| UniProt: | P37677 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12284 | ||
| Length: | 498 (488) | ||
| Sequences: | 5561 | ||
| Seq/Len: | 11.40 |
| LYXK
Paralog alert: 0.74 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 193_P | 203_E | 4.677 | 1.00 | |
| 21_D | 25_R | 4.413 | 1.00 | |
| 109_I | 144_E | 3.559 | 1.00 | |
| 381_M | 385_N | 3.125 | 1.00 | |
| 185_N | 192_D | 3.065 | 1.00 | |
| 356_F | 368_L | 3.061 | 1.00 | |
| 112_R | 144_E | 3.055 | 1.00 | |
| 381_M | 476_Y | 2.944 | 1.00 | |
| 17_A | 58_V | 2.929 | 1.00 | |
| 213_G | 216_E | 2.879 | 1.00 | |
| 411_Q | 415_D | 2.828 | 1.00 | |
| 19_L | 62_L | 2.8 | 1.00 | |
| 95_L | 149_R | 2.751 | 1.00 | |
| 184_Y | 211_V | 2.703 | 1.00 | |
| 447_N | 450_E | 2.636 | 1.00 | |
| 185_N | 188_L | 2.628 | 1.00 | |
| 446_H | 450_E | 2.603 | 1.00 | |
| 49_A | 166_C | 2.603 | 1.00 | |
| 89_D | 152_Q | 2.537 | 1.00 | |
| 420_R | 463_L | 2.526 | 1.00 | |
| 388_R | 419_L | 2.508 | 1.00 | |
| 190_E | 203_E | 2.501 | 1.00 | |
| 307_N | 372_I | 2.466 | 1.00 | |
| 330_L | 367_H | 2.46 | 1.00 | |
| 8_L | 55_C | 2.431 | 1.00 | |
| 125_L | 192_D | 2.407 | 1.00 | |
| 96_G | 146_E | 2.395 | 1.00 | |
| 37_L | 97_N | 2.379 | 1.00 | |
| 32_L | 61_A | 2.368 | 1.00 | |
| 86_F | 159_T | 2.357 | 1.00 | |
| 164_R | 240_G | 2.352 | 1.00 | |
| 381_M | 473_Q | 2.345 | 1.00 | |
| 52_W | 166_C | 2.312 | 1.00 | |
| 168_T | 237_V | 2.312 | 1.00 | |
| 30_Q | 61_A | 2.249 | 1.00 | |
| 32_L | 57_A | 2.165 | 1.00 | |
| 193_P | 197_D | 2.164 | 1.00 | |
| 241_L | 246_S | 2.158 | 1.00 | |
| 407_D | 460_R | 2.129 | 1.00 | |
| 18_G | 431_C | 2.122 | 1.00 | |
| 49_A | 93_K | 2.112 | 1.00 | |
| 196_T | 203_E | 2.104 | 1.00 | |
| 14_W | 31_R | 2.1 | 1.00 | |
| 90_K | 154_G | 2.092 | 1.00 | |
| 329_S | 366_A | 2.061 | 1.00 | |
| 56_M | 228_L | 2.018 | 1.00 | |
| 35_C | 50_E | 2.009 | 1.00 | |
| 6_L | 17_A | 1.991 | 1.00 | |
| 238_V | 441_G | 1.962 | 1.00 | |
| 396_T | 422_E | 1.932 | 1.00 | |
| 339_F | 356_F | 1.931 | 1.00 | |
| 322_E | 325_Q | 1.913 | 1.00 | |
| 170_V | 210_P | 1.912 | 1.00 | |
| 217_I | 238_V | 1.904 | 1.00 | |
| 10_C | 15_L | 1.903 | 1.00 | |
| 388_R | 393_D | 1.874 | 1.00 | |
| 465_D | 468_A | 1.865 | 1.00 | |
| 335_G | 367_H | 1.831 | 1.00 | |
| 476_Y | 480_Q | 1.83 | 1.00 | |
| 319_S | 322_E | 1.802 | 1.00 | |
