| UniProt: | P11553 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG10350 | ||
| Length: | 482 (468) | ||
| Sequences: | 5532 | ||
| Seq/Len: | 11.82 |
| FUCK
Paralog alert: 0.74 [within 20: 0.17] - ratio of genomes with paralogs Cluster includes: ARAB FUCK GLPK LSRK LYXK RHAB XYLB YGCE |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 204_P | 214_R | 4.894 | 1.00 | |
| 32_N | 36_K | 4.506 | 1.00 | |
| 120_V | 155_E | 4.054 | 1.00 | |
| 388_Q | 392_Q | 3.472 | 1.00 | |
| 123_N | 155_E | 3.171 | 1.00 | |
| 363_W | 375_F | 3.146 | 1.00 | |
| 28_A | 71_C | 3.141 | 1.00 | |
| 196_D | 203_S | 3.13 | 1.00 | |
| 419_Q | 423_N | 3.032 | 1.00 | |
| 222_E | 225_E | 2.966 | 1.00 | |
| 30_A | 75_I | 2.928 | 1.00 | |
| 106_L | 160_L | 2.865 | 1.00 | |
| 201_D | 214_R | 2.848 | 1.00 | |
| 195_L | 220_L | 2.822 | 1.00 | |
| 196_D | 199_Q | 2.738 | 1.00 | |
| 342_I | 374_H | 2.69 | 1.00 | |
| 395_E | 427_I | 2.677 | 1.00 | |
| 62_D | 177_R | 2.676 | 1.00 | |
| 454_N | 458_E | 2.642 | 1.00 | |
| 455_S | 458_E | 2.632 | 1.00 | |
| 100_D | 163_R | 2.614 | 1.00 | |
| 317_V | 379_A | 2.559 | 1.00 | |
| 428_P | 471_Y | 2.539 | 1.00 | |
| 41_A | 74_Q | 2.532 | 1.00 | |
| 19_L | 68_F | 2.521 | 1.00 | |
| 107_Y | 157_H | 2.502 | 1.00 | |
| 136_I | 203_S | 2.495 | 1.00 | |
| 175_N | 249_A | 2.481 | 1.00 | |
| 43_T | 74_Q | 2.439 | 1.00 | |
| 65_L | 177_R | 2.396 | 1.00 | |
| 97_A | 170_I | 2.388 | 1.00 | |
| 207_L | 214_R | 2.364 | 1.00 | |
| 179_T | 246_V | 2.316 | 1.00 | |
| 101_K | 165_H | 2.233 | 1.00 | |
| 43_T | 70_D | 2.224 | 1.00 | |
| 62_D | 104_N | 2.203 | 1.00 | |
| 25_N | 42_S | 2.2 | 1.00 | |
| 415_T | 468_R | 2.198 | 1.00 | |
| 250_G | 255_F | 2.197 | 1.00 | |
| 341_L | 373_G | 2.182 | 1.00 | |
| 204_P | 208_Q | 2.157 | 1.00 | |
| 395_E | 401_K | 2.118 | 1.00 | |
| 69_A | 237_M | 2.092 | 1.00 | |
| 29_I | 439_V | 2.086 | 1.00 | |
| 17_L | 28_A | 2.082 | 1.00 | |
| 181_E | 219_R | 2.074 | 1.00 | |
| 50_A | 108_P | 2.026 | 1.00 | |
| 21_C | 26_V | 1.993 | 1.00 | |
| 247_I | 449_G | 1.968 | 1.00 | |
| 347_D | 374_H | 1.948 | 1.00 | |
| 404_E | 430_K | 1.94 | 1.00 | |
| 351_M | 363_W | 1.935 | 1.00 | |
| 226_Q | 247_I | 1.915 | 1.00 | |
| 136_I | 205_Q | 1.855 | 1.00 | |
