| UniProt: | P46482 | Sequence |
Download Alignment We filter this alignment to remove sites that have > 75% gaps before running GREMLIN. |
| EcoGene: | EG12823 | ||
| Length: | 310 (287) | ||
| Sequences: | 5049 | ||
| Seq/Len: | 17.59 |
| AAEA
Paralog alert: 0.76 [within 20: 0.11] - ratio of genomes with paralogs Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH |
Legend: The darker and larger the blue dots, the higher coevolution strength.
Residue pairs sorted by coevolution strength:
| i | j | Scaled Score | Prob | |
| 70_K | 162_D | 4.549 | 1.00 | |
| 60_Q | 77_T | 4.362 | 1.00 | |
| 224_G | 265_I | 3.665 | 1.00 | |
| 91_Q | 149_K | 3.577 | 1.00 | |
| 87_L | 145_R | 3.512 | 1.00 | |
| 74_I | 156_V | 3.459 | 1.00 | |
| 70_K | 73_Q | 3.138 | 1.00 | |
| 227_D | 266_R | 3.046 | 1.00 | |
| 112_N | 128_N | 2.839 | 1.00 | |
| 80_Q | 84_Q | 2.637 | 1.00 | |
| 77_T | 156_V | 2.632 | 1.00 | |
| 98_Q | 142_Q | 2.624 | 1.00 | |
| 210_R | 223_K | 2.568 | 1.00 | |
| 225_T | 268_D | 2.565 | 1.00 | |
| 105_R | 135_L | 2.406 | 1.00 | |
| 212_E | 221_V | 2.399 | 1.00 | |
| 87_L | 149_K | 2.309 | 1.00 | |
| 115_G | 124_I | 2.306 | 1.00 | |
| 111_R | 119_M | 2.283 | 1.00 | |
| 210_R | 225_T | 2.279 | 1.00 | |
| 62_N | 77_T | 2.26 | 1.00 | |
| 205_V | 226_V | 2.255 | 1.00 | |
| 74_I | 158_R | 2.245 | 1.00 | |
| 225_T | 266_R | 2.196 | 1.00 | |
| 149_K | 153_E | 2.173 | 1.00 | |
| 205_V | 285_V | 2.118 | 1.00 | |
| 62_N | 74_I | 2.118 | 1.00 | |
| 111_R | 127_A | 2.106 | 1.00 | |
| 105_R | 109_G | 2.095 | 1.00 | |
| 159_A | 185_L | 2.068 | 1.00 | |
| 71_K | 162_D | 2.035 | 1.00 | |
| 84_Q | 152_L | 2.019 | 1.00 | |
| 67_Q | 73_Q | 2.01 | 1.00 | |
| 94_V | 145_R | 1.94 | 1.00 | |
| 88_E | 91_Q | 1.934 | 1.00 | |
| 193_V | 281_A | 1.869 | 1.00 | |
| 146_D | 149_K | 1.859 | 1.00 | |
| 53_D | 154_R | 1.825 | 1.00 | |
| 108_A | 131_L | 1.817 | 1.00 | |
| 211_A | 265_I | 1.805 | 1.00 | |
| 108_A | 112_N | 1.803 | 1.00 | |
| 84_Q | 88_E | 1.786 | 1.00 | |
| 91_Q | 145_R | 1.786 | 1.00 | |
| 163_G | 185_L | 1.778 | 1.00 | |
| 123_E | 126_Q | 1.774 | 1.00 | |
| 76_F | 157_I | 1.764 | 1.00 | |
| 68_L | 188_Q | 1.752 | 1.00 | |
| 139_A | 142_Q | 1.75 | 1.00 | |
| 131_L | 135_L | 1.736 | 1.00 | |
| 87_L | 91_Q | 1.714 | 1.00 | |
| 223_K | 268_D | 1.714 | 1.00 | |
| 128_N | 132_Q | 1.714 | 1.00 | |
| 105_R | 131_L | 1.711 | 1.00 | |
| 212_E | 223_K | 1.687 | 1.00 | |
| 83_Y | 155_T | 1.686 | 1.00 | |
| 94_V | 138_L | 1.624 | 1.00 | |
| 64_H | 67_Q | 1.618 | 1.00 | |
| 108_A | 128_N | 1.611 | 1.00 | |
| 197_M | 205_V | 1.594 | 1.00 | |
| 89_E | 144_T | 1.58 | 1.00 | |
| 68_L | 164_W | 1.577 | 1.00 | |
| 115_G | 121_R | 1.544 | 1.00 | |
| 132_Q | 135_L | 1.536 | 1.00 | |
| 75_L | 183_V | 1.525 | 1.00 | |
| 108_A | 124_I | 1.525 | 1.00 | |
| 215_P | 281_A | 1.518 | 1.00 | |
| 197_M | 285_V | 1.517 | 1.00 | |
| 177_T | 180_S | 1.503 | 1.00 | |
| 109_G | 112_N | 1.494 | 1.00 | |
| 147_L | 151_D | 1.465 | 1.00 | |
| 121_R | 125_D | 1.434 | 1.00 | |
| 87_L | 152_L | 1.414 | 1.00 | |
| 94_V | 98_Q | 1.414 | 1.00 | |
| 103_E | 107_E | 1.393 | 0.99 | |
