| UniProt: | P55138 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG13033 | ||
| Length: | 492 (461) | ||
| Sequences: | 5426 | ||
| Seq/Len: | 11.77 |
| YGCE
Paralog alert: 0.74 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 22_D | 26_N | 4.857 | 1.00 | |
| 159_E | 171_R | 4.01 | 1.00 | |
| 358_K | 362_D | 3.641 | 1.00 | |
| 333_M | 345_I | 3.33 | 1.00 | |
| 151_D | 158_S | 3.327 | 1.00 | |
| 18_V | 60_A | 3.308 | 1.00 | |
| 179_M | 182_T | 3.112 | 1.00 | |
| 156_A | 171_R | 3.046 | 1.00 | |
| 20_M | 64_L | 3.038 | 1.00 | |
| 389_Q | 393_D | 2.998 | 1.00 | |
| 151_D | 154_S | 2.83 | 1.00 | |
| 150_V | 177_V | 2.825 | 1.00 | |
| 51_D | 132_R | 2.778 | 1.00 | |
| 365_C | 397_L | 2.751 | 1.00 | |
| 398_P | 441_I | 2.719 | 1.00 | |
| 164_M | 171_R | 2.686 | 1.00 | |
| 425_D | 428_T | 2.664 | 1.00 | |
| 9_I | 57_L | 2.654 | 1.00 | |
| 39_H | 99_P | 2.643 | 1.00 | |
| 424_P | 428_T | 2.612 | 1.00 | |
| 130_T | 206_T | 2.585 | 1.00 | |
| 273_T | 349_I | 2.518 | 1.00 | |
| 134_T | 203_V | 2.502 | 1.00 | |
| 54_W | 132_R | 2.494 | 1.00 | |
| 33_G | 63_D | 2.421 | 1.00 | |
| 307_V | 344_W | 2.369 | 1.00 | |
| 207_T | 212_V | 2.334 | 1.00 | |
| 385_D | 438_D | 2.326 | 1.00 | |
| 31_G | 63_D | 2.297 | 1.00 | |
| 19_V | 409_S | 2.287 | 1.00 | |
| 7_I | 18_V | 2.278 | 1.00 | |
| 51_D | 95_T | 2.266 | 1.00 | |
| 33_G | 59_F | 2.236 | 1.00 | |
| 58_C | 194_A | 2.199 | 1.00 | |
| 15_S | 32_K | 2.189 | 1.00 | |
| 365_C | 371_F | 2.103 | 1.00 | |
| 204_V | 419_G | 2.092 | 1.00 | |
| 358_K | 451_D | 2.092 | 1.00 | |
| 358_K | 450_Y | 2.056 | 1.00 | |
| 11_G | 16_T | 2.05 | 1.00 | |
| 374_H | 400_R | 2.047 | 1.00 | |
| 443_I | 446_N | 2.045 | 1.00 | |
| 183_V | 204_V | 2.02 | 1.00 | |
| 312_N | 344_W | 2.001 | 1.00 | |
| 92_A | 120_A | 1.951 | 1.00 | |
| 316_T | 333_M | 1.944 | 1.00 | |
| 188_T | 191_A | 1.924 | 1.00 | |
| 136_E | 176_D | 1.922 | 1.00 | |
| 386_L | 390_I | 1.887 | 1.00 | |
| 306_C | 343_A | 1.882 | 1.00 | |
| 347_R | 351_E | 1.865 | 1.00 | |
| 42_D | 45_T | 1.864 | 1.00 | |
| 94_G | 131_H | 1.861 | 1.00 | |
| 7_I | 61_G | 1.851 | 1.00 | |
| 189_P | 193_L | 1.832 | 1.00 | |
| 396_N | 447_A | 1.797 | 1.00 | |
| 178_Q | 182_T | 1.794 | 1.00 | |