| 426_D | 476_P | 1.836 | 1.00 | |
| 232_N | 236_A | 1.83 | 1.00 | |
| 416_L | 420_I | 1.822 | 1.00 | |
| 231_Q | 234_A | 1.796 | 1.00 | |
| 275_E | 314_A | 1.789 | 1.00 | |
| 132_R | 135_A | 1.771 | 1.00 | |
| 221_V | 225_E | 1.752 | 1.00 | |
| 53_N | 56_W | 1.734 | 1.00 | |
| 17_L | 72_C | 1.732 | 1.00 | |
| 15_V | 38_V | 1.725 | 1.00 | |
| 371_T | 374_H | 1.718 | 1.00 | |
| 151_V | 155_E | 1.714 | 1.00 | |
| 122_D | 126_R | 1.713 | 1.00 | |
| 377_R | 381_E | 1.703 | 1.00 | |
| 407_L | 418_N | 1.696 | 1.00 | |
| 123_N | 127_L | 1.675 | 1.00 | |
| 103_G | 176_H | 1.668 | 1.00 | |
| 132_R | 136_I | 1.646 | 1.00 | |
| 98_L | 216_L | 1.64 | 1.00 | |
| 30_A | 79_L | 1.639 | 1.00 | |
| 392_Q | 395_E | 1.626 | 1.00 | |
| 132_R | 205_Q | 1.625 | 1.00 | |
| 119_A | 123_N | 1.621 | 1.00 | |
| 179_T | 228_G | 1.605 | 1.00 | |
| 16_I | 447_W | 1.593 | 1.00 | |
| 166_A | 182_F | 1.587 | 1.00 | |
| 175_N | 183_T | 1.576 | 1.00 | |
| 415_T | 431_V | 1.554 | 1.00 | |
| 98_L | 153_L | 1.536 | 1.00 | |
| 415_T | 470_F | 1.535 | 1.00 | |
| 351_M | 355_L | 1.533 | 1.00 | |
| 232_N | 242_V | 1.527 | 1.00 | |
| 86_G | 446_G | 1.523 | 1.00 | |
| 388_Q | 480_E | 1.521 | 1.00 | |
| 428_P | 469_Y | 1.521 | 1.00 | |
| 159_Q | 162_E | 1.517 | 1.00 | |
| 226_Q | 229_T | 1.517 | 1.00 | |
| 366_V | 370_T | 1.504 | 1.00 | |
| 74_Q | 78_E | 1.503 | 1.00 | |
| 93_G | 251_H | 1.499 | 1.00 | |
| 334_M | 337_E | 1.498 | 1.00 | |
| 152_W | 156_N | 1.491 | 1.00 | |
| 173_L | 177_R | 1.484 | 1.00 | |
| 266_E | 404_E | 1.477 | 1.00 | |
| 321_V | 379_A | 1.474 | 1.00 | |
| 60_S | 63_A | 1.446 | 1.00 | |
| 269_L | 421_K | 1.435 | 1.00 | |
| 349_V | 370_T | 1.435 | 1.00 | |
| 183_T | 221_V | 1.429 | 1.00 | |
| 319_E | 323_K | 1.428 | 1.00 | |
| 15_V | 30_A | 1.425 | 1.00 | |
| 338_E | 341_L | 1.422 | 1.00 | |
| 95_D | 109_I | 1.395 | 0.99 | |
| 41_A | 75_I | 1.394 | 0.99 | |
| 250_G | 445_F | 1.393 | 0.99 | |
| 65_L | 69_A | 1.393 | 0.99 | |
| 351_M | 379_A | 1.386 | 0.99 | |
| 361_A | 366_V | 1.382 | 0.99 | |
| 26_V | 67_R | 1.381 | 0.99 | |
| 430_K | 469_Y | 1.38 | 0.99 | |
| 41_A | 71_C | 1.377 | 0.99 | |
| 423_N | 473_Q | 1.375 | 0.99 | |
| 384_T | 420_I | 1.365 | 0.99 | |
