| UniProt: | P32171 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG11868 | ||
| Length: | 489 (474) | ||
| Sequences: | 5516 | ||
| Seq/Len: | 11.64 |
| RHAB
Paralog alert: 0.74 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 194_E | 204_K | 4.823 | 1.00 | |
| 24_E | 28_R | 4.489 | 1.00 | |
| 110_L | 145_E | 4.029 | 1.00 | |
| 113_Q | 145_E | 3.21 | 1.00 | |
| 380_A | 384_H | 3.207 | 1.00 | |
| 411_Q | 415_D | 3.154 | 1.00 | |
| 186_N | 193_D | 3.146 | 1.00 | |
| 18_V | 63_G | 3.092 | 1.00 | |
| 380_A | 475_V | 3.092 | 1.00 | |
| 20_L | 67_V | 2.967 | 1.00 | |
| 212_H | 215_N | 2.904 | 1.00 | |
| 96_V | 150_L | 2.899 | 1.00 | |
| 185_V | 210_P | 2.769 | 1.00 | |
| 186_N | 189_S | 2.735 | 1.00 | |
| 446_N | 449_D | 2.701 | 1.00 | |
| 54_D | 167_R | 2.666 | 1.00 | |
| 325_L | 366_E | 2.664 | 1.00 | |
| 191_D | 204_K | 2.643 | 1.00 | |
| 387_A | 419_I | 2.636 | 1.00 | |
| 380_A | 472_A | 2.625 | 1.00 | |
| 420_R | 464_T | 2.621 | 1.00 | |
| 90_D | 153_H | 2.549 | 1.00 | |
| 353_C | 367_L | 2.527 | 1.00 | |
| 445_N | 449_D | 2.525 | 1.00 | |
| 97_G | 147_Q | 2.511 | 1.00 | |
| 9_V | 60_I | 2.498 | 1.00 | |
| 126_R | 193_D | 2.454 | 1.00 | |
| 42_L | 98_L | 2.44 | 1.00 | |
| 165_S | 234_A | 2.397 | 1.00 | |
| 57_E | 167_R | 2.379 | 1.00 | |
| 33_R | 66_K | 2.367 | 1.00 | |
| 407_T | 461_T | 2.34 | 1.00 | |
| 197_L | 204_K | 2.337 | 1.00 | |
| 87_V | 160_M | 2.294 | 1.00 | |
| 324_A | 365_A | 2.257 | 1.00 | |
| 37_R | 66_K | 2.248 | 1.00 | |
| 91_Q | 155_A | 2.214 | 1.00 | |
| 194_E | 198_A | 2.205 | 1.00 | |
| 19_M | 430_T | 2.198 | 1.00 | |
| 54_D | 94_Q | 2.192 | 1.00 | |
| 235_S | 240_S | 2.185 | 1.00 | |
| 169_T | 230_V | 2.134 | 1.00 | |
| 387_A | 393_D | 2.098 | 1.00 | |
| 7_V | 18_V | 2.093 | 1.00 | |
| 352_A | 356_T | 2.078 | 1.00 | |
| 37_R | 62_L | 2.056 | 1.00 | |
| 171_K | 209_R | 2.021 | 1.00 | |
| 40_N | 55_S | 1.977 | 1.00 | |
| 11_L | 16_G | 1.974 | 1.00 | |
| 475_V | 479_H | 1.913 | 1.00 | |
| 317_A | 320_S | 1.899 | 1.00 | |
| 231_V | 440_T | 1.881 | 1.00 | |
| 216_V | 231_V | 1.877 | 1.00 | |
| 466_N | 469_S | 1.869 | 1.00 | |
| 369_R | 373_D | 1.867 | 1.00 | |
| 221_I | 224_Q | 1.832 | 1.00 | |
| 329_R | 366_E | 1.815 | 1.00 | |
| 7_V | 64_L | 1.787 | 1.00 | |
| 15_S | 36_H | 1.752 | 1.00 | |
