| UniProt: | P08204 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10053 | ||
| Length: | 566 (519) | ||
| Sequences: | 5078 | ||
| Seq/Len: | 9.78 |
| ARAB
Paralog alert: 0.73 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 20_D | 25_E | 4.622 | 1.00 | |
| 220_A | 236_S | 4.506 | 1.00 | |
| 127_E | 165_R | 4.053 | 1.00 | |
| 439_R | 443_E | 3.302 | 1.00 | |
| 439_R | 536_Y | 3.233 | 1.00 | |
| 130_E | 165_R | 3.198 | 1.00 | |
| 470_Q | 474_D | 3.195 | 1.00 | |
| 414_I | 426_L | 3.187 | 1.00 | |
| 16_A | 64_A | 3.097 | 1.00 | |
| 18_A | 68_V | 3.072 | 1.00 | |
| 102_L | 170_V | 2.987 | 1.00 | |
| 244_T | 247_I | 2.983 | 1.00 | |
| 211_H | 219_P | 2.824 | 1.00 | |
| 506_D | 509_S | 2.71 | 1.00 | |
| 439_R | 533_E | 2.707 | 1.00 | |
| 479_P | 523_Q | 2.707 | 1.00 | |
| 20_D | 23_T | 2.682 | 1.00 | |
| 446_T | 478_R | 2.664 | 1.00 | |
| 96_D | 173_S | 2.65 | 1.00 | |
| 55_R | 187_L | 2.614 | 1.00 | |
| 211_H | 214_W | 2.606 | 1.00 | |
| 385_N | 425_L | 2.585 | 1.00 | |
| 32_E | 67_T | 2.583 | 1.00 | |
| 341_I | 430_L | 2.575 | 1.00 | |
| 505_A | 509_S | 2.564 | 1.00 | |
| 185_P | 271_G | 2.561 | 1.00 | |
| 7_L | 61_M | 2.544 | 1.00 | |
| 93_A | 180_L | 2.541 | 1.00 | |
| 223_F | 236_S | 2.539 | 1.00 | |
| 216_G | 236_S | 2.511 | 1.00 | |
| 103_A | 167_D | 2.491 | 1.00 | |
| 189_S | 268_I | 2.478 | 1.00 | |
| 30_S | 67_T | 2.371 | 1.00 | |
| 466_Q | 520_K | 2.338 | 1.00 | |
| 32_E | 63_A | 2.325 | 1.00 | |
| 37_W | 115_M | 2.32 | 1.00 | |
| 13_S | 31_V | 2.319 | 1.00 | |
| 55_R | 100_N | 2.265 | 1.00 | |
| 58_I | 187_L | 2.235 | 1.00 | |
| 97_A | 175_A | 2.222 | 1.00 | |
| 210_W | 242_T | 2.216 | 1.00 | |
| 269_S | 500_A | 2.151 | 1.00 | |
| 297_T | 338_F | 2.148 | 1.00 | |
| 17_L | 490_A | 2.144 | 1.00 | |
| 5_I | 16_A | 2.14 | 1.00 | |
| 62_E | 259_R | 2.139 | 1.00 | |
| 272_A | 277_M | 2.133 | 1.00 | |
| 35_P | 56_D | 2.105 | 1.00 | |
| 446_T | 451_A | 2.046 | 1.00 | |
| 220_A | 224_D | 2.026 | 1.00 | |
| 394_V | 414_I | 2.006 | 1.00 | |
| 384_K | 424_P | 1.978 | 1.00 | |
| 9_F | 14_V | 1.954 | 1.00 | |
| 454_N | 481_Q | 1.952 | 1.00 | |
| 525_C | 528_Q | 1.943 | 1.00 | |
| 248_P | 269_S | 1.937 | 1.00 | |
| 536_Y | 540_Q | 1.927 | 1.00 | |
| 390_H | 425_L | 1.906 | 1.00 | |
| 428_G | 432_A | 1.885 | 1.00 | |
| 254_P | 258_Q | 1.885 | 1.00 | |
| 467_V | 471_A | 1.864 | 1.00 | |
| 146_Y | 219_P | 1.839 | 1.00 | |
| 477_N | 529_A | 1.829 | 1.00 | |