| 334_M | 338_E | 1.365 | 0.99 | |
| 19_L | 72_C | 1.364 | 0.99 | |
| 120_V | 151_V | 1.363 | 0.99 | |
| 26_V | 68_F | 1.361 | 0.99 | |
| 345_G | 348_G | 1.351 | 0.99 | |
| 39_A | 75_I | 1.342 | 0.99 | |
| 271_S | 421_K | 1.333 | 0.99 | |
| 226_Q | 245_P | 1.318 | 0.99 | |
| 338_E | 373_G | 1.313 | 0.99 | |
| 404_E | 428_P | 1.312 | 0.99 | |
| 266_E | 406_L | 1.307 | 0.99 | |
| 360_N | 367_T | 1.304 | 0.99 | |
| 100_D | 104_N | 1.299 | 0.99 | |
| 221_V | 227_I | 1.296 | 0.99 | |
| 62_D | 66_Q | 1.294 | 0.99 | |
| 198_Q | 284_V | 1.29 | 0.99 | |
| 337_E | 341_L | 1.284 | 0.99 | |
| 147_L | 210_T | 1.28 | 0.99 | |
| 241_P | 244_I | 1.279 | 0.99 | |
| 19_L | 28_A | 1.277 | 0.99 | |
| 186_I | 200_R | 1.274 | 0.99 | |
| 154_K | 161_L | 1.269 | 0.99 | |
| 160_L | 163_R | 1.268 | 0.99 | |
| 420_I | 424_M | 1.264 | 0.99 | |
| 447_W | 453_F | 1.262 | 0.99 | |
| 98_L | 150_L | 1.255 | 0.99 | |
| 207_L | 217_F | 1.254 | 0.99 | |
| 339_A | 416_L | 1.251 | 0.99 | |
| 431_V | 470_F | 1.246 | 0.98 | |
| 99_V | 168_L | 1.241 | 0.98 | |
| 16_I | 452_E | 1.232 | 0.98 | |
| 195_L | 199_Q | 1.229 | 0.98 | |
| 388_Q | 425_L | 1.225 | 0.98 | |
| 66_Q | 70_D | 1.225 | 0.98 | |
| 159_Q | 163_R | 1.212 | 0.98 | |
| 87_I | 244_I | 1.21 | 0.98 | |
| 48_D | 63_A | 1.209 | 0.98 | |
| 131_Q | 135_A | 1.205 | 0.98 | |
| 31_V | 37_I | 1.203 | 0.98 | |
| 76_N | 84_I | 1.196 | 0.98 | |
| 337_E | 340_R | 1.195 | 0.98 | |
| 64_I | 170_I | 1.19 | 0.98 | |
| 229_T | 243_G | 1.189 | 0.98 | |
| 116_R | 152_W | 1.181 | 0.98 | |
| 68_F | 72_C | 1.18 | 0.98 | |
| 33_R | 452_E | 1.178 | 0.98 | |
| 61_L | 108_P | 1.177 | 0.98 | |
| 132_R | 209_A | 1.175 | 0.98 | |
| 30_A | 84_I | 1.168 | 0.97 | |
| 413_R | 435_A | 1.166 | 0.97 | |
| 125_E | 130_A | 1.163 | 0.97 | |
| 118_A | 122_D | 1.163 | 0.97 | |
| 119_A | 122_D | 1.161 | 0.97 | |
| 60_S | 108_P | 1.158 | 0.97 | |
| 205_Q | 208_Q | 1.158 | 0.97 | |
| 226_Q | 449_G | 1.158 | 0.97 | |
| 175_N | 227_I | 1.155 | 0.97 | |
| 267_P | 402_A | 1.153 | 0.97 | |
| 68_F | 174_I | 1.15 | 0.97 | |
| 476_P | 480_E | 1.148 | 0.97 | |
| 384_T | 421_K | 1.146 | 0.97 | |
| 15_V | 83_H | 1.142 | 0.97 | |
| 94_V | 191_T | 1.138 | 0.97 | |
| 313_L | 316_G | 1.137 | 0.97 | |
