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OPENSEQ.org
MDTE - Multidrug resistance protein MdtE
UniProt: P37636 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG12240
Length: 385 (353)
Sequences: 9913
Seq/Len: 28.08
MDTE
Paralog alert: 0.77 [within 20: 0.16] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
74_K 91_Q 3.297 1.00
334_E 347_S 3.133 1.00
323_D 329_Q 3.105 1.00
88_S 171_N 3.079 1.00
84_N 177_T 3.064 1.00
119_R 123_N 2.949 1.00
331_R 353_D 2.902 1.00
105_K 164_T 2.71 1.00
254_G 274_A 2.685 1.00
40_T 354_R 2.639 1.00
318_T 330_L 2.456 1.00
126_A 130_K 2.428 1.00
101_L 160_V 2.402 1.00
43_P 351_A 2.394 1.00
57_V 211_D 2.392 1.00
126_A 143_R 2.356 1.00
112_L 157_K 2.292 1.00
125_Q 134_V 2.291 1.00
321_I 331_R 2.27 1.00
143_R 147_N 2.235 1.00
67_Q 169_Y 2.202 1.00
257_K 275_I 2.2 1.00
56_T 210_V 2.19 1.00
91_Q 171_N 2.17 1.00
306_Q 343_W 2.165 1.00
84_N 87_D 2.14 1.00
94_P 98_Q 2.111 1.00
76_N 91_Q 2.105 1.00
125_Q 142_A 2.045 1.00
327_V 368_K 2.041 1.00
129_L 139_Y 2.034 1.00
303_L 342_Q 2.034 1.00
76_N 88_S 2.004 1.00
88_S 173_T 1.99 1.00
136_R 140_D 1.983 1.00
119_R 150_E 1.977 1.00
239_P 253_T 1.97 1.00
212_L 291_A 1.959 1.00
41_L 352_G 1.949 1.00
174_S 202_V 1.931 1.00
44_G 342_Q 1.895 1.00
43_P 300_N 1.893 1.00
336_S 346_T 1.889 1.00
350_Q 353_D 1.888 1.00
72_I 185_V 1.881 1.00
322_L 369_A 1.835 1.00
336_S 344_V 1.828 1.00
212_L 274_A 1.813 1.00
181_G 203_Q 1.81 1.00
85_Q 177_T 1.81 1.00
44_G 303_L 1.807 1.00
154_T 157_K 1.806 1.00
115_A 146_L 1.8 1.00
122_F 139_Y 1.799 1.00
117_N 121_T 1.795 1.00
108_L 153_V 1.793 1.00
82_K 179_V 1.787 1.00
328_V 356_I 1.787 1.00
333_I 345_V 1.76 1.00
146_L 150_E 1.747 1.00
102_N 105_K 1.74 1.00
329_Q 365_P 1.736 1.00
334_E 346_T 1.729 1.00
122_F 126_A 1.7 1.00
129_L 136_R 1.682 1.00
209_Y 273_R 1.674 1.00
161_E 164_T 1.671 1.00
110_K 152_N 1.646 1.00
335_A 343_W 1.639 1.00
321_I 353_D 1.634 1.00
98_Q 102_N 1.628 1.00
108_L 160_V 1.602 1.00
72_I 90_Y 1.6 1.00
45_S 299_Q 1.579 1.00
319_A 333_I 1.579 1.00
119_R 146_L 1.577 1.00
41_L 302_L 1.565 1.00
109_A 112_L 1.555 1.00
122_F 146_L 1.548 1.00
70_G 92_I 1.533 1.00
138_D 141_T 1.527 1.00
112_L 116_S 1.498 1.00
304_V 355_V 1.496 1.00
337_K 344_V 1.495 1.00
49_L 292_L 1.495 1.00
147_N 150_E 1.489 1.00
204_R 207_P 1.484 1.00
56_T 208_I 1.467 1.00
298_R 344_V 1.461 1.00
157_K 161_E 1.459 1.00
38_V 322_L 1.446 1.00
211_D 271_T 1.436 1.00
123_N 126_A 1.434 1.00
180_S 200_V 1.428 1.00
115_A 119_R 1.413 1.00
78_I 81_D 1.409 1.00
241_Q 292_L 1.407 0.99
60_E 204_R 1.405 0.99
215_S 218_D 1.392 0.99