| 393_V | 538_R | 1.812 | 1.00 | |
| 75_E | 78_A | 1.805 | 1.00 | |
| 46_P | 49_Q | 1.79 | 1.00 | |
| 3_I | 27_I | 1.779 | 1.00 | |
| 253_C | 256_W | 1.769 | 1.00 | |
| 146_Y | 221_S | 1.763 | 1.00 | |
| 191_T | 241_D | 1.75 | 1.00 | |
| 377_A | 380_E | 1.744 | 1.00 | |
| 189_S | 250_G | 1.74 | 1.00 | |
| 18_A | 74_V | 1.731 | 1.00 | |
| 5_I | 65_L | 1.725 | 1.00 | |
| 94_P | 238_L | 1.717 | 1.00 | |
| 243_W | 247_I | 1.714 | 1.00 | |
| 161_L | 165_R | 1.711 | 1.00 | |
| 99_G | 186_A | 1.7 | 1.00 | |
| 417_L | 421_T | 1.676 | 1.00 | |
| 443_E | 446_T | 1.674 | 1.00 | |
| 407_N | 547_E | 1.661 | 1.00 | |
| 126_E | 130_E | 1.657 | 1.00 | |
| 142_D | 146_Y | 1.649 | 1.00 | |
| 422_D | 425_L | 1.641 | 1.00 | |
| 457_A | 469_M | 1.635 | 1.00 | |
| 67_T | 71_E | 1.63 | 1.00 | |
| 466_Q | 522_L | 1.63 | 1.00 | |
| 466_Q | 482_I | 1.62 | 1.00 | |
| 474_D | 525_C | 1.6 | 1.00 | |
| 142_D | 145_R | 1.595 | 1.00 | |
| 4_A | 498_A | 1.589 | 1.00 | |
| 129_E | 133_R | 1.587 | 1.00 | |
| 183_W | 187_L | 1.56 | 1.00 | |
| 68_V | 72_L | 1.552 | 1.00 | |
| 82_G | 497_A | 1.55 | 1.00 | |
| 254_P | 264_E | 1.549 | 1.00 | |
| 436_F | 535_L | 1.541 | 1.00 | |
| 394_V | 398_F | 1.537 | 1.00 | |
| 479_P | 521_T | 1.532 | 1.00 | |
| 130_E | 134_L | 1.531 | 1.00 | |
| 28_A | 68_V | 1.522 | 1.00 | |
| 379_T | 465_N | 1.514 | 1.00 | |
| 382_W | 467_V | 1.506 | 1.00 | |
| 53_H | 56_D | 1.503 | 1.00 | |
| 481_Q | 521_T | 1.495 | 1.00 | |
| 248_P | 251_T | 1.492 | 1.00 | |
| 394_V | 430_L | 1.49 | 1.00 | |
| 378_L | 427_F | 1.484 | 1.00 | |
| 169_A | 172_Q | 1.48 | 1.00 | |
| 381_A | 424_P | 1.48 | 1.00 | |
| 14_V | 61_M | 1.463 | 1.00 | |
| 272_A | 496_F | 1.453 | 1.00 | |
| 18_A | 72_L | 1.453 | 1.00 | |
| 381_A | 384_K | 1.446 | 1.00 | |
| 392_P | 421_T | 1.445 | 1.00 | |
| 89_G | 273_F | 1.445 | 1.00 | |
| 14_V | 60_S | 1.427 | 1.00 | |
| 288_A | 456_M | 1.422 | 1.00 | |
| 482_I | 522_L | 1.418 | 1.00 | |
| 484_A | 517_A | 1.416 | 0.99 | |
| 289_L | 452_V | 1.416 | 0.99 | |
| 291_K | 472_C | 1.412 | 0.99 | |
| 474_D | 528_Q | 1.401 | 0.99 | |
| 94_P | 163_V | 1.387 | 0.99 | |
| 91_T | 116_F | 1.374 | 0.99 | |
| 412_G | 417_L | 1.374 | 0.99 | |
| 288_A | 454_N | 1.363 | 0.99 | |
| 435_A | 471_A | 1.363 | 0.99 | |
| 377_A | 381_A | 1.36 | 0.99 | |
| 162_H | 166_Q | 1.354 | 0.99 | |
| 293_I | 472_C | 1.354 | 0.99 | |
| 345_F | 430_L | 1.352 | 0.99 | |
| 335_Q | 437_G | 1.344 | 0.99 | |
