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OPENSEQ.org
MDTA - Multidrug resistance protein MdtA
UniProt: P76397 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG14056
Length: 415 (337)
Sequences: 5917
Seq/Len: 17.56
MDTA
Paralog alert: 0.71 [within 20: 0.08] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
100_A 117_E 3.29 1.00
353_T 366_A 3.253 1.00
131_Q 190_Q 3.169 1.00
127_L 186_V 3.13 1.00
110_K 203_D 3.102 1.00
145_R 149_A 3.028 1.00
342_N 348_S 2.995 1.00
350_H 372_D 2.901 1.00
114_L 197_R 2.864 1.00
138_K 183_E 2.662 1.00
274_G 294_A 2.612 1.00
66_T 373_R 2.529 1.00
200_A 228_I 2.505 1.00
152_Q 156_K 2.477 1.00
152_Q 169_Q 2.467 1.00
346_K 387_K 2.446 1.00
340_V 350_H 2.421 1.00
134_L 179_I 2.407 1.00
151_Y 160_V 2.331 1.00
120_P 124_K 2.201 1.00
69_E 370_A 2.178 1.00
82_I 236_L 2.176 1.00
337_F 349_K 2.169 1.00
93_R 195_W 2.147 1.00
110_K 113_D 2.109 1.00
155_A 165_L 2.106 1.00
117_E 197_R 2.097 1.00
352_V 364_I 2.07 1.00
355_G 365_R 2.066 1.00
83_T 237_V 2.05 1.00
67_A 371_G 2.017 1.00
187_A 190_Q 2.004 1.00
145_R 176_E 1.995 1.00
341_L 388_V 1.983 1.00
277_L 295_R 1.981 1.00
151_Y 168_Q 1.98 1.00
128_A 131_Q 1.971 1.00
98_L 211_V 1.941 1.00
348_S 384_E 1.927 1.00
102_H 114_L 1.917 1.00
102_H 117_E 1.916 1.00
111_A 203_D 1.914 1.00
206_V 226_V 1.908 1.00
347_V 375_V 1.859 1.00
134_L 186_V 1.855 1.00
162_R 166_D 1.845 1.00
180_K 183_E 1.844 1.00
124_K 128_A 1.825 1.00
148_L 165_L 1.804 1.00
172_V 176_E 1.754 1.00
141_L 172_V 1.746 1.00
338_V 352_V 1.741 1.00
114_L 199_T 1.738 1.00
183_E 187_A 1.724 1.00
353_T 365_R 1.712 1.00
324_I 374_V 1.695 1.00
238_F 294_A 1.694 1.00
69_E 320_N 1.692 1.00
323_V 361_K 1.69 1.00
173_S 176_E 1.674 1.00
135_A 138_K 1.672 1.00
136_K 178_T 1.67 1.00
169_Q 173_S 1.653 1.00
369_S 372_D 1.642 1.00
155_A 162_R 1.612 1.00
148_L 152_Q 1.583 1.00
67_A 322_V 1.582 1.00
340_V 372_D 1.576 1.00
326_T 362_V 1.572 1.00
108_Q 205_R 1.562 1.00
143_N 147_D 1.559 1.00
71_A 319_Q 1.556 1.00
355_G 363_V 1.553 1.00
64_A 341_L 1.545 1.00
342_N 346_K 1.545 1.00
61_P 389_E 1.539 1.00
259_V 273_E 1.53 1.00
235_D 293_K 1.513 1.00
124_K 193_L 1.513 1.00
98_L 116_A 1.505 1.00
145_R 172_V 1.479 1.00
86_N 230_Q 1.474 1.00
96_G 118_I 1.451 1.00
238_F 311_A 1.441 1.00
375_V 382_L 1.436 1.00
75_Y 312_R 1.431 1.00
129_Q 185_S 1.43 1.00
82_I 234_I 1.426 1.00
236_L 311_A 1.419 1.00
123_F 196_S 1.415 1.00
104_Q 107_Q 1.414 1.00
322_V 370_A 1.41 1.00
149_A 152_Q 1.408 1.00
354_P 362_V 1.404 0.99