| 134_T | 185_G | 1.792 | 1.00 | |
| 63_D | 67_Q | 1.789 | 1.00 | |
| 233_I | 269_K | 1.76 | 1.00 | |
| 377_I | 388_M | 1.756 | 1.00 | |
| 5_Y | 28_V | 1.744 | 1.00 | |
| 447_A | 451_D | 1.739 | 1.00 | |
| 341_D | 344_W | 1.738 | 1.00 | |
| 121_Y | 137_F | 1.738 | 1.00 | |
| 362_D | 365_C | 1.72 | 1.00 | |
| 385_D | 440_F | 1.694 | 1.00 | |
| 130_T | 138_K | 1.692 | 1.00 | |
| 20_M | 70_G | 1.686 | 1.00 | |
| 316_T | 320_W | 1.682 | 1.00 | |
| 6_I | 417_A | 1.664 | 1.00 | |
| 159_E | 165_D | 1.663 | 1.00 | |
| 97_A | 119_V | 1.649 | 1.00 | |
| 385_D | 401_R | 1.647 | 1.00 | |
| 403_A | 435_R | 1.636 | 1.00 | |
| 221_D | 431_D | 1.611 | 1.00 | |
| 393_D | 443_I | 1.611 | 1.00 | |
| 84_R | 208_S | 1.605 | 1.00 | |
| 224_T | 374_H | 1.602 | 1.00 | |
| 138_K | 178_Q | 1.601 | 1.00 | |
| 398_P | 439_I | 1.584 | 1.00 | |
| 128_Y | 132_R | 1.578 | 1.00 | |
| 77_G | 416_T | 1.577 | 1.00 | |
| 64_L | 68_F | 1.553 | 1.00 | |
| 336_F | 340_M | 1.543 | 1.00 | |
| 393_D | 446_N | 1.533 | 1.00 | |
| 277_L | 349_I | 1.531 | 1.00 | |
| 227_I | 391_F | 1.523 | 1.00 | |
| 225_A | 372_A | 1.512 | 1.00 | |
| 183_V | 186_H | 1.511 | 1.00 | |
| 207_T | 415_N | 1.499 | 1.00 | |
| 400_R | 439_I | 1.495 | 1.00 | |
| 49_P | 52_D | 1.492 | 1.00 | |
| 16_T | 56_S | 1.482 | 1.00 | |
| 189_P | 199_A | 1.478 | 1.00 | |
| 331_G | 336_F | 1.471 | 1.00 | |
| 16_T | 57_L | 1.47 | 1.00 | |
| 98_A | 116_N | 1.464 | 1.00 | |
| 20_M | 68_F | 1.461 | 1.00 | |
| 29_C | 64_L | 1.459 | 1.00 | |
| 54_W | 58_C | 1.457 | 1.00 | |
| 224_T | 376_I | 1.451 | 1.00 | |
| 88_A | 125_F | 1.45 | 1.00 | |
| 229_L | 391_F | 1.445 | 1.00 | |
| 5_Y | 20_M | 1.441 | 1.00 | |
| 401_R | 440_F | 1.43 | 1.00 | |
| 150_V | 154_S | 1.414 | 1.00 | |
| 330_R | 337_D | 1.41 | 1.00 | |
| 37_P | 52_D | 1.402 | 0.99 | |
| 178_Q | 184_L | 1.401 | 0.99 | |
| 301_N | 384_S | 1.394 | 0.99 | |
| 275_S | 279_D | 1.389 | 0.99 | |
| 9_I | 61_G | 1.382 | 0.99 | |
| 354_A | 390_I | 1.38 | 0.99 | |
| 183_V | 202_P | 1.374 | 0.99 | |
| 198_P | 201_L | 1.366 | 0.99 | |
| 374_H | 398_P | 1.36 | 0.99 | |
| 303_K | 306_C | 1.36 | 0.99 | |
| 390_I | 394_V | 1.359 | 0.99 | |
| 314_L | 340_M | 1.346 | 0.99 | |
| 417_A | 423_Y | 1.341 | 0.99 | |