| 126_R | 195_S | 1.748 | 1.00 | |
| 408_L | 412_L | 1.742 | 1.00 | |
| 93_G | 166_Y | 1.74 | 1.00 | |
| 211_T | 215_N | 1.725 | 1.00 | |
| 314_D | 317_A | 1.719 | 1.00 | |
| 141_R | 145_E | 1.693 | 1.00 | |
| 122_D | 125_Q | 1.69 | 1.00 | |
| 399_I | 410_N | 1.683 | 1.00 | |
| 45_Q | 48_Y | 1.683 | 1.00 | |
| 363_S | 366_E | 1.643 | 1.00 | |
| 169_T | 218_G | 1.643 | 1.00 | |
| 5_N | 30_L | 1.631 | 1.00 | |
| 88_L | 206_W | 1.63 | 1.00 | |
| 112_A | 116_Q | 1.622 | 1.00 | |
| 396_Q | 422_I | 1.615 | 1.00 | |
| 109_G | 113_Q | 1.615 | 1.00 | |
| 407_T | 463_F | 1.613 | 1.00 | |
| 113_Q | 117_Q | 1.585 | 1.00 | |
| 384_H | 387_A | 1.583 | 1.00 | |
| 6_C | 438_L | 1.58 | 1.00 | |
| 122_D | 126_R | 1.574 | 1.00 | |
| 165_S | 173_N | 1.569 | 1.00 | |
| 76_S | 437_Q | 1.555 | 1.00 | |
| 252_A | 396_Q | 1.531 | 1.00 | |
| 319_I | 406_N | 1.53 | 1.00 | |
| 156_H | 172_M | 1.515 | 1.00 | |
| 358_Q | 362_E | 1.509 | 1.00 | |
| 83_G | 236_H | 1.502 | 1.00 | |
| 420_R | 462_T | 1.498 | 1.00 | |
| 66_K | 70_E | 1.495 | 1.00 | |
| 149_E | 152_P | 1.493 | 1.00 | |
| 163_Y | 167_R | 1.486 | 1.00 | |
| 188_N | 270_P | 1.482 | 1.00 | |
| 318_L | 368_A | 1.477 | 1.00 | |
| 331_I | 477_Q | 1.472 | 1.00 | |
| 216_V | 219_H | 1.465 | 1.00 | |
| 88_L | 143_L | 1.461 | 1.00 | |
| 255_L | 413_C | 1.453 | 1.00 | |
| 313_N | 317_A | 1.453 | 1.00 | |
| 332_I | 353_C | 1.452 | 1.00 | |
| 122_D | 195_S | 1.452 | 1.00 | |
| 415_D | 466_N | 1.449 | 1.00 | |
| 322_T | 408_L | 1.446 | 1.00 | |
| 470_E | 474_Y | 1.429 | 1.00 | |
| 407_T | 423_A | 1.428 | 1.00 | |
| 142_A | 146_Q | 1.423 | 1.00 | |
| 300_L | 304_Q | 1.418 | 1.00 | |
| 173_N | 211_T | 1.408 | 1.00 | |
| 253_A | 394_F | 1.405 | 0.99 | |
| 235_S | 436_I | 1.39 | 0.99 | |
| 16_G | 60_I | 1.39 | 0.99 | |
| 16_G | 59_A | 1.39 | 0.99 | |
| 222_C | 226_N | 1.388 | 0.99 | |
| 52_D | 55_S | 1.387 | 0.99 | |
| 321_A | 365_A | 1.387 | 0.99 | |
| 57_E | 61_R | 1.385 | 0.99 | |
| 377_L | 474_Y | 1.38 | 0.99 | |
| 317_A | 321_A | 1.362 | 0.99 | |
| 297_I | 378_L | 1.348 | 0.99 | |
| 90_D | 94_Q | 1.344 | 0.99 | |
| 320_S | 324_A | 1.342 | 0.99 | |
| 252_A | 398_H | 1.342 | 0.99 | |
| 9_V | 18_V | 1.334 | 0.99 | |
| 332_I | 371_I | 1.328 | 0.99 | |
| 110_L | 141_R | 1.324 | 0.99 | |
| 321_A | 324_A | 1.321 | 0.99 | |
