_Q | 1.291 | 0.99 | |
| 347_G | 352_L | 1.29 | 0.99 | |
| 84_D | 88_R | 1.29 | 0.99 | |
| 389_S | 413_Q | 1.289 | 0.99 | |
| 405_M | 409_I | 1.285 | 0.99 | |
| 208_I | 226_P | 1.283 | 0.99 | |
| 104_E | 133_L | 1.281 | 0.99 | |
| 253_L | 406_L | 1.274 | 0.99 | |
| 418_T | 452_E | 1.273 | 0.99 | |
| 246_A | 264_E | 1.27 | 0.99 | |
| 5_I | 14_V | 1.268 | 0.99 | |
| 203_Y | 209_T | 1.266 | 0.99 | |
| 5_I | 56_M | 1.264 | 0.99 | |
| 408_D | 461_R | 1.258 | 0.99 | |
| 378_D | 473_R | 1.257 | 0.99 | |
| 136_Q | 143_F | 1.254 | 0.99 | |
| 177_L | 181_K | 1.24 | 0.98 | |
| 293_S | 296_S | 1.237 | 0.98 | |
| 46_E | 50_Q | 1.236 | 0.98 | |
| 378_D | 469_R | 1.223 | 0.98 | |
| 312_A | 315_A | 1.222 | 0.98 | |
| 316_A | 319_Q | 1.221 | 0.98 | |
| 142_I | 145_Q | 1.21 | 0.98 | |
| 317_A | 362_A | 1.206 | 0.98 | |
| 168_M | 182_R | 1.205 | 0.98 | |
| 129_A | 192_C | 1.201 | 0.98 | |
| 45_P | 92_P | 1.197 | 0.98 | |
| 463_A | 467_P | 1.191 | 0.98 | |
| 34_S | 47_Q | 1.188 | 0.98 | |
| 245_D | 388_Q | 1.184 | 0.98 | |
| 82_L | 132_L | 1.182 | 0.98 | |
| 102_A | 106_T | 1.182 | 0.98 | |
| 403_R | 455_H | 1.177 | 0.98 | |
| 60_G | 68_V | 1.172 | 0.98 | |
| 374_A | 410_S | 1.169 | 0.97 | |
| 189_L | 199_M | 1.168 | 0.97 | |
| 19_E | 438_P | 1.162 | 0.97 | |
| 60_G | 63_H | 1.154 | 0.97 | |
| 141_E | 145_Q | 1.151 | 0.97 | |
| 100_R | 134_W | 1.149 | 0.97 | |
| 71_L | 225_V | 1.147 | 0.97 | |
| 310_V | 313_L | 1.145 | 0.97 | |
| 211_A | 224_T | 1.142 | 0.97 | |
| 50_Q | 54_R | 1.132 | 0.97 | |
| 25_A | 63_H | 1.13 | 0.97 | |
| 433_Q | 439_E | 1.126 | 0.97 | |
| 157_R | 209_T | 1.124 | 0.97 | |
| 16_L | 68_V | 1.12 | 0.96 | |
| 105_C | 123_M | 1.12 | 0.96 | |
| 312_A | 316_A | 1.119 | 0.96 | |
| 370_G | 406_L | 1.119 | 0.96 | |
| 103_Q | 106_T | 1.117 | 0.96 | |
| 208_I | 435_A | 1.103 | 0.96 | |
| 113_P | 117_V | 1.102 | 0.96 | |
| 41_S | 97_N | 1.098 | 0.96 | |
| 169_S | 279_H | 1.092 | 0.96 | |
| 57_K | 61_D | 1.091 | 0.96 | |
| 31_L | 51_A | 1.089 | 0.96 | |
| 54_R | 58_A | 1.089 | 0.96 | |
| 187_V | 190_Q | 1.088 | 0.96 | |
| 398_R | 420_G | 1.084 | 0.96 | |
| 195_S | 198_Q | 1.082 | 0.96 | |
| 451_L | 454_S | 1.081 | 0.95 | |
| 17_L | 23_V | 1.079 | 0.95 | |
| 78_H | 173_G | 1.079 | 0.95 | |
| 369_V | 396_G | 1.073 | 0.95 | |
| 371_Y | 409_I | 1.07 | 0.95 | |
| 33_V | 43_Q | 1.063 | 0.95 | |
| 313_L | 317_A | 1.062 | 0.95 | |
| 146_I | 198_Q | 1.06 | 0.95 | |
| 143_F | 146_I | 1.06 | 0.95 | |
| 52_T | 56_M | 1.056 | 0.95 | |
| 183_D | 201_A | 1.054 | 0.95 | |
| 317_A | 401_Y | 1.051 | 0.94 | |
| 168_M | 177_L | 1.05 | 0.94 | |
| 45_P | 81_T | 1.045 | 0.94 | |
| 314_I | 362_A | 1.044 | 0.94 | |
| 305_T | 361_L | 1.042 | 0.94 | |
| 25_A | 62_Q | 1.042 | 0.94 | |
| 83_L | 150_L | 1.041 | 0.94 | |
| 397_A | 420_G | 1.04 | 0.94 | |
| 44_D | 92_P | 1.039 | 0.94 | |
| 99_G | 124_M | 1.036 | 0.94 | |
| 114_Q | 191_A | 1.035 | 0.94 | |
| 377_M | 410_S | 1.035 | 0.94 | |
| 211_A | 226_P | 1.032 | 0.94 | |
| 52_T | 156_L | 1.03 | 0.94 | |
| 349_F | 365_V | 1.029 | 0.94 | |
| 217_A | 222_M | 1.024 | 0.93 | |
| 326_P | 363_R | 1.023 | 0.93 | |
| 73_I | 156_L | 1.023 | 0.93 | |
| 297_C | 329_F | 1.022 | 0.93 | |
| 70_A | 228_V | 1.021 | 0.93 | |
| 245_D | 248_Q | 1.017 | 0.93 | |
| 370_G | 409_I | 1.008 | 0.93 | |
| 478_Q | 482_L | 1.008 | 0.93 | |
| 363_R | 401_Y | 1.006 | 0.93 | |
| 234_N | 258_V | 1.004 | 0.93 | |
| 57_K | 219_A | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3ifrA | 2 | 0.9938 | 100 | 0.057 | Contact Map | 0.732 |
| 3hz6A | 1 | 0.9917 | 100 | 0.063 | Contact Map | 0.634 |
| 3ll3A | 2 | 0.9917 | 100 | 0.069 | Contact Map | 0.743 |
| 2itmA | 2 | 0.9979 | 100 | 0.07 | Contact Map | 0.769 |
| 3jvpA | 4 | 0.9938 | 100 | 0.089 | Contact Map | 0.726 |
| 3g25A | 4 | 0.9876 | 100 | 0.115 | Contact Map | 0.844 |
| 2p3rA | 8 | 0.9855 | 100 | 0.116 | Contact Map | 0.861 |
| 2zf5O | 2 | 0.9793 | 100 | 0.117 | Contact Map | 0.83 |
| 3l0qA | 2 | 0.9917 | 100 | 0.119 | Contact Map | 0.716 |
| 3h3nX | 2 | 0.9876 | 100 | 0.119 | Contact Map | 0.786 |
Sequence Conservation (Image Generated using WebLogo v3)