| 529_A | 533_E | 1.343 | 0.99 | |
| 127_E | 161_L | 1.343 | 0.99 | |
| 30_S | 68_V | 1.341 | 0.99 | |
| 30_S | 64_A | 1.337 | 0.99 | |
| 388_L | 391_L | 1.324 | 0.99 | |
| 132_T | 140_N | 1.322 | 0.99 | |
| 443_E | 540_Q | 1.319 | 0.99 | |
| 58_I | 62_E | 1.318 | 0.99 | |
| 484_A | 519_E | 1.318 | 0.99 | |
| 3_I | 18_A | 1.318 | 0.99 | |
| 471_A | 475_V | 1.309 | 0.99 | |
| 413_V | 546_A | 1.298 | 0.99 | |
| 380_E | 384_K | 1.295 | 0.99 | |
| 54_P | 115_M | 1.295 | 0.99 | |
| 337_A | 340_D | 1.293 | 0.99 | |
| 411_K | 418_N | 1.291 | 0.99 | |
| 18_A | 80_V | 1.287 | 0.99 | |
| 286_P | 304_D | 1.287 | 0.99 | |
| 7_L | 65_L | 1.284 | 0.99 | |
| 4_A | 503_V | 1.283 | 0.99 | |
| 263_P | 266_V | 1.282 | 0.99 | |
| 454_N | 479_P | 1.281 | 0.99 | |
| 141_V | 145_R | 1.28 | 0.99 | |
| 443_E | 536_Y | 1.277 | 0.99 | |
| 142_D | 221_S | 1.276 | 0.99 | |
| 157_W | 226_L | 1.276 | 0.99 | |
| 94_P | 160_I | 1.274 | 0.99 | |
| 379_T | 383_A | 1.263 | 0.99 | |
| 541_Q | 545_S | 1.259 | 0.99 | |
| 28_A | 72_L | 1.258 | 0.99 | |
| 69_L | 80_V | 1.257 | 0.99 | |
| 498_A | 504_H | 1.249 | 0.98 | |
| 243_W | 249_V | 1.247 | 0.98 | |
| 164_T | 171_A | 1.245 | 0.98 | |
| 55_R | 59_E | 1.238 | 0.98 | |
| 96_D | 100_N | 1.235 | 0.98 | |
| 170_V | 173_S | 1.231 | 0.98 | |
| 185_P | 249_V | 1.219 | 0.98 | |
| 83_I | 266_V | 1.217 | 0.98 | |
| 374_L | 377_A | 1.217 | 0.98 | |
| 21_C | 503_V | 1.211 | 0.98 | |
| 169_A | 173_S | 1.21 | 0.98 | |
| 248_P | 267_V | 1.206 | 0.98 | |
| 469_M | 522_L | 1.205 | 0.98 | |
| 391_L | 428_G | 1.204 | 0.98 | |
| 435_A | 475_V | 1.204 | 0.98 | |
| 57_Y | 180_L | 1.202 | 0.98 | |
| 7_L | 16_A | 1.196 | 0.98 | |
| 74_V | 79_A | 1.195 | 0.98 | |
| 470_Q | 522_L | 1.191 | 0.98 | |
| 142_D | 225_E | 1.185 | 0.98 | |
| 248_P | 500_A | 1.184 | 0.98 | |
| 3_I | 79_A | 1.183 | 0.98 | |
| 95_I | 178_I | 1.182 | 0.98 | |
| 434_T | 461_I | 1.181 | 0.98 | |
| 341_I | 394_V | 1.173 | 0.97 | |
| 195_Q | 318_G | 1.172 | 0.97 | |
| 251_T | 265_S | 1.168 | 0.97 | |
| 163_V | 170_V | 1.165 | 0.97 | |
| 343_A | 347_R | 1.164 | 0.97 | |
| 61_M | 65_L | 1.162 | 0.97 | |
| 128_A | 151_Y | 1.155 | 0.97 | |
| 66_K | 70_A | 1.149 | 0.97 | |
| 298_C | 334_G | 1.146 | 0.97 | |
| 544_M | 547_E | 1.146 | 0.97 | |
| 59_E | 63_A | 1.145 | 0.97 | |
| 210_W | 214_W | 1.142 | 0.97 | |
| 289_L | 455_V | 1.137 | 0.97 | |
| 216_G | 241_D | 1.135 | 0.97 | |
| 439_R | 476_L | 1.135 | 0.97 | |
| 61_M | 184_V | 1.132 | 0.97 | |