| 222_T | 225_T | 1.796 | 1.00 | |
| 223_A | 227_A | 1.794 | 1.00 | |
| 125_L | 194_C | 1.728 | 1.00 | |
| 370_Q | 374_E | 1.72 | 1.00 | |
| 408_V | 412_M | 1.717 | 1.00 | |
| 338_F | 478_R | 1.709 | 1.00 | |
| 61_A | 65_H | 1.694 | 1.00 | |
| 267_A | 304_S | 1.687 | 1.00 | |
| 418_G | 469_H | 1.686 | 1.00 | |
| 6_L | 59_I | 1.686 | 1.00 | |
| 212_V | 216_E | 1.684 | 1.00 | |
| 364_T | 367_H | 1.673 | 1.00 | |
| 349_G | 487_Q | 1.658 | 1.00 | |
| 140_R | 144_E | 1.655 | 1.00 | |
| 40_Q | 43_W | 1.654 | 1.00 | |
| 92_D | 165_W | 1.653 | 1.00 | |
| 202_A | 206_H | 1.649 | 1.00 | |
| 108_E | 112_R | 1.647 | 1.00 | |
| 4_Y | 27_A | 1.643 | 1.00 | |
| 399_V | 410_M | 1.624 | 1.00 | |
| 152_Q | 155_C | 1.622 | 1.00 | |
| 121_K | 124_P | 1.593 | 1.00 | |
| 121_K | 125_L | 1.59 | 1.00 | |
| 407_D | 462_L | 1.571 | 1.00 | |
| 385_N | 388_R | 1.558 | 1.00 | |
| 155_C | 171_K | 1.546 | 1.00 | |
| 168_T | 219_G | 1.545 | 1.00 | |
| 87_L | 207_A | 1.543 | 1.00 | |
| 324_N | 406_S | 1.542 | 1.00 | |
| 5_W | 439_R | 1.531 | 1.00 | |
| 19_L | 68_V | 1.528 | 1.00 | |
| 164_R | 172_G | 1.512 | 1.00 | |
| 75_G | 438_A | 1.51 | 1.00 | |
| 258_T | 396_T | 1.505 | 1.00 | |
| 339_F | 343_L | 1.502 | 1.00 | |
| 407_D | 423_L | 1.501 | 1.00 | |
| 111_R | 115_E | 1.489 | 1.00 | |
| 112_R | 116_D | 1.486 | 1.00 | |
| 326_A | 366_A | 1.484 | 1.00 | |
| 422_E | 461_T | 1.474 | 1.00 | |
| 82_G | 242_F | 1.471 | 1.00 | |
| 484_A | 487_Q | 1.471 | 1.00 | |
| 148_E | 151_A | 1.457 | 1.00 | |
| 91_N | 155_C | 1.454 | 1.00 | |
| 420_R | 461_T | 1.449 | 1.00 | |
| 223_A | 233_A | 1.448 | 1.00 | |
| 162_Y | 166_C | 1.433 | 1.00 | |
| 485_A | 489_F | 1.42 | 1.00 | |
| 19_L | 66_S | 1.417 | 1.00 | |
| 359_M | 363_H | 1.414 | 1.00 | |
| 261_A | 413_L | 1.412 | 1.00 | |
| 62_L | 66_S | 1.405 | 0.99 | |
| 339_F | 372_I | 1.402 | 0.99 | |
| 141_W | 145_H | 1.399 | 0.99 | |
| 378_F | 475_K | 1.391 | 0.99 | |
| 415_D | 465_D | 1.391 | 0.99 | |
| 172_G | 212_V | 1.39 | 0.99 | |
| 47_D | 50_E | 1.386 | 0.99 | |
| 121_K | 194_C | 1.384 | 0.99 | |
| 326_A | 329_S | 1.384 | 0.99 | |
| 217_I | 220_E | 1.382 | 0.99 | |
| 15_L | 54_C | 1.373 | 0.99 | |
| 423_L | 462_L | 1.37 | 0.99 | |
| 311_F | 372_I | 1.369 | 0.99 | |
| 354_S | 359_M | 1.369 | 0.99 | |
| 87_L | 142_L | 1.364 | 0.99 | |