| 304_A | 386_L | 1.339 | 0.99 | |
| 222_D | 240_K | 1.334 | 0.99 | |
| 300_L | 346_Y | 1.334 | 0.99 | |
| 450_Y | 454_N | 1.333 | 0.99 | |
| 6_I | 422_L | 1.331 | 0.99 | |
| 403_A | 437_K | 1.323 | 0.99 | |
| 141_I | 155_W | 1.317 | 0.99 | |
| 85_C | 146_G | 1.312 | 0.99 | |
| 65_M | 75_I | 1.311 | 0.99 | |
| 303_K | 343_A | 1.308 | 0.99 | |
| 51_D | 55_A | 1.308 | 0.99 | |
| 78_I | 201_L | 1.307 | 0.99 | |
| 170_P | 173_M | 1.295 | 0.99 | |
| 86_C | 100_L | 1.293 | 0.99 | |
| 31_G | 64_L | 1.291 | 0.99 | |
| 31_G | 60_A | 1.273 | 0.99 | |
| 388_M | 440_F | 1.268 | 0.99 | |
| 9_I | 18_V | 1.266 | 0.99 | |
| 50_D | 99_P | 1.259 | 0.99 | |
| 186_H | 200_G | 1.252 | 0.99 | |
| 153_K | 242_L | 1.25 | 0.99 | |
| 21_Y | 27_V | 1.249 | 0.99 | |
| 53_L | 125_F | 1.246 | 0.98 | |
| 23_L | 422_L | 1.239 | 0.98 | |
| 288_D | 291_A | 1.234 | 0.98 | |
| 353_V | 381_G | 1.232 | 0.98 | |
| 62_H | 66_S | 1.229 | 0.98 | |
| 358_K | 395_F | 1.226 | 0.98 | |
| 55_A | 59_F | 1.223 | 0.98 | |
| 164_M | 174_L | 1.219 | 0.98 | |
| 268_R | 272_W | 1.215 | 0.98 | |
| 91_K | 95_T | 1.209 | 0.98 | |
| 316_T | 349_I | 1.209 | 0.98 | |
| 130_T | 184_L | 1.197 | 0.98 | |
| 90_L | 123_T | 1.197 | 0.98 | |
| 57_L | 129_L | 1.191 | 0.98 | |
| 301_N | 305_S | 1.19 | 0.98 | |
| 354_A | 391_F | 1.189 | 0.98 | |
| 302_K | 306_C | 1.183 | 0.98 | |
| 156_A | 176_D | 1.181 | 0.98 | |
| 310_G | 313_G | 1.179 | 0.98 | |
| 281_L | 345_I | 1.179 | 0.98 | |
| 29_C | 68_F | 1.176 | 0.98 | |
| 20_M | 75_I | 1.173 | 0.98 | |
| 183_V | 419_G | 1.172 | 0.98 | |
| 221_D | 373_K | 1.167 | 0.97 | |
| 383_N | 405_N | 1.162 | 0.97 | |
| 358_K | 454_N | 1.16 | 0.97 | |
| 46_A | 104_Q | 1.159 | 0.97 | |
| 57_L | 61_G | 1.159 | 0.97 | |
| 347_R | 386_L | 1.157 | 0.97 | |
| 5_Y | 74_D | 1.149 | 0.97 | |
| 210_K | 234_A | 1.147 | 0.97 | |
| 70_G | 74_D | 1.143 | 0.97 | |
| 155_W | 179_M | 1.131 | 0.97 | |
| 354_A | 394_V | 1.131 | 0.97 | |
| 59_F | 63_D | 1.128 | 0.97 | |
| 186_H | 202_P | 1.126 | 0.97 | |
| 187_I | 201_L | 1.126 | 0.97 | |
| 333_M | 349_I | 1.122 | 0.97 | |
| 273_T | 316_T | 1.121 | 0.97 | |
| 221_D | 224_T | 1.12 | 0.96 | |
| 414_I | 433_M | 1.12 | 0.96 | |
| 39_H | 52_D | 1.119 | 0.96 | |