70_Q 323_V 1.385 0.99
207_G 229_T 1.384 0.99
64_A 390_V 1.38 0.99
142_A 145_R 1.373 0.99
190_Q 194_D 1.372 0.99
70_Q 361_K 1.354 0.99
241_P 244_D 1.352 0.99
150_R 166_D 1.34 0.99
132_G 184_A 1.334 0.99
237_V 291_K 1.325 0.99
262_A 296_F 1.321 0.99
230_Q 233_P 1.31 0.99
335_G 351_L 1.299 0.99
64_A 373_R 1.297 0.99
138_K 142_A 1.294 0.99
77_T 312_R 1.293 0.99
261_E 312_R 1.293 0.99
200_A 203_D 1.291 0.99
257_P 275_T 1.276 0.99
364_I 368_I 1.274 0.99
257_P 273_E 1.271 0.99
87_T 227_V 1.268 0.99
101_L 213_V 1.254 0.99
152_Q 165_L 1.247 0.99
116_A 209_K 1.232 0.98
165_L 169_Q 1.228 0.98
186_V 190_Q 1.221 0.98
356_I 363_V 1.213 0.98
188_S 192_Q 1.205 0.98
99_I 120_P 1.204 0.98
164_E 167_A 1.203 0.98
148_L 172_V 1.199 0.98
77_T 310_N 1.194 0.98
137_D 175_T 1.181 0.98
127_L 193_L 1.173 0.98
261_E 273_E 1.173 0.98
137_D 182_D 1.169 0.97
318_E 363_V 1.165 0.97
278_S 293_K 1.164 0.97
141_L 145_R 1.16 0.97
147_D 167_A 1.154 0.97
276_L 292_V 1.151 0.97
131_Q 135_A 1.141 0.97
345_N 373_R 1.133 0.97
127_L 131_Q 1.131 0.97
71_A 320_N 1.128 0.97
236_L 309_V 1.126 0.97
171_L 175_T 1.123 0.97
86_N 213_V 1.122 0.97
92_S 198_I 1.121 0.97
126_A 129_Q 1.119 0.96
167_A 171_L 1.114 0.96
142_A 173_S 1.113 0.96
98_L 217_I 1.111 0.96
66_T 371_G 1.111 0.96
128_A 187_A 1.11 0.96
163_Q 167_A 1.109 0.96
114_L 117_E 1.103 0.96
108_Q 301_D 1.097 0.96
107_Q 113_D 1.096 0.96
130_A 182_D 1.095 0.96
252_Q 255_G 1.09 0.96
176_E 180_K 1.087 0.96
354_P 364_I 1.08 0.95
345_N 387_K 1.073 0.95
148_L 169_Q 1.07 0.95
99_I 119_D 1.067 0.95
283_I 290_I 1.066 0.95
147_D 151_Y 1.064 0.95
153_Q 157_T 1.062 0.95
100_A 213_V 1.048 0.94
324_I 338_V 1.045 0.94
95_D 219_S 1.036 0.94
127_L 190_Q 1.035 0.94
347_V 388_V 1.034 0.94
120_P 196_S 1.033 0.94
275_T 295_R 1.029 0.94
339_W 384_E 1.022 0.93
103_F 206_V 1.022 0.93
209_K 212_D 1.017 0.93
209_K 226_V 1.008 0.93
63_Q 377_D 1.008 0.93
332_G 349_K 1.003 0.93
103_F 226_V 1.002 0.92
141_L 179_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vf7A130.84581000.337Contact Map0.83
3lnnA20.83611000.352Contact Map0.71
4l8jA10.7591000.372Contact Map0.604
4dk0A10.79761000.373Contact Map0.603
3fppA20.77591000.377Contact Map0.748
3ne5B20.9061000.395Contact Map0.696
4kkuA40.70841000.447Contact Map0.772
2f1mA40.64341000.469Contact Map0.774
2k32A10.277199.90.751Contact Map0.601
2dneA10.245899.60.811Contact Map0.58
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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