| 309_E | 313_A | 1.358 | 0.99 | |
| 333_A | 336_D | 1.356 | 0.99 | |
| 259_L | 394_V | 1.352 | 0.99 | |
| 30_Q | 58_V | 1.346 | 0.99 | |
| 322_E | 326_A | 1.341 | 0.99 | |
| 241_L | 437_A | 1.341 | 0.99 | |
| 15_L | 55_C | 1.34 | 0.99 | |
| 377_V | 412_M | 1.338 | 0.99 | |
| 258_T | 398_R | 1.338 | 0.99 | |
| 325_Q | 329_S | 1.336 | 0.99 | |
| 353_T | 360_Q | 1.336 | 0.99 | |
| 28_G | 62_L | 1.335 | 0.99 | |
| 323_I | 369_L | 1.328 | 0.99 | |
| 52_W | 56_M | 1.327 | 0.99 | |
| 4_Y | 19_L | 1.326 | 0.99 | |
| 301_S | 379_S | 1.314 | 0.99 | |
| 63_L | 73_I | 1.312 | 0.99 | |
| 337_L | 363_H | 1.308 | 0.99 | |
| 263_M | 413_L | 1.302 | 0.99 | |
| 415_D | 468_A | 1.3 | 0.99 | |
| 355_G | 486_L | 1.297 | 0.99 | |
| 412_M | 416_V | 1.294 | 0.99 | |
| 396_T | 420_R | 1.291 | 0.99 | |
| 327_V | 408_V | 1.285 | 0.99 | |
| 212_V | 218_C | 1.272 | 0.99 | |
| 30_Q | 62_L | 1.271 | 0.99 | |
| 89_D | 93_K | 1.253 | 0.99 | |
| 149_R | 152_Q | 1.252 | 0.99 | |
| 143_K | 150_Y | 1.252 | 0.99 | |
| 84_G | 98_A | 1.248 | 0.99 | |
| 217_I | 236_P | 1.246 | 0.98 | |
| 8_L | 59_I | 1.246 | 0.98 | |
| 8_L | 17_A | 1.245 | 0.98 | |
| 481_H | 485_A | 1.243 | 0.98 | |
| 109_I | 140_R | 1.24 | 0.98 | |
| 49_A | 53_Q | 1.238 | 0.98 | |
| 232_K | 235_T | 1.228 | 0.98 | |
| 469_H | 473_Q | 1.228 | 0.98 | |
| 107_M | 111_R | 1.22 | 0.98 | |
| 385_N | 476_Y | 1.213 | 0.98 | |
| 184_Y | 188_L | 1.211 | 0.98 | |
| 175_E | 189_G | 1.209 | 0.98 | |
| 196_T | 208_L | 1.205 | 0.98 | |
| 439_R | 445_Y | 1.193 | 0.98 | |
| 121_K | 198_W | 1.189 | 0.98 | |
| 76_I | 235_T | 1.182 | 0.98 | |
| 385_N | 480_Q | 1.182 | 0.98 | |
| 87_L | 139_L | 1.179 | 0.98 | |
| 51_L | 159_T | 1.178 | 0.98 | |
| 5_W | 444_V | 1.174 | 0.98 | |
| 105_R | 141_W | 1.17 | 0.97 | |
| 136_V | 199_L | 1.167 | 0.97 | |
| 28_G | 66_S | 1.158 | 0.97 | |
| 22_R | 444_V | 1.149 | 0.97 | |
| 148_E | 152_Q | 1.143 | 0.97 | |
| 20_Y | 26_E | 1.142 | 0.97 | |
| 336_D | 370_Q | 1.141 | 0.97 | |
| 220_E | 234_G | 1.14 | 0.97 | |
| 48_M | 97_N | 1.135 | 0.97 | |
| 377_V | 413_L | 1.133 | 0.97 | |
| 381_M | 417_S | 1.133 | 0.97 | |
| 405_H | 427_E | 1.133 | 0.97 | |
| 324_N | 328_A | 1.131 | 0.97 | |
| 164_R | 218_C | 1.13 | 0.97 | |
| 410_M | 462_L | 1.128 | 0.97 | |
| 157_M | 171_K | 1.127 | 0.97 | |
| 37_L | 50_E | 1.125 | 0.97 | |
