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OPENSEQ.org
MDTN - Multidrug resistance protein MdtN
UniProt: P32716 Sequence
 Download Alignment
We filter this alignment to remove sites that have > 75% gaps before running GREMLIN.
EcoGene: EG11954
Length: 343 (319)
Sequences: 6130
Seq/Len: 19.22
MDTN
Paralog alert: 0.81 [within 20: 0.13] - ratio of genomes with paralogs
Cluster includes: AAEA ACRA ACRE EMRA EMRK MACA MDTA MDTE MDTN YBHG YDHJ YHII YIAV YIBH
GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Scaled Score Prob
71_K 216_D 4.139 1.00
61_E 78_R 3.887 1.00
279_G 320_I 3.434 1.00
75_L 210_T 3.35 1.00
88_L 199_I 3.022 1.00
92_E 203_K 2.986 1.00
141_E 158_R 2.934 1.00
282_D 321_M 2.692 1.00
71_K 74_D 2.691 1.00
264_P 278_E 2.598 1.00
99_D 196_E 2.576 1.00
141_E 145_K 2.505 1.00
81_P 85_E 2.412 1.00
134_T 138_R 2.403 1.00
78_R 210_T 2.396 1.00
140_T 149_V 2.364 1.00
134_T 165_E 2.328 1.00
127_R 172_L 2.311 1.00
95_L 192_R 2.301 1.00
63_A 78_R 2.254 1.00
280_K 323_D 2.247 1.00
75_L 212_R 2.243 1.00
280_K 321_M 2.231 1.00
123_V 168_L 2.223 1.00
264_P 280_K 2.214 1.00
140_T 157_A 2.128 1.00
144_L 154_V 2.091 1.00
130_A 161_Q 2.044 1.00
72_Q 216_D 1.993 1.00
158_R 162_R 1.95 1.00
120_N 179_A 1.932 1.00
153_D 156_R 1.927 1.00
54_E 208_M 1.923 1.00
193_A 196_E 1.897 1.00
137_L 141_E 1.882 1.00
63_A 75_L 1.868 1.00
203_K 207_E 1.856 1.00
259_I 340_L 1.825 1.00
137_L 161_Q 1.812 1.00
68_Q 74_D 1.812 1.00
259_I 281_V 1.809 1.00
88_L 203_K 1.801 1.00
213_A 239_L 1.795 1.00
85_E 206_L 1.78 1.00
92_E 199_I 1.75 1.00
95_L 199_I 1.743 1.00
84_Y 209_A 1.739 1.00
124_E 127_R 1.719 1.00
69_A 218_R 1.714 1.00
130_A 134_T 1.711 1.00
251_F 259_I 1.708 1.00
117_D 120_N 1.702 1.00
106_Q 189_V 1.684 1.00
266_T 276_T 1.683 1.00
161_Q 165_E 1.681 1.00
266_T 278_E 1.67 1.00
134_T 161_Q 1.667 1.00
137_L 154_V 1.663 1.00
89_A 92_E 1.66 1.00
217_G 239_L 1.629 1.00
137_L 158_R 1.626 1.00
144_L 151_A 1.624 1.00
265_A 320_I 1.618 1.00
169_N 172_L 1.583 1.00
88_L 92_E 1.575 1.00
123_V 175_A 1.566 1.00
127_R 131_K 1.565 1.00
200_A 203_K 1.538 1.00
85_E 89_A 1.536 1.00
88_L 206_L 1.535 1.00
165_E 169_N 1.534 1.00
278_E 323_D 1.513 1.00
69_A 242_T 1.498 1.00
127_R 168_L 1.494 1.00
247_V 336_A 1.472 1.00
76_L 237_F 1.456 1.00
246_Y 319_K 1.455 1.00
281_V 318_V 1.44 1.00
65_T 68_Q 1.435 1.00
154_V 158_R 1.432 1.00
132_Q 136_T 1.429 1.00
162_R 165_E 1.422 1.00
151_A 155_D 1.421 1.00
90_K 198_D 1.419 1.00
61_E 226_V 1.417 1.00
249_A 338_A 1.414 1.00
231_S 234_R 1.411 1.00
123_V 172_L 1.4 0.99
283_S 319_K 1.399 0.99
44_A 247_V 1.386 0.99