| 376_A | 412_L | 1.318 | 0.99 | |
| 470_E | 473_H | 1.315 | 0.99 | |
| 250_S | 268_Q | 1.312 | 0.99 | |
| 302_L | 371_I | 1.309 | 0.99 | |
| 33_R | 37_R | 1.305 | 0.99 | |
| 257_S | 413_C | 1.304 | 0.99 | |
| 211_T | 217_I | 1.298 | 0.99 | |
| 412_L | 416_A | 1.293 | 0.99 | |
| 31_T | 67_V | 1.289 | 0.99 | |
| 23_Y | 29_S | 1.285 | 0.99 | |
| 9_V | 64_L | 1.285 | 0.99 | |
| 262_L | 267_S | 1.284 | 0.99 | |
| 351_A | 358_Q | 1.283 | 0.99 | |
| 5_N | 20_L | 1.279 | 0.99 | |
| 33_R | 67_V | 1.273 | 0.99 | |
| 106_R | 142_A | 1.269 | 0.99 | |
| 176_Y | 190_D | 1.268 | 0.99 | |
| 88_L | 140_L | 1.263 | 0.99 | |
| 33_R | 63_G | 1.257 | 0.99 | |
| 396_Q | 420_R | 1.254 | 0.99 | |
| 6_C | 443_E | 1.254 | 0.99 | |
| 54_D | 58_S | 1.25 | 0.99 | |
| 418_G | 471_I | 1.25 | 0.99 | |
| 268_Q | 290_R | 1.246 | 0.98 | |
| 384_H | 479_H | 1.244 | 0.98 | |
| 384_H | 475_V | 1.24 | 0.98 | |
| 423_A | 463_F | 1.239 | 0.98 | |
| 56_L | 160_M | 1.237 | 0.98 | |
| 415_D | 469_S | 1.228 | 0.98 | |
| 425_P | 455_S | 1.224 | 0.98 | |
| 216_V | 229_P | 1.223 | 0.98 | |
| 144_T | 151_I | 1.209 | 0.98 | |
| 262_L | 266_E | 1.208 | 0.98 | |
| 77_I | 228_I | 1.208 | 0.98 | |
| 219_H | 227_E | 1.207 | 0.98 | |
| 137_L | 200_S | 1.207 | 0.98 | |
| 225_G | 228_I | 1.201 | 0.98 | |
| 108_N | 112_A | 1.2 | 0.98 | |
| 115_Q | 120_K | 1.192 | 0.98 | |
| 89_L | 158_L | 1.19 | 0.98 | |
| 203_N | 206_W | 1.188 | 0.98 | |
| 376_A | 413_C | 1.183 | 0.98 | |
| 121_R | 125_Q | 1.182 | 0.98 | |
| 85_D | 99_P | 1.179 | 0.98 | |
| 380_A | 417_C | 1.177 | 0.98 | |
| 53_V | 98_L | 1.177 | 0.98 | |
| 150_L | 153_H | 1.175 | 0.98 | |
| 185_V | 189_S | 1.174 | 0.98 | |
| 322_T | 369_R | 1.17 | 0.97 | |
| 410_N | 463_F | 1.169 | 0.97 | |
| 111_M | 131_F | 1.168 | 0.97 | |
| 438_L | 444_L | 1.164 | 0.97 | |
| 84_V | 181_T | 1.162 | 0.97 | |
| 122_D | 199_W | 1.155 | 0.97 | |
| 154_I | 206_W | 1.152 | 0.97 | |
| 25_R | 443_E | 1.15 | 0.97 | |
| 319_I | 323_Q | 1.144 | 0.97 | |
| 62_L | 66_K | 1.142 | 0.97 | |
| 125_Q | 272_T | 1.141 | 0.97 | |
| 68_C | 74_I | 1.134 | 0.97 | |
| 149_E | 153_H | 1.131 | 0.97 | |
| 422_I | 462_T | 1.13 | 0.97 | |
| 58_S | 62_L | 1.128 | 0.97 | |
| 49_V | 103_R | 1.128 | 0.97 | |
| 60_I | 64_L | 1.125 | 0.97 | |
| 411_Q | 463_F | 1.124 | 0.97 | |