98_Q 167_L 1.392 0.99
210_V 291_A 1.357 0.99
51_E 290_T 1.351 0.99
18_L 21_C 1.347 0.99
97_L 170_A 1.345 0.99
89_L 200_V 1.337 0.99
141_T 145_Q 1.327 0.99
302_L 351_A 1.322 0.99
237_S 255_T 1.318 0.99
38_V 371_A 1.31 0.99
74_K 187_V 1.299 0.99
35_E 370_R 1.298 0.99
306_Q 341_D 1.297 0.99
316_K 332_E 1.291 0.99
116_S 119_R 1.29 0.99
210_V 289_V 1.288 0.99
248_K 282_D 1.287 0.99
38_V 354_R 1.271 0.99
39_V 357_V 1.266 0.99
51_E 292_L 1.264 0.99
116_S 147_N 1.244 0.98
75_R 187_V 1.244 0.98
61_V 201_T 1.233 0.98
63_E 198_S 1.225 0.98
139_Y 143_R 1.218 0.98
255_T 275_I 1.218 0.98
103_S 159_A 1.213 0.98
356_I 363_I 1.213 0.98
101_L 105_K 1.208 0.98
124_R 140_D 1.197 0.98
256_L 272_L 1.191 0.98
150_E 154_T 1.187 0.98
323_D 327_V 1.181 0.98
258_F 273_R 1.173 0.98
174_S 177_T 1.173 0.98
213_T 271_T 1.172 0.98
237_S 253_T 1.171 0.98
45_S 300_N 1.169 0.97
108_L 112_L 1.168 0.97
73_I 93_D 1.148 0.97
345_V 349_L 1.146 0.97
105_K 109_A 1.144 0.97
40_T 352_G 1.142 0.97
183_S 186_T 1.142 0.97
242_L 276_F 1.14 0.97
106_G 158_A 1.137 0.97
77_F 87_D 1.132 0.97
69_G 193_A 1.131 0.97
304_V 319_A 1.131 0.97
278_N 281_G 1.127 0.97
126_A 139_Y 1.12 0.96
81_D 87_D 1.117 0.96
301_V 344_V 1.116 0.96
137_Q 141_T 1.116 0.96
127_S 131_T 1.115 0.96
264_D 267_T 1.112 0.96
263_V 270_V 1.108 0.96
88_S 91_Q 1.107 0.96
160_V 164_T 1.105 0.96
82_K 281_G 1.099 0.96
90_Y 200_V 1.094 0.96
122_F 143_R 1.084 0.96
79_E 182_K 1.082 0.96
121_T 125_Q 1.079 0.95
219_F 270_V 1.072 0.95
111_A 149_A 1.069 0.95
176_I 202_V 1.068 0.95
211_D 273_R 1.064 0.95
118_A 149_A 1.06 0.95
101_L 167_L 1.059 0.95
162_Q 166_N 1.057 0.95
77_F 183_S 1.055 0.95
121_T 141_T 1.05 0.94
73_I 94_P 1.045 0.94
104_A 156_A 1.043 0.94
100_E 103_S 1.041 0.94
55_R 268_G 1.04 0.94
309_V 343_W 1.039 0.94
90_Y 172_V 1.033 0.94
115_A 153_V 1.033 0.94
164_T 168_Q 1.027 0.94
66_P 172_V 1.024 0.93
207_P 277_P 1.023 0.93
108_L 157_K 1.021 0.93
116_S 120_I 1.012 0.93
306_Q 338_A 1.011 0.93
100_E 166_N 1.006 0.93
209_Y 275_I 1.004 0.93
207_P 275_I 1.003 0.93
67_Q 71_I 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
1vf7A130.91691000.311Contact Map0.84
3lnnA20.89611000.338Contact Map0.757
3fppA20.8391000.357Contact Map0.769
4l8jA10.82081000.358Contact Map0.616
4dk0A10.85451000.361Contact Map0.611
3ne5B20.89871000.379Contact Map0.764
4kkuA40.74031000.403Contact Map0.776
2f1mA40.71171000.455Contact Map0.768
2k32A10.298799.90.734Contact Map0.598
2dneA10.264999.60.798Contact Map0.6
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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