316_F 334_A 1.371 0.99
95_L 196_E 1.363 0.99
138_R 141_E 1.344 0.99
249_A 320_I 1.337 0.99
57_G 79_I 1.336 0.99
130_A 165_E 1.334 0.99
59_I 77_F 1.333 0.99
60_V 78_R 1.331 0.99
102_I 189_V 1.33 0.99
62_L 226_V 1.328 0.99
252_R 255_D 1.314 0.99
95_L 99_D 1.304 0.99
102_I 192_R 1.301 0.99
131_K 135_D 1.3 0.99
77_F 211_V 1.3 0.99
45_S 248_I 1.294 0.99
269_L 336_A 1.285 0.99
204_L 208_M 1.281 0.99
87_N 201_L 1.279 0.99
94_S 191_Q 1.256 0.99
60_V 80_D 1.253 0.99
251_F 340_L 1.25 0.99
96_A 99_D 1.249 0.99
123_V 127_R 1.246 0.98
201_L 205_H 1.236 0.98
112_Q 115_G 1.22 0.98
87_N 205_H 1.217 0.98
136_T 156_R 1.211 0.98
230_A 236_I 1.211 0.98
213_A 216_D 1.209 0.98
266_T 341_E 1.199 0.98
248_I 317_P 1.196 0.98
120_N 175_A 1.188 0.98
89_A 200_A 1.179 0.98
99_D 192_R 1.179 0.98
59_I 224_T 1.165 0.97
131_K 134_T 1.153 0.97
219_V 237_F 1.145 0.97
168_L 172_L 1.137 0.97
139_R 155_D 1.135 0.97
267_I 336_A 1.133 0.97
156_R 160_A 1.128 0.97
70_V 76_L 1.12 0.96
267_I 322_V 1.119 0.96
176_Q 179_A 1.118 0.96
265_A 279_G 1.117 0.96
141_E 154_V 1.115 0.96
130_A 168_L 1.103 0.96
75_L 78_R 1.103 0.96
103_M 106_Q 1.103 0.96
251_F 318_V 1.101 0.96
81_P 209_A 1.095 0.96
91_A 195_V 1.089 0.96
94_S 194_A 1.087 0.96
155_D 158_R 1.087 0.96
160_A 163_A 1.084 0.96
138_R 142_P 1.083 0.96
196_E 200_A 1.082 0.96
49_I 215_F 1.078 0.95
135_D 155_D 1.076 0.95
186_D 189_V 1.065 0.95
248_I 319_K 1.06 0.95
220_I 240_I 1.057 0.95
93_A 197_A 1.051 0.94
106_Q 185_V 1.049 0.94
244_H 321_M 1.047 0.94
116_A 175_A 1.037 0.94
199_I 203_K 1.032 0.94
268_R 339_N 1.027 0.94
116_A 179_A 1.027 0.94
87_N 90_K 1.023 0.93
54_E 58_R 1.017 0.93
126_A 171_V 1.01 0.93
104_L 184_G 1.001 0.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Scaled Score = (raw_score/average(raw_scores)) > 1 are listed. For all 3L/2 predictions, click on one of the links below.
HHsearch Results: GREMLIN results overlayed on top 10 PDB hits:
Legend: Blue filled circles are GREMLIN results (Scaled_score >1). The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on 10 HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov P(%) HHΔ   Acc
3fppA20.77841000.416Contact Map0.76
4dk0A10.8281000.42Contact Map0.644
2f1mA40.70551000.44Contact Map0.734
3lnnA20.7931000.466Contact Map0.733
1vf7A130.72591000.481Contact Map0.776
4l8jA10.69971000.495Contact Map0.769
3ne5B20.69971000.511Contact Map0.771
4kkuA40.56851000.583Contact Map0.795
2k32A10.335399.80.689Contact Map0.654
2dneA10.294599.60.761Contact Map0.696
Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.
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