| 216_V | 440_T | 1.123 | 0.97 | |
| 195_S | 198_A | 1.121 | 0.97 | |
| 176_Y | 185_V | 1.12 | 0.96 | |
| 165_S | 217_I | 1.116 | 0.96 | |
| 151_I | 154_I | 1.114 | 0.96 | |
| 60_I | 164_F | 1.112 | 0.96 | |
| 375_L | 403_G | 1.109 | 0.96 | |
| 7_V | 20_L | 1.104 | 0.96 | |
| 52_D | 98_L | 1.104 | 0.96 | |
| 249_G | 252_A | 1.098 | 0.96 | |
| 39_N | 59_A | 1.09 | 0.96 | |
| 376_A | 416_A | 1.089 | 0.96 | |
| 319_I | 407_T | 1.078 | 0.95 | |
| 42_L | 55_S | 1.078 | 0.95 | |
| 119_G | 199_W | 1.077 | 0.95 | |
| 4_R | 73_R | 1.07 | 0.95 | |
| 191_D | 209_R | 1.066 | 0.95 | |
| 105_S | 132_L | 1.062 | 0.95 | |
| 79_I | 164_F | 1.057 | 0.95 | |
| 65_N | 69_E | 1.054 | 0.95 | |
| 176_Y | 210_P | 1.053 | 0.95 | |
| 20_L | 74_I | 1.049 | 0.94 | |
| 4_R | 75_D | 1.045 | 0.94 | |
| 220_W | 228_I | 1.041 | 0.94 | |
| 147_Q | 150_L | 1.039 | 0.94 | |
| 330_F | 362_E | 1.038 | 0.94 | |
| 41_G | 51_W | 1.033 | 0.94 | |
| 109_G | 112_A | 1.033 | 0.94 | |
| 383_L | 417_C | 1.03 | 0.94 | |
| 377_L | 416_A | 1.029 | 0.94 | |
| 97_G | 143_L | 1.026 | 0.94 | |
| 66_K | 69_E | 1.025 | 0.93 | |
| 197_L | 207_F | 1.024 | 0.93 | |
| 238_T | 262_L | 1.023 | 0.93 | |
| 369_R | 408_L | 1.021 | 0.93 | |
| 321_A | 368_A | 1.017 | 0.93 | |
| 123_I | 183_Q | 1.016 | 0.93 | |
| 5_N | 73_R | 1.013 | 0.93 | |
| 249_G | 395_S | 1.008 | 0.93 | |
| 435_G | 450_F | 1.007 | 0.93 | |
| 249_G | 451_R | 1.006 | 0.93 | |
| 11_L | 59_A | 1.005 | 0.93 | |
| 306_V | 367_L | 1.004 | 0.93 | |
| 231_V | 441_L | 1.003 | 0.93 | |
| 472_A | 476_A | 1 | 0.92 | |
| 381_D | 479_H | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3ll3A | 2 | 0.9571 | 100 | 0.112 | Contact Map | 0.76 |
| 3ifrA | 2 | 0.9571 | 100 | 0.117 | Contact Map | 0.735 |
| 3hz6A | 1 | 0.9571 | 100 | 0.118 | Contact Map | 0.642 |
| 2uytA | 1 | 0.9877 | 100 | 0.122 | Contact Map | 0.625 |
| 3g25A | 4 | 0.9571 | 100 | 0.14 | Contact Map | 0.878 |
| 3jvpA | 4 | 0.9652 | 100 | 0.141 | Contact Map | 0.755 |
| 2zf5O | 2 | 0.9489 | 100 | 0.141 | Contact Map | 0.85 |
| 2p3rA | 8 | 0.9571 | 100 | 0.143 | Contact Map | 0.888 |
| 3h3nX | 2 | 0.9591 | 100 | 0.144 | Contact Map | 0.828 |
| 2w40A | 4 | 0.9571 | 100 | 0.145 | Contact Map | 0.757 |
Sequence Conservation (Image Generated using WebLogo v3)