| 150_L | 154_R | 1.393 | 0.99 | |
| 56_G | 78_I | 1.391 | 0.99 | |
| 198_E | 201_K | 1.382 | 0.99 | |
| 44_S | 194_L | 1.367 | 0.99 | |
| 226_V | 263_V | 1.36 | 0.99 | |
| 261_V | 279_T | 1.352 | 0.99 | |
| 214_T | 284_V | 1.351 | 0.99 | |
| 102_Q | 105_R | 1.327 | 0.99 | |
| 124_I | 128_N | 1.319 | 0.99 | |
| 86_A | 147_L | 1.31 | 0.99 | |
| 86_A | 151_D | 1.307 | 0.99 | |
| 213_I | 281_A | 1.304 | 0.99 | |
| 95_A | 98_Q | 1.302 | 0.99 | |
| 90_A | 141_A | 1.295 | 0.99 | |
| 107_E | 126_Q | 1.295 | 0.99 | |
| 194_L | 264_R | 1.295 | 0.99 | |
| 60_Q | 172_T | 1.286 | 0.99 | |
| 195_A | 283_V | 1.279 | 0.99 | |
| 110_R | 125_D | 1.274 | 0.99 | |
| 69_V | 75_L | 1.271 | 0.99 | |
| 59_T | 77_T | 1.259 | 0.99 | |
| 87_L | 148_A | 1.246 | 0.98 | |
| 111_R | 122_E | 1.241 | 0.98 | |
| 165_V | 183_V | 1.227 | 0.98 | |
| 61_V | 172_T | 1.212 | 0.98 | |
| 101_A | 131_L | 1.189 | 0.98 | |
| 145_R | 149_K | 1.189 | 0.98 | |
| 88_E | 146_D | 1.184 | 0.98 | |
| 76_F | 182_A | 1.18 | 0.98 | |
| 228_S | 264_R | 1.179 | 0.98 | |
| 106_Q | 125_D | 1.177 | 0.98 | |
| 212_E | 286_T | 1.175 | 0.98 | |
| 59_T | 79_D | 1.173 | 0.98 | |
| 211_A | 224_G | 1.173 | 0.98 | |
| 94_V | 142_Q | 1.171 | 0.98 | |
| 43_F | 193_V | 1.167 | 0.97 | |
| 195_A | 265_I | 1.165 | 0.97 | |
| 58_I | 170_V | 1.159 | 0.97 | |
| 142_Q | 146_D | 1.153 | 0.97 | |
| 58_I | 76_F | 1.15 | 0.97 | |
| 112_N | 124_I | 1.143 | 0.97 | |
| 53_D | 57_L | 1.137 | 0.97 | |
| 153_E | 158_R | 1.123 | 0.97 | |
| 66_N | 228_S | 1.119 | 0.96 | |
| 93_D | 97_Y | 1.113 | 0.96 | |
| 176_I | 182_A | 1.113 | 0.96 | |
| 197_M | 263_V | 1.105 | 0.96 | |
| 50_I | 183_V | 1.102 | 0.96 | |
| 213_I | 267_L | 1.1 | 0.96 | |
| 52_P | 176_I | 1.1 | 0.96 | |
| 159_A | 162_D | 1.095 | 0.96 | |
| 25_I | 29_W | 1.088 | 0.96 | |
| 109_G | 113_R | 1.059 | 0.95 | |
| 26_F | 30_V | 1.055 | 0.95 | |
| 92_A | 143_A | 1.052 | 0.95 | |
| 47_V | 184_A | 1.048 | 0.94 | |
| 214_T | 221_V | 1.045 | 0.94 | |
| 59_T | 62_N | 1.037 | 0.94 | |
| 86_A | 148_A | 1.033 | 0.94 | |
| 41_A | 45_A | 1.031 | 0.94 | |
| 102_Q | 106_Q | 1.016 | 0.93 | |
| 74_I | 77_T | 1.01 | 0.93 | |
| 213_I | 283_V | 1.008 | 0.93 | |
| 90_A | 93_D | 1.006 | 0.93 | |
| 48_V | 161_A | 1 | 0.92 |
- Text file of predictions (all 3L/2 predictions)
- Generate restraints for ROSETTA Structure Modeling
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
| PDB | Chains | Cov | P(%) | HHΔ | Acc | |
| 2f1mA | 4 | 0.8355 | 100 | 0.392 | Contact Map | 0.728 |
| 3lnnA | 2 | 0.9032 | 100 | 0.431 | Contact Map | 0.697 |
| 4dk0A | 1 | 0.9323 | 100 | 0.434 | Contact Map | 0.617 |
| 3fppA | 2 | 0.871 | 100 | 0.438 | Contact Map | 0.744 |
| 1vf7A | 13 | 0.8613 | 100 | 0.47 | Contact Map | 0.772 |
| 4l8jA | 1 | 0.8355 | 100 | 0.472 | Contact Map | 0.751 |
| 3ne5B | 2 | 0.8355 | 100 | 0.499 | Contact Map | 0.732 |
| 4kkuA | 4 | 0.6419 | 100 | 0.582 | Contact Map | 0.781 |
| 2k32A | 1 | 0.3677 | 99.8 | 0.674 | Contact Map | 0.638 |
| 2dneA | 1 | 0.3258 | 99.6 | 0.747 | Contact Map | 0.649 |
Sequence Conservation (Image Generated using WebLogo v3)