| 103_A | 163_V | 1.131 | 0.97 | |
| 63_A | 67_T | 1.129 | 0.97 | |
| 252_L | 266_V | 1.125 | 0.96 | |
| 518_V | 521_T | 1.125 | 0.96 | |
| 92_P | 177_W | 1.125 | 0.96 | |
| 34_Y | 60_S | 1.123 | 0.96 | |
| 382_W | 428_G | 1.12 | 0.96 | |
| 194_P | 319_Q | 1.117 | 0.96 | |
| 82_G | 269_S | 1.116 | 0.96 | |
| 125_V | 129_E | 1.113 | 0.96 | |
| 414_I | 430_L | 1.107 | 0.96 | |
| 275_C | 298_C | 1.106 | 0.96 | |
| 19_V | 26_E | 1.101 | 0.96 | |
| 385_N | 389_D | 1.096 | 0.96 | |
| 379_T | 466_Q | 1.096 | 0.96 | |
| 127_E | 166_Q | 1.094 | 0.96 | |
| 435_A | 472_C | 1.094 | 0.96 | |
| 69_L | 72_L | 1.093 | 0.96 | |
| 464_K | 486_D | 1.091 | 0.96 | |
| 381_A | 427_F | 1.091 | 0.96 | |
| 442_M | 476_L | 1.091 | 0.96 | |
| 171_A | 174_A | 1.09 | 0.96 | |
| 440_A | 540_Q | 1.089 | 0.96 | |
| 122_H | 152_S | 1.087 | 0.95 | |
| 161_L | 171_A | 1.08 | 0.95 | |
| 50_F | 120_K | 1.079 | 0.95 | |
| 380_E | 383_A | 1.076 | 0.95 | |
| 28_A | 71_E | 1.071 | 0.95 | |
| 216_G | 220_A | 1.068 | 0.95 | |
| 36_R | 52_H | 1.061 | 0.95 | |
| 96_D | 102_L | 1.055 | 0.94 | |
| 337_A | 341_I | 1.055 | 0.94 | |
| 527_E | 530_Q | 1.046 | 0.94 | |
| 285_Q | 288_A | 1.044 | 0.94 | |
| 126_E | 129_E | 1.044 | 0.94 | |
| 269_S | 501_A | 1.037 | 0.94 | |
| 2_A | 79_A | 1.036 | 0.94 | |
| 5_I | 18_A | 1.034 | 0.94 | |
| 123_T | 162_H | 1.032 | 0.94 | |
| 102_L | 173_S | 1.029 | 0.93 | |
| 128_A | 158_A | 1.029 | 0.93 | |
| 37_W | 56_D | 1.025 | 0.93 | |
| 9_F | 60_S | 1.023 | 0.93 | |
| 161_L | 227_D | 1.02 | 0.93 | |
| 174_A | 238_L | 1.019 | 0.93 | |
| 54_P | 93_A | 1.016 | 0.93 | |
| 66_K | 259_R | 1.014 | 0.93 | |
| 319_Q | 327_G | 1.013 | 0.93 | |
| 533_E | 537_R | 1.001 | 0.92 | |
| 251_T | 267_V | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3jvpA | 4 | 0.9558 | 100 | 0.189 | Contact Map | 0.753 |
| 3ifrA | 2 | 0.8834 | 100 | 0.19 | Contact Map | 0.74 |
| 3hz6A | 1 | 0.8728 | 100 | 0.195 | Contact Map | 0.629 |
| 3ll3A | 2 | 0.8816 | 100 | 0.201 | Contact Map | 0.752 |
| 2itmA | 2 | 0.8463 | 100 | 0.215 | Contact Map | 0.777 |
| 3l0qA | 2 | 0.9223 | 100 | 0.231 | Contact Map | 0.747 |
| 2w40A | 4 | 0.8551 | 100 | 0.239 | Contact Map | 0.758 |
| 2p3rA | 8 | 0.8657 | 100 | 0.24 | Contact Map | 0.869 |
| 2d4wA | 2 | 0.8622 | 100 | 0.241 | Contact Map | 0.795 |
| 2zf5O | 2 | 0.8587 | 100 | 0.242 | Contact Map | 0.847 |
Sequence Conservation (Image Generated using WebLogo v3)