| 348_G | 377_R | 1.134 | 0.97 | |
| 70_D | 74_Q | 1.127 | 0.97 | |
| 418_N | 470_F | 1.127 | 0.97 | |
| 383_L | 411_G | 1.127 | 0.97 | |
| 363_W | 379_A | 1.126 | 0.97 | |
| 14_E | 85_R | 1.122 | 0.97 | |
| 213_P | 216_L | 1.121 | 0.97 | |
| 201_D | 219_R | 1.115 | 0.96 | |
| 164_A | 216_L | 1.105 | 0.96 | |
| 73_R | 237_M | 1.101 | 0.96 | |
| 317_V | 351_M | 1.101 | 0.96 | |
| 161_L | 164_A | 1.101 | 0.96 | |
| 385_A | 424_M | 1.1 | 0.96 | |
| 335_L | 376_Y | 1.093 | 0.96 | |
| 121_M | 141_A | 1.087 | 0.96 | |
| 391_L | 425_L | 1.084 | 0.96 | |
| 17_L | 30_A | 1.083 | 0.96 | |
| 331_P | 334_M | 1.08 | 0.95 | |
| 73_R | 77_S | 1.079 | 0.95 | |
| 14_E | 83_H | 1.066 | 0.95 | |
| 384_T | 424_M | 1.065 | 0.95 | |
| 76_N | 81_E | 1.059 | 0.95 | |
| 186_I | 220_L | 1.059 | 0.95 | |
| 186_I | 195_L | 1.058 | 0.95 | |
| 342_I | 346_A | 1.051 | 0.94 | |
| 57_H | 113_K | 1.042 | 0.94 | |
| 121_M | 148_Y | 1.039 | 0.94 | |
| 201_D | 204_P | 1.037 | 0.94 | |
| 336_I | 414_N | 1.036 | 0.94 | |
| 230_L | 244_I | 1.036 | 0.94 | |
| 107_Y | 153_L | 1.031 | 0.94 | |
| 377_R | 416_L | 1.028 | 0.94 | |
| 39_A | 78_E | 1.023 | 0.93 | |
| 325_F | 375_F | 1.021 | 0.93 | |
| 412_S | 435_A | 1.02 | 0.93 | |
| 120_V | 156_N | 1.019 | 0.93 | |
| 419_Q | 470_F | 1.018 | 0.93 | |
| 115_P | 142_F | 1.013 | 0.93 | |
| 339_A | 377_R | 1.012 | 0.93 | |
| 133_L | 193_Q | 1.01 | 0.93 | |
| 86_G | 247_I | 1.007 | 0.93 | |
| 229_T | 245_P | 1.007 | 0.93 | |
| 157_H | 160_L | 1.003 | 0.93 | |
| 370_T | 374_H | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 3ll3A | 2 | 0.9606 | 100 | 0.145 | Contact Map | 0.761 |
| 3hz6A | 1 | 0.9585 | 100 | 0.147 | Contact Map | 0.644 |
| 3ifrA | 2 | 0.9606 | 100 | 0.15 | Contact Map | 0.743 |
| 3jvpA | 4 | 0.9689 | 100 | 0.177 | Contact Map | 0.745 |
| 2itmA | 2 | 0.944 | 100 | 0.183 | Contact Map | 0.788 |
| 2w40A | 4 | 0.9585 | 100 | 0.193 | Contact Map | 0.761 |
| 2p3rA | 8 | 0.9564 | 100 | 0.197 | Contact Map | 0.867 |
| 2zf5O | 2 | 0.9461 | 100 | 0.201 | Contact Map | 0.847 |
| 3h3nX | 2 | 0.9544 | 100 | 0.203 | Contact Map | 0.818 |
| 4e1jA | 4 | 0.971 | 100 | 0.205 | Contact Map | 0.816 |
Sequence Conservation (Image Generated using WebLogo v3)