| 194_C | 197_D | 1.124 | 0.97 | |
| 83_K | 180_E | 1.116 | 0.96 | |
| 120_E | 124_P | 1.115 | 0.96 | |
| 53_Q | 57_A | 1.107 | 0.96 | |
| 36_A | 46_R | 1.106 | 0.96 | |
| 57_A | 61_A | 1.105 | 0.96 | |
| 19_L | 73_I | 1.105 | 0.96 | |
| 55_C | 163_L | 1.103 | 0.96 | |
| 217_I | 441_G | 1.088 | 0.96 | |
| 104_R | 131_W | 1.086 | 0.96 | |
| 467_T | 470_Q | 1.08 | 0.95 | |
| 96_G | 142_L | 1.078 | 0.95 | |
| 376_V | 403_P | 1.078 | 0.95 | |
| 47_D | 97_N | 1.076 | 0.95 | |
| 44_A | 102_S | 1.076 | 0.95 | |
| 324_N | 407_D | 1.075 | 0.95 | |
| 108_E | 111_R | 1.072 | 0.95 | |
| 60_R | 64_T | 1.069 | 0.95 | |
| 377_V | 416_V | 1.068 | 0.95 | |
| 270_S | 296_I | 1.066 | 0.95 | |
| 202_A | 207_A | 1.065 | 0.95 | |
| 68_V | 72_Q | 1.062 | 0.95 | |
| 63_L | 66_S | 1.059 | 0.95 | |
| 150_Y | 153_I | 1.056 | 0.95 | |
| 382_T | 480_Q | 1.054 | 0.95 | |
| 325_Q | 328_A | 1.053 | 0.95 | |
| 114_Q | 119_P | 1.051 | 0.94 | |
| 34_L | 54_C | 1.051 | 0.94 | |
| 190_E | 210_P | 1.05 | 0.94 | |
| 175_E | 184_Y | 1.048 | 0.94 | |
| 307_N | 339_F | 1.046 | 0.94 | |
| 60_R | 228_L | 1.042 | 0.94 | |
| 378_F | 416_V | 1.042 | 0.94 | |
| 122_L | 182_N | 1.031 | 0.94 | |
| 110_V | 130_L | 1.03 | 0.94 | |
| 220_E | 236_P | 1.029 | 0.94 | |
| 78_I | 163_L | 1.028 | 0.94 | |
| 118_I | 198_W | 1.027 | 0.94 | |
| 384_L | 417_S | 1.025 | 0.93 | |
| 6_L | 19_L | 1.018 | 0.93 | |
| 425_Q | 457_H | 1.017 | 0.93 | |
| 370_Q | 408_V | 1.012 | 0.93 | |
| 4_Y | 72_Q | 1.012 | 0.93 | |
| 153_I | 207_A | 1.01 | 0.93 | |
| 175_E | 211_V | 1.007 | 0.93 | |
| 75_G | 238_V | 1.005 | 0.93 | |
| 4_Y | 68_V | 1.002 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3ifrA | 2 | 0.99 | 100 | 0.08 | Contact Map | 0.734 |
| 3hz6A | 1 | 0.988 | 100 | 0.083 | Contact Map | 0.64 |
| 3ll3A | 2 | 0.9839 | 100 | 0.09 | Contact Map | 0.762 |
| 3jvpA | 4 | 0.994 | 100 | 0.106 | Contact Map | 0.729 |
| 2itmA | 2 | 0.9618 | 100 | 0.118 | Contact Map | 0.784 |
| 2zf5O | 2 | 0.9739 | 100 | 0.14 | Contact Map | 0.851 |
| 3g25A | 4 | 0.9679 | 100 | 0.141 | Contact Map | 0.87 |
| 2p3rA | 8 | 0.9799 | 100 | 0.141 | Contact Map | 0.881 |
| 3l0qA | 2 | 0.99 | 100 | 0.146 | Contact Map | 0.727 |
| 2w40A | 4 | 0.9618 | 100 | 0.146 | Contact Map | 0.743 |
Sequence Conservation (Image Generated using WebLogo v3)