| 304_A | 347_R | 1.114 | 0.96 | |
| 355_L | 394_V | 1.113 | 0.96 | |
| 77_G | 204_V | 1.11 | 0.96 | |
| 90_L | 121_Y | 1.107 | 0.96 | |
| 445_S | 448_K | 1.096 | 0.96 | |
| 141_I | 177_V | 1.095 | 0.96 | |
| 225_A | 375_V | 1.095 | 0.96 | |
| 4_K | 76_V | 1.092 | 0.96 | |
| 141_I | 150_V | 1.087 | 0.96 | |
| 5_Y | 70_G | 1.086 | 0.96 | |
| 7_I | 20_M | 1.078 | 0.95 | |
| 80_L | 129_L | 1.078 | 0.95 | |
| 226_V | 378_T | 1.065 | 0.95 | |
| 65_M | 68_F | 1.064 | 0.95 | |
| 334_I | 461_L | 1.064 | 0.95 | |
| 62_H | 194_A | 1.062 | 0.95 | |
| 299_L | 303_K | 1.06 | 0.95 | |
| 287_Q | 291_A | 1.06 | 0.95 | |
| 389_Q | 440_F | 1.059 | 0.95 | |
| 382_S | 405_N | 1.059 | 0.95 | |
| 11_G | 57_L | 1.057 | 0.95 | |
| 11_G | 56_S | 1.052 | 0.95 | |
| 299_L | 302_K | 1.05 | 0.94 | |
| 361_Y | 395_F | 1.049 | 0.94 | |
| 302_K | 305_S | 1.043 | 0.94 | |
| 21_Y | 404_I | 1.042 | 0.94 | |
| 65_M | 72_K | 1.041 | 0.94 | |
| 235_L | 361_Y | 1.041 | 0.94 | |
| 455_K | 459_K | 1.041 | 0.94 | |
| 204_V | 420_L | 1.041 | 0.94 | |
| 89_L | 173_M | 1.037 | 0.94 | |
| 63_D | 66_S | 1.034 | 0.94 | |
| 94_G | 137_F | 1.03 | 0.94 | |
| 30_E | 406_G | 1.027 | 0.94 | |
| 213_E | 378_T | 1.026 | 0.94 | |
| 443_I | 447_A | 1.025 | 0.93 | |
| 4_K | 74_D | 1.02 | 0.93 | |
| 49_P | 99_P | 1.02 | 0.93 | |
| 85_C | 103_W | 1.018 | 0.93 | |
| 417_A | 422_L | 1.015 | 0.93 | |
| 71_N | 74_D | 1.014 | 0.93 | |
| 103_W | 232_Y | 1.01 | 0.93 | |
| 58_C | 62_H | 1.009 | 0.93 | |
| 323_N | 326_E | 1.005 | 0.93 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3ifrA | 2 | 0.9472 | 100 | 0.155 | Contact Map | 0.714 |
| 3hz6A | 1 | 0.9309 | 100 | 0.158 | Contact Map | 0.644 |
| 3ll3A | 2 | 0.9431 | 100 | 0.159 | Contact Map | 0.766 |
| 3jvpA | 4 | 0.9878 | 100 | 0.162 | Contact Map | 0.747 |
| 2itmA | 2 | 0.9045 | 100 | 0.182 | Contact Map | 0.76 |
| 3l0qA | 2 | 0.9634 | 100 | 0.208 | Contact Map | 0.72 |
| 2zf5O | 2 | 0.9167 | 100 | 0.21 | Contact Map | 0.861 |
| 3g25A | 4 | 0.9106 | 100 | 0.212 | Contact Map | 0.862 |
| 2p3rA | 8 | 0.9309 | 100 | 0.213 | Contact Map | 0.865 |
| 2w40A | 4 | 0.9065 | 100 | 0.214 | Contact Map | 0.736 |
Sequence Conservation (Image Generated using WebLogo v3)